1,232 research outputs found
Development and inter-rater reliability of the Liverpool adverse drug reaction causality assessment tool.
Get PDFTo develop and test a new adverse drug reaction (ADR) causality assessment tool (CAT)
Ca2+-activated Nucleotidase 1, a Novel Target Gene for the Transcriptional Repressor DREAM (Downstream Regulatory Element Antagonist Modulator), Is Involved in Protein Folding and Degradation.
No full textDREAM is a Ca(2+)-dependent transcriptional repressor highly expressed in neuronal cells. A number of genes have already been identified as the target of its regulation. Targeted analysis performed on cerebella from transgenic mice expressing a dominant active DREAM mutant (daDREAM) showed a drastic reduction of the amount of transcript of Ca(2+)-activated nucleotidase 1 (CANT1), an endoplasmic reticulum (ER)-Golgi resident Ca(2+)-dependent nucleoside diphosphatase that has been suggested to have a role in glucosylation reactions related to the quality control of proteins in the ER and the Golgi apparatus. CANT1 down-regulation was also found in neuroblastoma SH-SY5Y cells stably overexpressing wild type (wt) DREAM or daDREAM, thus providing a simple cell model to investigate the protein maturation pathway. Pulse-chase experiments demonstrated that the down-regulation of CANT1 is associated with reduced protein secretion and increased degradation rates. Importantly, overexpression of wtDREAM or daDREAM augmented the expression of the EDEM1 gene, which encodes a key component of the ER-associated degradation pathway, suggesting an alternative pathway to enhanced protein degradation. Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation
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The Competency Pipeline: Examining the Association of Doctoral Training with Early Career Outcomes
Get PDFParticipants from earlier nationwide studies on predictors of internship match were contacted 7-10 years after obtaining their doctoral degree to gather additional data concerning their attained early career competencies and benchmarks (e.g., scores on the national licensing exam). In this sample (N = 190), licensure exam scores were significantly positively associated with scores obtained on the Graduate Record Examination (GRE), family of origin socioeconomic status, and student debt load. However, obtained licensure scores were not found to be significantly associated with any pre-doctoral training variables (e.g., intervention/ assessment hours, number of integrated reports, number of publications, rank order of matched internship site) or most post-doctoral early career activities. Weak positive associations between licensures scores and engaging in teaching / supervision / consultation services were observed. Few self-reported early career competencies were found to be weakly positively associated with scores on the national licensing exam (i.e., integrity, seeking supervision, scientific mindedness, evidence-based practice). Significantly inverse associations were found between national licensing exam scores and self-reported competencies in the areas of management and systems change. Findings are discussed and implications for the national licensing exam considered
Interpolation of Vector Measures
Get PDF[EN] Let (Omega, Sigma) be a measurable space and m(0) : Sigma -> X-0 and m(1) : Sigma -> X-1 be positive vector measures with values in the Banach Kothe function spaces X-0 and X-1. If 0 < alpha < 1, we define a new vector measure [m(0), m(1)](alpha) with values in the Calderon lattice interpolation space (X01-alpha X1 alpha) and we analyze the space of integrable functions with respect to measure [m(0), m(1)](alpha) in order to prove suitable extensions of the classical Stein-Weiss formulas that hold for the complex interpolation of L-p-spaces. Since each p-convex order continuous Kothe function space with weak order unit can be represented as a space of p-integrable functions with respect to a vector measure, we provide in this way a technique to obtain representations of the corresponding complex interpolation spaces. As applications, we provide a Riesz-Thorin theorem for spaces of p-integrable functions with respect to vector measures and a formula for representing the interpolation of the injective tensor product of such spaces.Supported by La Junta de Andalucia, D.G.I. under projects MTM2006-11690-C02, MTM2009-14483-C02 (M.E.C. Spain) and FEDERDel Campo Acosta, R.; Fernández Carrión, A.; Mayoral, F.; Naranjo, F.; Sánchez Pérez, EA. (2011). Interpolation of Vector Measures. Acta Mathematica Sinica. 