6,384 research outputs found
Synthesis of photoactivable probes for the study of glycosphingolipid-protein interactions
No full textSYNTHESIS OF PHOTOACTIVABLE PROBES FOR THE STUDY OF GLYCOSPHINGOLIPID-PROTEIN INTERACTIONS
Giuseppina Brasile,1 Federica Compostella,1 Laura Mauri,2Sandro Sonnino2 and Fiamma Ronchetti1
Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano
1Via Saldini 50, 20133-Milano, Italy; 2Via Fratelli Cervi 93, 20190- Segrate (Milano), Italy
E-mail:[email protected]
It is widely accepted that glycosphingolipids (GSLs) at the level of the plasma membrane can affect the biological functions of protein molecules, such as cell surface receptors or transporters. The interactions between GSLs and proteins belonging to specific membrane microdomains, called lipid rafts, could be responsible for the modulation of the functional properties of membrane proteins participating in signal transduction. GSL-protein interactions can be investigated by cell photolabelling experiments using radioactive photoactivable GSLs, which yield, when illuminated, a very reactive intermediate that covalently binds to the molecules in the environment, i.e. proteins.1,2
In this context, we have designed a fatty acid probe with two nitrophenylazide photoactivable groups, one at position 2 and the other at the end of the acyl chain. The conjugation of the fatty acid to a radioactive sphingoglycolipid generates a species to be used for photolabelling experiments. In this way, the simultaneous identification of the proteins belonging to both the leaflets of the plasma membrane, the cytoplasmatic and the extracellular one, will be realized.
Herein we describe a general synthetic strategy to obtain not commercially available α,ω-diamino acids, the synthetic precursors of the labelled fatty acids, which we have applied to the synthesis of a C-18 derivative. Furthermore, it will be described the preparation of a photolabelled radioactive GSL as a case study.
1. Aureli M., Prioni S., Mauri L. Loberto N., Casellato R., Ciampa M.G., Chigorno V., Prinetti, A.; Sonnino S. J. Lipid Res. 2010, 51, 798-808
2. Mauri L., Prioni S., Loberto N., Chigorno V., Prinetti A., Sonnino S. Glycoconj. J. 2004, 20, 11-23
Función homenaje a Rosita Mauri
No full textDe cada obra s'ha digitalitzat un programa sencer. De la resta s'han digitalitzat les parts que són diferents.Empresa: José F. ArquerNota informativa que anuncia una funció extraordinària pel festiu de l'1 de maig, i una funció en homenatge a la ballarina Rosita Mauri, en commemoració del centenari del seu naixemen
Qui sont les Dii mauri ?
No full textThe author reviews the various but rare interpretations of the divine collectivity referred to by the name of Dii Mauri. From a re-examination of the literary or epigraphic mentions of the 50 specifically African local or regional divinities, and of the 20 dedications to the Dii Mauri known to this day, he believes he can propose the relationship, even the identity, between the local gods and the Dii Mauri. The comparison between the authors of the dedications shows that the worship of the local gods principally concerned « civilians » (82,5 %), whereas the Dii Mauri were invoked by governors, imperial procurators, soldiers (81,25 %). Moreover the Dii Mauri are invoked as often in Numidia and in Africa as in Caesarian Mauretania (they are unknown in Tingitana). Therefore the term of "maurus" is not linked to the Roman administrative carving, it applies to what is rebellious to Latin culture, to what is specifically native and unassimilable. Dii Mauri and African gods are the same divinities, only the dedicators change.The author reviews the various but rare interpretations of the divine collectivity referred to by the name of Dii Mauri. From a re-examination of the literary or epigraphic mentions of the 50 specifically African local or regional divinities, and of the 20 dedications to the Dii Mauri known to this day, he believes he can propose the relationship, even the identity, between the local gods and the Dii Mauri. The comparison between the authors of the dedications shows that the worship of the local gods principally concerned « civilians » (82,5 %), whereas the Dii Mauri were invoked by governors, imperial procurators, soldiers (81,25 %). Moreover the Dii Mauri are invoked as often in Numidia and in Africa as in Caesarian Mauretania (they are unknown in Tingitana). Therefore the term of "maurus" is not linked to the Roman administrative carving, it applies to what is rebellious to Latin culture, to what is specifically native and unassimilable. Dii Mauri and African gods are the same divinities, only the dedicators change.Camps Gabriel. Qui sont les Dii mauri ?. In: Antiquités africaines, 26,1990. pp. 131-153
L'epigramma italiano dal risorgimento delle lettere ai tempi moderni, con cenni storici, biografie e note bibliografiche; opera dilettevole che forma la "Storia dell' epigramma in Italia" e "Supplemento alle attuali storie letterarie" ...
