27 research outputs found
An invitation to abstract mathematics
No full textThis undergraduate textbook promotes an active transition to higher mathematics. Problem solving is the heart and soul of this book: each problem is carefully chosen to demonstrate, elucidate, or extend a concept. More than 300 exercises engage the reader in extensive arguments and creative approaches, while exploring connections between fundamental mathematical topics. Divided into four parts, this book begins with a playful exploration of the building blocks of mathematics, such as definitions, axioms, and proofs. A study of the fundamental concepts of logic, sets, and functions follows, before focus turns to methods of proof. Having covered the core of a transition course, the author goes on to present a selection of advanced topics that offer opportunities for extension or further study. Throughout, appendices touch on historical perspectives, current trends, and open questions, showing mathematics as a vibrant and dynamic human enterprise. This second edition has been reorganized to better reflect the layout and curriculum of standard transition courses. It also features recent developments and improved appendices. An Invitation to Abstract Mathematics is ideal for those seeking a challenging and engaging transition to advanced mathematics, and will appeal to both undergraduates majoring in mathematics, as well as non-math majors interested in exploring higher-level concepts. From reviews of the first edition: Bajnok’s new book truly invites students to enjoy the beauty, power, and challenge of abstract mathematics. … The book can be used as a text for traditional transition or structure courses … but since Bajnok invites all students, not just mathematics majors, to enjoy the subject, he assumes very little background knowledge. Jill Dietz, MAA Reviews The style of writing is careful, but joyously enthusiastic…. The author’s clear attitude is that mathematics consists of problem solving, and that writing a proof falls into this category. Students of mathematics are, therefore, engaged in problem solving, and should be given problems to solve, rather than problems to imitate. The author attributes this approach to his Hungarian background … and encourages students to embrace the challenge in the same way an athlete engages in vigorous practice. John Perry, zbMATH
Rising plasma nociceptin level during development of HCC: A case report
No full textAIM: Although liver cirrhosis is a predisposing factor for hepatocellular carcinoma (HCC), relatively few reports are available on HCC in primary biliary cirrhosis. High plasma nociceptin (N/OFQ) level has been shown in Wilson disease and in patients with acute and chronic pain.
METHODS: We report a follow-up case of HCC, which developed in a patient with primary biliary cirrhosis. The tumor appeared 18 years after the diagnosis of PBC and led to death within two years. Alfa fetoprotein and serum nociceptin levels were monitored before and during the development of HCC. Nociceptin content was also measured in the tumor tissue.
RESULTS: The importance and the curiosity of the presented case was the novel finding of the progressive elevation of plasma nociceptin level up to 17-fold (172 pg/mL) above the baseline (9.2 +/- 1.8 pg/mL) parallel with the elevation of alpha fetoprotein (from 13 ng/mL up to 3 480 ng/mL) during tumor development. Nociceptin content was more than 15-fold higher in the neoplastic tissue (0.16 pg/mg) than that in the tumor-free liver tissue samples (0.01 pg/mg) taken during the autopsy.
CONCLUSION: Results are in concordance with our previous observation that a very high plasma nociceptin level may be considered as an indicator for hepatocellular carcinoma
Újabb barangolások a primer aldosteronismusnak nevezett rengetegben = More Ramblings in the Plethora Called Primary Aldosteronism
No full textA primer (hyper)aldosteronismus (PA) kérdésköre sok ellentmondással terhelt, a beazonosítására tett kísérletek fontosak, de méltatlanul ritkán történnek meg. Az utóbbi időben bevezetett, gyakorlati haszonnal is járó hisztológiai módszer újabb aspektusát jelzi a spektrumbetegség jellegnek, és egy forradalmi tanulmány is megjelent a PA funkcionális (izotópos) képalkotásával kapcsolatban. Trend lett a kivizsgálás egyszerűsítése, elsősorban a szedett gyógyszerek melletti szűrés elfogadása. A szerző kísérletet tesz az ellátási algoritmusok közös nevezőre hozására és egy lehető legegyszerűbb, de legitim megközelítés megfogalmazására.