27(1):119-134. https://doi.org/10.1007/s10114-011-9542-8S119134271Stein, E. M., Weiss, G.: Interpolation of operators with change of measures. Trans. Amer. Math. Soc., 87, 159–172 (1958)Bergh, J., Löfström, J.: Interpolation Spaces, An Introduction, Grundlehren der Mathematischen Wissenschaften, 223, Springer-Verlag, Berlin, 1976Calderón, A. P.: Intermediate spaces and interpolation, the complex method. Studia Math., 24, 113–190, (1964)Curbera, G. P.: Operators into L 1 of a vector measure and applications to Banach lattices. Math. Ann., 293, 317–330 (1992)Fernández, A., Mayoral, F., Naranjo, F., et al.: Spaces of p-integrable functions with respect to a vector measure. Positivity, 10, 1–16 (2006)Sánchez-Pérez, E. A.: Compactness arguments for spaces of p-integrable functions with respect to a vector measure and factorization of operators through Lebesgue-Bochner spaces. Illinois J. Math., 45, 907–923 (2001)Lindenstrauss, J., Tzafriri, L.: Classical Banach Spaces II, Function Spaces, Ergebnisse der Mathematik und ihre Grenzgebiete, 97, Springer-Verlag, Berlin, Heidelberg, New York, 1979Lozanovskiĭ, G. Ja.: Certain Banach lattices. Sibirsk. Mat. Ž., 10, 584–599 (1969)Šestakov, V. A.: Complex interpolation in Banach spaces of measurable functions. Vestnik Leningrad. Univ., 19, 64–68 (1974)Krein, S. G., Petunin, Ju. I., Semenov, E. M.: Interpolation of Linear Operators, Translations of Mathematical Monographs, 54, American Mathematical Society, Providence, RI, 1985Reisner, S.: On two theorems of Lozanovskiĭ concerning intermediate Banach lattices, Geometric aspects of functional analysis (1986/87), Lecture Notes in Math., 1317, Springer, Berlin, 1988, 67–83Diestel, J., Uhl, J. J., Jr.: Vector Measures, Mathematical Surveys, 15, American Mathematical Society, Providence, RI, 1977Kluvánek, I., Knowles, G.: Vector Measures and Control Systems, North-Holland, Notas de Matemática, 58, Amsterdam, 1975Lewis, D. R.: Integration with respect to vector measures. Pacific J. Math., 33, 157–165 (1970)Lewis, D. R.: On integrability and summability in vector spaces. Illinois J. Math., 16, 294–307 (1972)Fernández, A., Mayoral, F., Naranjo, F., et al.: Complex interpolation of spaces of integrable functions with respect to a vector measure. Collect. Math., 61(3), 241–252 (2010)Musiał, K.: A Radon-Nikodym theorem for the Bartle-Dunford-Schwartz integral. Atti Sem. Mat. Fis. Univ. Modena, XLI, 227–233 (1993)Kouba, O.: On the interpolation of injective or projective tensor products of Banach spaces. J. Func. Anal., 96, 38–61 (1991)Defant, A., Michels, C.: A complex interpolation formula for tensor products of vector valued Banach function spaces. Arch. Math., 74, 441–451 (2000
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Radionuclide Concentrations in Soils and Vegetation at Low-Level Radioactive Waste Disposal Area G during the 1997 Growing Season
Get PDFSoil and overstory and understory vegetation (washed and unwashed) collected at eight locations within and around Area G-a low-level radioactive solid-waste disposal facility at Los Alamos National Laboratory-were analyzed for 3H, 238Pu, 239Pu, 137CS, 234U, 235U, 228AC, Be, 214Bi, 60Co, 40& 54Mn, 22Na, 214Pb and 208Tl. In general, most radionuclide concentrations, with the exception of 3Ef and ~9Pu, in soils and overstory and understory vegetation collected from within and around Area G were within upper (95'%) level background concentrations. Although 3H concentrations in vegetation from most sites were significantly higher than background (>2 pCi mL-l), concentrations decreased markedly in comparison to last year's results. The highest `H concentration in vegetation was detected from a juniper tree that was growing over tritium shaft /+150; it contained 530,000 pCi 3H mL-l. Also, as in the pas~ the transuranic waste pad area contained the highest levels of 239Pu in soils and in understory vegetation as compared to other areas at Area G
Radionuclide Concentrations in Soils and Vegetation at Low-Level Radioactive Waste Disposal Area G during the 1997 Growing Season
