274,364 research outputs found
Diagnosing peanut allergy with skin prick and specific IgE testing
No full textBackgroundFood allergy is common in childhood. It has been suggested that the magnitude of a skin prick test or specific IgE result can improve diagnostic usefulness, but this has been addressed in only a few tertiary challenge-based studies.
ObjectiveTo determine the predictive value of a wheal ? 8 mm or serum specific IgE ? 15 kUA/L for clinical allergy and investigate whether results are generalizable.
MethodsAll subjects, up to 16 years of age, who had been investigated with a peanut or tree nut food challenge were eligible for the study. Subjects were referred from either a tertiary allergy clinic or a community birth cohort. All subjects with a history suggestive of food allergy were offered a challenge unless there were features of anaphylaxis. Details of challenges were prospectively recorded. Results were modeled by using logistic regression.
ResultsThere was a total of 161 peanut challenges. Recent skin prick (longest wheal diameter) and specific IgE data were available for 135 and 136 challenges, respectively. The results suggest that a skin prick result ? 8 mm and a specific IgE ? 15 kUA/L have predictive values of 95% (95% CI, 76.2% to 99.9%) and 92.0% (74.0% to 99.0%), respectively, for a positive challenge. Age, the type of nut, and referral pattern of the subject did not appear to alter this relationship.
ConclusionThese data suggest that a skin prick result ? 8 mm or a specific IgE ? 15 kUA/L have a high predictive value for clinical allergy to peanut and that these cutoff figures appear generalizable to different populations of children undergoing an assessment for peanut allergy
Comparative study of minimal fresh gas flow used in Lack-Plus and Lack’s circuit in spontaneously breathing anesthetized adults
No full textSunchai Theerapongpakdee, Thepakorn Sathitkarnmanee, Sirirat Tribuddharat, Siwalai Sucher, Maneerat Thananun, Duangthida Nonlhaopol Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Background: The Lack’s circuit is a co-axial Mapleson A breathing system commonly used in spontaneously breathing anesthetized adults but still requires high fresh gas flow (FGF). The Lack-Plus circuit was invented with the advantage of lower FGF requirement. The authors compared the Lack-Plus and Lack’s circuit for the minimal FGF requirement with no rebreathing in spontaneously breathing anesthetized adults.Methods: This was a randomized crossover study. We enrolled 24 adult patients undergoing supine elective surgery, with a body mass index ≤30 kg/m2 and an American Society of Anesthesiologists physical status I–II. They were randomly allocated to group 1 (LP-L) starting with Lack-Plus then switching to Lack’s circuit or group 2 (L-LP) (with the reverse pattern). After induction and intubation, anesthesia was maintained with 50% N2O/O2 and desflurane (4%–6%) plus fentanyl titration to maintain an optimal respiratory rate between 10 and 16/min. Starting with the first circuit, all the patients were spontaneously breathing with a FGF of 4 L/min for 10 min, gradually decreased by 0.5 L/min every 5 min until FGF was 2.5 L/min. End-tidal CO2, inspired minimum CO2 (ImCO2), mean arterial pressure, and oxygen saturation were recorded until rebreathing (ImCO2 >0 mmHg) occurred. The alternate anesthesia breathing circuit was used and the measurements were repeated.Results: The respective minimal FGF at the point of rebreathing for the Lack-Plus and Lack’s circuit was 2.7±0.8 and 3.3±0.5 L/min, respectively, p<0.001. At an FGF of 2.5 L/min, the respective ImCO2 was 1.5±2.0 and 4.2±2.6 mmHg, respectively, p<0.001.Conclusion: The Lack-Plus circuit can be used safely and effectively, and it requires less FGF than Lack’s circuit in spontaneously breathing anesthetized adults. Keywords: spontaneous breathing, anesthesia, non-rebreathing anesthetic circuit, modified Mapleson A breathing system, coaxial breathing system, rebreathin
Première symphonie de L. van Beethoven, arrangée pour deux pianos, par A. Lavignac et Th. Lack
No full textTitre uniforme : Beethoven, Ludwig van (1770-1827). Compositeur. [Symphonies. No 1. Op. 21. Do majeur]Comprend : 1ère Symphonie pr. 2 pian
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Papaver orientale L.
No full textPapaver orientale L., Sp. Pl.: 508. 1753. Lectotypus (GOLDBLATT, 1974a: 288): SINE LOCO: Herb. LINN nº 669/10 (Fig. 7). = Papaver monanthum Trautv. in Bull. Acad. Imp. Sci. Saint-Pétersbourg 10: 393. 1866. Papaver orientale var. monanthum (Trautv.) Trautv. in Trudy Imp. S.-Peterburgsk. Bot. Sada 4: 346. 1876. Lectotypus (designated by MICHEEV, 1993: 118): GEORGIA: “Schambobell – Geb.”, 9.VII.1865, Radde 117 (LE image seen, Fiche 75/C 1 in GELTMAN, 1995b); isolecto-: LE image seen, Fiche 75/B 8 in GELTMAN, 1995b). = Papaver orientale var. paucifoliatum Trautv. in Trudy Imp. S.-Peterburgsk. Bot. Sada 4: 346. 1876. Papaver paucifoliatum (Trautv.) Fedde in Engl., Pflanzenr. 40: 366. 1909. Lectotypus (designated by GOLDBLATT, 1974a: 289): GEORGIA: “ad lacum Tabizchuri”, 1875, Raddi 73 (L; isolecto-: LE image seen, Fiche 75/C 7 in GELTMAN, 1995b). For further synonyms see GOLDBLATT (1974a). Notes. – The isolectotype of the name P. orientale var. paucifoliatum Trautv. in LE has not been mentioned in the original lectotypification (GOLDBLATT, 1974a: 289). Although stated (MICHEEV, 1993), this name has not been lectotypified in Flora SSSR (POPOV, 1937) because the expression “ type ” or its equivalents have not been used in this treatment.Published as part of Lack, H. Walter, 2019, The discovery and naming of Papaver orientale s. l. (Papaveraceae) with notes on its nomenclature and early cultivation, pp. 47-64 in Candollea 74 (1) on page 60, DOI: 10.15553/c2019v741a7, http://zenodo.org/record/572466
Lack-of-fit tests in semiparametric mixed models.
No full textIn this paper we obtain the asymptotic distribution of restricted likelihood ratio tests in mixed linear models with a fixed and finite number of random effects. We explain why for such models the often quoted 50:50 mixture of a chi-s quared random variable with one degree of freedom and a point mass at zero does not hold. Our motivation is a study of the use of wavelets for lack-of-fit testing within a mixed model framework. Even though wavelet shave received a lot of attention in the last say 15 years for the estimation of piecewise smooth functions, much less is known about their ability to check the adequacy of a parametric model when fitting the observed data. In particular we study the testing power of wavelets for testing a hypothesized parametric model within a mixed model framework. Experimental results show that in several situations the wavelet-based test significantly outperforms the com-petitor based on penalized regression splines. The obtained results are also applicable for testing in mixed models in general, and shed some new insight into previous results.Lack-off-fittest; Likelihood ratio test; Mixed models; One-sided test; Penalization; Restricted maximum likelihood; Variance components; Wavel; Asymptotic distribution; Distribution; Likelihood; Tests; Models; Model; Random effects; Effects; Studies; Lack-of-fit; Mixed model; Framework; Functions; Data; Power; Regression;
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