1,720,958 research outputs found
Quality-by-Design approach to monitor the operation of a batch bioreactor in an industrial avian vaccine manufacturing process
No full texttMonitoring batch bioreactors is a complex task, due to the fact that several sources of variability can affecta running batch and impact on the final product quality. Additionally, the product quality itself may notbe measurable on line, but requires sampling and lab analysis taking several days to be completed. Inthis study we show that, by using appropriate process analytical technology tools, the operation of anindustrial batch bioreactor used in avian vaccine manufacturing can be effectively monitored as thebatch progresses. Multivariate statistical models are built from historical databases of batches alreadycompleted, and they are used to enable the real time identification of the variability sources, to reliablypredict the final product quality, and to improve process understanding, paving the way to a reductionof final product rejections, as well as to a reduction of the product cycle time. It is also shown thatthe product quality “builds up” mainly during the first half of a batch, suggesting on the one side thatreducing the variability during this period is crucial, and on the other side that the batch length canpossibly be shortened. Overall, the study demonstrates that, by using a Quality-by-Design approachcentered on the appropriate use of mathematical modeling, quality can indeed be built “by design” intothe final product, whereas the role of end-point product testing can progressively reduce its importancein product manufacturing
Transfer of process monitoring models between plants: Batch systems
No full texttIn this paper, the problem of transferring a process monitoring model between different batch plants is addressed.By exploiting the data coming from a source plant similar to the target plant to which a batch production needs to betransferred, it is possible to transfer a process monitoring model to the target plant under the assumption that thesource plant and the target plant are driven by the same fundamental laws. Two transfer methodologies are proposed.The first one is based on multiway principal component analysis, and exploits the information of similar (“common”)variables that are measured both in the source plant and in the target plant. The second methodology is based on theuse of multiway joint-Y partial least-squares regression and exploits all the measured data, i.e. common variables aswell as variables that are measured only in one of the two plants. The effectiveness of the proposed methodologiesis demonstrated using a benchmark simulated fed-batch fermentation process for penicillin production
Monitoring an industrial batch process for the manufacturing of avian vaccines through Quality-by-Design methodologies
No full textTrasferimento di modelli per il monitoraggio di processi continui e batch mediante tecniche statistiche multivariate
Full text linkSviluppo di metodi per il trasferimento di modelli per il monitoraggio affinché un impianto possa essere monitorato in modo efficiente fin dagli istanti iniziali di funzionament
Trasferimento di modelli per il monitoraggio di processi continui e batch mediante tecniche statistiche multivariate
Full text linkSviluppo di metodi per il trasferimento di modelli per il monitoraggio affinché un impianto possa essere monitorato in modo efficiente fin dagli istanti iniziali di funzionamentoope
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Predizione del titolo virale in un processo industriale di produzione di reovirus impiegati per la formulazione di vaccini aviari
Full text linkNella Tesi è stato studiato il processo biologico-farmaceutico Merial, e in particolare lo stadio di fermentazione, in cui vengono prodotti reovirus impiegati per la formulazione di vaccini atti a prevenire artriti aviarie. Sono stati sviluppati diversi sensori virtuali, tramite modellazione col metodo statistico multivariato avanzato PLS, al fine di predire il titolo virale finale del reovirus sia a batch concluso che in tempo reale, per batch in specifica e fuori specifica di produzione.ope
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