365 research outputs found
Thiol Enzymes Protecting Mitochondria Against Oxidative Damage
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Le tradizioni della traduzione: Shakespeare e il caso Dom Casmurro
No full textSonia Netto Salomão’s study examines the mechanism by which models - that belong to very specific cultural traditions - are transplanted and acculturated in post-colonial 19th-century Brazil. It focuses on Machado de Assis, an author who exemplified confrontation with the western canon, both ancient and modern, to illustrate how translations do not simply “transport” meaning. Salomão thus shows how a Shakespearean simile becomes a metaphor in Dom Casmurro, through a French eighteenth version. As she says, translations belong to diverse traditions and create other traditions, based on the reception of a given author’s poetics. She takes as a historical-cultural and theoretical backdrop a specific process within Brazilian culture, defined in the context of avant-garde Brazilian modernism as “Cannibalism”, and traces it back to the second half of the 19th century, demonstrating its power as a cultural paradigm
The Thiol-specific Antioxidant Enzyme Prevents Mitochondrial Permeability Transition: Evidence For The Participation Of Reactive Oxygen Species In This Mechanism
No full textMitochondrial swelling and membrane protein thiol oxidation associated with mitochondrial permeability transition induced by Ca2+ and inorganic phosphate are inhibited in a dose-dependent manner either by catalase, the thiol-specific antioxidant enzyme (TSA), a protein recently demonstrated to present thiol peroxidase activity, or ebselen, a selenium-containing heterocycle which also possesses thiol peroxidase activity. This inhibition of mitochondrial permeability transition is due to the removal of mitochondrial-generated H2O2 which can easily diffuse to the extramitochondrial space. Whereas ebselen required the presence of reduced glutathione as a reductant to grant its protective effect, TSA was fully reduced by mitochondrial components. Decrease in the oxygen concentration of the reaction medium also inhibits mitochondrial permeabilization and membrane protein thiol oxidation, in a concentration-dependent manner. The results presented in this report confirm that mitochondrial permeability transition induced by Ca2+ and inorganic phosphate is reactive oxygen species- dependent. The possible importance of TSA as an intracellular antioxidant, avoiding the onset of mitochondrial permeability transition, is discussed in the text.273211276612769Gunter, T.E., Gunter, K.K., Sheu, S.-S., Gavin, C.E., (1994) Am. J. Physiol., 267, pp. C313-C339Zoratti, M., Szabó, I., (1995) Biochim. Blophys. Acta, 1241, pp. 139-176Lehninger, A.L., Vercesi, A.E., Bababunmi, E.A., (1978) Proc. Natl. Acad. Sci. U. S. A., 79, pp. 6842-6846Vercesi, A.E., Kowaltowski, A.J., Grijalba, M.T., Meinicke, A.R., Castilho, R.F., (1997) Biosci. Rep., 17, pp. 43-52Castilho, R.F., Kowaltowski, A.J., Meinicke, A.R., Vercesi, A.E., (1995) Free Radical Biol. & Med., 18, pp. 479-486Kowaltowski, A.J., Castilho, R.F., Vercesi, A.E., (1995) Am. J. Physiol., 269, pp. C141-C147Valle, V.G.R., Fagian, M.M., Parentoni, L.S., Meinicke, A.R., Vercesi, A.E., (1993) Arch. Biockem. Biophys., 307, pp. 1-7Kowaltowski, A.J., Castilho, R.F., Vercesi, A.E., (1996) FEBS Lett., 378, pp. 150-152Kowaltowski, A.J., Castilho, R.F., Grijalba, M.T., Bechara, E.J.H., Vercesi, A.E., (1996) J. Biol. Chem., 271, pp. 2929-2934Fagian, M.M., Pereira-da-Silva, L., Martins, I.S., Vercesi, A.E., (1990) J. Biol. Chem., 265, pp. 19955-19960Castilho, R.F., Kowaltowski, A.J., Vercesi, A.E., (1996) J. Bioenerg. Biomembr., 28, pp. 523-529Scorrano, L., Petronilli, V., Bernardi, P., (1997) J. Biol. Chem., 272, pp. 12295-12299Pastorino, J.G., Snyder, J.W., Serroni, A., Hoek, J.B., Farber, J.L., (1993) J. Biol. Chem., 268, pp. 13791-13798Griffiths, E., Halestrap, A.P., (1995) Biochem. J., 307, pp. 93-98Zamzami, N., Hirsch, T., Dallaporta, B., Petit, P.X., Kroemer, G., (1997) J. Bioenerg. Biomembr., 29, pp. 185-193Skulachev, V.P., (1996) FEBS Lett., 397, pp. 7-10Kim, K., Kim, I.H., Lee, K.-Y., Rhee, S.G., Stadtman, E.R., (1988) J. Biol. Chem., 263, pp. 4704-4711Chae, H.Z., Robison, K., Poole, L.B., Church, G., Storz, G., Rhee, S.G., (1994) Proc. Natl. Acad. Sci. U. S. A., 91, pp. 7017-7021Chae, H.Z., Chung, S.J., Rhee, S.G., (1994) J. Biol. Chem., 269, pp. 27670-27678Netto, L.E.S., Chae, H.Z., Kang, S.