10 research outputs found
Downstream valley hazard classification of itabira municipality dams
No full textThe potential for dam failures and public pressure for a safer environment make the development of risk evaluation instruments mandatory in contemporary society. In Brazil, Law 12.334 of September 20, 2010 is the new keystone legislation in the field of dam safety. It establishes the national dam safety policy and defines the main instruments for the national dam safety policy, including a system for the classification of dams according to risk and downstream hazard.
This paper presents the downstream valley hazard classification of five dams located in Itabiruçu Municipality, in the context of the new Brazilian dam safety law.01-10ppDHA/NR
Herverkaveling in de stadsrandzone
No full textWat zijn de mogelijkheden om herverkaveling, volgens de landinrichtingswetgeving, in te zetten in de stadsrand, om de daar aanwezige problemen op te lossen of tegen te gaan? De stadsrand is een aantrekkelijke vestigingsplaats voor bedrijvigheid, wat leidt tot verrommeling. Kan deze bedrijvigheid, evenals andere functies geclusterd worden om negatieve effecten zoals geluidsoverlast, verkeersoverlast en vosile verstoring te voorkomen? Deze mogelijkheden zijn er niet of zeer beperkt op basis van de huidige landinrichtingswetgeving. Er bestaat ook geen draagvlak om de problemen met herverkaveling op te lossen en er zijn geen aanwijzingen dat dit in de toekomst zal veranderen. Er bestaan andere, minder complexe en minder ingrijpende instrumenten die beter passen bij de problemen in de stadsrand.GeomaticsCivil Engineering and Geoscience
Capability Maturity Model of Corporate Social responsibility
No full textThe development of a CSR capability maturity model to assess an organization's CSR performance, based on the actions and expectations that are given by the ISO26000 guideline. The research includes a study to view CSR as an organizational innovation, which has been established theoretically and validated through interviews. The development of the CSR capability maturity model first starts with the development of a CSR maturity model. The maturity model has been validated through a session of interviews and a questionnaire. A qualitative study categorizes all CSR actions and expectations from the ISO26000 guideline into the maturity model, transforming the maturity model into the CSR capability maturity model. The CSR capability maturity model has then been tested in a case study research on one organization.Management of TechnologyPhilosophyTechnology, Policy and Managemen
Hedging with Stochastic and Local Volatility
No full textWe derive the local volatility hedge ratios that are consistent with a stochastic instantaneous volatility and show that this ‘stochastic local volatility’ model is equivalent to the market model for implied volatilities. We also show that a common feature of all Markovian single factor stochastic volatility models, (log)normal mixture option pricing models and ‘sticky delta’ models is that they predict incorrect dynamics for implied volatility. As a result they over-hedge the Black-Scholes model in the presence of a market skew and this explains the poor delta hedging performance of these models reported in the literature. Whilst the traditional ‘sticky tree’ local volatility models do not possess this unfortunate property, they cannot be used for pricing without exogenous and ad hoc smoothing of results. However the stochastic local volatility framework allows one to extend a good pricing model into a good hedging model. The theoretical results are supported by an empirical analysis of the hedging performance of seven models, each with different volatility characteristics, on the SP500 index skew.Local volatility, stochastic volatility, implied volatility, hedging, dynamic delta hedging, volatility dymamics
SRSF6 modulates histone-chaperone HIRA splicing to orchestrate AR and E2F activity in prostate cancer
No full textDespite novel therapeutic strategies, advanced-stage prostate cancer (PCa) remains highly lethal, pointing out the urgent need for effective therapeutic strategies. While dysregulation of the splicing process is considered a cancer hallmark, the role of certain splicing factors remains unknown in PCa. This study focuses on characterizing the levels and role of SRSF6 in this disease. Comprehensive analyses of SRSF6 alterations (copy number/mRNA/ protein) were conducted across eight well-characterized PCa cohorts and the Hi-MYC transgenic model. SRSF6 was up-regulated in PCa samples, correlating with adverse clinical parameters. Functional assays, both in vitro (cell proliferation, migration, colony, and tumorsphere