28 research outputs found
Coded Submissions and Publications (from the Project <i>"Opening the File Drawer: Assessing and Understanding Publication Bias in the Social, Economic, and Behavioral Sciences" </i>)
No full textThe project “Opening the File Drawer: Assessing and Understanding Publication Bias in the Social, Economic, and Behavioral Sciences” aims to assess the prevalence of publication bias and to identify its risk factors. Our interest lies in understanding the decision-making processes that lead researchers to selectively publish certain results, while others remain in the “file drawer.” Specifically, we examined successful study submissions by external researchers to two German probabilistic panels (the GESIS Panel and SOEP-IS), and analyzed discrepancies between, among other things, the research questions and hypotheses stated in the original study submissions and how they were presented in the subsequent publication(s). In a first step, we collected detailed information on the study submissions, the publications, and the authors. In a second step, we conducted an author survey among the submission authors. The present dataset contains the coding dataset – that is, all information extracted from the study submissions and the corresponding publications. The following six files are published here: – PubBias_Analysis dataset.dta (i.e., the final analysis dataset) – PubBias_Analysis dataset_Codebook.xlsx (i.e., the codebook for the analysis dataset) – PubBias_Coding scheme.xlsx (i.e., the coding scheme used to extract information from the submission documents and corresponding publications) – PubBias_Data preparation code.do (i.e., the data preparation code that converts the raw dataset into the analysis dataset) – PubBias_Data preparation_Log file.log (i.e., the log file containing the output of the data preparation) – PubBias_Raw dataset.xlsx (i.e., the raw dataset derived from coding of the submission documents and corresponding publications) The project “Opening the File Drawer: Assessing and Understanding Publication Bias in the Social, Economic, and Behavioral Sciences” aims to assess the prevalence of publication bias and to identify its risk factors. Our interest lies in understanding the decision-making processes that lead researchers to selectively publish certain results, while others remain in the “file drawer.” Specifically, we examined successful study submissions by external researchers to two German probabilistic panels (the GESIS Panel and SOEP-IS), and analyzed discrepancies between, among other things, the research questions and hypotheses stated in the original study submissions and how they were presented in the subsequent publication(s). In a first step, we collected detailed information on the study submissions, the publications, and the authors. In a second step, we conducted an author survey among the submission authors. The present dataset contains the coding dataset – that is, all information extracted from the study submissions and the corresponding publications. The following six files are published here: – PubBias_Analysis dataset.dta (i.e., the final analysis dataset) – PubBias_Analysis dataset_Codebook.xlsx (i.e., the codebook for the analysis dataset) – PubBias_Coding scheme.xlsx (i.e., the coding scheme used to extract information from the submission documents and corresponding publications) – PubBias_Data preparation code.do (i.e., the data preparation code that converts the raw dataset into the analysis dataset) – PubBias_Data preparation_Log file.log (i.e., the log file containing the output of the data preparation) – PubBias_Raw dataset.xlsx (i.e., the raw dataset derived from coding of the submission documents and corresponding publications) </p
Growth and division of active droplets provides a model for protocells
