150,982 research outputs found
Bhatia koreana Kwon & Lee 1979
No full textBhatia koreana (Kwon & Lee, 1979) Koreanopsis koreana Kwon & Lee, 1979: 166. Bhatia koreana, Zhang & Webb, 1996: 12, Figs 139–144, 490; Shang et al., 2006 a: 566, Figs 13 –17. Distribution: China (Shaanxi); South Korea.Published as part of Qu, Ling, Webb, M. D. & Dai, Ren-Huai, 2015, A new genus and species of the leafhopper subtribe Paraboloponina from China (Hemiptera, Cicadellidae), pp. 260-270 in Zootaxa 3919 (2) on page 261, DOI: 10.11646/zootaxa.3919.2.2, http://zenodo.org/record/24119
Nabicerus Kwon 1985
No full textGenus Nabicerus Kwon, 1985: 68. Nabicerus baculatus Xue & Zhang, 2014: 396, Figs. 2 A–D, 4A–H Distribution. China: Hainan (Mt. Bawangling).Published as part of Zhang, Bin & Webb, M. D., 2019, A checklist and key to the idiocerine leafhoppers (Hemiptera: Cicadellidae) of Hainan Island, with description of a new genus and new species, pp. 581-587 in Zootaxa 4576 (3) on page 582, DOI: 10.11646/zootaxa.4576.3.10, http://zenodo.org/record/371568
Drabescoides Kwon & Lee
No full textKey to male species of the Genus Drabescoides Kwon & Lee 1. Aedeagal shaft with collar-shaped process on dorsal margin in dorsal view........................................ 2 - Aedeagal shaft without collar-shaped process on dorsal margin in dorsal view..................................... 3 2. Aedeagal shaft with pair of broad lamellae above collar-shaped process........................... D. complexa sp. nov. - Aedeagal shaft without pair of broad lamellae above collar-shaped process............ D. undomarginata Cen & Cai, 2002 3. Connective stem obviously concave at apical margin, X-shaped.......................... D. longiarma Li & Li, 2010 - Connective stem not concave at apical margin, T-shaped or n-shaped............................................. 4 4. Pygofer lobe with elongated ventral margin; connective stem apex greatly expanded, T-shaped... D. nuchalis (Jacobi, 1943) - Pygofer lobe without elongated ventral margin; connective stem apex not expended, n-shaped.................................................................................................. D. umbonata Shang & Zhang, 2003Published as part of Qu, Ling, Li, Hu & Dai, Ren-Huai, 2014, Key to species of leafhopper genus Drabescoides Kwon & Lee (Hemiptera, Cicadellidae), with description of a new species from Southern China, pp. 347-358 in Zootaxa 3811 (3) on page 348, DOI: 10.11646/zootaxa.3811.3.5, http://zenodo.org/record/22750
Stirellus yeongnamensis Kwon & Lee 1979
No full textStirellus yeongnamensis (Kwon & Lee, 1979) n. rec., comb. nov. (Figs. 27–29) Doratulina yeongnamensis Kwon & Lee, 1979: 100, plate I; Lee, 1979: 331, Figs. 224–226. Length. Male: 3.0– 4.3mm; female: 3.4–4.8mm. Color. General color yellow green throughout (Figs. 27–28). Frontoclypeus stramineous with fuscous arcs from lateral frontal suture reaching only part way across (Figs. 27 F, 28F). Body. Head nearly subequal in width to pronotum, subconical, anterior margin rounded to face, acutely angled (Figs. 27 A–E, 28A–E). Vertex nearly as long as width between eyes or somewhat longer (Figs. 27 A–E, 28A–D). Ocellus next to eye on anterior margin (Fig. 28 E). Eye relatively large (Figs. 27 A–E, 28A–E). Anteclypeus nearly parallel-sided, extending beyond normal curve of genae (Figs. 27 F, 28F). Pronotum median length nearly as long as median length of crown. Mesonotum and scutellum shorter than pronotum (Figs. 27 A–E, 28A–D). Forewing macropterous, sometimes exposing apex of abdomen (Figs. 27 A–E, 28A–E). Male. Pygofer side without macrosetae, apex as in Fig. 29 A. Subgenital plate slightly concave laterally, macrosetae not uniseriate laterally (Fig. 29 D). Style narrow, apophysis digitate, laterally curved (Fig. 29 E–G). Connective stem shorter than arms (Fig. 29 H). Aedeagal shaft bent at near base, straight, tip slightly curved dorsad, parallel to aedeagal base (Fig. 29 I–J). Female. Hind margin of seventh sternum nearly straight (Fig. 28 G). Material