formation) and in vivo (xenograft tumors), demonstrated the impact of SRSF6 modulation on critical cancer hallmarks. Mechanistically, SRSF6 regulates the splicing pattern of the histone-chaperone HIRA, consequently affecting the activity of H3.3 in PCa and breast cancer cell models and disrupting pivotal oncogenic pathways (AR and E2F) in PCa cells. These findings underscore SRSF6 as a promising therapeutic target for PCa/advanced-stage PCa.We deeply thank all the patients and the patients\u2019 families for donating the samples and clinical data for research purposes. Special thanks to the staff of Biobank of the iMiBic and the experimental animal service (SAe) of the UcO/iMiBic. Funding: this work was supported by the Spanish Ministry of Science, innovation, and Universities, grants Pid2022-1381850B-i00 (R.M.l.), Pid2019-105564RB-i00 (R.M.l.), FPU16/05059 (A.c.F.-F), FPU17/00263 (P.S.-M.), FPU18/02485 (A.J.M.-H.), FPU18/06009 (J.M.P.-G.), FPU18/02275 (R.B.-e.), and PRe2020-094225 (F.P.-P.); instituto de Salud carlos iii, co-funded by european Union (eRdF/ eSF, \u201Cinvesting in your future\u201D grant dtS20/00050 (R.M.l.); Junta de Andalucia BiO-0139 (R.M.l.); Junta de Andalucia grant Pi-0094-2020 (A.S.-c.); Prostate cancer UK travelling Prize Fellowship (J.M.J.-v.); Wellcome trust clinical Research career development Fellowship (A.S.); and ciBeRobn (ciBeR is an initiative of instituto de Salud carlos iii, Ministerio de Sanidad, Servicios Sociales e igualdad, Spain) Acknowledgments: We deeply thank all the patients and the patients\u2019families for donating the samples and clinical data for research purposes. Special thanks to the staff of Biobank of the iMiBic and the experimental animal service (SAe) of the UcO/iMiBic. Funding: this work was supported by the Spanish Ministry of Science, innovation, and Universities, grants Pid2022-1381850B-i00 (R.M.l.), Pid2019-105564RB-i00 (R.M.l.), FPU16/05059 (A.c.F.-F), FPU17/00263 (P.S.-M.), FPU18/02485 (A.J.M.-H.), FPU18/06009 (J.M.P.-G.), FPU18/02275 (R.B.-e.), and PRe2020-094225 (F.P.-P.); instituto de Salud carlos iii, co-funded by european Union (eRdF/ eSF, \u201Cinvesting in your future\u201Dgrant dtS20/00050 (R.M.l.); Junta de Andalucia BiO-0139 (R.M.l.); Junta de Andalucia grant Pi-0094-2020 (A.S.-c.); Prostate cancer UK travelling Prize Fellowship (J.M.J.-v.); Wellcome trust clinical Research career development Fellowship (A.S.); and ciBeRobn (ciBeR is an initiative of instituto de Salud carlos iii, Ministerio de Sanidad, Servicios Sociales e igualdad, Spain). Author contributions: conceptualization: A.J.M.-H., J.M.J.-v., P.S.-M., A.c.F.-F., J.c.-v., A.J.M.-F., J.P.c., M.d.-G., and R.M.l. data curation: A.J.M.-H., J.M.J.-v., A.J.M.-F., and R.M.l. Formal analysis: A.J.M.-H., J.M.J.-v., P.S.-M., J.M.P.-G., R.B.-e., A.S.-c., A.J.M.-F., d.O., and R.M.l. Funding acquisition: J.P.c. and R.M.l. investigation: A.J.M.-H., J.M.J.-v., e.G.-G., F.P.-P., P.S.-M., J.M.P.-G., A.c.F.-F., R.B.-e., e.c., P.J.l.-S., A.S.-c., A.J.M.-F., and R.M.l. Methodology: A.J.M.-H., J.M.J.-v., P.S.-M., A.c.F.-F., J.c.-v., A.J.M.-F., J.P.c., d.O., M.d.-G., and R.M.l. Project administration: J.M.J.-v., A.J.M.-F., d.O., M.d.-G., and R.M.l. Resources: A.J.M.-H., F.P.-P., J.M.P.-G., R.S.-S., t.G.-S., e.c., J.c.-v., A.J.M.-F., J.P.c., d.O., and R.M.l. Software: J.M.J.-v., R.B.e., J.c.-v., and A.J.M.-F. Supervision: J.M.J.-v., A.J.M.-F., A.S., M.d.-G., and R.M.l. validation: A.J.M.-H., J.M.J.-v., P.S.-M., e.c., J.c.-v., A.J.M.-F., d.O., and R.M.l. visualization: A.J.M.-H., J.M.J.-v., e.G.-G., R.B.-e., e.c., A.J.M.-F., and R.M.l. Writing\u2014original draft: A.J.M.-H., J.M.J.-v., A.J.M.-F., e.e., and R.M.l. Writing\u2014review and editing: A.J.M.-H., J.M.J.-v., P.S.-M., A.c.F.-F., R.B.-e., e.c., A.J.M.-F., e.e., J.P.c., A.S., and R.M.l. Competing interests: A.S. is an employee of the icR, which has a commercial interest in abiraterone, poly(adenosine 5\u2032-diphosphate\u2013ribose) polymerase inhibition in dnA repair defective cancers, and phosphatidylinositol 3-kinase/Akt pathway inhibitors (no personal income). A.S. has received travel support from Sanofi, Roche-Genentech, and nurix and speaker honoraria from Astellas Pharma and Merck Sharp & dohme. He has served as an advisor to de Shaw Research, cHARM therapeutics, ellipses Pharma, and droia ventures. A.S. has been the ci/Pi of industry-sponsored clinical trials. the other authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.Peer-reviewe
"Rotterdam econometrics": publications of the econometric institute 1956-2005
No full textThis paper contains a list of all publications over the period 1956-2005, as reported in the Rotterdam Econometric Institute Reprint series during 1957-2005.