No full textNature Physics | Article Print Share/bookmark Growth and division of active droplets provides a model for protocells David Zwicker, Rabea Seyboldt, Christoph A. Weber, Anthony A. Hyman & Frank Jülicher Affiliations Contributions Corresponding author Nature Physics 13, 408–413 (2017) doi:10.1038/nphys3984 Received 29 April 2016 Accepted 10 November 2016 Published online 12 December 2016 Article tools PDF Citation Reprints Rights & permissions Article metrics Abstract Abstract• Introduction• Division of active droplets• Chemically active droplets as a model for protocells• Methods• References• Acknowledgements• Author information• Supplementary information It has been proposed that during the early steps in the origin of life, small droplets could have formed via the segregation of molecules from complex mixtures by phase separation. These droplets could have provided chemical reaction centres. However, whether these droplets could divide and propagate is unclear. Here we examine the behaviour of droplets in systems that are maintained away from thermodynamic equilibrium by an external supply of energy. In these systems, droplets grow by the addition of droplet material generated by chemical reactions. Surprisingly, we find that chemically driven droplet growth can lead to shape instabilities that trigger the division of droplets into two smaller daughters. Therefore, chemically active droplets can exhibit cycles of growth and division that resemble the proliferation of living cells. Dividing active droplets could serve as a model for prebiotic protocells, where chemical reactions in the droplet play the role of a prebiotic metabolism
Algeria's energy sector: A quantitative analysis
No full textAlgeria's economy depends almost exclusively on hydrocarbon exports for its foreign exchange revenues. At the same time, domestic energy consumption is expected to grow rapidly in response to population increases and future economic growth. Therefore, meeting future energy needs has the potential to impose serious burdens on export availability and, therefore, on the country's development process.As a result, the purpose of this study is to understand the demand behavior of all consumers in the energy sector in the period between 1975 and 1992 and develop a demand management tool. This tool would allow policymakers to use both price and non-price instruments to control the growth of energy demand and introduce a more efficient use of energy.Based on the Cobb-Douglas production function, we estimate price and income elasticities of energy demand by fuel (oil, gas, electricity, coal) and by sector (industry, household/commercial, transportation, agriculture) using the ordinary least squares (OLS) regression technique. The results are then used to forecast energy demand using different scenarios based on various future trends in the exogenous variables.The initial business as usual (BAU) scenario highlights energy demand trends under a moderate rise in energy prices. The second category of scenarios, the subsidy phase-out (SPO), analyzes the impacts of pricing instruments on energy trends. The last category, the autonomous energy efficiency increase (AEEI), estimates the impact of technical efficiency measures.The results suggest that energy demand will be strong throughout the forecasting period (1993-2010) and that price and non-price instruments can be used to dampen it and develop a more efficient use of energy. Linking the consumption block to a supply module, the energy balance of the country is derived and the potential hydrocarbon export availability and revenues are estimated. The revenues can be substantially enhanced using the demand management tools. In addition, introducing a SPO or AEEI leads to an increase in energy efficiency and a decrease in carbon emissions.In sum, the findings highlight the importance of energy demand management on various economic and environmental indicators, potentially contributing to the development process. This management tool is even more pertinent in the case of a hydrocarbon export-dependent economy like Algeria.Source: Dissertation Abstracts International, Volume: 57-03, Section: A, page: 1237.Ph.D. American University 1995.Englis
Elizabeth Bowen's "narrative language at white heat" : a literary-linguistic perspective
No full textDiese literarisch-linguistische Arbeit bezieht neuroästhetische, neurolinguistische sowie literaturwissenschaftliche Forschung ein und entwickelt, basierend auf existierenden Modellen, ein Modell des Satzverstehens im Lesen literarischer Texte, welches den Zusammenhang zwischen sprachlicher Form und ästhetischer Wirkung erklärt. Die Arbeit zeigt anhand vieler Satzbeispiele aus drei Romanen Elizabeth Bowens, The Last September, The Heat of the Day und To the North, wie Ambiguität, Negation, Parallelismus, Alliteration und Reim sich auf das Satzverstehen und Lesevergnügen auswirken können.This literary-linguistic dissertation includes research from the fields of neuroaesthetics, neurolinguistics and literary scholarship to develop, based on existing models, a model of literary sentence processing which explains the relationship between sentence form and aesthetic effects. Using examples from Elizabeth Bowen’s novels The Last September, The Heat of the Day and To the North, the author demonstrates how ambiguity, negation, parallelism, alliteration and rhyme may impact sentence processing and aesthetic pleasure