-W., Rhee, S.G., Stadtman, E.R., (1996) J. Biol. Chem., 271, pp. 15315-15321Nogoceke, E., Gommel, D.U., Kieb, M., Kalisz, H.M., Flohé, L., (1997) Biol. Chem., 378, pp. 827-836Kim, I.H., Kim, K., Rhee, S.G., (1989) Proc. Natl. Acad. Sci. U. S. A., 86, pp. 6018-6022Watabe, S., Kohno, H., Kouyama, H., Hiroi, T., Yago, N., Nakazawa, T., (1994) J. Biochem. (Tokyo), 115, pp. 648-654Ishii, T., Kawane, T., Taketani, S., Bannai, S., (1995) Biochem. Biophys. Res. Commun., 216, pp. 970-975Sies, H., (1993) Free Radical Biol. & Med., 14, pp. 313-323Kowaltowski, A.J., Vercesi, A.E., Castilho, R.F., (1997) Biochim. Biophys. Acta, 1318, pp. 385-402Boveris, A., Martino, E., Stoppani, A.O.M., (1977) Anal. Biochem., 80, pp. 145-158Chae, H.Z., Uhm, T.B., Rhee, S.G., (1994) Proc. Natl. Acad. Sci. U. S. A., 91, pp. 7022-7026Tsuji, K., Copeland, N.G., Jenkins, N.A., Obinata, M., (1995) Biochem. J., 307, pp. 377-381Zhang, P., Liu, B., Kang, S.W., Seo, M.S., Rhee, S.G., Obeid, L.M., (1997) J. Biol. Chem., 272, pp. 30615-3061
A presença do mar em Dom Casmurro: filigranas machadianas
No full textThe presence of the sea in Dom Casmurro
This article is a critical study of water symbolism and the presence of the sea in a
novel of Machado de Assis mature phase. Time, memory, and change flow in the confrontation
between the jealous Bento Santiago, a man of the land with eroding power,
and the personal merit of women with the astute intelligence of Capitu or the pragmatism
of an emerging merchant class to which Escobar belongs. The latter drowns in
a stormy sea that finally engulfs Bento’s marriage to Capitolina. Machado’s filigrees
form a narrative palimpsest, with traces of readings that must be pieced together to
fully construct the meaning that also nature provides, beginning with the psychological
and social incorporation of the characters. Capitu’s “undertow eyes”, an obsessive
image of the waves and the sea in Dom Casmurro, are the product of work patiently
developed over many years in other texts by the Rio de Janeiro author
Fronteiras da alma de um caudilho assinalado : histórias e ficções de Antônio de Souza Netto
No full textPersonagem recorrente em obras do escritor Tabajara Ruas, Antônio de Souza Netto tem, historicamente, um papel protagonista em muitas das guerras que movimentaram as políticas de nações independentes recém constituídas no sul do continente americano durante o século XIX. Em Os varões assinalados, Netto perde sua alma e As cartas do domador (ou Netto e o domador de cavalos), o autor expõe uma personagem revestida de realidade e ficção, em que é possível perceber uma trajetória que parte de uma apresentação calcada mais na história para se chegar a uma representação inventada de Netto. Para situar essa abordagem realizada pela literatura, apontam-se, neste trabalho, alguns conceitos relevantes para a interpretação proposta, como regionalismo, fronteira e heroicidade, fazendo-se o confronto de diferentes posições presentes na historiografia e assim, no questionamento de definições tradicionais, mostrar possibilidades que conferem uma identificação múltipla da personagem em análise. O diálogo com outras obras literárias de autores variados também é aqui apresentado, evidenciando desse modo, através de análises comparatistas intertextuais e interdisciplinares, perspectivas outras para a compreensão de fatos e personagens que compõem a cultura gaúcha.A recurring character in the books from the writer Tabajara Ruas, Antônio de Souza Netto has, historically, a main role in many wars that moved the politics of the recently formed nations from the south of the American continent during the 19th century. In Os varões assinalados, Netto perde sua alma and As cartas do domador (or Netto e o domador de cavalos), the author shows a character coated of reality and fiction, where it is possible to perceive a trajectory that goes from an introduction based on history to get to a made-up representation of Netto. To situate this approach made by literature, some relevant concepts for the proposed interpretation are shown here in this paper, like regionalism, the notion of frontier and the role of the hero, making the comparison of different positions present in historiography and thus, on the questioning of traditional definitions, showing possibilities that confer a multiple identification of the character in question. This work also deals with the dialogue of other literary compositions from varied authors, pointing out to, through such interdisciplinary and intertextual comparative analysis, other perspectives for the comprehension of facts and characters that make up the gaúcho‟s culture.Personaje recorriente en obras del escritor Tabajara Ruas, Antônio de Souza Netto tiene, históricamente, un