examined. China, Fujian Prov.: 1Ƌ, 1♀, Wuping County, 320m, 1 September 2008, coll. Gao Xia & Li Xiaoqing; Guangdong Prov.: 3♀, Shenzhen City, August 1986, coll. Zhang Yalin; Guangxi Prov.: 58Ƌ, 3♀, Shangsi County, 28 November 2001, coll. He Zhiqiang; Hainan Prov.: 5Ƌ, 2♀, Mt. Wuzhi, 20 May 2007, coll. Duan Yani; 5Ƌ, 2♀, Mt. Jianfeng, 29 May 2007, coll. Duan Yani; Sichuan Prov.: 2Ƌ, Mt. Emei, Wanshou Temple, 24 July 2009, coll. Zhang Xinmin; Yunnan Prov.: 1Ƌ, 1♀, Menglun, 19 June 1991, coll. Wang Yinglun & Tian Rungang; 5Ƌ, 3♀, Simao, 1331m, 19 July 2005, coll. Lu Lin; Zhejiang Prov.: 1♀, Mt. Qingliang, 530m, 9 August 2008, coll. Xiao Bin. Distribution. Korea; China (Fujian, Guangdong, Guangxi, Hainan, Sichuan, Yunnan, Zhejiang). Remarks. This species was described from the following specimens from Korea with the following data: “Holotype Ƌ, Whasan, IX 1974; allotype ♀, the same with holotype, and paratypes: 15Ƌ, 18♀, the same with holotype and allotype; Taegu, 1♀, 24, VII, 1971; Samsan near Taegu, 1♀, 15, VI, 1975.”. The types have not been examined and the identity of the species is based on the figures of Kwon & Lee (1979). This species is similar to S. dindorensis (Pruthi, 1930: 38, plate III, 6 & 6a, text-fig. 51–53), but differs in having the male pygofer without macrosetae. This species is also similar to S. lahorensis (Distant), but the latter has a longer and more acute vertex (see Khatri & Webb, 2010, Fig. 24.)Published as part of Duan, Yani, Webb, M. D. & Zhang, Yalin, 2016, Review of the leafhopper tribe Stenometopiini (Hemiptera: Cicadellidae: Deltocephalinae) from China with description of four new species, pp. 101-138 in Zootaxa 4171 (1) on pages 133-135, DOI: 10.11646/zootaxa.4171.1.4, http://zenodo.org/record/25585
Reaction of Terfenol-D melts with SiO2 crucibles
No full textThe interaction between Terfenol-D (Tb(x)Dy(1-x)Fey (0.27 <= x <= 0.30, y <= 2)) melts and quartz crucibles has been studied. A rare earth silicide was formed next to a rare earth oxide on SiO2 substrate and a surface layer of rare earth oxide appeared on top of the silicide layer. The reaction was controlled by diffusion with an activation energy E-a = 1.59 eV. The effect of Si contamination on the magneto-elastic property was evaluated. Maximum mangnetostriction of Terfenol-D decreased by 300 ppm while Si addition increased up to 1.0 at.%. (c) 2005 Elsevier B.V. All rights reserved
Hyukmin Harry Kwon, Violin
No full textScherzo from the Sonatensatz in C minor, Op. posth., FAE Sonata / J. Brahms; Chaconne in D minor, from Solo Violin Partita No. 2, BWV 1004 / J. S. Bach; Violin Concerto No. 2 in G minor, Op. 63 / S. Prokofie
Effect of D-lactate on the physiological activity of the ArcB sensor kinase in Escherichia coli
No full textThe Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory growth conditions. Under anoxic growth conditions ArcB autophosphorylates and transphosphorylates ArcA, which in turn represses or activates its target operons. The anaerobic metabolite D-lactate has been shown to stimulate the in vitro autophosphorylating activity of ArcB. In this study, the in vivo effect of D-lactate on the kinase activity of ArcB was assessed. The results demonstrate that D-lactate does not act as a direct signal for activation of ArcB, as previously proposed, but acts as a physiologically significant effector that amplifies ArcB kinase activity.open
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Optimation of the lead MD77