No full textSoil and overstory and understory vegetation (washed and unwashed) collected at eight locations within and around Area G-a low-level radioactive solid-waste disposal facility at Los Alamos National Laboratory-were analyzed for 3H, 238Pu, 239Pu, 137CS, 234U, 235U, 228AC, Be, 214Bi, 60Co, 40& 54Mn, 22Na, 214Pb and 208Tl. In general, most radionuclide concentrations, with the exception of 3Ef and ~9Pu, in soils and overstory and understory vegetation collected from within and around Area G were within upper (95'%) level background concentrations. Although 3H concentrations in vegetation from most sites were significantly higher than background (>2 pCi mL-l), concentrations decreased markedly in comparison to last year's results. The highest `H concentration in vegetation was detected from a juniper tree that was growing over tritium shaft /+150; it contained 530,000 pCi 3H mL-l. Also, as in the pas~ the transuranic waste pad area contained the highest levels of 239Pu in soils and in understory vegetation as compared to other areas at Area G
Effects of light/darkness, thermal shocks and inhibitory components on germination of Pinus canariensis, Pinus halepensis and Pinus pinea
No full textKnowledge of the germination characteristics of Pinus species can help in the understanding, prediction and management of the regeneration of pine forests. In the Canary Islands, several exotic pines (Pinus halepensis L. and Pinus pinea L.) were planted with Pinus canariensis Chr. Sm. Ex DC, the only native pine species, and there is now an interest in controlling these exotic species to restore the original forest. The main objective of the present study is to determine the germination response of P. canariensis, P. halepensis and P. pinea to different light regimes (darkness and light/darkness), thermal shocks and the presence of inhibitory substances from the leaves and litter of P. canariensis. P. halepensis seeds showed the highest viability and germination rate. Darkness accelerated P. halepensis germination, while exudates accelerated P. canariensis germination. Only treatments of 200 A degrees C for 5 min and 300 A degrees C for 5 min significantly decreased the germination of all three pine species. In the absence of strong differences in germination among species after treatments, the key for fire management or prescribed burning in this case may be the sprouting ability of P. canariensis. A possible management strategy to control the two obligate seeder exotic species could be to use one intense prescribed fire followed by a low-intensity prescribed fire after seed bank germination in the field, so in this way, only P. canariensis could resprout after fire and it would eliminate only the exotic pines in a mixed stand.91790990,9491,682Q1Q2SCI
Assessing the impacts of land use and climate change on the distribution patterns of "Ulex europaeus" L. (Fabaceae) in the Canary Islands
No full textBiological invasions are one of the major threats to biodiversity, but their impact is particularly detrimental on oceanic islands like the Canary Archipelago. The common gorse (Ulex europaeus L. (Fabaceae)) is a highly invasive shrub with established populations in Tenerife, the sole island of the archipelago where it is present. Understanding the habitat preferences of U. europaeus is essential for predicting its current and potential future distribution across Tenerife and other Canary Islands, guiding effective local management practices. In 2019 and 2020, we surveyed different populations of U. europaeus in Tenerife, retrieving information on its abundance, presence of other invasive species and most frequent natural and anthropogenic characteristics of the landscape. We used this information to build explanatory and predictive models to identify the key natural and anthropogenic drivers of U. europaeus abundance in Tenerife and estimate the potential distribution of the species across the whole archipelago under current and future climatic conditions. Our findings showed that U. europaeus thrives in humid areas impacted by human activities where other invasive species persist. Both current and future climatic conditions do not support the presence of the species in the more arid islands of the archipelago (i.e., Fuerteventura and Lanzarote), rather highlight that the windwards, and thus more humid, areas of the other islands might support the species also under future warmer climatic scenarios. These findings deepen our understanding of U. europaeus local dynamics and are crucial to inform targeted management strategies to mitigate its impact across the Canary Archipelago and, ultimately, oceanic islands.170,942,9Q1Q2SCIE10,
Molecular and cytological characterization of homozygous plants of Citrus clementina Hort. ex Tan., candidates to citrus genome sequencing. .
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