390,550 research outputs found
A Concert of Harp, Piano, and Vocal Music: Angela Kwan Le-Fox and Frederick S. Fox in a Guest Artist Concert
Full text linkThis is the program for the guest artist concert featuring harp and piano player Angela Kwan Lu-Fox and pianist and bass-baritone Frederick S. Fox. This recital took place on April 29, 1988, in the Mabee Fine arts Center Recital Hall
Enantioselective capillary electrophoresis : fundamental aspects and application to the "in vitro" assessment of CYP3A4 mediated ketamine N-demethylation
Full text linkA large number of pharmaceutical substances are administered as racemates, consisting of two enantiomers with typically different pharmacodynamic and pharmacokinetic profiles. Thus, stereoselective analysis is important in drug development, therapeutic drug monitoring and research. Chiral separation by chromatographic methods such as HPLC and GC require expensive stationary phases. In contrast, in capillary electrophoresis (CE), enantioselective separation can be obtained using one or several chiral selectors which are added to the background electrolyte. Separation of enantiomers is based on different binding affinities with the enantiomers and/or different migration velocities of the formed analyte-selector complexes. High resolution can be achieved by varying type and concentration of chiral selector as well as buffer properties (pH, ionic strength, other additives etc.). Typical chiral selectors are neutral or charged cyclodextrins, proteins and bile acids. The simplicity of the technique makes enantioselective CE an attractive, promising and economic methodology for drug and metabolite analysis in pharmaceutical preparations, body fluids, tissues and microsomal preparations.
In the first part of this thesis, fundamental aspects of enantioselective CE were investigated using computer simulation. Dynamic computer simulators provide insight into the buffer system and improve understanding of the electrophoretic separation process. Simulation allows to predict proper separation and detection conditions for analytes prior to experiments. Using an extended version of the dynamic computer simulator GENTRANS, the interaction of methadone and its main metabolite EDDP with neutral chiral selectors were simulated. Experimentally determined complexation constants and mobilites of the formed complexes were employed as additional input parameters. Simulated electropherograms were qualitatively in good agreement with the experimental results.
In the second and third parts of the thesis, enantioselective CE was applied to study ketamine metabolism in an off-line study. Ketamine is a chiral phencyclidine derivative used in anesthesia. In vitro and also in vivo studies showed a higher affinity for the NMDA-receptors, higher anesthetic potency and shorter recovery time for S-ketamine compared to R-ketamine. The aims in this project were to characterize the kinetics of CYP 3A4 mediated ketamine N-demethylation in vitro including KM, Vmax and to investigate the stereoselective metabolism of this pathway. Furthermore, the inhibition kinetics of this pathway by ketoconazole, a potent CYP3A4 inhibitor, was investigated. Results showed a higher formation rate for S-norketamine after incubation of racemic ketamine as well as incubation of the single enantiomers. Data obtained in the absence of ketoconazole revealed that the N-demethylation occurred stereoselectively. Inhibition kinetics by ketoconazole fitted best to a one-site competitive model and no stereoselectivity could be demonstrated.
In the forth and final part of this thesis, an on-line method was developed to investigate the in vitro N-demethylation of ketamine via CYP3A4, with the incubation performed in-capillary with subsequent electrophoretic separation and detection of the ketamine enantiomers. Kinetic parameters obtained compared well with those of the off-line study mentioned above and the metabolic step was stereoselective, confirming the results of the off-line assay. After additional improvements, the in-capillary method should be widely applicable to assess enzymatic activity in a fast, low-cost and automated way
IP protection for DSP algorithms' FPGA implementation.
