1,721,120 research outputs found
Contributo allo studio del dialetto valdostano
No full textLuzzatto L. Contributo allo studio del dialetto valdostano. In: Romania, tome 25 n°98, 1896. pp. 315-320
Decreased number of circulating BFU-Es in Paroxysmal Nocturnal Hemoglobinuria
No full textIn order to quantitate early erythroid progenitor cells in paroxysmal nocturnal hemoglobinuria (PNH), we have cultured peripheral blood mononuclear cells from 7 PNH patients in a 0.8% methylcellulose medium containing erythropoietin, 2 U/ml. In our experimental conditions, the number of erythroid colonies obtained per 5 X 10(5) mononuclear cells plated was 20.1 +/- 1.9 (SEM) in normal subjects and 2.8 +/- 0.56 (SEM) in PNH patients. In plates from PNH subjects, 38 of 117 showed no growth of erythroid colonies, whereas plates from normal subjects always had colonies. Our findings suggest that PNH patients, despite their hemolytic condition, have a depleted erythroid precursor compartment, and this may play a major role in the pathogenesis of their anemia
Genetic variants of human erythrocyte glucose-6-phosphate dehydrogenase. Discrete conformational states stabilized by NADP+ and NADPH
No full textSomatic mutations in Paroxysmal Nocturnal Hemoglobinuria: a blessing in disguise ?
No full textImpact Factor:40.0
Somatic mutations in Paroxysmal Nocturnal Hemoglobinuria: a blessing in disguise ?
No full textImpact Factor:40.0
Genetic Variants of glucose 6-phosphate dehydrogenase from human erythrocytes: unique properties of the A-Variant isolated from “deficient” cells
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Congenital dyserythropoietic anemia type II in human patients is not due to mutations in the erythroid anion exchanger 1
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