The issue of primary (hyper)aldosteronism (PA) is fraught with many contradictions, attempts to identify it are important but undeservedly rare. The recently introduced histological method with practical benefits indicates a new aspect of the spectrum disease character and a revolutionary study has also been published regarding the functional (radionuclide) imaging of PA. The trend has become the simplification of the examinations, primarily the acceptance of screening in the presence of the medications taken. The author attempts to bring the treatment algorithms to a common denominator and formulate the simplest possible but legitimate approach
[Extracto y materiales suplementarios para] Transformar la enfermería a través del conocimiento
No full textThis item record pertains to an excerpt from Transformar la EnfermerÃa a través del conocimiento, which is provided free of charge by the publisher.
To request a review copy for course adoption, order additional books, buy in bulk, or purchase for corporate use, contact Sigma Marketplace at 888.654.4968 (US/Canada toll-free), +1.317.687.2256 (International), or [email protected].
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Diagonal form factors and heavy-heavy-light three-point functions at weak coupling
No full textIn this paper we consider a special kind of three-point functions of HHL type at weak coupling in N = 4 SYM theory and analyze its volume dependence. At strong coupling this kind of three-point functions were studied recently by Bajnok, Janik and Wereszczynski. The authors considered some cases of HHL correlator in the su(2) sector and, relying on their explicit results, formulated a conjecture about the form of the volume dependence of the symmetric HHL structure constant to be valid at any coupling up to wrapping corrections. In order to test this hypothesis we considered the HHL correlator in su(2) sector at weak coupling and directly showed that, up to one loop, the finite volume dependence has exactly the form proposed in. Another side of the conjecture suggests that computation of the symmetric structure constant is equivalent to computing the corresponding set of infinite volume form factors, which can be extracted as the coefficients of finite volume expansion. In this sense, extracting appropriate coefficients from our result gives a prediction for the corresponding infinite volume form factors
Comments upon Two Fragments of a Cryptographic Papyrus
No full textThis short notification tries to examine the two remained fragments of a Greek magical cryptographic papyrus (POsl III, 75, and PMich inv. 534) from new aspects. Regarding the characters of the cryptographic alphabet used in the text, it seems plausible that Greek music notation had a significant effect on the development of the cipher, as far as the transformation methods are concerned. The next section draws attention not only to the uncertain parts of the present transcription but also to the problematic points of Karl Preisendanz's interpretation of the whole magic spell. It also implies a new interpretation, which does not assume that the author “confused” the names of Typhon and Osiris but suggests that the spell is addressed to much more vicious powers than Isis
Mélyítjük vagy áthidaljuk? avagy Léteznek-e generációs ellentétek a könyvtárosok között?
No full textThe author of the article, who has worked both as staff and as a senior librarian, as well as a graduate workplace mentor, examines how the dynamics between staff in libraries, with a special focus on workplace cooperation and conflict, evolve in the light of the insights of the increasingly popular theory of generational theory. Do generational conflicts exist among Hungarian librarians? Do those involved perceive any conflicts related to age groups? If so, are they able to separate them from other, personal conflicts? The questionnaire research, supplemented by mini-interviews, sets up three hypotheses: 1. Librarians do not identify workplace conflicts as generational; 2. For older generations, lack of respect and low work ethic are the main sources of conflict; 3. Younger generations believe that the conservative professional attitude, slow work pace and lack of IT skills of older generations generate most of the conflicts.The findings outlined in the course of the problem statement and analysis should be used both in professional work and in tertiary LIS education, since conflicts arising from generational differences can significantly reduce the performance of library staff, which strongly affects the success of the given institution and the satisfaction of library users.A tanulmány szerzője, aki dolgozott beosztott és vezető könyvtárosként is, valamint diplomás munkahelyi mentor, azt vizsgálja, hogy a napjainkban egyre nagyobb teret nyerő generációelmélet megállapításait figyelembe véve hogyan alakul a könyvtárakban a munkatársak közötti dinamika, különös tekintettel a munkahelyi együttműködésre, illetve konfliktusokra. Léteznek-e a magyar könyvtárosok között generációs ellentétek, maguk az érdekeltek észlelnek-e korosztályokhoz köthető konfliktusokat, és el tudják-e különíteni azokat más, személyes jellegű konfliktusoktól? A miniinterjúkkal kiegészített kérdőíves kutatás három hipotézist állít fel: 1. A könyvtárosok nem generációs ellentétként azonosítják a munkahelyi konfliktusokat; 2. Az idősebb generációk számára a tisztelet hiánya és az alacsony munkamorál a konfliktusok fő forrása; 3. A fiatal generációk szerint az idősebb generációk konzervatív szakmai hozzáállása, a lassú munkatempó és az informatikai tudás hiánya miatt alakul ki a legtöbb konfliktus.
