1,721,099 research outputs found
From anecdotal evidence of cannabinoids in multiple sclerosis to emerging new therapeutical approaches
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From anecdotal evidence of cannabinoids in multiple sclerosis to emerging new therapeutical approaches.
No full textGenetic and biotechnological approaches to preserve food quality against climate change
Full text linkIn this past decade, the bond between agriculture, food security, and climate change has become increasingly strong. Agriculture is recognized as one of the most endangered systems adversely affected by human activities and environmental issues. In particular, abiotic stress limits the quantity and quality of plant-based food. Heat stress, drought, and salinity impact plants at all different life stages, inducing morphological and physiological changes and provoking a reduction in their nutritional value. Accordingly, low-quality food results in a serious risk for the health of people worldwide. In this scenario, different genetic and biotechnological strategies have been investigated, including the use of New Plant Breeding Techniques (NBTs) and plant cell cultures. In this review, we describe how abiotic stresses alter the property and availability of nutritious food. In addition, we illustrate the advanced techniques that could be employed to address these issues and ameliorate the agricultural practices
2’, 3’-cyclic nucleotide 3’-phosphodiesterase (CNPase) is a GTP binding protein: a new functional property revealed by both biochemical and structural modelling investigations
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The anandamide analogue, Met-F-AEA, controls human breast cancer cell migration via the RhoA/Rho kinase signaling pathway.
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Molecular mechanism of cannabinoids in cancer progression [*Pagano C. *Navarra G. co-first authors]
No full textCannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer prolifera-tion, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis
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