1,721,208 research outputs found
Introduzione
No full textSi tratta dell'introduzione a un volume dedicato ai censimenti italiani unitari, comprendente saggi storici e comparativi. L'introduzione colloca l'operazione storiografica nel contesto dell'evoluzione dell'organizzazione e delle tecniche di rilevazione censuaria dall'ottocento pre-unitario fino ai giorni nostri, e include una bibliografia dettagliata dei 14 censimenti unitari
Synthesis of Bivalent Natural Products-Based Inhibitors of SARS-CoV-2 Spike Protein
No full textSARS-CoV-2 is a virus responsible for COVID-19 pandemic, which caused more than 6.7 million deaths worldwide. Viral mutations could compromise the efficacy of vaccines, so developing drugs capable of suppressing viral replication to treat COVID-19 remains an open therapeutic challenge. In SARS-CoV-2 morphology, a crucial region is the receptor-binding domain (RBD), located in subunit S1 of Spike glycoproteins, since it is involved in the binding with Angiotensin-Converting Enzyme 2 (ACE2) receptor of human cells in the early internalization step. Through virtual screening of the RBD active recognition region, several natural products (NPs) capable to bind in two different portions of the RBD were identified. Triterpenoids were reported as pocket 1 binders, while bile acids derivatives should bind to pocket 5. In this work, bivalent compounds formed by a triterpenoid and a bile acid linked by a spacer were developed, with the aim of obtaining more potent and selective antiviral molecules capable of blocking the fusion between SARS-CoV-2 and host cell. Computational studies have guided the synthesis, providing indications on the size and flexibility of the compounds. Azide-alkyne cycloadditions and amide couplings were used as synthetic strategies to connect the selected triterpenoids (betulinic acid and glycyrrhetinic acid) and bile acid (obeticolic acid). Neutralization assays using pseudotyping lentiviral particles with specific SARS-CoV-2 Spike proteins were performed to evaluate the antiviral activity of these bivalent compounds, demonstrating a higher ability to reduce SARS-CoV-2 infection than single natural products
Mortality in the first years of life: socio-economic determinants in an Italian nineteenth-century population
No full textMortalità infantile e condizione socio-economica. Una riflessione sull'esperienza italiana Fra '800 e '900
No full textItalia ha representado en el panorama europeo, un caso de transición demográfica retardada Este fenómeno ha sido interpretado generalmente come una consecuencia del tardío descenso de la mortalidad infantil en el país. Diversos estudios han documentado ampliamente el estrecho lazo existente entre la condición socioeconómica y la mortalidad infantil, y la influencia de la mejora de la primera en la disminución de la segunda. El presente trabajo se propone revisar el caso italiano tomando en consideración los conocimientos actuales sobre el papel que los factores socioeconómicos han jugado sobre la mortalidad infantil y juvenil en el contexto italiano. Los datos agregados permiten sustentar la hipótesis de una influencia directa e indirecta de la situación económica tanto sobre la tendencia temporal de la mortalidad infantil como sobre las diferenciaciones regionales en el interior del territorio italiano. Pero los estudios agregados nos informan poco acerca dolos mecanismos causales reales de este fenómeno. Sólo recientemente, a través de reconstrucciones de biografías de comunidades enteras del siglo XIX ha sido posible comprobar la validez de las hipótesis formuladas antes a nivel agregado, y también aclarar los mecanismos más íntimos que relacionan, mediante vínculos complejos, las condiciones ambientales, la estructura familiar, la historia reproductiva de las madres y la condición socioeconómica de las familias en que nacían los niños y donde transcurrían sus primeros años de vida, con el correspondiente riesgo de muerte
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Procedure for the execution of detailed geomechanical structural surveys on rock masses with a rigid behavior.
No full textEd. H.P. Rossmanit
Avversione al matrimonio? L'esperienza della popolazione irlandese dopo la grande carestia (1851:1911)
No full text- …
