103 research outputs found
A LITERARY REVIEW OFTHE CONTENTS OF THULASI ENNAI (PEDIATRIC SIDDHA FORMULATION) IN THE MANAGEMENT OF PEDIATRIC BRONCHIAL ASTHMA
No full textObjectives: The purpose of this review article is focused on the photochemical constituents and therapeutic potential of Thulasi Ennai to combat pediatric bronchial asthma.
Methods: The electronic databases such as Google Scholar, Medline/PubMed, Web of Science, Science Direct, Scopus and Directory of Open Access Journals (DOAJ), and reference lists have been looked to identify publications pertinent to the individual herbs of Thulasi Ennai.
Results: The pharmacological effects of the herbs found in Thulasi Ennai possess anti-asthmatic, anti-inflammatory, antibacterial, antiviral, and other pharmacological effects relevant to the management of bronchial asthma.
Conclusion: The present review concluded the safety of the Thulasi Ennai in preclinical studies. Further, clinical studies of Thulasi Ennai would need to be performed in humans to assess the efficacy of Thulasi Ennai
Data-driven models to evaluate root causes of energy performance gaps in office buildings
No full textDesigners develop high-performance office building designs with efficient envelopes, and Heating, Ventilation and Air Conditioning (HVAC) systems utilizing energy modeling tools with forecasted occupancy, plug load, and operational profiles as inputs. Their expected performance is often not met due to discrepancies between modeled and actual energy behaviors resulting in energy performance gaps. Energy performance gaps stemming out of design, construction and operation phases, pose serious challenges to the credibility of the design and engineering sectors in achieving predicted energy goals of the project.
Data-driven models, based on the actual building energy consumption data, offer an excellent means to evaluate significant root-causes of energy performance gaps; occupancy, envelope and HVAC operations. On the one hand, this supports the feedback loop to the design process from real-time building energy performance to predict energy performance accurately, choose optimal design solutions and, mitigate construction quality management issues in future designs. On the other hand, this provides perfect feedback to optimize energy performance in existing buildings.
This doctoral research presents data-driven modeling methodologies leveraging energy consumption data, advanced statistical methods, and expert domain knowledge, to assess the occupancy profiles, envelope thermal response, and HVAC systems’ performance, in office buildings. The study proposes data-driven techniques to generate evidence-based knowledge to designers about the real-time energy performance of their design decisions and required inputs for energy simulation models, that support the development of high-performance office designs in the future with minimal energy performance gaps.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-05-01The student, Thulasi Ram Khamma, accepted the attached license on 2020-04-10 at 22:26.The student, Thulasi Ram Khamma, submitted this Dissertation for approval on 2020-04-10 at 22:56.This Dissertation was approved for publication on 2020-04-15 at 11:37.DSpace SAF Submission Ingestion Package generated from Vireo submission #14960 on 2020-08-25 at 17:40:05Made available in DSpace on 2020-08-27T00:49:55Z (GMT). No. of bitstreams: 5
KHAMMA-DISSERTATION-2020.pdf: 6855179 bytes, checksum: f7b918323231efd7b1b68ad97c54f164 (MD5)
PhD_Dissertation_Khamma_04-10-2020.docx: 10185874 bytes, checksum: f5b69509e36a44e94e8f33ad82829e94 (MD5)
PhD_Dissertation_Khamma_04-13-2020_Corrected.docx: 10188914 bytes, checksum: 8e91fec30b49b70d614d8b072f5cc6f2 (MD5)
PhD_Dissertation_Khamma_04-14-2020_Corrected-1.docx: 10188245 bytes, checksum: 75afa95b917a4948663808ed2d078f05 (MD5)
LICENSE.txt: 4215 bytes, checksum: d8cd4b50b8b145f8021aacba158b1bf2 (MD5)
Previous issue date: 2020-04-15Embargo set by: Seth Robbins for item 115862
Lift date: 2022-08-27T00:50:22Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 115862
Lift date: 2022-08-27T00:51:40Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemAuthor requested closed access (OA after 2yrs) in Vireo ETD systemLimite
Biosynthesis Of Pha-Co-Phv By Alcaligenes Latus Mtcc 2309: Molecular And Biochemical Characterization
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
To Identify the Clinical Parameters Suggestive of Stroke in Patients Presenting to Emergency Department with Vertigo
No full textBackground and Purpose: Investigating every vertigo patient for central or peripheral MRI and other treatments is expensive and taxing for the system. Thus, emergency physicians must identify stroke patients and give immediate treatment to minimize disastrous results.
Methods: 500-bed BGS Global hospital prospective cohort research. Consecutive vertigo patients endure history, head impulse, nystagmus, skew deviation, and neurological symptoms such leg or truncal ataxia. Scheduled brain MRIs. MRI found strokes. Clinical assessment and normal MRI found peripheral lesions.
Results: Of the 102 acute vertigo patients, 70 were peripheral and 32 central (29 posterior circulation stroke, 2 anterior circulation, and 1 central venous thrombosis). Vertigo patients averaged 49.64706 ± 14.3931 (SD). 36 women, 66 males (64.3%). ED presentation averages 12.54902 ± 10.76355 (SD) hours. Central and peripheral causes were explored. Vomiting, hearing problems, headaches, and tinnitus did not discriminate central from peripheral causes (p <0.01). Diplopia, Dysphagia, Dysarthria, Head impulse test, Nystagmus examination, Skew deviation test, and neurological indicators such limb or truncal ataxia separate central from peripheral causes (p <0.01). Diplopia, Dysarthria, Dysphagia, Nystagmus, Skew deviation, and ataxia have poor sensitivity and high specificity. High-sensitivity, low-specificity head impulse test. This study shows that individual characteristics cannot distinguish central from peripheral vertigo. The study showed good sensitivity 92.31% (0.63 to 0.99) and specificity 100% (0.87 to 1). This test distinguishes central from peripheral vertigo.
