28 research outputs found
« Pourtant Dürer lui a donné des ailes » : La Mélancolie ou le démon de Stagyre de Tinan
No full textInternational audienceAs a disciple of Maurice Barrès, Tinan has adopted the precepts of the Culte du moi: feel as much as possible in order to analyse as much as possible. This quest for self-knowledge influenced by a method that claims to be scientific can, however, lead to a form of sentimental dryness. Tinan's work is characterised by its diversity of forms (novels, essays, chronicles) and his constant use of autofiction. Among his many aborted projects, La Mélancolie ou le démon de Stagyre (Melancholy or the Demon of Stagyre) (1898), in which the author sought to classify the ‘intellectual states of melancholy’. This makes Tinan an ideal candidate for the study of how the melancholy of knowledge is embodied in a young man at the end of the nineteenth century, halfway between symbolism and naturalism, between scientific training and literary sensibility. We will see how life's pain is expressed in different ways in his personal writings, based on his published work, but also on unpublished sources. An anxiety of the unfinished emerges throughout the corpus, becoming more and more pronounced until the author's death at the age of twenty-four.Disciple de Maurice Barrès, Tinan a fait siens les préceptes du Culte du moi : « sentir le plus possible, pour analyser le plus possible ». Cette quête de la connaissance de soi, influencée par une méthode se voulant scientifique, n’est pas sans conséquences : elle peut confiner à une forme de « sécheresse » sentimentale.L’œuvre de Tinan se caractérise par une diversité des formes (romans, essais, chroniques) et par son recours constant à l’autofiction. Parmi ses nombreux projets avortés se distingue La Mélancolie ou le démon de Stagyre (1898), où l’auteur cherche à classifier les « états intellectuels de la mélancolie ». Ces éléments font de Tinan un candidat idéal pour étudier comment s’incarne la mélancolie de la connaissance chez un jeune homme de la fin du XIXe siècle, à mi-chemin entre symbolisme et naturalisme, entre cursus scientifique et sensibilité littéraire.Nous nous intéresserons à l’expression du mal de vivre dans les différentes formes de son écriture personnelle, à partir de son œuvre publiée et de sources inédites. Une angoisse de l’inaccompli se détache de l’ensemble du corpus, de plus en plus prégnante au fur et à mesure que la maladie de l’auteur progresse, jusqu’à l’emporter à ses vingt-quatre ans
Porto-Sinusoidal Vascular Disease: A Pediatric Study of 30 Patients
No full textInternational audienceObjectives: Porto-sinusoidal vascular disease (PSVD) refers to a broad spectrum of histological lesions and phenotypic expressions. There are only a few reported pediatric cases in the literature. The primary outcomes of this study were to describe the phenotype of children with PSVD, to specify their mode of presentation and their clinical, biological, histological, and radiological characteristics as well as to identify their underlying etiologies. Methods: This is a descriptive, retrospective, and monocentric study of children followed at our reference center for rare vascular liver diseases. Results: Our study included 30 children ages 2months to 17.4years at the time of diagnosis. in most cases, the diagnosis was made incidentally without manifestation of any clinical symptom but rather on the finding of splenomegaly on physical examination (n = 9) or biological abnormalities (n = 13). In the other cases, the main presenting symptom was an upper gastrointestinal bleeding (n = 6). At the first visit, liver laboratory values were either normal (37%) or slightly disturbed. Anemia and/or thrombocytopenia associated with hypersplenism were found in 60% of patients. Liver biopsy was necessary for diagnosis. A total of 80% of cases had no identified etiology. After a median follow-up of 4.5 years, 33% had not developed portal hypertension (PHT) and we reported the first pediatric case of hepatocellular carcinoma in PSVD children. Conclusions: PSVD is responsible for nonspecific symptomatology with variable evolution sometimes marked by serious complications requiring invasive treatments or even liver transplantation. Regular monitoring is essential to prevent, detect, and treat complications
Re-enacting historical memories on social media through profile-based works: a perspectivist approach
No full textThe possibility of passing for someone else did not emerge with social media. However, the fact that, as the saying goes, “on the Internet, nobody knows you’re a dog,” has made building fictitious identities much easier. In this paper, we will explore the hypothesis that beyond trivial experiments with pseudonyms, the option of experimenting with “versions of oneself” on social platforms has given rise to a new genre, that we term “fictional profiles.” We will consider the fictional profile as a symbiotic agent, pointer and witness to contemporary society. After a general introduction to the genre and a critical discussion of methodologies to identify its specificities, we will focus on two re-enactments of historical events and figures on Facebook and Instagram. We will discuss the problematic nature of these works in terms of valorization, preservation and archiving insofar as, on the one hand, they question the classical categories of the work, the author and the reader; and, on the other hand, they are fundamentally dependent on their publication platforms.A possibilidade de se fazer passar por outra pessoa não surgiu com as redes sociais. No entanto, o facto de, como diz o ditado, "na Internet, ninguém sabe que és um cão", facilitou muito a construção de identidades fictícias. Neste painel, vamos explorar a hipótese de que, para além das experiências triviais com pseudónimos, a opção de experimentar "versões de si próprio" nas plataformas sociais deu origem a um novo género, que designamos por "perfis fictícios". Consideraremos o perfil ficcional como um agente simbiótico, apontador e testemunha da sociedade contemporânea. Após uma introdução geral ao género e uma discussão crítica de metodologias para identificar as suas especificidades, centrar-nos-emos em duas reencenações de eventos e figuras históricas no Facebook e no Instagram. Discutiremos a natureza problemática destas obras em termos de valorização, preservação e arquivo, na medida em que, por um lado, questionam as categorias clássicas da obra, do autor e do leitor; e, por outro, são fundamentalmente dependentes das suas plataformas de publicação
