1,464 research outputs found
Correction: A case of novel DYT6 dystonia variant with serious complications after deep brain stimulation therapy: a case report
No full textFollowing publication of the original article [1], the authors reported an error in author group. Author M. Zech should be affiliated to affiliations 6 and 7. The original article [1] has been updated
Abnormal low density lipoprotein metabolism in apolipoprotein E deficiency
No full textApolipoprotein(apo) E deficiency is an inherited disease characterized by type III hyperlipoproteinemia and less than 1% normal plasma apoE concentration. The role of apoE in LDL metabolism was investigated by quantitating the metabolism of radiolabeled normal and apoE-deficient LDL in both normal and apoE-deficient subjects. ApoE deficiency resulted in an accumulation of plasma IDL, and a decreased synthesis of LDL consistent with a block in the conversion of IDL to LDL. The LDL isolated from the apoE-deficient patient was similar to normal LDL in hydrated density, size, and composition. However, the apoE-deficient LDL was kinetically abnormal with delayed catabolism in both normal subjects and the apoE-deficient patient. In addition, the catabolism of normal LDL in the apoE-deficient subject was increased. These results were interpreted as indicating that apoE is necessary for the conversion of IDL to LDL and the formation of kinetically normal LDL. The rapid catabolism of normal LDL in the apoE-deficient patient suggests an up-regulation of the hepatic LDL receptor pathway. Based on these results, apoE is proposed to play an important role in the conversion of IDL to LDL, the formation of kinetically normal LDL, and the regulation of LDL receptor functio
An exile in Buenos Aires: The stroll in the Argentinean works of Paul Zech (1933-1946)
No full textEn 1933 el escritor alemán Paul Zech debe huir de Alemania y refugiarse en Buenos Aires, donde vivirá hasta su muerte en 1946. Allí tendrá una intensa actividad literaria, llevada adelante en difíciles condiciones de vida, tanto en cuanto a su condición misma de exiliado, como por sus cambiantes y conflictivos vínculos al interior de la colectividad alemana. En esta obra, una inclinación a la caminata por la ciudad nos muestra una imagen de la Argentina de la década de 1930 desde el novedoso punto de vista de un autor exiliado en estas tierras.En este trabajo nos preguntamos cómo se constituye en la obra argentina de Zech el paseo en el exilio (si acaso es posible el paseo en el exilio) y cómo se recorta, por sus particularidades, de los otros registros urbanos escritos «a pie» en su misma época (Benjamin, Kracauer).In 1933 the German writer Paul Zech had to flee from Germany and go into exile in Buenos Aires, where he would live until his death in 1946. There, he would have an intense literary activity, carried out under difficult living conditions, both because of his condition as an exile and because of his changing and con-flictive links within the German community. Within Zech’s works during these years, an inclination to walk around the city shows us an image of Argentina in the 1930s from the novel point of view of an author exiled in these lands.In this work we inquire how the strollin exile (whether it is possible to stroll in exile) is constituted in Zech’s Argentinean work and how it is cut out, due to its particularities, from the other urban records written «by foot» in his same period (Benjamin, Kracauer).Fil: Sufotinsky Reynoso, Eric Tomás. Universidad Nacional de Rosario. Facultad de Humanidades y Artes. Instituto de Estudios Críticos en Humanidades. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Estudios Críticos en Humanidades; Argentin
Astronomy and astrophysics abstracts: author and subject indexes to volumes 1-10, literature 1969-1973
No full textAstronomy and Astrophysics Abstracts, which has appeared in semi-annual volumes since 1969, is devoted to the recording, summarizing and indexing of astronomical publications through out the world. It is prepared under the auspices of the Interna tional Astronomical Union (according to a resolution adopted at the 14th General Assembly in 1970). Astronomy and Astrophysics Abstracts aims to present a com prehensive documentation of literature in all fields of astronomy and astrophysics. Volume 15/16 contains author and subject indexes of volumes 1 - 10, covering the literature from 1969 to 1973. It is a pleasure to express our warmest thanks to Miss Helga Ballmann, Mrs. Monika Betz, Dr. Siegfried B6hme, Mrs. Karola Gud6, Miss Lore Kiefert, and Mrs. Ingrid Wolf for their kind support in the preparation of the indexes. Heidelberg, June 1976 Ute Esser Inge Heinrich Frieda Henn Dietlinde Krahn Hans Scholl Gert Zech v Introduction The Author Index contains 110 180 references to publications initial letter following the first names. of 28654 different authors. The Subject Index contains 38145 An effort has been made to cite Russian names according to references to 7170 different key words. the following transliteration: The main characteristics of the concept of Astronomy and r Astrophysics Abstracts, Author and Subject Indexes may be A a P p a summarized briefly
Comparison of two-dimensional binned data distributions using the energy test
No full textFor the purposes of monitoring HEP experiments, comparison is often made between regularly acquired histograms of data and reference histograms which represent the ideal state of the equipment. With the larger experiments now starting up, there is a need for automation of this task since the volume of comparisons would overwhelm human operators. However, the two-dimensional histogram comparison tools currently available in ROOT have noticeable shortcomings. We present a new comparison test for 2D histograms, based on the Energy Test of Aslan and Zech, which provides more decisive discrimination between histograms of data coming from different distributions
INVIVO METABOLISM OF A MUTANT FORM OF APOLIPOPROTEIN A-I, APO A-I(MILANO), ASSOCIATED WITH FAMILIAL HYPOALPHALIPOPROTEINEMIA