Full text linkWith today's system-on-chip (SOC) technology, we are able to design larger and more complicated application-specific integrated circuits (ASICs) and field programmable gate array (FPGA) in shorter time period. The key point of the success of SOC technology is the reuse of intellectual property (IP) cores. Consequently the copyright protection for these IP cores becomes the major concern for the development pace of SOC technology. Watermarking technology has been proved to be an effective way of copyright protection. In this thesis, the author presents two new watermarking algorithms respectively at algorithm level and FPGA layout level. The simulations and implementation results show that the new proposals have much less design and hardware implementation overheads, lower watermark embedding and extraction cost, as well as higher security strength, compared to the previously proposed methods.Dept. of Electrical and Computer Engineering. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2004 .D39. Source: Masters Abstracts International, Volume: 43-03, page: 0929. Advisers: H. K. Kwan; H. Wu. Thesis (M.A.Sc.)--University of Windsor (Canada), 2004
Erratum to: Physical modeling of baffles influence on landslide debris mobility [Landslides, 10.1007/s10346-014-0476-y]
No full textThe original version of this article, unfortunately, contained an error. One of the authors’ names was incorrectly spelled as J. H. S. Kwan. The correct spelling is J. S. H. Kwan and is now correctly given in this article
The nanostructure and degradation of C-S-H in Portland and blended cements
Full text linkThe microstructure and composition of water and KOH activated hardened pastes of commercial neat white Portland cement (WPC) and blends with 30% fly ash (PFA) have been characterised using a multi-technique approach, With particular emphasis on the nature of the C-S-H phase. The neat and fly ash blended pastes were activated with water or a 5M KOH solution and cured for one year at 25'C, one month at 55'C and one month at 85'C. The mean length of the aluminosilicate anion structure of C-S-H (29 Si MAS NMR) increased with age and it was higher in the fly ash blended systems. Formulae were presented for the average structural units in the C-S-H present in the systems analysed by TEM-EDX. SEM micrographs showed that as hydration occurred,
the microstructure became denser because outer product C-S-H was formed in the water filled spaces and additional C-S-H resulted from the pozzolanic reaction. The chemical
composition of C-S-H could not be determined by SEM-EDX because of intermixing with other phases; TEM-EDX was necessary. Inner product C-S-H morphology was fine and homogeneous and that of outer product C-S-H was fibrillar in the water activated systems and foil-like with alkali activation. Fly ash replacement did not change the morphology of lp and Op C-S-H. Small fully hydrated cement and PFA particles were filled with a less dense lp C-S-H with morphology very similar to the foil-like one. TEM-EDX showed that, in general, the mean Ca/(AI+Si) atomic ratio was lower in the water activated blends than that in the neat cement pastes due to the fly ash reaction. The composition- structure data were discussed in terms of models for the nanostructure of C-S-H.
Higher curing temperature accelerated the rate of the cement hydration. The mean length of the aluminosilicate of the C-S-H anions was much higher than that of C-S-H formed at lower temperatures, and it was also higher in the blended pastes than with neat cement. Backscattered electron images showed that the grey level of C-S-H in the
systems cured at 55T and 85T was in places quite similar to that of the calcium hydroxide: that is, it was brighter than in pastes cured at lower temperature. SEM also showed that the microstructure of the systems cured at higher temperature exhibited non uniform porosity. Inner product C-S-H with a fine scale, homogeneous morphology,
was abundant in all systems cured at 55'C and 85'C. Op C-S-H was generally fibrillar with Nvater, and foil-like with alkali. However, the higher temperature curing did result
in coarser fibrillar morphology (water activated systems) than that formed at lower temperatures.
The C-S-H gel formed in the commercial WPC-30% PFA blended paste hydrated for one year at 25'C and water leached for twelve weeks was also characterised in this work. A matrix effect was clearly observed by 29 Si MAS NMR. Cross-linking of the aluminosilicate anion structure of C-S-H occurred after leaching the sample for four weeks. Formulae were also presented for the average structural units in the C-S-H
present in the unleached and four weeks water leached systems analysed by TEM-EDX. lp C-S-H morphology was fine and homogeneous and Op C-S-H had fibrillar morphology. There were many areas in the microstructure of the leached sample where Op C-S-H with foil-like morphology coexisted with fibrillar Op C-S-H
Perwujudan Representational Meaning Kim Shin Kwan Kong Di Klenteng Hok an Kiong Surabaya
Full text linkHok An Kiong chinese temple is the Tri Dharma's place of worship in Surabaya city, East Java. The research was conducted at Kwan Kong god statue and interior elements contained in the temple's main altar hall. This interior hall was designed by Fujian (Southern China) culture style and has been constructed since 1821 that are rich of original Chinese cultural values and historical values. The process of analysis using the iconography method by van Leeuwen, the purpose of this method is to determine the meaning of Kwan Kong god statue with first layer. The main function of Kwan Kong god statue physicaly as the worship orientation for the temple's worshipers, but by iconography method shows the impact who manifested in some of the interior elements in the temple's main altar hall
Cheung, S.-C, Kwan, P.-S., Kong Y.-C. Bencao yanjiu rumen (An Introduction to Pen-ts'ao Study)
No full textMétailié Georges. Cheung, S.-C, Kwan, P.-S., Kong Y.-C. Bencao yanjiu rumen (An Introduction to Pen-ts'ao Study). In: Journal d'agriculture traditionnelle et de botanique appliquée, 31ᵉ année, bulletin n°3-4, Juillet-décembre 1984. pp. 266-267
Nam Kwan's artistic World : With emphasis on the abstract art
No full text이 논문은 한국의 대표적 추상화가의 한 사람인 남 관(南 寬, 1911~ )의 작품세계에 관한 연구로, 그의 대표적 작품을 분석하여, 독자적 작품세계의 형성과 전개 그리고 그 특성을 연구하고 미술사적 의의를 고찰하였다.