No full textThe investigation which led to the identification of our lead MD771 began from a screening (dual-luciferase assay system) of chemical libraries, performed in collaboration with our colleagues of the Korean Research Institute of Bioscience and Biotechnology (KRIBB). From this preliminary screening, several STAT3 inhibitors were identified. Based on the further information gained through conformational and docking studies, a number of derivatives were synthesized, characterized and evaluated by means of different biological assays. The obtained results led to the discovery of a molecule (MD77) as a promising lead compound. MD77 exerted positive results in the dual-luciferase assay, showing 20% inhibition at 5 μM. It was also able to significantly interact with STAT3-SH2 domain, with a dose-dependent profile and an IC50 of 17.7 μM (AlphaScreen-based assay). Moreover, it displayed a significant growth inhibitory activity evaluated on a panel of tumor cell lines with a GI50 around 2 μM for most of them. Modeling, docking and crystallographic studies were also performed and they gave a key support in understanding the binding mode of MD77 to the STAT3-SH2 domain. In light of these results, MD77 became our starting point for the development of new direct STAT3 inhibitors. Initially, the optimized derivatives were designed following the classical methodologies of medicinal chemistry, in which the molecule undergoes a gradual modification on the basis of SAR studies and with the support of molecular modeling studies. In particular, the substitution of the amidic functionality with a bioisosteric thioamidic group and the nature of the substituent at position 5 were considered. In detail, alkyl groups or halogens were introduced at different positions of the aromatic ring. In addition, since docking studies on MD77 suggested that in the binding mode of its favoured conformation to the SH2 domain, which is comparable to that of phosphorylated Tyr-705, the trifluoromethyl group could play an important role by establishing three hydrogen bond interactions with the guanidine moiety of Arg-595 residue, we synthesized the analogue lacking the substituent to verify this hypothesis.
1. Masciocchi D., Villa S., Meneghetti F., Pedretti A., Barlocco D., Legnani L.,Toma L., Kwon BM, Nakano S., Asai A., Gelain A. Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors. MedChemComm (2012), 3, 592-59
Jae kyung Kwon
No full text학위논문(석사)--아주대학교 일반대학원 :신경과학기술과정,2019. 2I.INTRODUCTION 1
A. Astrocyte 1
1. Reactive astrocytes 1
2. Expression of stem cell markers in reactive astrocytes 2
B. Inwardly rectifying potassium channel 4.1 (Kir4.1) 3
1. Inwardly rectifying K+ channel (KIR channel) 3
2. Function of Kir4.1 in normal glial cells 3
3. Kir4.1 related to pathological conditions 4
C. Specific Aims 5
II. Materials and methods 6
A. Sphere culture from neonate slice 6
B. Primary neural stem cell culture 6
C. Western blot 7
D. Immunohistochemistry 7
E. Real time PCR 8
IIII. RESULTS 10
A. Co-expression of Kir4.1 and Sox2 in astrocytes in injured brain10
B. Expression and roles of Kir4.1 in acquisition phase of stemness 15
C. Expression and roles of Kir4.1 in differentiation phase of neural stem cells19
IV. DISCUSSION 23
V. CONCLUSION 25
REFERENCES26
국문요약 31MasterIn response to damage of the brain, astrocytes are activated and increase expression of GFAP. In this study, I found that activated astrocytes increased expression of Kir4.1, a major potassium channel in astrocytes, with markers of neural stem cells including Sox2 and nestin. Kir4.1 expression was also increased with that of nestin and Sox2 when spheres were formed from dissociated P7 mouse brain. In experiments to find out correlation between Kir4.1 and acquisition of stemness, BaCl2, an inhibitor of Kir4.1, dose-dependently increased size of spheres and Sox2 levels although nestin levels were little changed. In further experiments, expression and functions of Kir4.1 in differentiation of neural stem cells were examined. For this, stem cells were cultured from E13 mouse brain were differentiated. At 1 d after differentiation of stem cells was induced by withdrawing EGF and FGF from the culture media, Kir4.1 expression sharply increased, and then decreased thereafter to 5 d while Sox 2 and nestin levels continuously decreased to 5 d. BaCl2, however, did not change expression levels of Sox2 and nestin as well as differentiation markers, GFAP and TUJ-1. Taken together, these results suggest that Kir4.1 may control gain of stemness but not differentiation of stem cells
- …
