1,035 research outputs found
Alzheimer's Disease pathology is not sufficient for CCR2(+) bone marrow engraftment in the CNS
No full textAlzheimer's Disease pathology is not sufficient for CCR2(+) bone marrow engraftment in the CNS
No full textDistinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease
No full textMononuclear phagocytes are important modulators of Alzheimer's disease (AD), but the specific functions of resident microglia, bone marrow-derived mononuclear cells, and perivascular macrophages have not been resolved. To elucidate the spatiotemporal roles of mononuclear phagocytes during disease, we targeted myeloid cell subsets from different compartments and examined disease pathogenesis in three different mouse models of AD (APPswe/PS1,APPswe, andAPP23mice). We identified chemokine receptor 2 (CCR2)-expressing myeloid cells as the population that was preferentially recruited to β-amyloid (Aβ) deposits. Unexpectedly, AD brains with dysfunctional microglia and devoid of parenchymal bone marrow-derived phagocytes did not show overt changes in plaque pathology and Aβ load. In contrast, restriction of CCR2 deficiency to perivascular myeloid cells drastically impaired β-amyloid clearance and amplified vascular Aβ deposition, while parenchymal plaque deposition remained unaffected. Together, our data advocate selective functions of CCR2-expressing myeloid subsets, which could be targeted specifically to modify disease burden in AD.</jats:p
Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine
No full textpeer reviewedLocus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on Alzheimer's disease pathology, we evaluated NE effects on microglial key functions. NE stimulation of mouse microglia suppressed Abeta-induced cytokine and chemokine production and increased microglial migration and phagocytosis of Abeta. Induced degeneration of the locus ceruleus increased expression of inflammatory mediators in APP-transgenic mice and resulted in elevated Abeta deposition. In vivo laser microscopy confirmed a reduced recruitment of microglia to Abeta plaque sites and impaired microglial Abeta phagocytosis in NE-depleted APP-transgenic mice. Supplying the mice the norepinephrine precursor L-threo-DOPS restored microglial functions in NE-depleted mice. This indicates that decrease of NE in locus ceruleus projection areas facilitates the inflammatory reaction of microglial cells in AD and impairs microglial migration and phagocytosis, thereby contributing to reduced Abeta clearance. Consequently, therapies targeting microglial phagocytosis should be tested under NE depletion
Aligning Requirements and Testing - Working Together Toward the Same Goal [Elektronisk resurs]
No full textThe proper alignment of requirements engineering and testing (RET) can be key to software's success. Three practices can provide effective RET alignment: using test cases as requirements, harvesting trace links, and reducing distances between requirements engineers and testers. The Web extra https://youtu.be/M65ZKxfxqME is an audio podcast of author Elizabeth Bjarnason reading the the Requirements column she cowrote with Markus Borg.</p
OCID – Object Clutter Indoor Dataset
No full text<h2>OCID – Object Clutter Indoor Dataset</h2><p>Developing robot perception systems for handling objects in the real-world requires computer vision algorithms to be carefully scrutinized with respect to the expected operating domain. This demands large quantities of ground truth data to rigorously evaluate the performance of algorithms.</p><p>The Object Cluttered Indoor Dataset is an RGBD-dataset containing point-wise labeled point-clouds for each object. The data was captured using two ASUS-PRO Xtion cameras that are positioned at different heights. It captures diverse settings of objects, background, context, sensor to scene distance, viewpoint angle and lighting conditions. The main purpose of OCID is to allow systematic comparison of existing object segmentation methods in scenes with increasing amount of clutter. In addition OCID does also provide ground-truth data for other vision tasks like object-classification and recognition.</p><p>OCID comprises 96 fully built up cluttered scenes. Each scene is a sequence of labeled pointclouds which are created by building a increasing cluttered scene incrementally and adding one object after the other. The first item in a sequence contains no objects, the second one object, up to the final count of added objects.</p><h3>Dataset</h3><p>The dataset uses 89 different objects that are chosen representatives from the Autonomous Robot Indoor Dataset(ARID)[1] classes and YCB Object and Model Set (YCB)[2] dataset objects.</p><p>The ARID20 subset contains scenes including up to 20 objects from ARID. The ARID10 and YCB10 subsets include cluttered scenes with up to 10 objects from ARID and the YCB objects respectively. The scenes in each subset are composed of objects from only one set at a time to maintain separation between datasets. Scene variation includes different floor (plastic, wood, carpet) and table textures (wood, orange striped sheet, green patterned sheet). The complete set of data provides 2346 labeled point-clouds.</p><p>OCID subsets are structured so that specific real-world factors can be individually assessed.