여기서는 남 관의 작품세계를 모색기, 파리, 시대, 서울 시대의 세 시기로 나누어 분석하였다. 그는 모색기에 이미 탁월한 뎃상 실력과 서양 전통의 구상적 표현 기법을 철저하게 익히고 있었으며, 파리 시대에는 동양의 에스프리와 자신의 체험을 서양의 견고한 재료를 통해 표현하는 독자적 작품세계를 형성하게 되었으며 이러한 그의 작품이 국제 화단의 인정을 받게 된다. 1958년 이후 6회에 걸친 살롱 드메(Salon de Mai)의 초대 출품과 1966년 망통 회화 비엔날(Biennale de Peinture, Menton) 에서의 대상 수상 그리고 국내외 화랑에서 가진 개인전과 초대전을 통해 도리발(B. Dorival), 레베크(J. J. Leveque )등 현대 미술 평가의 권위자들부터 호평을 받았다. 서울 시대에는 파리 시대에 형성했던 자신의 예술 원칙을 일관성있게 지켜가면서, 그 원칙 안에서 다양한 변모를 추구하여 한층 심화된 예술 경지를 보여주고 있다.
그리고 남 관 작품의 일반적 특성은 천태만상의 인간상 표현, 마스크와 상형문자와 같은 기호에 의한 공간 구성, 청색을 주조로 한 서정적 색채와 창의적인 꼴라쥬 기법에 의한 독특한 마티에르에 있다.
그리하여, 이 논문의 연구 결과, 남 관은 한국 내지 동양의 문화적 전통을 그의 뛰어난 감성과 능숙한 서양화 기법을 통해 현대적인 추상 회화로 발전시켰으며, 동양적인 특색을 지닌 그의 작품은 국제화단에서 그 예술성이 높이 평가됨으로써 한국 현대 미술사상 처음으로 큰 국제적 성과를 거두었으며, 이 점에서 미술사적 의의가 있다는 것을 알게되었다.;This dissertation is an analysis of the works of Nam Kwan, one of the most outstanding abstract painters in Korea, and a study of the formation and the development of the works of Nam Kwan, and an investigation of the art- historical significance.
This dissertation analyed the works o f Nam Kwan as three period-the first period when he was in search of the ways and means, the second period when he was in Paris , the third period when he was in Seoul. completely the excellent dessin In the first period he already learned capability and the plastic techniques of western style . In the second period he formed the artistic realm of his own expressing the oriental esprit and his experiences through the firm materials of the west. and his art like that became to be acknowledged in the international painting circles.
Accordingly he was invited to participate in the Salon de Mai Exhibition six times from 1958, and the received the Grand prix of the Biennale Exhibition of Paintings,Menton, in 1966. Returning Homeland 1968, in the third period he consistantly maintains the rules which he formed in the second period and he shows the various transformations and deepend stage under such rules.
The important motive of the art of Nam Kwan is the human image which he view through his experience based on. Oriental spirit, and the specific character of the art of Nam Kwan is the fact that combining the motive with the Korean-traditional mask and pictograph, he expresses that motive by means of peculiar western style techniques and delicate color mainly composed with blue.
The result of this dissertation shows the fact that the art of Nam Kwan became to be highly estimated in the international painting, circles in the respect that he expressed the Korean or oriental spirit through the skilled and peculiar western style techniques. Therefore the art of Nam Kwan has art historical meaning as a first international outcome of modern art of Korea.논문개요 = ⅷ
Ⅰ. 서론 = 1
Ⅱ. 예술형성의 배경 = 3
A. 생애와 예술관 = 3
B. 사회적 배경 = 14
Ⅲ. 시기별 활동 및 작품 = 17
A. 모색기 : 1935 ∼ 1954 = 17
B. 파리 시대 : 1955 ∼ 1968 = 24
C. 서울 시대 : 1968 ∼ = 37
Ⅳ. 작품의 특성과 의의 = 44
A. 작품의 특성 = 44
1. 모티브 = 44
2. 포름 (형상) = 48
3. 색채 = 55
4. 재료와 기법 = 58
B. 미술사적 의의 = 60
Ⅴ. 결론 = 66
참고문헌 = 68
연보 = 71
그림 = 75
ABSTRACT = 9
Cheung Kwan-hin and Bauer Robert S. : The representation of Cantonese with Chinese characters
No full textYau Shun-chiu. Cheung Kwan-hin and Bauer Robert S. : The representation of Cantonese with Chinese characters. In: Cahiers de linguistique - Asie orientale, vol. 33 2, 2004. pp. 251-268
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