No full textAt head of title: L. de Mauri (Ernesto Sarasíno)Mode of access: Internet
Mauri Hono: A Mauri sensory methodology
No full textWithin a Māori cultural context, the manifestation of mauri instilled in all living things, both animate and inanimate gives life. Previous research suggests Māori can experience somatic exchanges of energy such as mauri from both other people, as well as within the natural environment. Accordingly, Mauri Hono: A Mauri Sensory Methodology provides a foundation to understanding knowledge by tuning into our senses and using mauri states to help elicit meaning about ourselves and our relationships with natural environments when immersed in those environments. In this study, four key phases of the methodology are detailed; Rongo, Mōhio, Mārama and Mātau and applied to a case study which sought to understand how Māori draw meaning from their experience of being immersed in a natural environment. Ten participants undertook a hīkoi (walk) within a national forest park of regenerating, native, bush. Findings revealed the importance of tuning into one’s senses and having the time and space to interpret different experiences. Furthermore, Mauri Hono, as a Māori methodology is predicated on the belief that experiential knowledge aids in providing a more complete understanding of phenomena than theoretical knowledge alone. It further highlights that whilst knowledge can come into fruition within the timeframe of the project, there is opportunity for insights to arise afterwards, comprising various layers of knowing.fals
Mauri Gilman at the Esplanade, 1937 [picture] .
No full textTitle from caption on label.; Condition: Good.; Lent for copying.; Part of the collection: Lewis collection of photographs. Group portrait of : "Mauri Gilman at the Esplanade, 1937 L to R: Back row - Sammy Lawrence, drums ; Fred Dyke, piano. Front row: Roy Starfield, Frank Dyke, Ross Floyd, Bunny Austin, Mauri Gilman (leader), Barbara James (vocals), Cec Williams, George Trevare" --Printed on label
Oltre il ritratto: Intellettuale di Fabio Mauri
No full textIl 31 maggio 1975, in occasione dell’inaugurazione della Galleria d’Arte Moderna di Bologna, ha luogo la performance Intellettuale di Fabio Mauri (1926-2009) con Pier Paolo Pasolini come protagonista. In cima alle scale d’ingresso del museo, contro la porta, Pasolini siede su un alto sgabello e sul suo torace, vestito con una camicia bianca, è proiettato il suo film Il Vangelo secondo Matteo. Il contributo propone una lettura dell’opera in dialogo con l’intera ricerca di Mauri e, attraverso il confronti con altre opere nonché con la categoria del ritratto, mira a individuare una prospettiva di analisi, non esaurita nella centralità fisica e simbolica di Pasolini, ma aperta verso il dialogo fra forme linguistiche diverse, come la performance e il cinema, il rapporto fra autore e opera nonché fra regista e pubblico, suggerendo la considerazione di Intellettuale come esercizio dialettico che supera la specificità del soggetto coinvolto e dunque la il genere del ritratto
Asca platensis Mauri & Alzuet 1969
No full text<p> <b> <i>Asca platensis</i> Mauri & Alzuet</b> , <b>1969</b></p> <p> <i>Asca platensis</i> Mauri & Alzuet, 1969: 15.</p> <p>TYPE DEPOSITORY: División Entomológica, Facultad de Ciencias Naturales y Museo de La Plata, Buenos Aires, Argentina.</p> <p>TYPE LOCALITY AND HABITAT: Buenos Aires city, Argentina, in moss.</p>Published as part of <i>De Moraes, Gilberto J., Britto, Erika P. J., Mineiro, Jefferson L. De C. & Halliday, Bruce, 2016, Catalogue of the mite families Ascidae Voigts & Oudemans, Blattisociidae Garman and Melicharidae Hirschmann (Acari: Mesostigmata), pp. 1-299 in Zootaxa 4112 (1)</i> on page 104, DOI: 10.11646/zootaxa.4112.1.1, <a href="http://zenodo.org/record/399477">http://zenodo.org/record/399477</a>
Casa Mauri a la Pobla de Segur
No full textVista de la façana de la casa Mauri, actual seu de l' ajuntament de la Pobla de Segu
Botrychium lanceolatum Seb. et Mauri
No full textE. lanceolatum Seb. et Mauri Steinige, buschige Orte. Am Rhoneknie in denDistr. l und2, entdeckt1915von H.GAMS. l: Mehrfach im Gebiet Collonges-Dorenaz, 550-900 m (Garns). - 2: Ob Branson-Fully, 845 bis 1100m (Garns).Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-55
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