Sustainable positive response to sirolimus in juvenile polyposis of infancy
No full textInternational audienc
Evolution of hepatobiliary involvement in cystic fibrosis children on CFTR modulators
No full textInternational audienceBackground: There are great changes in cystic fibrosis (CF) disease following introduction of modulator treatments. We aimed to focus on the evolution of hepatobiliary involvement following lumacaftor-ivacaftor (LI) and elexacaftor-tezacaftor-ivacaftor (ETI) initiation. Methods: A retrospective monocentric observational study included 62 CF children treated with CFTR modulators. Data were collected at initiation and after one year of treatment. The primary objective was to describe the evolution of hepatobiliary involvement under CFTR modulator treatment. Results: We identified hepatobiliary involvement before treatment in 37 patients (59.7 %). Fifteen had persistently (during >6 months) elevated liver enzymes (mostly ALT); 17 had abnormal ultrasound including 3 with nodular liver and 3 with pathological elastography; 5 had isolated splenomegaly. Biliary involvement was found in 19 patients. The evolution of hepatic parameters in the overall population was not significant (p > 0.05). However, we observed a trend towards improvement in laboratory values under treatment. There was only one inaugural diagnosis of nodular liver under LI and none under ETI. All patients had preserved liver function (PT>50 %). Conclusions: We did not find a significant improvement or worsening of hepatobiliary involvement under CFTR modulators. We hypothesize that it could be stabilized with these treatments, but this will need confirmation through further studies with longer follow-up and larger cohorts. The other hypothesis proposed is that biological monitoring may not be an accurate assessment of the hepatobiliary response to modulators. This study supports the safety of CFTR modulator use
Author response: Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
No full textSelection
No full textThe study selection process will include four steps (Levac et al.): 1) identifying the relevant studies from the literature, 2) screening the studies by applying the criteria to the titles and abstracts, 3) defining the eligibility of the studies by applying criteria to the full papers, and 4) the inclusion of the studies by re-applying criteria to the full papers during data extraction.
For the first step (identification) after a search of databases, duplicates will be automatically removed in the Covidence software (Veritas Health Innovation, s. d.).
For the second, third and fourth steps (screening, eligibility and inclusion), two co-authors (OO and NL) will independently complete the review, documented the reason for exclusion and then compare their results. Disagreements between the two co-authors will either be resolved by consensus or another co-author (BM) with experience conducting literature reviews will resolve them acting as a third reviewer. Percentage of agreement will be calculated for each of these steps
Selection
No full textThe study selection process will include four steps (Levac et al.): 1) identifying the relevant studies from the literature, 2) screening the studies by applying the criteria to the titles and abstracts, 3) defining the eligibility of the studies by applying criteria to the full papers, and 4) the inclusion of the studies by re-applying criteria to the full papers during data extraction.
For the first step (identification) after a search of databases, duplicates will be automatically removed in the Covidence software (Veritas Health Innovation, s. d.).
For the second, third and fourth steps (screening, eligibility and inclusion), two co-authors (OO and NL) will independently complete the review, documented the reason for exclusion and then compare their results. Disagreements between the two co-authors will either be resolved by consensus or another co-author (BM) with experience conducting literature reviews will resolve them acting as a third reviewer. Percentage of agreement will be calculated for each of these steps
Selection
No full textThe study selection process will include four steps (Levac et al.): 1) identifying the relevant studies from the literature, 2) screening the studies by applying the criteria to the titles and abstracts, 3) defining the eligibility of the studies by applying criteria to the full papers, and 4) the inclusion of the studies by re-applying criteria to the full papers during data extraction.
For the first step (identification) after a search of databases, duplicates will be automatically removed in the Covidence software (Veritas Health Innovation, s. d.).
For the second, third and fourth steps (screening, eligibility and inclusion), two co-authors (OO and NL) will independently complete the review, documented the reason for exclusion and then compare their results. Disagreements between the two co-authors will either be resolved by consensus or another co-author (BM) with experience conducting literature reviews will resolve them acting as a third reviewer. Percentage of agreement will be calculated for each of these steps
