126,305 research outputs found
Data from: Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks
No full textThe data in this collection relates to the publication titled “Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks”, authored by Wright, Leger, et al. The majority of the collection is dedicated to the phenotypic and genetic data presented in figure two of the manuscript, and for related traits collected for this study. This collection also included raw phenotypic measurements for each of the 6,147 rats used in this study. GWAS data was collected and analyzed as described in “Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose” by Chitre et al., 2020 in continuation of this study. Additionally, this collection contains genotype data collected as part of the NIDA Center for GWAS in Outbred rats and more than 10 additional research projects that use N/NIH heterogeneous stock (HS) outbred rats. We obtain genotypes for DNA samples derived from rats that are phenotyped by different research projects. We use these genotypes to perform genome wide association studies (GWAS) and a number of related analyses
St Leger, Selwyn: transcript of an audio interview (27-Jul-2000)
No full textInterview with Dr Selwyn St Leger, conducted by Dr Andy Ness, for the History of Twentieth Century Medicine Research Group, UCL, 11 July 2000. Transcribed by Mrs Jaqui Carter, and edited by Professor Tilli Tansey and Dr Hugh Thomas. Dr Antony Selwyn St Leger FFCM (b. 1948) has been a consultant and senior lecturer in public health medicine at the University of Manchester since 1980. He was at the MRC Epidemiology Unit (South Wales) from 1974 to 1980.The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity (no. 210183). The current interview was funded by a Wellcome Trust grant (059533; 1999-2001; awarded to Professor G Davey-Smith, Dr A R Ness and Dr E M Tansey), and its publication by a Wellcome Trust Strategic Award entitled “Makers of modern biomedicine: testimonies and legacy” (2012-2017; awarded to Professor Tilli Tansey)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
MCID of 6 commonly-used performance tests in patients with chronic musculoskeletal pain
No full textBackground
Functional tests are widely used to measure performance in patients with chronic musculoskeletal pain. Our objective was to determine the Minimal Clinically Important Differences (MCID) for the 6-minute walk test (6MWT), the Steep Ramp Test (SRT), the 1-minute stair climbing test (1MSCT), the sit-to-stand test (STS), the Jamar dynamometer test (JAM) and the lumbar Progressive Isoinertial Lifting Evaluation (PILE) in chronic musculoskeletal pain patients.
Methods
A single-center prospective observational study was conducted in a rehabilitation center. Patients with upper-limb, lower-limb or neck/back lesions were included over a period of 21 months. The anchor-based, distribution-based and opinion-based approaches were used to determine the MCIDs.
Results
838 chronic musculoskeletal pain patients were included. The estimation method and the lesion location had a significant influence on the results. MCIDs were estimated at +75m and +62m for the 6MWT (lower-limb and neck/back lesions, respectively), +18 steps and +19 steps for the 1MSCT (lower-limb and neck/back lesions, respectively) and +6kg for the JAM. The anchor-based method could not provide valid estimations for the three other scales, but distribution and opinion-based methods provided rough values of MCIDs for the SRT (+44w to +61w), the STS (-6 sec to -9 sec) and the PILE (+4kg to +7kg).