Corrigendum: Environmental distribution of Cryptococcus neoformans and C. gattii around the Mediterranean basin [FEMS, (2016), 16, 4] doi: http://dx.doi.org/10.1093/femsyr/fow045
No full textThe original article published in FEMS Yeast Research Vol. 16. Iss. 4; doi: http://dx.doi.org/10.1093/femsyr/fow045 This paper has been updated to correct a spelling error concerning an author name. It previously showed as Giuseppe Griseo, however the correct spelling is Giuseppe Criseo. © FEMS 2016. All rights reserved
Corrigendum: Environmental distribution of Cryptococcus neoformans and C. gattii around the Mediterranean basin [FEMS, (2016), 16, 4] doi: http://dx.doi.org/10.1093/femsyr/fow045
No full textThe original article published in FEMS Yeast Research Vol. 16. Iss. 4; doi: http://dx.doi.org/10.1093/femsyr/fow045 This paper has been updated to correct a spelling error concerning an author name. It previously showed as Giuseppe Griseo, however the correct spelling is Giuseppe Criseo. © FEMS 2016. All rights reserved
Prevalência de fatores de risco cardiovasculares em adolescentes e associação da lipemia sérica com a variabilidade nos polimorfismos dos genes APOA5 e APOB, composição corporal e aptidão cardiorrespiratória em adolescentes e pais
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2011Objetivo: Verificar a prevalência de fatores de risco cardiovasculares em adolescentes e analisar a associação da lipemia sérica, variabilidade alélica dos polimorfismos rs662799 do gene APOA5 e rs693 do gene APOB, gordura corporal e aptidão cardiorrespiratória em adolescentes e seus pais com ancestralidade européia. Métodos: Estudo transversal conduzido em adolescentes (11-17 anos) e seus respectivos pais do município de Saudades-SC. Participaram das análises descritivas e de prevalência, 274 adolescentes. Para a descrição das análises do polimorfismo -1131T>C do gene APOA5 foram analisados 173 adolescentes (78 pais e 95 mães); e, para a análise do polimorfismo XbaI do gene APOB, 213 adolescentes (121 pais e 158 mães). As variáveis investigadas foram: demográficas (sexo, idade e área de domicílio), maturação sexual, antropométricas (massa corporal, estatura, perímetro do abdôme, gordura corporal relativa), bioquímicas (colesterol total, HDL-c, LDL-c e triglicerídeos), genéticas [polimorfismos rs662799 do gene APOA5 (-1131T>C) e rs693 do gene APOB (XbaI)] e aptidão cardiorrespiratória. Resultados: Verificou-se que 12,3%, 42,9% e 59,8% dos adolescentes tinham excesso de peso, obesidade abdominal e gordura corporal alta, respectivamente. Ademais, 46% apresentaram níveis reduzidos de HDL-c, 41,9% hipercolesterolemia, 18,0% níveis elevados de LDL-c e 13,6% hipertrigliceridemia. Adolescentes com excesso de peso corporal apresentaram mais chance de terem níveis reduzidos de HDL-c. Nenhuma diferença foi verificada nos valores médios da lipemia sérica entre as variantes alélicas do polimorfismo -1131T>C do gene APOA5 e XbaI do gene APOB. Em relação às diferenças entre os sexos, observou-se que as moças portadoras do genótipo TT do polimorfismo -1131T>C do gene APOA5 apresentaram médias mais altas de colesterol total, LDL-c e triglicerídeos quando comparadas aos rapazes. Além disso, observou-se que aquelas portadoras do genótipo TC+CC apresentaram médias mais elevadas de triglicerídeos que os rapazes. A partir das análises de associação, filhos de pais com gordura corporal elevada tinham quase quatro vezes mais chance de apresentarem níveis reduzidos de HDL-c (pC do gene APOA5 e XbaI do gene APOB dos pais e a lipemia sérica em adolescentes. Conclusão: Não foi verificada associação da lipemia sérica com as variantes alélicas do polimorfismo -1131T>C do gene APOA5 e XbaI do gene APOB entre adolescentes e seus pais.Objective: To examine the prevalence of cardiovascular risk factors in adolescents and to determine the association between serum lipemia, the variability of allelic polymorphisms rs662799 of the APOA5 gene and rs693 of the APOB gene, body composition and cardiorespiratory fitness in adolescents and their parents with European ancestry. Methods: Cross-sectional study conducted in adolescents (11-17 years) and their parents in Saudades-SC. Participating in the descriptive analysis and prevalence, 274 adolescents. For a description of the analysis -1131T>C polymorphism APOA5 gene were examined 173 adolescents (78 mothers and 95 fathers) and, for the analysis of XbaI polymorphism APOB gene, 213 adolescents (121 fathers and 158 mothers). Variables were: demographics (gender, age and area of residence), sexual maturation, and anthropometric (weight, height, abdome circumference, relative body fat), biochemical (total