Conclusions: Absence of Diplopia, Dysphagia, Dysarthria, abnormal head impulse test, No direction-changing Nystagmus, and absence of Skew deviation in the first clinical visit with vertigo can reliably exclude central cause and discharged home from ED safely without further investigations and imaging.
 
Surgically assisted medical management of interstitial ectopic pregnancy
No full textAn interesting case of interstitial ectopic pregnancy in a primigravida managed by surgically assisted medical management with intracardiac instillation of KCl and methotrexate. It was diagnosed based on transvaginal and transabdominal ultrasound and procedure was done as USG guided under local anaesthesia in OPD by transabdominal route and immediate disappearance of foetal cardiac activity was noted on Doppler. She was followed up with serial sβ-hCG and TVS. She had no post procedure complication and was discharged on day 2 of procedure.
A RETROSPECTIVE STUDY OF MANAGEMENT OF ACUTE PANCREATITIS IN A PERIPHERAL TERTIARY HOSPITAL
No full textPedagogical Implications of Service-Learning Integration in Engineering Education
No full textToday, researchers and engineering educators are much concerned about the future of engineering students who do not receive sufficient practical knowledge about their field and its context. Some criticize the issues related to the use of resources and retention while others feel that the teaching practices in terms of effective pedagogy do not match the required learning strategies and approaches of engineering students. Thus, many educators see service-learning as one of the most crucial solution to several problems and issues that arise in the field of engineering education currently. It has been observed that over the years, the curriculum of engineering education has been subjected to fluctuations. Much work exists that focuses on the theoretical aspects of engineering education but less work has been done on the practical aspects of engineering education. In this paper we assess the potential contributions of service-learning in helping out engineering students in developing the required knowledge and skills which are applicable in the field of engineering. The results showed that integration of service-learning in engineering education was found useful for engineering students in many respects. It was found that integrating service-learning into the engineering programme was offered practical learning opportunities, experiences, contexts, and motivation to engineering students. It was further found that service-learning also promoted the goals of engineering education by engaging engineering students in a real life practical learning which enhanced their capability towards problem solving and critical thinking
DDX3 interacts with Influenza A virus NS1 and NP proteins and exerts antiviral function through regulation of stress granule formation
No full textDDX3 belongs to the DEAD box RNA helicase family and is a multifunctional protein affecting the life cycle of a variety of viruses. However, its role in influenza virus infection is unknown. In this study, we explored the potential role of DDX3 in influenza virus life cycle and discovered that DDX3 is an antiviral protein. Since many host proteins affect virus life cycle by interacting with certain components of the viral machinery, we first verified whether DDX3 has any viral interaction partners. Immunoprecipitation studies revealed NS1 and NP as direct interaction partners of DDX3. Stress granules (SGs) are known to be antiviral and do form in influenza virus-infected cells expressing defective NS1 protein. Additionally, a recent study showed that DDX3 is an important SG-nucleating factor. We thus explored whether DDX3 plays a role in influenza virus infection through regulation of SGs. Our results showed that SGs were formed in infected cells upon infection with a mutant influenza virus lacking functional NS1 (del NS1) protein, and DDX3 colocalized with NP in SGs. We further determined that the DDX3 helicase domain did not interact with NS1 and NP; however, it was essential for DDX3 localization in virus-induced SGs. Knockdown of DDX3 resulted in impaired SG formation and led to increased virus titers. Taken together, our results identified DDX3 as an antiviral protein with a role in virus-induced SG formation
Data from: Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties
No full textBackground: Krishna Tulsi, a member of Lamiaceae family, is a herb well known for its spiritual, religious and medicinal importance in India. The common name of this plant is ‘Tulsi’ (or ‘Tulasi’ or ‘Thulasi’) and is considered sacred by Hindus. We present the draft genome of Ocimum tenuiflurum L (subtype Krishna Tulsi) in this report. The paired-end and mate-pair sequence libraries were generated for the whole genome sequenced with the Illumina Hiseq 1000, resulting in an assembled genome of 374 Mb, with a genome coverage of 61 % (612 Mb estimated genome size). We have also studied transcriptomes (RNA-Seq) of two subtypes of O. tenuiflorum, Krishna and Rama Tulsi and report the relative expression of genes in both the varieties. Results: The pathways leading to the production of medicinally-important specialized metabolites have been studied in detail, in relation to similar pathways in Arabidopsis thaliana and other plants. Expression levels of anthocyanin biosynthesis-related genes in leaf samples of Krishna Tulsi were observed to be relatively high, explaining the purple colouration of Krishna Tulsi leaves. The expression of six important genes identified from genome data were validated by performing q-RT-PCR in different tissues of five different species, which shows the high extent of urosolic acid-producing genes in young leaves of the Rama subtype. In addition, the presence of eugenol and ursolic acid, implied as potential drugs in the cure of many diseases including cancer was confirmed using mass spectrometry. Conclusions: The availability of the whole genome of O.tenuiflorum and our sequence analysis suggests that small amino acid changes at the functional sites of genes involved in metabolite synthesis pathways confer special medicinal properties to this herb
- …