Elizabeth Bowen's "narrative language at white heat" : a literary-linguistic perspective
No full textDiese literarisch-linguistische Arbeit bezieht neuroästhetische, neurolinguistische sowie literaturwissenschaftliche Forschung ein und entwickelt, basierend auf existierenden Modellen, ein Modell des Satzverstehens im Lesen literarischer Texte, welches den Zusammenhang zwischen sprachlicher Form und ästhetischer Wirkung erklärt. Die Arbeit zeigt anhand vieler Satzbeispiele aus drei Romanen Elizabeth Bowens, The Last September, The Heat of the Day und To the North, wie Ambiguität, Negation, Parallelismus, Alliteration und Reim sich auf das Satzverstehen und Lesevergnügen auswirken können.This literary-linguistic dissertation includes research from the fields of neuroaesthetics, neurolinguistics and literary scholarship to develop, based on existing models, a model of literary sentence processing which explains the relationship between sentence form and aesthetic effects. Using examples from Elizabeth Bowen’s novels The Last September, The Heat of the Day and To the North, the author demonstrates how ambiguity, negation, parallelism, alliteration and rhyme may impact sentence processing and aesthetic pleasure.254 Seite
Discovery of new Schiff bases of the disalicylic acid scaffold as DNA gyrase and topoisomerase IV inhibitors endowed with antibacterial properties
No full textDNA gyrase and topoisomerase IV show great potential as targets for antibacterial
medicines. In recent decades, various categories of small molecule inhibitors
have been identified; however, none have been effective in the market. For the
first time, we developed a series of disalicylic acid methylene/Schiff bases hybrids
(5a-k) to act as antibacterial agents targeting DNA gyrase and topoisomerase IV.
The findings indicated that the new targets 5f-k exhibited significant antibacterial
activity against Gram-positive and Gram-negative bacteria, with efficacy ranging
from 75% to 115% of the standard ciprofloxacin levels. Compound 5h
demonstrated the greatest efficacy compared to the other compounds tested,
with minimum inhibitory concentration (MIC) values of 0.030, 0.065, and
0.060 μg/mL against S. aureus, E. coli, and P. aeruginosa. 5h had a MIC value
of 0.050 μg/mL against B. subtilis, which is five times less potent than
ciprofloxacin. The inhibitory efficacy of the most potent antibacterial
derivatives 5f, 5h, 5i, and 5k against E. coli DNA gyrase was assessed. The
tested compounds demonstrated inhibitory effects on E. coli DNA gyrase,
with IC 50 values ranging from 92 to 112 nM. These results indicate that 5f, 5h,
5i, and 5k are more effective than the reference novobiocin, which had an IC50
value of 170 nM. Compounds 5f, 5h, 5i, and 5k were subjected to additional
assessment against E. coli topoisomerase IV. Compounds 5h and 5i, which have
the highest efficacy in inhibiting E. coli gyrase, also demonstrated promising
effects on topoisomerase IV. Compounds 5h and 5i exhibit IC50 values of 3.50 μM
and 5.80 μM, respectively. These results are much lower and more potent than
novobiocin’s IC50 value of 11 μM. Docking studies demonstrate the potential of
OPEN ACCESS
EDITED BY
Anton V. Dolzhenko,
Monash University, Australia
REVIEWED BY
Juliana Amorim,
Catholic University of Cuenca, Ecuador
Vijaya Bhaskar Baki,
University of California, Riverside, United States
Chunli Wu,
Zhengzhou University, China
*CORRESPONDENCE
Bahaa G. M. Youssif,
[email protected],
[email protected]
Stefan Bräse,
[email protected]
RECEIVED 17 April 2024
ACCEPTED 24 May 2024
PUBLISHED 07 June 2024
CITATION
Al-Wahaibi LH, Mahmoud MA, Alzahrani HA,
Abou-Zied HA, Gomaa HAM, Youssif BGM,
Bräse S and Rabea SM (2024), Discovery of new
Schiff bases of the disalicylic acid scaffold as
DNA gyrase and topoisomerase IV inhibitors
endowed with antibacterial properties.
Front. Chem. 12:1419242.
doi: 10.3389/fchem.2024.1419242
COPYRIGHT
© 2024 Al-Wahaibi, Mahmoud, Alzahrani,
Abou-Zied, Gomaa, Youssif, Bräse and Rabea.