rol protagonista en muchas de las guerras que movieron las políticas de naciones independientes recién constituidas en el sur del continente americano durante el siglo XIX. En Os varões assinalados, Netto perde sua alma y As cartas do domador (o Netto e o domador de cavalos), el autor expone un personaje revestido de realidad y ficción, en que es posible percibir una trayectoria que parte de una presentación calcada más en la historia para llegarse a una representación inventada de Netto. Para situar ese abordaje realizado por la literatura, se apuntan, en este trabajo, algunos conceptos relevantes para la interpretación propuesta, como regionalismo, frontera y heroicidad, haciéndose el confronto de diferentes posiciones presentes en la historiografía y así, en el cuestionamiento de definiciones tradicionales, mostrar posibilidades que confieren una identificación múltiple del personaje en análisis. El diálogo con otras obras literarias de autores variados también es aquí presentado, evidenciando de ese modo, a través de análisis comparatistas intertextuales e interdisciplinares, perspectivas otras para la comprensión de hechos y personajes que componen la cultura gaucha
Marxismo, Psicoanálisis y Trabajo Social. Comentario a la ponencia central de José Paulo Netto
No full textThe author in his response to Jose Paulo Netto emphasizes the role of psychoanalysis to explain and update the Marxist problematic, which supposes a double meeting of psychoanalysis with Marxism, the Marxism with psychoanalysis. In this meeting Karsz indicates that social work practices teach that ideology and unconscious are not two impenetrable universes, but only two specific dimensions of a single human subject.El autor en su respuesta a José Paulo Netto enfatiza el rol de psicoanálisis en la explicación y actualización de la problemática marxista; lo cual supone un doble encuentro, del psicoanálisis con el marxismo, del marxismo con el psicoanálisis; en este encuentro Karsz señala que las prácticas del trabajo social enseñan que ideología e inconsciente no son dos universos impermeables, sino apenas dos dimensiones específicas de un solo y único sujeto humano
A presença do mar em Dom Casmurro: fligranas machadianas
No full textThis article is a critical study of water symbolism and more specifically the presence of the sea in Dom Casmurro (1899), a novel written by Machado de Assis during his mature phase. Time, memory, and change flow in the confrontation between the jealous Bento Santiago, a man of the land and of eroding power, and the personal merit of women with the astute intelligence of Capitu or with the pragmatism of an emerging merchant class to which Escobar belongs. The latter drowns in a stormy sea that engulfs once and for all Bento Santiago’s marriage to Capitolina. Machado’s filigrees form a kind of narrative palimpsest, with traces of readings that must be put together to fully construct the meaning system that nature provides, beginning with the psychological and social incorporation of the characters. Capitu’s “undertow eyes”, an obsessive image of the waves and the sea in Dom Casmurro, are the product of work patiently developed over many years and in many other texts by the author from Rio de Janeiro
A ESTRUTURA SINCRÉTICA DO SERVIÇO SOCIAL NO PENSAMENTO DE JOSÉ PAULO NETTO: PRIMEIRAS APROXIMAÇÕES: THE SYNCRETIC STRUCTURE OF SOCIAL SERVICE IN THE THOUGHT OF JOSÉ PAULO NETTO: FIRST APPROACHES
No full textRESUMO: O presente trabalho analisa o pensamento de José Paulo Netto, considerando a tese da estrutura sincrética do Serviço Social, defendida no Programa de Pós-Graduação em Serviço Social pela PUC-SP, no ano de 1990, e publicada na obra intitulada “Capitalismo monopolista e serviço social”, em 1992. Nesse sentido, temos por objetivo central apreender a estrutura sincrética do Serviço Social a partir da formulação de José Paulo Netto. A metodologia utilizada foi a pesquisa teórica, de abordagem qualitativa, a partir da leitura aprofundada. Como um dos principais resultados, verificamos que a trajetória teórica traçada por José Paulo Netto foi marcada por denso aprofundamento da Teoria Social Crítica Marxiana e da Tradição Marxista; e no que tange a estrutura sincrética do Serviço Social, formulada por Netto (2011), observamos que o autor contribuiu para o adensamento dos fundamentos do Serviço Social, especificamente no Brasil. Sua análise foi produzida sob a perspectiva da direção social de “intenção de ruptura”, ancorada no referencial marxista e marxiano. Palavras-chave: Serviço social; Estrutura sincrética; Capitalismo monopolista.