No full textApo A-IMilano is a mutant form of apo A-I in which cysteine is substituted for arginine at amino acid 173. Subjects with apo A-IMilano are characterized by having low levels of plasma HDL cholesterol and apo A-I. To determine the kinetic etiology of the decreased plasma levels of the apo A-I in these individuals, normal and mutant apo A-I were isolated, radiolabeled with either 125I or 131I, and both types of apo A-I were simultaneously injected into two normal control subjects and two subjects heterozygous for apo A-IMilano. In the normal subjects, apo A-IMilano was catabolizcd more rapidly than the normal apo A-I (mean residence times of 5.11 d for normal apo A-I vs. 3.91 d for apo A-IMilano), clearly establishing that apo A-IMilano is kinetically abnormal and that it has a shortened residence time in plasma. In the two apo A-IMilano subjects, both types of apo A-I were catabolized more rapidly than normal (residence times ranging from 2.63 to 3.70 d) with normal total apo A-I production rates (mean of 10.3 vs. 10.4 mg/kg per d in the normal subjects). Therefore, in the subjects with apo A-IMilano, the decreased apo A-I levels are caused by rapid catabolism of apo A-I and not to a decreased production rate, and the abnormal apo A-IMilano leads to the rapid catabolism of both the normal and mutant forms of apo A-I in the affected subjects
Balance, gait, and navigation performance are related to physical exercise in blind and visually impaired children and adolescents
No full textSelf-motion perception used for locomotion and navigation requires the integration of visual, vestibular, and proprioceptive input. In the absence of vision, postural stability and locomotor tasks become more difficult. Previous research has suggested that in visually deprived children, postural stability and levels of physical activity are overall lower than in sighted controls. Here we hypothesized that visually impaired and blind children and adolescents differ from sighted controls in postural stability and gait parameters, and that physically active individuals outperform sedentary peers in postural stability and gait parameters as well as in navigation performance. Fourteen blind and visually impaired children and adolescents (8–18 years of age) and 14 matched sighted individuals took part. Assessments included postural sway, single-leg stance time, parameters of gait variability and stability, self-reported physical activity, and navigation performance. Postural sway was larger and single-leg stance time was lower in blind and visually impaired participants than in blindfolded sighted individuals. Physical activity was higher in the sighted group. No differences between the group of blind and visually impaired and blindfolded sighted participants were observed for gait parameters and navigation performance. Higher levels of physical activity were related to lower postural sway, longer single-leg stance time, higher gait stability, and superior navigation performance in blind and visually impaired participants. The present data suggest that physical activity may enhance postural stability and gait parameters, and thereby promote navigation performance in blind and visually impaired children and adolescents
Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing
No full textExtracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) to modulate immune function in both inflammasome-dependent and -independent manners. In this study, P2X7-/- mice, the pharmacological agonists ATP-magnesium salt (Mg-ATP; 100 mg/kg, EC50 ≈ 1.32 mM) and benzoylbenzoyl-ATP (Bz-ATP; 10 mg/kg, EC50 ≈ 285 μM), and antagonist oxidized ATP (oxi-ATP; 40 mg/kg, IC50 ≈ 100 μM) were used to show that P2X7R activation is crucial for the control of mortality, bacterial dissemination, and inflammation in cecal ligation and puncture-induced polymicrobial sepsis in mice. Our results with P2X7-/- bone marrow chimeric mice, adoptive transfer of peritoneal macrophages, and myeloid-specific P2X7-/- mice indicate that P2X7R signaling on macrophages is essential for the protective effect of P2X7Rs. P2X7R signaling protects through enhancing bacterial killing by macrophages, which is independent of the inflammasome. By using the connexin (Cx) channel inhibitor Gap27 (0.1 mg/kg, IC50 ≈ 0.25 μM) and pannexin channel inhibitor probenecid (10 mg/kg, IC50 ≈ 11.7 μM), we showed that ATP release through Cx is important for inhibiting inflammation and bacterial burden. In summary, targeting P2X7Rs provides a new opportunity for harnessing an endogenous protective immune mechanism in the treatment of sepsis.-Csóka, B., Németh, Z. H., Töro, G., Idzko, M., Zech, A., Koscsó, B., Spolarics, Z., Antonioli, L., Cseri, K., Erdélyi, K., Pacher, P., Haskó, G. Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing
Imaging of Hepatocellular Carcinoma by Computed Tomography and Magnetic Resonance Imaging: State of the Art
No full textHepatocellular carcinoma (HCC) is a very frequent tumor worldwide. Its incidence is linked to the distribution of liver cirrhosis and viral hepatitis, which are the main risk factors for the development of HCC. For the evaluation of the cirrhotic liver and for the diagnosis of HCC, multidetector computed tomography (MDCT) proved to be a robust and reliable tool. In MDCT the diagnosis of HCC can be made based on neovascularization with increased arterial and decreased portal venous supply. With modern magnetic resonance imaging (MRI), spatial resolution and robustness increased dramatically. Beside the evaluation of neovascularization by means of gadolinium-enhanced early dynamic MRI, the main advantages of MRI are additional information on tissue composition and liver-specific function. With diffusion-weighted imaging or plain T(1)- and T(2)-weighted sequences, different tissue elements like fat, hemorrhage, glycogen, edema and cellular density can be evaluated. Liver-specific contrast agents give insight into the Kupffer cell density or the hepatocellular function. The integration of all these parts into the MR examination allows for a very high detection rate for overt HCC nowadays, although very small HCCs are still a challenge. Moreover, insight into the different stages of hepatocarcinogenesis can be possible with MRI. Despite its limited availability in some countries, it has to be rendered to be the modality of choice for the distinct evaluation of the cirrhotic liver. Copyright (C) 2009 S. Karger AG, Base
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