This is an open-access article distributed under
the terms of the Creative Commons Attribution
License (CC BY). The use, distribution or
reproduction in other forums is permitted,
provided the original author(s) and the
copyright owner(s) are credited and that the
original publication in this journal is cited, in
accordance with accepted academic practice.
No use, distribution or reproduction is
permitted which does not comply with these
terms.
Frontiers in Chemistry frontiersin.org01
TYPE Original Research
PUBLISHED 07 June 2024
DOI 10.3389/fchem.2024.1419242
compound 5h as an effective dual inhibitor against E. coli DNA gyrase and
topoisomerase IV, with ADMET analysis indicating promising pharmacokinetic
profiles for antibacterial drug development
Eduard Hildebrandts „Wunderbild“ in einem Brief von Alexander von Humboldt an Henriette Mendelssohn, geb. Meyer
No full textZusammenfassung
Die 2011 von Sebastian Panwitz und Ingo Schwarz herausgegebene Korrespondenz Alexander von Humboldts mit den Mendelssohns dokumentiert ihre lebenslange Verbundenheit. Ein Brief von Humboldt an Henriette Mendelssohn, den die Mendelssohn-Gesellschaft von einem privaten Sammler erwarb, und der erst seit diesem Jahr in der Mendelssohn-Remise in Berlin-Mitte, in der Dauerausstellung Die Mendelssohns in der Jägerstraße zu sehen ist, war zum Zeitpunkt der Veröffentlichung noch nicht zugänglich. Dieser Brief lässt das gesellschaftliche und künstlerische Leben der Stadt um 1850 sichtbar werden und enthält einige Rätsel: Was hat es mit dem unkommentierten Zettel auf sich, auf dem ein nicht korrekt wiedergegebener Buchtitel der amerikanischen Autorin Harriet Beecher Stowe geschrieben steht und welches „Wunderbild“ erwähnt der weltberühmte Forschungsreisende in dem Brief an Henriette Mendelssohn?
Abstract
Alexander von Humboldt‘s correspondence with the Mendelssohn family, published in 2011 by Sebastian Panwitz and Ingo Schwarz, documents their lifelong solidarity. A letter from Humboldt to Henriette Mendelssohn, which the Mendelssohn Society acquired from a private collector and which has only been on view since this year in the Mendelssohn Remise in Berlin-Mitte, in the permanent exhibition Die Mendelssohns in der Jägerstraße, was not yet accessible at the time of publication. This letter reveals the social and artistic life of the city around 1850 and contains a number of puzzles: what is behind the uncommented note containing an incorrectly reproduced book title by the American author Harriet Beecher Stowe? What „miracle picture“ does the world-famous explorer mention in the letter to Henriette Mendelssohn?
Resumen
La correspondencia de Alexander von Humboldt con la familia Mendelssohn, publicada en 2011 por Sebastian Panwitz e Ingo Schwarz, documenta su solidaridad de por vida. Una carta de Humboldt a Henriette Mendelssohn, que la Sociedad Mendelssohn adquirió de un coleccionista privado y que sólo se puede ver desde este año en la Mendelssohn Remise de Berlín-Mitte, en la exposición permanente Die Mendelssohns in der Jägerstraße, todavía no estaba disponible en el momento de su publicación. Esta carta revela la vida social y artística de la ciudad alrededor de 1850 y contiene una serie de enigmas: ¿qué hay detrás de la nota que contiene un título de libro por la autora estadounidense Harriet Beecher Stowe apuntado incorrectamente? ¿Qué “imagen milagrosa” menciona el famoso explorador en la carta a Henriette Mendelssohn
Author Correction: Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling
No full textEduard Hildebrandts „Wunderbild“ in einem Brief von Alexander von Humboldt an Henriette Mendelssohn, geb. Meyer
