1,721,034 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Expression von Checkpointmolekülen und Zusammensetzung des Inflammasoms in malignen Speicheldrüsentumoren im Kopf-Hals-Bereich
No full textDas Speicheldrüsenkarzinom gehört zu den seltenen Karzinomen des Menschen. Die in Einzelfällen berichtete Anwendung von Checkpointinhibitoren (PD-1/-L1) beim Speicheldrüsenkarzinom zeigt, verglichen mit der jetzigen Standarttherapie, gute Resultate. Der Programmed-Death-Ligand 1 (PD-L1) hemmt durch die Bindung an den Programmed Death (PD)-1-Rezeptor der T-Zellen, die T-Zell-Migration und Proliferation. Zytotoxische T-Zellen verlieren ihre Fähigkeit zur Abtötung der Zielzellen. Bei der Entwicklung von Neoplasien führt dies zur Unterdrückung der Antwort des Immunsystems.
Das Ziel dieser Arbeit war die Analyse der PD-L1-Expression bei einer Kohorte maligner Speicheldrüsentumoren unter Anwendung etablierter Scoringsysteme. Hierdurch sollten Entitäten ausfindig gemacht werden, die für eine Therapie mit Checkpointinhibitoren in Frage kommen.
Es wurden 94 Patienten mit Speicheldrüsenkarzinom eingeschlossen. Die einzelnen Entitäten waren 41 Adenoidzystischen Karzinomen (AdCC), 21 Mucoepidermoid Karzinome (MEC), 16 Azinuszellkarzinome (ACC), zwölf Adenokarzinome NOS (AC NOS), zwei Karzinome ex pleomorphem Adenom (CA ex PA), ein Speichelgangkarzinom (SDC) und ein epithelial-myoephitheliales Karzinom. Für die immunhistochemischen Färbungen wurde anti-CD-3 (2GV6), anti-CD-20 (L26), anti-PD-L1 (SP263) und anti-p53 (DO-7) verwendet. Es wurde der tumor proportion score (TPS), der combined positivity score (CPS), der immune cell (IC) score und, an ausgewählten Proben, der TP53-Mutationsstatus erhoben.
Patienten mit einem AC NOS wiesen im Vergleich zum AdCC, zum MEC (beide p<0,001) und zum ACC (p<0,01) einen signifikant höheren TP und CP Score auf. Verglichen mit allen anderen Entitäten hat das AC NOS in 67 % der Proben einen signifikant höheren IC Score von 2 oder 3 (p=0,0031) und war mit einem schlechteren progressionsfreien Überleben (p<0,0001) und Gesamtüberleben (p<0,0001) assoziiert. Der CPS war mit nodal-positiven Erkrankungen assoziiert (p=0,0106). Außerdem korrelierte der CPS mit einer starken oder keiner p53-Anfärbbarkeit beim AC NOS, aber nicht beim SDC.
Durch diese Arbeit konnten das AC NOS durch seine einzigartigen Eigenschaften als vielversprechende Entität für die Therapie mit Immuncheckpoint-Inhibitoren identifiziert werden
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Tumor-infiltrating CD103+ tissue-resident memory T cells and CD103-CD8+ T cells in HNSCC are linked to outcome in primary but not metastatic disease
No full textPurpose: High numbers of tumor-infiltrating lymphocytes (TIL) are linked to better survival in patients with cancer. Tissue-resident memory T cells (TRM; CD8þCD103þ) are recognized as a key player of anticancer immune response. To assess TRM cells in primary, metastatic, and recurrent head and neck squamous cell carcinoma (HNSCC), we developed a tissue microarray (TMA) and used multiplex IHC (MxIHC). Experimental Design: Samples from primary tumors of 379 HNSCC cases treated at Southampton Hospitals between 2000 and 2016 were collected and analyzed. Of these, 105 cases had lymph node metastases and 82 recurrences. A TMA was generated with triplicate cores for each sample. MxIHC with a stain-and-strip approach was performed using CD8, CD103, and TIM3. Scanned slides were analyzed (digital image analysis) and quality checked (QC). Results: After QC, 194 primary tumors, 76 lymph node metastases, and 65 recurrences were evaluable. Alcohol consumption was statistically significantly correlated with a reduction of TRM cells in primary tumors (nondrinker vs. heavy drinker: P ¼ 0.0036). The known survival benefit of TRM cell infiltration in primary tumors was not found for lymph node metastasis. In recurrences, a high TRM cell number led to a favorable outcome after 12 months. The checkpoint molecule TIM3, was expressed significantly higher on TRM and non-TRM cells in the lymph node compared with primary tumors (P < 0.0001), which was also seen in recurrences (P ¼ 0.0134 and P ¼ 0.0007, respectively). Conclusions: We confirm the prognostic impact of TIL in primary tumors and in recurrences. TRM cell density in lymph node metastases was not linked to outcome. The role of TIM3, as a therapeutic target remains to be defined
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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