cholesterol, HDL-c, LDL-c and triglycerides), genetic [polymorphisms rs662799 of the APOA5 gene (-1131T>C) and rs693 of the APOB gene (XbaI)] and cardiorespiratory fitness. Results: We found that 12.3%, 42.9% and 59.8% of adolescents, respectively, overweight, abdominal obesity and high body composition. Furthermore, 46% have low levels of HDL-c, 41.9% hypercholesterolemia, 18.0% and 13.6% had high LDL-c and hypertriglycerimia, respectively. Adolescents with overweight have greater odds of having low levels of HDL-c. Regarding the differences between the genders, it was observed that the girls carrying the TT genotype of polymorphism -1131T>C in APOA5 gene had higher mean total cholesterol, LDL-C and triglycerides when compared to boys. In addition, we found that those girls with the TC+CC genotype showed higher triglyceride levels than boys. From the analysis of association, children of parents with high body fat were nearly four times more likely to have reduced levels of HDL-C (pC and APOA5 gene XbaI gene ApoB serum lipemia parents and adolescents. Conclusion: There was no association of serum lipemia with allelic variants of the polymorphism -1131T>C of the APOA5 gene and XbaI of the ApoB gene between adolescents and their parents
Jesuit collegiate education in England, 1794 1914
No full textIn 1773 the Society of Jesus was formally suppressed and the Fathers of the English Province entered a period of limbo which their school at St. Omers survived in a variety of guises. The first chapter of this thesis describes the arrival of the teachers and pupils of this school in England; and examines the manner in which the College and Order were reconstituted on English soil. The nature of the curriculum, finances and social class composition are considered -inter alia. The second and third chapters relate the way in which the work undertaken at the founding College, Stonyhurst, was expanded. These chapters describe the revival of day Colleges by the Society, and analyse the way in which the new Colleges, both day and boarding, were managed. An important feature examined, is the extension of educational provision for middle class pupils coupled with the curricular and financial adaptations undertaken. One element which is common to all chapters is an analysis of the relationship of the Order to the Hierarchy. In Chapter 4 this becomes a central concern of the study as the attempts by the Jesuits to begin a College in Manchester resulted in a direct confrontation with the local Bishop and ultimately with the whole English Hierarchy, The attitude and machinations of the Cardinal Archbishop, Henry Edward Manning, led to the defeat of the Order in a canonical dispute in Rome, a result which blighted the Jesuits' work for more than a decade. The chapter also examines the educational circumstances and effects of this dispute, the case in canon law awaits exploration. Chapters 5 and 6 examine the work of the Order in the light of the Bull Romanos Pontifices which followed the defeat in Rome. The former considers the Fathers' efforts to improve their educational service to Catholic youth while effectively prevented from opening new schools. The latter examines the revitalisation of the English Province's Colleges in the Archiepiscopate of Cardinal Vaughan, but also demonstrates the inexorable financial difficulties facing the opening and conduct of schools. In the penultimate chapter, a departure is made to examine the progress made by the Jesuits in boarding education in the Stonyhurst tradition. The opening and evolution of Beaumont College and the assimilation of the Order's schools into the community of Public schools are important factors under scrutiny. The final chapter considers the relationship of the Jesuit day Colleges to the State. As the State expanded its role and the Jesuit schools sought additional finance, they were ineluctably drawn together. The evolutionary nature of this relationship and its political ramifications are considered as they moved to a position of mutually agreed neutrality, if not satisfaction, an appropriate point, before the overwhelming cataclysm of the First World War, to terminate this thesis. The foundations upon which this thesis was constructed lie in the study of much manuscript material. Like many of the sources for Catholic history, these records are widely dispersed and have had to be correlated. As the study makes clear, there are few secondary guides. University theses have often contained the only indications of the work of the Bishops, or other Catholic educators. It is hoped that this thesis will, in its turn, serve to guide others in a terrain where there are many areas yet unexplored
