1,721,051 research outputs found
Proteomic and peptidomic analysis for characterization of food matrices
No full texthe discovery of functional natural compounds in raw or processed foods is emerging as a topic of great importance in food science. The interest in these compounds resides in their different biological and nutritional properties, which also include the potential health benefits. Typical compounds include functional fatty acids, vitamins, phenolic acids, flavonoids, but also proteins and peptides. These two last were not much studied until the improvement of proteomic analysis. The study of bioactive peptides found in various food products represents a new field of research and application field of proteomic analysis.
The bioactive peptides derived from food are constituted by short sequences of amino acids (mainly from 2 to 20, with some up to 40 residues) are inactive within the native protein, but that once hydrolyzed may show numerous biological activities. These peptides can be released in different ways: during the gastrointestinal digestion, by hydrolysis in the food, with the maturation, fermentation or cooking, or by hydrolysis in vitro due to proteolytic enzymes. The bioactive peptides have a wide range of biological functions such as antimicrobial, lowering of blood pressure and cholesterol, antithrombotic and antioxidant. They can be used as functional compounds, additives for foods, bio-preservatives or pharmaceutical products. In order to investigate the presence and activity of bioactive peptides, the proteomics and peptidomics analysis have recently been applied to the study of different food matrices. These techniques are generally based on separation techniques, such as gel electrophoresis (mono and two-dimensional) or liquid chromatography, coupled to high-resolution mass spectrometry. The results are then extracted with bioinformatic tools dedicated, in order to obtain the protein identifications, peptide sequences and the biological functions. There are several databases of bioactive peptides studied until now, as PeptideDB, BIOPEP and CAMP; CAMP is a specific database for antimicrobial peptides and has a free tool to predict the bioactivity of peptides not previously studied.
Another important goal of discovery of bioactive peptides is the study of waste products. This kind of products are normally seen as a problem, for economy and ambient, because they need to be disposed of. They could be better employed, not only as feeding for animals but, for example, as a source of bioactive compounds.
Therefore the purpose of this doctoral project was to develop effective analytical strategies for the study of peptides and discovery of bioactive sequences
Impiego di metodi cromatografici miniaturizzati applicati allo studio e alla caratterizzazione di nuovi integratori alimentari
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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