</p><h4>ARID20-structure</h4><ul><li>location: floor, table</li><li>view: bottom, top</li><li>scene: sequence-id</li><li>free: clearly separated (objects 1-9 in corresponding sequence)</li><li>touching: physically touching (objects 10-16 in corresponding sequence)</li><li>stacked: on top of each other (objects 17-20 in corresponding sequence)</li></ul><h4>ARID10-structure</h4><ul><li>location: floor, table</li><li>view: bottom, top</li><li>box: objects with sharp edges (e.g. cereal-boxes)</li><li>curved: objects with smooth curved surfaces (e.g. ball)</li><li>mixed: objects from both the box and curved</li><li>fruits: fruit and vegetables</li><li>non-fruits: mixed objects without fruits</li><li>scene: sequence-id</li></ul><h4>YCB10-structure</h4><ul><li>location: floor, table</li><li>view: bottom, top</li><li>box: objects with sharp edges (e.g. cereal-boxes)</li><li>curved: objects with smooth curved surfaces (e.g. ball)</li><li>mixed: objects from both the box and curved</li><li>scene: sequence-id</li></ul><h3>Structure:</h3><p>You can find all labeled pointclouds of the ARID20 dataset for the first sequence on a table recorded with the lower mounted camera in this directory:</p><p>./ARID20/table/bottom/seq01/pcd/</p><p>In addition to labeled organized point-cloud files, corresponding depth, RGB and 2d-label-masks are available:</p><ul><li>pcd: 640×480 organized XYZRGBL-pointcloud file with ground truth</li><li>rgb: 640×480 RGB png-image</li><li>depth: 640×480 16-bit png-image with depth in mm</li><li>label: 640×480 16-bit png-image with unique integer-label for each object at each pixel</li></ul><h4>Dataset creation using EasyLabel:</h4><p>OCID was created using EasyLabel – a semi-automatic annotation tool for RGBD-data. EasyLabel processes recorded sequences of organized point-cloud files and exploits incrementally built up scenes, where in each take one additional object is placed. The recorded point-cloud data is then accumulated and the depth difference between two consecutive recordings are used to label new objects. The code is available here.</p><p>OCID data for instance recognition/classification</p><p>For ARID10 and ARID20 there is additional data available usable for object recognition and classification tasks. It contains semantically annotated RGB and depth image crops extracted from the OCID dataset.</p><p>The structure is as follows:</p><ul><li>type: depth, RGB</li><li>class name: eg. banana, kleenex, …</li><li>class instance: eg. banana_1, banana_2, kleenex_1, kleenex_2,…</li></ul><p>The data is provided by Mohammad Reza Loghmani.</p><p> </p><h3>Research paper</h3><p>If you found our dataset useful, please cite the following paper:</p><blockquote><p>@inproceedings{DBLP:conf/icra/SuchiPFV19,</p><p> author = {Markus Suchi and</p><p> Timothy Patten and</p><p> David Fischinger and</p><p> Markus Vincze},</p><p> title = {EasyLabel: {A} Semi-Automatic Pixel-wise Object Annotation Tool for</p><p> Creating Robotic {RGB-D} Datasets},</p><p> booktitle = {International Conference on Robotics and Automation, {ICRA} 2019,</p><p> Montreal, QC, Canada, May 20-24, 2019},</p><p> pages = {6678--6684},</p><p> year = {2019},</p><p> crossref = {DBLP:conf/icra/2019},</p><p> url = {https://doi.org/10.1109/ICRA.2019.8793917},</p><p> doi = {10.1109/ICRA.2019.8793917},</p><p> timestamp = {Tue, 13 Aug 2019 20:25:20 +0200},</p><p> biburl = {https://dblp.org/rec/bib/conf/icra/SuchiPFV19},</p><p> bibsource = {dblp computer science bibliography, https://dblp.org}</p><p>}</p></blockquote><p> </p><blockquote><p>@proceedings{DBLP:conf/icra/2019,</p><p> title = {International Conference on Robotics and Automation, {ICRA} 2019,</p><p> Montreal, QC, Canada, May 20-24, 2019},</p><p> publisher = {{IEEE}},</p><p> year = {2019},</p><p> url = {http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=8780387},</p><p> isbn = {978-1-5386-6027-0},</p><p> timestamp = {Tue, 13 Aug 2019 20:23:21 +0200},</p><p> biburl = {https://dblp.org/rec/bib/conf/icra/2019},</p><p> bibsource = {dblp computer science bibliography, https://dblp.org}</p><p>}</p></blockquote><p> </p><h3>Contact & credits</h3><p>For any questions or issues with the OCID-dataset, feel free to contact the author:</p><ul><li>Markus Suchi – email: [email protected]</li><li>Tim Patten – email: [email protected]</li></ul><p>For specific questions about the OCID-semantic crops data please contact:</p><ul><li>Mohammad Reza Loghmani – email: [email protected]</li></ul><h3>References</h3><p>[1] Loghmani, Mohammad Reza et al. "Recognizing Objects in-the-Wild: Where do we Stand?" 2018 IEEE International Conference on Robotics and Automation (ICRA) (2018): 2170-2177.</p><p>[2] Berk Calli, Arjun Singh, James Bruce, Aaron Walsman, Kurt Konolige, Siddhartha Srinivasa, Pieter Abbeel, Aaron M Dollar, Yale-CMU-Berkeley dataset for robotic manipulation research, The International Journal of Robotics Research, vol. 36, Issue 3, pp. 261 – 268, April 2017.</p>
Connecting the time evolution of the turbulence interface to coherent structures - Corrigendum
No full textThe above mentioned article was submitted with incorrect author affiliations for George Haller and Markus Holzner. This has since been rectified in the online PDF and HTML copies.(J. Fluid Mech. (2020) 898 (A3) DOI: 10.1017/jfm.2020.414)</p
