291,847 research outputs found
Control and Filtering for Discrete Linear Repetitive Processes with H infty and ell 2--ell infty Performance
No full textRepetitive processes are characterized by a series of sweeps, termed passes, through a set of dynamics defined over a finite duration known as the pass length. On each pass an output, termed the pass profile, is produced which acts as a forcing function on, and hence contributes to, the dynamics of the next pass profile. This can lead to oscillations which increase in amplitude in the pass to pass direction and cannot be controlled by standard control laws. Here we give new results on the design of physically based control laws for the sub-class of so-called discrete linear repetitive processes which arise in applications areas such as iterative learning control. The main contribution is to show how control law design can be undertaken within the framework of a general robust filtering problem with guaranteed levels of performance. In particular, we develop algorithms for the design of an H? and dynamic output feedback controller and filter which guarantees that the resulting controlled (filtering error) process, respectively, is stable along the pass and has prescribed disturbance attenuation performance as measured by and – norms
Clarence Lam for Congress: Candidate Interview
No full text2024 Primary Election Candidate Interview with State Senator Clarence Lam from District 12 now running for Congress in Maryland’s Third District, which is centered on Howard and Anne Arundel counties. The MD3 race is a crowded field. You can find interviews with other candidates in the I Hate Politics library on all major streaming platforms. Music for the episode are two piano compositions from Kensington resident Adam Bobrow.https://open.spotify.com/episode/00crjPiehMHmPDOkDkHVS
The Four Onions : Amy Ching-Yan Lam
No full text"These poems started with food. I was writing down what I talked about most, and I talked a lot about the things I eat and don’t eat. For example, beef jerky vs. eggs. I realize now that food was the beginning because 1) my parents ran a café/diner during my adolescence and 2) I am learning about the relationship between history and the senses." -- Amy Ching-Yan Lam, publisher's website
Rozpoznanie i leczenie limfangioleiomiomatozy (LAM) z grupy PEComa
No full textNaczyniakowatość limfatyczna (limfangioleiomiomatoza; LAM) to rzadka rozrostowa choroba płuc, prowadząca do postępującego uszkodzenia ich struktury, zaliczana do rodziny nowotworów typu PEComa. U chorych może dochodzić do powstawania lito-torbielowatych mas, określanych jako lymphangioleiomyoma lub pozapłucna postać LAM (E-LAM). Ogniska E-LAM opisano w śródpiersiu, nadobojczykowych węzłach chłonnych, wątrobie, ścianie jelita cienkiego i grubego, trzustce, krezce. Masy E-LAM mogą osiągać bardzo duże rozmiary — opisywano przypadki guzów o największej średnicy długości 15–22 cm. Opierając się na pozytywnych wynikach badań klinicznych, sirolimus, lek z grupy inhibitorów kinazy mTOR, został zarejestrowany w maju 2015 roku przez amerykańską Agencję Żywności i Leków (FDA) jako pierwszy i obecnie jedyny lek do systemowej terapii LAM. Zastosowanie sirolimusu wskazane jest u pacjentek z LAM, której towarzyszy szybko postępujące pogorszenie funkcji układu oddechowego lub FEV1 ≤ 70% wartości należnej, oraz u pacjentów z objawowymi opłucnowymi wysiękami chłonnymi, przed zastosowaniem inwazyjnych metod leczenia
Tapsundersøkelse for lam i Sørfjella beiteområde i Verdal kommune, 2024
No full textDødsårsaker hos lam i to tapsutsatte sauebesetninger i Sørfjella beiteområde i Verdal kommune er kartlagt. Av 115 lam instrumenterte med mortalitetssendere (dødsvarslere), døde 14 lam på beite. Seks ble tatt av fredet rovvilt (fem drept av ulv og ett av kongeørn), for to lam var tapsårsaken ikke fredet rovvilt, ett lam hadde ukjent tapsårsak og fem lam ble ikke funnet og fikk status savnet på beite. Ulveangrep ble dokumentert av prosjektet midt i juli. Dette utløste fellingstillatelse og ulven ble felt etter en måneds tid. Dessverre sviktet mange av dødsvarslerne og peilearbeidet måtte innstilles tidligere enn planlagt. Dette er årsaken til at andelen lam med status savnet på beite er relativt høy.Tapsundersøkelse for lam i Sørfjella beiteområde i Verdal kommune, 2024publishedVersio
Clinical Utility of a Commercial LAM-ELISA Assay for TB Diagnosis in HIV-Infected Patients Using Urine and Sputum Samples
No full textBackground: The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB (R)-ELISA) may have some utility for the diagnosis of TB in HIV-infected patients; however, the precise subgroup that may benefit from this technology requires clarification. The utility of LAM in sputum samples has, hitherto, not been evaluated.Methods: LAM was measured in sputum and urine samples obtained from 500 consecutively recruited ambulant patients, with suspected TB, from 2 primary care clinics in South Africa. Culture positivity for M. tuberculosis was used as the reference standard for TB diagnosis.Results: Of 440 evaluable patients 120/387 (31%) were HIV-infected. Urine-LAM positivity was associated with HIV positivity (p = 0.007) and test sensitivity, although low, was significantly higher in HIV-infected compared to uninfected patients (21% versus 6%; p<0.001), and also in HIV-infected participants with a CD4 <200 versus <200 cells/mm(3) (37% versus 0%; p = 0.003). Urine-LAM remained highly specific in all 3 subgroups (95%-100%). 25% of smear-negative but culture-positive HIV-infected patients with a CD4 <200 cells/mm(3) were positive for urine-LAM. Sputum-LAM had good sensitivity (86%) but poor specificity (15%) likely due to test cross-reactivity with several mouth-residing organisms including actinomycetes and nocardia species.Conclusions: These preliminary data indicate that in a high burden primary care setting the diagnostic usefulness of urine-LAM is limited, as a rule-in test, to a specific patient subgroup i.e. smear-negative HIV-infected TB patients with a CD4 count <200 cells/mm(3), who would otherwise have required further investigation. However, even in this group sensitivity was modest. Future and adequately powered studies in a primary care setting should now specifically target patients with suspected TB who have advanced HIV infection
Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies.
