1,721,173 research outputs found
CADET-Julia: Version 0.2.0
No full textCADET-Julia is a numerical solver for a family of chromatography models and is a streamlined and computationally efficient adaption of the more comprehensive CADET-Core project, and is based on a spatial Discontinuous Galerkin Spectral Element Method (DGSEM), similar to the DGSEM implemented in CADET-Core. If you find it useful for your own work, we would appreciate acknowledgements of this software and citations of our papers: Jesper Frandsen, Jan M. Breuer, Eric von Lieres, Johannes Schmölder, Jakob K. Huusom, Krist V. Gernaey, Jens Abildskov: Discontinuous Galerkin spectral element method for continuous chromatography: Application to the Lumped Rate Model without pores, Computer Aided Chemical Engineering, 53, 3325-3330
ChemInform Abstract: Process Intensification Tools in the Small‐Scale Pharmaceutical Manufacturing of Small Molecules
No full textA Perspective on PSE in Fermentation Process Development and Operation
Full text linkCompared to the chemical industry, the use of PSE methods and tools is not as widespread in industrial fermentation processes. This paper gives an overview of some of the main engineering challenges in industrial fermentation processes. Furthermore, a number of mathematical models are highlighted as examples of PSE methods and tools that are used in the context of industrial fermentation technology. Finally, it is discussed what could be done to increase the future use of PSE methods and tools within the industrial fermentation technology area
Process Design of a Multi-Product Lignocellulosic Biorefinery
No full textSeveral alternative process pathways including biochemical and thermochemical conversions are available for the second generation biorefineries. In this view conceptual design of a superstructure and optimization methods for process synthesis are widely used in order to find the optimal process flowsheet (Stefanakis et al., 2014). In the present work the flowsheet resulting from the economic optimization of a multiproduct lignocellulosic biorefinery superstructure was simulated by a process simulator (Aspen Plus). As a result, rigorous methods were used to calculate the stream thermodynamic properties and to model the process units. Economic analysis was applied to assess the economic feasibility of the process. Sensitivity analysis on the size of the plant, the product prices and the biomass price was carried out as well
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling
No full textIn this work an optimization framework is presented to support the model builder in
postulating compartmental models that plausibly describe data that is obtained during
experimentation. In the proposed approach, one specifies a priori the maximum number
of compartments and the type of flows (e.g., zero order, first order, second order rate
flows) to contemplate. With this input, the mathematical model follows a “flexible”
approach, which inherently considers all feasible flows between any pair of
compartments. The model activates those flows/compartments that provide the optimal
fit for a given set of experimental data. A regularized log-likelihood function is
formulated as performance metric in order to handle parameter over-fitting. To deal
with the resulting set of differential equations orthogonal collocation on finite elements
is employed. A case study related to the pharmacokinetics of an oncological agent is
reported to demonstrate the advantages and limitations of the proposed approach.
Numerical results show that the proposed approach can provide 33 % smaller mean
prediction errors in comparison with a compartmental model previously suggested in
the literature that employs a larger number of parameters
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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