ABSTRACT: The present work analyzes the thought of José Paulo Netto, considering the thesis of the syncretic structure of Social Work, defended in the Graduate Program in Social Work at PUC-SP, in 1990, and published in the work entitled "Monopoly capitalism and social service", in 1992. In this sense, our main objective is to apprehend the syncretic structure of Social Work from the formulation of José Paulo Netto. The methodology used was theoretical research, with a qualitative approach, based on in-depth reading. As one of the main results, we found that the theoretical trajectory traced by José Paulo Netto was marked by a dense deepening of the Marxian Critical Social Theory and the Marxist Tradition; and with regard to the syncretic structure of Social Work, formulated by Netto (2011), we observe that the author contributed to the densification of the foundations of Social Work, specifically in Brazil. Its analysis was produced from the perspective of the social direction of "intention of rupture", anchored in the Marxist and Marxian framework. Keywords: Social services; Syncretic structure; Monopoly capitalism
Igualdad, Estado de Bienestar y Trabajo Social. Comentario a la ponencia central de José Paulo Netto
No full textThe author discusses Prof. Netto’s presentation regarding three dimensions: the equality concept, the welfare state subject, and the consequences of the former discussion for social work. First, he questions the dichotomy equality/individualism argued by Prof. Netto through the distinction between Marxism and Neo-liberalism he does transversally in his presentation, accusing it as subcomplex, if we want to give a proper image of contemporary world and its intervention problems. Secondly, the author talks about welfare state and the difficulties in achieving expectations posed in it- since a political centre can not answer all the demands coming from a modern society. Finally, Mascareño indicates challenges for social work regarding to its commitment with the discipline, the professional practice and the ethical action.El autor discute sobre la ponencia del Prof. Netto en torno a tres ejes: el concepto de igualdad; el tema del estado de bienestar; y las consecuencias para el trabajo social. En primer lugar, pone en cuestión la antinomia igualdad/individualismo presentada por el profesor Netto a través de la distinción entre marxismo y neoliberalismo que cruza su trabajo, y la acusa de subcompleja, si se trata de dar una imagen adecuada del mundo contemporáneo y sus problemas de intervención. En segundo lugar, se refiere al estado de bienestar y distingue la dificultad de cumplir las expectativas que sobre él se generan –pues un centro político no puede ya absorber la totalidad de las múltiples demandas de una sociedad moderna–. Por último, el autor plantea desafíos para el trabajo social en torno a su compromiso con la disciplina, con el ejercicio profesional y con el ejercicio ético
El orden social contemporáneo como desafío central
No full textThe author takes the challenge posed by Congress: the unequal contemporary order, and calls for a professional commitment framed by what he describes as a critical social service, which seeks to frontally resist the kingdom of inequality. Professor Netto concerns inequality in Brazil and Latin America and argues that this condition rather than a simple call for an ethical principle or an aspiration or a subjective demand of ideological-political left sectors, for Social Service is a major civil requirement. To explain the situation, the author describes the consequences of neoliberal adjustment in the region and establishes that the challenge for social service does not fall within the scope of techniques or procedures of the intervention, but it falls within the scope of understanding the social meaning of the intervention, which is based on the conditions under which social relations are processed in contemporary society.El autor recoge el desafío planteado por el Congreso: el desigual orden contemporáneo, y hace un llamado por un compromiso profesional enmarcado en lo que él describe como un Servicio Social crítico, que busca contraponerse frontalmente al reino de las desigualdades. El profesor Netto se refiere a la desigualdad en Brasil y América Latina y sostiene que superar esta condición, más que una simple petición de un principio ético o una aspiración subjetiva o una demanda político-ideológica de sectores de izquierda, es para el Servicio Social una insoslayable exigencia cívica. Para explicar la situación describe las consecuencias del ajuste neoliberal en la región y establece que el desafío para el servicio social no se sitúa en el ámbito de técnicas o procedimientos interventivos - vale decir, no se insertan en el circuito instrumental, si no éste se inscribe en el ámbito de la comprensión del significado social de su intervención, y este significado sólo es inteligible si se dilucidan las condiciones en que las relaciones sociales se procesan en la sociedad contemporánea
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