No full textDie 2011 von Sebastian Panwitz und Ingo Schwarz herausgegebene Korrespondenz Alexander von Humboldts mit den Mendelssohns dokumentiert ihre lebenslange Verbundenheit. Ein Brief von Humboldt an Henriette Mendelssohn, den die Mendelssohn-Gesellschaft von einem privaten Sammler erwarb, und der erst seit diesem Jahr in der Mendelssohn-Remise in Berlin-Mitte, in der Dauerausstellung Die Mendelssohns in der Jägerstraße zu sehen ist, war zum Zeitpunkt der Veröffentlichung noch nicht zugänglich. Dieser Brief lässt das gesellschaftliche und künstlerische Leben der Stadt um 1850 sichtbar werden und enthält einige Rätsel: Was hat es mit dem unkommentierten Zettel auf sich, auf dem ein nicht korrekt wiedergegebener Buchtitel der amerikanischen Autorin Harriet Beecher Stowe geschrieben steht und welches „Wunderbild“ erwähnt der weltberühmte Forschungsreisende in dem Brief an Henriette Mendelssohn?Alexander von Humboldt‘s correspondence with the Mendelssohn family, published in 2011 by Sebastian Panwitz and Ingo Schwarz, documents their lifelong solidarity. A letter from Humboldt to Henriette Mendelssohn, which the Mendelssohn Society acquired from a private collector and which has only been on view since this year in the Mendelssohn Remise in Berlin-Mitte, in the permanent exhibition Die Mendelssohns in der Jägerstraße, was not yet accessible at the time of publication. This letter reveals the social and artistic life of the city around 1850 and contains a number of puzzles: what is behind the uncommented note containing an incorrectly reproduced book title by the American author Harriet Beecher Stowe? What „miracle picture“ does the world-famous explorer mention in the letter to Henriette Mendelssohn?La correspondencia de Alexander von Humboldt con la familia Mendelssohn, publicada en 2011 por Sebastian Panwitz e Ingo Schwarz, documenta su solidaridad de por vida. Una carta de Humboldt a Henriette Mendelssohn, que la Sociedad Mendelssohn adquirió de un coleccionista privado y que sólo se puede ver desde este año en la Mendelssohn Remise de Berlín-Mitte, en la exposición permanente Die Mendelssohns in der Jägerstraße, todavía no estaba disponible en el momento de su publicación. Esta carta revela la vida social y artística de la ciudad alrededor de 1850 y contiene una serie de enigmas: ¿qué hay detrás de la nota que contiene un título de libro por la autora estadounidense Harriet Beecher Stowe apuntado incorrectamente? ¿Qué “imagen milagrosa” menciona el famoso explorador en la carta a Henriette Mendelssohn
Exhaled breath SARS-CoV-2 shedding patterns across variants of concern
No full textOBJECTIVES: We performed exhaled breath (EB) and nasopharyngeal (NP) quantitative polymerase chain reaction (qPCR) and NP rapid antigen testing (NP RAT) of SARS-CoV-2 infections with different variants. METHODS: We included immuno-naïve alpha-infected (n = 11) and partly boosted omicron-infected patients (n = 8) as high-risk contacts. We compared peak NP and EB qPCR cycle time (ct) values between cohorts (Wilcoxon-Mann-Whitney test). Test positivity was compared for three infection phases using Cochran Q test. RESULTS: Peak median NP ct was 11.5 (interquartile range [IQR] 10.1-12.1) for alpha and 12.2 (IQR 11.1-15.3) for omicron infections. Peak median EB ct was 25.2 (IQR 24.5-26.9) and 28.3 (IQR 26.4-30.8) for alpha and omicron infections, respectively. Distributions did not differ between cohorts for NP (P = 0.19) or EB (P = 0.09). SARS-CoV-2 shedding peaked on day 1 in EB (confidence interval [CI] 0.0 - 4.5) and day 3 in NP (CI 1.5 - 6.0). EB qPCR positivity equaled NP qPCR positivity on D0-D1 (P = 0.44) and D2-D6 (P = 1.0). It superseded NP RAT positivity on D0-D1 (P = 0.003) and D2-D6 (P = 0.008). It was inferior to both on D7-D10 (P < 0.001). CONCLUSION: Peak EB and nasopharynx shedding were comparable across variants. EB qPCR positivity matched NP qPCR and superseded NP RAT in the first week of infection