A problémafelvetés és -elemzés során körvonalazódott megállapításokat érdemes mind a szakmai munkában, mind a felsőfokú könyvtárosképzésben felhasználni, hiszen a generációs ellentétekből adódó konfliktusok jelentős mértékben csökkenthetik a könyvtári munkatársak teljesítményét, ami erősen befolyásolja az intézmény sikerességét, a könyvtárhasználók elégedettségét is
The Impact of Anti-TNF Therapy on CD4+ and CD8+ Cell Subsets in Ankylosing Spondylitis
No full text<b><i>Objectives:</i></b><i></i> Ankylosing spondylitis (AS) is a chronic, progressive immune-mediated inflammatory disease, driven primarily by Th1 and Th17 cells. Anti-TNF therapies are successfully used in AS to achieve and maintain remission. However, their influence on the composition of T-cell subsets is not clear. We aimed to characterize the changes in the T-cell repertoire after a long-term anti-TNF treatment in AS patients. <b><i>Methods:</i></b><i></i> Twenty-two AS patients under long-term anti-TNF therapy were evaluated (15 anti-TNF responders and 7 nonresponders). A wide range of cell subtypes was analyzed with flow cytometry and compared with therapy-naïve and short-term data too. <b><i>Results:</i></b><i></i> Key findings include decreased proportions of naïve CD4 and CD8 cells, increased frequencies of Th1 and Th17 cells and higher Th1/Th2 ratios in the long-term anti-TNF-treated patients (responders, nonresponders and total), which was found to be significant not only when compared with healthy controls, but also with therapy-naïve and short-term anti-TNF-treated AS patients. We noted several alterations within the various activated T-cell subsets – increase in CD4HLADR cells in responders, in CD8HLADR cells in the whole AS group and in responders, and in CD4CD25 cells in responders, and decrease in CD4CD69 cell percentages in long-term treated patients – becoming evident only after long-term anti-TNF therapy. <b><i>Conclusions:</i></b> This study provides a comprehensive assessment of the impact of anti-TNF therapy on the T-cell repertoire in AS. Changes in T-cell phenotype seem to develop progressively during therapy, even in inactive disease, and reflect an ongoing effector T-cell differentiation and activation, along with the parallel compensatory increase in regulatory T cells.</jats:p
The Prognostic Role of Postablative Non-Stimulated Thyroglobulin in Differentiated Thyroid Cancer
No full textThyroglobulin (Tg) is the most important tumor marker in differentiated thyroid cancer (DTC). The aim of this study was to assess the diagnostic and prognostic roles of postoperative stimulated and postablative lowest, highest, and one-year non-stimulated Tg values obtained during the follow-up of patients with DTC. In this retrospective study, 222 radioiodine-treated, anti-thyroglobulin antibody (TgAb)-negative DTC patients having at least 9 months’ follow-up time were included (172 papillary and 50 follicular cancers; median age: 48 (from 15 to 91) years; female–male ratio: 158/64; median (quartiles) follow-up time: 54 (22–97) months). The 2015 American Thyroid Association guidelines were applied as criteria of the therapeutic response. Postoperative stimulated Tg values had significantly lower diagnostic accuracy than any of the non-stimulated postablative Tg values. One-year non-stimulated Tg had excellent prognostic value for structural disease: a cut-off value of 0.85 ng/mL had an 88.1% diagnostic accuracy. If the Tg value did not decrease below 0.75 ng/mL at any time during follow-up, the risk of residual disease was 25 times higher. The highest non-stimulated Tg during follow-up was the best predictor of residual disease (e.g., a Tg value exceeding 7.7 ng/mL indicated a 30-fold increase in risk). Non-stimulated Tg values measured during follow-up have excellent diagnostic accuracy to predict structural disease in DTC patients. The risk classification of a patient can safely be modified based on even a single Tg measurement