Conclusion
The above MCID estimations for the 6MWT, 1MSCT and JAM can be used in chronic musculoskeletal pain patients participating in vocational multidisciplinary rehabilitation programs or in therapeutic trials. The use of specific anchors might give better estimations of MCIDs for the three other scales in future research
miRNA and chronic pain
No full textThe quality of life for millions of people worldwide is affected by chronic pain. In addition to the effect of chronic pain on well-being, chronic pain has also been associated with poor health conditions and increased mortality. Due to its multifactorial origin, the classification of pain types remains challenging. MicroRNAs (miRNA) are small molecules that regulate gene expression. They are released into the bloodstream in a stable manner under normal and pathological conditions and have been described as potential biomarkers. This study aimed to screen expression levels of a large number of microRNA in a population of chronic pain patients following traumatic skeletal muscle injury. In the first part of the study, entitled “discovery”, we screened expression levels of 186 microRNA from 5 different groups of subjects. We then validate a selection of 10 most discriminating microRNA in 2 subtypes of chronic pain patients.We finally suggest a model of classification of patients using 2 microRNAs able to discriminate nociceptive and neuropathic origin of chronic pain (AUC 0.76)
Pendataan Ruas Jalan (Leger Jalan) pada Ruas Jalan Palembang - Betung
No full textAbstractAs national assets, roads are vital to establish the means of national development, especially in term of achieving balanced inter-regional development and equitable distribution of national outcomes. The Palembang-Betung road segment is managed in every fiscal year because it plays a key role in economic development for South Sumatra which links South Sumatra with other Provinces. This certainly leads to the change of the road condition, so it is necessary to collect data related to leger road for road network development plans and programs. Thus, this research issue is how to produce a Leger Road document which includes information about the Palembang - Betung road and its contents.This study aimed at identifying the overall asset data in the Palembang-Betung road section and then analyzing the data as an evaluation material for road maintenance in the form of leger road document data so that road segments need to be collected (road leger).The study results showed that Leger Road Documents had 5 parts, namely road summary cards, road cards (technical data), road cards (situations and pieces), album cards and bridge cards.The area of the Road owned space  is 9,749,109 m2 of road segment. The average data of daily traffic for the km segment was 16 + 500 up to 17 + 250 equal to 33,034. The thickness of Road pavement was AC-WC = 0.04 m, AC –BC = 0.05, AC-Base = 0.075 m, Aggregate class A = 0.25 m, Aggregate class B = 0.30 m.The type of damage on road pavement was exfoliated with an area of 7.75 m², perforated area of 2.85 m², Crocodile cracking area of 7.62 m2, wavy area of 22.42 m², cracked lengthwise to an area of 7.86 m '.Keywords : Road Maintenance, Road LegerAbstrakJalan merupakan aset Negara yang pada hakekatnya mempunyai peranan penting dalam rangka mewujudkan sarana pembangunan Nasional, terutama yang menyangkut perwujudan perkembangan antar daerah yang seimbang dan pemerataan hasil pembangunan. Ruas jalan Palembang-Betung setiap tahun anggaran dilakukan penanganan karena ruas jalan ini memegang peranan penting sebagai roda perekonomian di Sumatera Selatan karena menghubungkan Provinsi Sumatera Selatan dengan Provinsi lainnya. Hal ini tentunya membawa perubahan kondisi pada ruas jalan ini, maka perlu dilakukan pendataan leger jalan untuk penyusunan rencana dan program pembinaan jaringan jalan.Permasalahan pada penelitian ini adalah Bagaimana cara menghasilkan Dokumen Leger Jalan yang memuat informasi mengenai ruas jalan Palembang – Betung beserta isinya. Penelitian ini untuk mengetahui data aset secara keseluruhan yang terkandung pada ruas jalan Palembang- Betung kemudian dilakukan analisa data sebagai bahan evaluasi untuk perawatan jalan yang berupa data dokumen leger jalan sehingga perlu dilakukan pendataan ruas jalan (leger jalan).Hasil penelitian Dokumen Leger Jalan di bagi menjadi 5 bagian yaitu kartu ringkasan jalan, kartu jalan (data teknik), kartu jalan (situasi dan potongan), kartu album dan kartu jembatan.Luas area Ruang Milik Jalan diperoleh 9.749.109 m2 persegmen ruas jalan. Data lalu lintas Harian rata-rata untuk segmen km. 16 + 500 s/d 17 + 250 sebesar 33.034. Perkerasan jalan diperoleh tebal AC-WC = 0,04 m, AC –BC= 0,05, AC-Base= 0,075 m, Agregat klas A = 0,25 m, Agregat klas B = 0,30 m.Jenis kerusakan yang terjadi pada perkerasan jalan adalah terkelupas dengan luas 7,75 m², berlubang luas 2,85 m², Retak Buaya luas 7,62 m2, bergelombang luas 22,42 m², Retak Memanjang luas 7,86 m’.Kata kunci : Pemeliharaan Jalan, Leger Jala
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Dr. Edwin Wright Collection: Author Unknown
No full textNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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