RFID-gestützte Medikation im Krankenhaus: Ein Erfahrungsbericht
No full textInnerhalb des vorliegenden Beitrags wird die Anwendung der RFID- Funktechnologie in der Medikationsunterstützung im Krankenhaus anhand einer realen Umsetzung am Universitätsklinikum Jena untersucht. Hierzu werden mittels problemzentrierter Experteninterviews die praktischen Erfahrungen analysiert, um die zentralen Faktoren, die die Einführung einer RFID-Lösung beeinflussen, zu identifizieren. Ein besonderer Schwerpunkt liegt dabei auf technischen, sozialen und betriebswirtschaftlichen Fragestellungen. So werden technische Schwierigkeiten identifiziert, die zusammen mit den hohen Betriebskosten den Einsatz der RFID-Technologie für die Medikationsunterstützung in Frage stellen. Ergebnis der Untersuchung ist, dass ein optisches System unter den gegebenen Umständen besser geeignet scheint. Auch wenn ein flächendeckender Einsatz als wenig sinnvoll erachtet wird, kann die RFID-Technologie dennoch in bestimmten Teilbereichen der Medikationsunterstützung zu einem Mehrwert führen
The sense of a beginning : Bakhtinian dialogic criticism on 'the gospel' in Mark.
No full textContemporary literary approaches have caused paradigm shifts in Biblical Studies in the last two decades as it appears in a great deal of Markan studies using narrative, reader-response, deconstructive, feminist, and new historicist approaches. However, literary studies on the Gospel of Mark have not taken into account theoretical questions underlying those approaches. As a result biblical critics are driven by new trends without ever having a chance to examine the critical baggage of the approaches. Consequently, there is a gap of communication between the old and the new one. Therefore this thesis is an attempt to meet the need of enhancing the quality of critical endeavour in biblical studies. In the light of most recent competing critical theories of literature, the first contribution of this thesis is the methodological finding that Bakhtinian dialogic criticism contains the most profound philosophical and practical foundations for solving some crucial theoretical problems in contemporary literary theories. It is a critique to a Saussurian linguistic system of language which becomes the very foundation of modern and postmodern literary criticism. Bakhtinian literary theory shifts the foundation of literary criticism on linguistic signs into the creative activity of the socio-cultural production of human communication. The shift into socio-cultural reality of language communication makes the notion of 'genre' very important to unlock the problem of text and context in literary studies. Since the Gospel of Mark has fascinated most literary critics in Biblical Studies, the problem of 'genre' of this gospel is chosen as the focus of this study. Secondly, as no agreement is reached as to what 'genre' the Gospel of Mark belongs, this thesis makes its contribution to the discussion by locating the problem of 'genre' of Mark in the context of genre theories and argues that the Bakhtinian suggestion to find genre in the socio-cultural sphere by analysing artistic intercourse between narrative agents in Mark has freed the competing analysis from the unresolved problem between the kerygmatic (content oriented) approach and the analogical (form oriented) approach. To achieve finding 'genre' in the socio-cultural sphere, this thesis focuses on Bakhtinian analysis of the process of artistic intercourse between narrative agents. The narrative communicative interrelationships between narrative agents is constructed in this thesis as a 'stereophonic' Bakhtinian model of dialogic communication. This model is an original contribution of this thesis for revising the traditional two dimensional model of narrative communication. Based on this dialogical model of communication, a special role is given to the Bakhtinian 'author-creator' in the realization process of genre through the interaction of polyphonic voices. Through the interaction of voices of the author-artist and the hero we are led to discover a relatively stable type of portraying and controlling reality in Mark, known as the genre of Roman 'satire'. The closest literary affinity is Satyrica by Petronius. This narrative strategy of 'satire' in Mark has its root in the prophetic discourse of the Old Testament which is saturating the speech of the narrator, John the Immerser, the centurion, the people, and even Jesus. Finally, the whole search for Markan 'genre' culminates in the analysis of the realization of genre through the analysis of Bakhtinian chronotope. The reality of the genre of Mark is its social reality that is in its role as dpxrj/ 'beginning'. As the Gospel of Mark proclaims itself as 'a beginning', it defines its claim of socio-cultural 'authority' in early Christianity. It is this 'sense of beginning' which enables the narrating and the narrated world of Mark to interact dialogically
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
No full textGenetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10<sup>−11</sup>; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes
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