No full textDetection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency. This can be achieved at the point-of-care within just 30 minutes using the Determine TB-LAM, which is a commercially available, lateral-flow urine 'strip test' assay. The assay has been shown to have useful diagnostic accuracy in patients enrolling in antiretroviral treatment services or in HIV-infected patients requiring admission to hospital medical wards in sub-Saharan Africa. Such patients have high mortality risk and have most to gain from rapid diagnosis of TB and immediate initiation of treatment. However, few studies using this assay have yet been reported and many questions remain concerning the correct use of the assay, interpretation of results, the role of the assay as an add-on test within existing diagnostic algorithms and the types of further studies needed. In this paper we address a series of questions with the aim of informing the design, conduct and interpretation of future studies. Specifically, we clarify which clinical populations are most likely to derive benefit from use of this assay and how patients enrolled in such studies might best be characterised. We describe the importance of employing a rigorous microbiological diagnostic reference standard in studies of diagnostic accuracy and discuss issues surrounding the specificity of the assay in different geographical areas and potential cross-reactivity with non-tuberculous mycobacteria and other organisms. We highlight the importance of careful procedures for urine collection and storage and the critical issue of how to read and interpret the test strips. Finally, we consider how the assay could be used in combination with other assays and outline the types of studies that are required to build the evidence base concerning its use
Tapsårsaker hos lam i Ørpen-Redalen beiteområde, Krødsherad 2007
No full textTapsårsaker hos lam i tre besetninger i Ørpen-Redalen beiteområde, Krødsherad kommune, ble kartlagt sommeren 2007 ved hjelp av mortalitetssendere (”dødsvarslere”). 34 av 182 radiomerkede lam omkom på beite (18,7 %). Fem radiomerkede lam hadde ukjent dødsårsak. Blant de 29 omkomne ”radiolammene” med kjent dødsårsak ble 27 lam (93,1 %) antatt eller dokumentert tatt av gaupe, mens ett døde av sjukdom (3,45 %) og ett omkom i ulykke (3,45 %). Totalt omkom 50 av 241 lam som ble sluppet i dette beiteområdet (20,8 %). Det var ingen signifikant forskjell i tapstallene mellom lam med og uten dødsvarsler.publishedVersio
Tapsundersøkelser. Dødsårsak blant lam i rode 5 i Beiarn 2002
No full textTapsundersøkelser på lam ved hjelp av mortalitetssendere (”dødsvarslere”) har blitt gjennomført en rekke steder i landet de senere år. Disse har gitt god kunnskap om årsakene til og tidspunktene for lammetap i de ulike forsøksområdene de spesifikke år. Denne undersøkelsen kartlegger dødsårsakene blant lam i rode 5 i Beiarn beitesesongen 2002.publishedVersio
A review of conducting polymers in electrical contact applications
No full textA review of recent developments in fretting studies in electrical contacts is presented, focusing on developments in conducting polymer surfaces. Fretting is known to be a major cause of contact deterioration and failure; commonly exhibited as the contact resistance increases from a few milliohms, in the case of a new metallic contacts, to in excess of several ohms for exposed contacts. Two technologies are discussed; firstly extrinsically conducting polymer (ECP), where highly conductive interconnects are formed using metallized particles embedded within a high temperature polymer compound, and secondly; intrinsically conducting polymers (ICPs) are discussed. These latter surfaces are new developments which are beginning to show potential for the application discussed. This paper presents the work on the ICPs using poly(3,4-ethylenedioxythiophene)/poly(4-styrenesulfonate) (PEDOT /PSS) and its blends from secondary doping of dimethylformamide (DMF)PEDOT/PSS. Two different processing techniques namely dropcoating and spin coating have been employed to develop test samples and their functionality were assessed by two independent studies of temperature and fretting motion. The review leads to a number of recommendations for further studies into the application of conducting polymers for contacts with micro-movement.<br/
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