372 research outputs found
Disgust and the rubber hand illusion: A registered replication report of Jalal, Krishnakumar, and Ramachandran (2015)
No full textHeightened experience of disgust is a feature of obsessive-compulsive disorder (OCD), particularly in contamination-related OCD (C-OCD). Previous studies of the rubber hand illusion (RHI) reported that the sense of body ownership is related to the interaction between vision, touch, and proprioception. A recent study demonstrated a link between the RHI and disgust, reporting an interaction between these three perceptual modalities and disgust (Jalal, Krishnakumar, Ramachandran, 2015). However, there have been no direct replications of this initial study. We proposed a direct replication of Jalal et al.’s (2015) study. Based on a power analysis, we examined a minimum of 119 participants to determine whether placing contamination-related stimuli on a rubber hand causes OCD-like disgust among healthy participants while experiencing the RHI. In addition, we tested the cross-cultural validity of the previous findings, testing whether Japanese participants experience more intense disgust when a rubber hand and a participant’s hidden hand were stroked synchronously, compared with asynchronous stroking. This replication provides insight into potential applications of this study protocol in the treatment of OCD
Disgust and the rubber hand illusion: A registered replication report of Jalal, Krishnakumar, and Ramachandran (2015)
No full textHeightened experience of disgust is a feature of obsessive-compulsive disorder (OCD), particularly in contamination-related OCD (C-OCD). Previous studies of the rubber hand illusion (RHI) reported that the sense of body ownership is related to the interaction between vision, touch, and proprioception. A recent study demonstrated a link between the RHI and disgust, reporting an interaction between these three perceptual modalities and disgust (Jalal, Krishnakumar, Ramachandran, 2015). However, there have been no direct replications of this initial study. We proposed a direct replication of Jalal et al.’s (2015) study. Based on a power analysis, we examined a minimum of 119 participants to determine whether placing contamination-related stimuli on a rubber hand causes OCD-like disgust among healthy participants while experiencing the RHI. In addition, we tested the cross-cultural validity of the previous findings, testing whether Japanese participants experience more intense disgust when a rubber hand and a participant’s hidden hand were stroked synchronously, compared with asynchronous stroking. This replication provides insight into potential applications of this study protocol in the treatment of OCD
Disgust and the rubber hand illusion: A registered replication report of Jalal, Krishnakumar, and Ramachandran (2015) (Registered Report, Stage 1)
No full textRegistered Report, Stage 1:
Heightened experience of disgust is a feature of
obsessive-compulsive disorder (OCD), particularly in contamination-related OCD
(C-OCD). Previous studies of the rubber hand illusion (RHI) reported that the
sense of body ownership is related to the interaction between vision, touch,
and proprioception. A recent study demonstrated a link between the RHI and
disgust, reporting an interaction between these three perceptual modalities and
disgust (Jalal, Krishnakumar, Ramachandran, 2015). However, there have been no
direct replications of this initial study. We proposed a direct replication of
Jalal et al.’s (2015) study. Based on a power analysis, we will examine a minimum
of 119 participants to determine whether placing contamination-related stimuli
on a rubber hand causes OCD-like disgust among healthy participants while
experiencing the RHI. In addition, we will test the cross-cultural validity of the
previous findings, testing whether Japanese participants experience more
intense disgust when a rubber hand and a participant’s hidden hand were stroked
synchronously, compared with asynchronous stroking. This replication will provide
insight into potential applications of this study protocol in the treatment of
OCD.</p
Immunocytochemical staining of Drosophila larval body-wall muscles
No full textFirst author Preethi Ramachandran is a doctoral student in the Neuroscience Program in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.Over the last two decades, the Drosophila larval neuromuscular junction (NMJ) has gained immense popularity as a model system for the study of synaptic development, function, and plasticity. With this model, it is easy to visualize synapses and manipulate the system genetically with a high degree of temporal and spatial control, which makes it ideal for resolving problems in synaptic physiology and development. This article describes a procedure for labeling various proteins with antibodies in dissected larval body-wall muscles and visualizing their localization and distribution in the brain, NMJ, and muscle.Neuroscienc
Dissection of Drosophila larval body-wall muscles
No full textFirst author Preethi Ramachandran is a doctoral student in the Neuroscience Program in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.Over the last two decades, the Drosophila larval neuromuscular junction has gained immense popularity as a model system for the study of synaptic development, function, and plasticity. With this model, it is easy to visualize synapses and manipulate the system genetically with a high degree of temporal and spatial control, which makes it ideal for resolving problems in synaptic physiology and development. A number of different techniques have been used to dissect third-instar larval preparations to expose the body-wall muscles. Here, we describe a procedure that uses magnetic chambers and pins to allow for fine control in spreading the larval body wall.Neuroscienc
Khoo Kay Kim, professor of Malaysian history : a biobibliometric study
Get PDFPresents an analysis of the publication productivity, authorship pattern, channels of communication, journal preference and language preference of Professor Dato' Khoo Kay Kim, Professor of Malaysian History in the University of Malaya, Kuala Lumpur. The results of this biobibliometric study indicate that he can be a role model for future Malaysian historians to emulate his various achievements especially in the field of history education
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs
Get PDFIntroduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. Methods: Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM) or high concentrations (1 to 1,000 nM) of CNP, interleukin-1? (IL-1?), and/or KT-5823 (inhibits cyclic GMP-dependent protein kinase II (PKGII)). Anabolic and catabolic activities were assessed as follows: nitric oxide (NO) and prostaglandin E2 (PGE2) release, and [3H]-thymidine and 35SO4 incorporation were quantified by using biochemical assays. Gene expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), aggrecan, and collagen type II were assessed with real-time quantitative PCR (qPCR). Two-way ANOVA and the post hoc Bonferroni-corrected t tests were used to examine data. Results: CNP reduced NO and PGE2 release and partially restored [3H]-thymidine and 35SO4 incorporation in constructs cultured with IL-1?. The response was dependent on the concentration of CNP, such that 100 pM increased [3H]-thymidine incorporation (P < 0.001). This is in contrast to 35SO4 incorporation, which was enhanced with 100 or 1000 nM CNP in the presence and absence of IL-1? (P < 0.001). Stimulation by both dynamic compression and CNP and/or the PKGII inhibitor further reduced NO and PGE2 release and restored [3H]-thymidine and 35SO4 incorporation. In the presence and absence of IL-1?, the magnitude of stimulation for [3H]-thymidine and 35SO4 incorporation by dynamic compression was dependent on the concentration of CNP and the response was inhibited with the PKGII inhibitor. In addition, stimulation by CNP and/or dynamic compression reduced IL-1?-induced iNOS and COX-2 expression and restored aggrecan and collagen type II expression. The catabolic response was not further influenced with the PKGII inhibitor in IL-1?-treated constructs. Conclusions: Treatment with CNP and dynamic compression increased anabolic activities and blocked catabolic effects induced by IL-1?. The anabolic response was PKGII mediated and raises important questions about the molecular mechanisms of CNP with mechanical signals in cartilage. Therapeutic agents like CNP could be administered in conjunction with controlled exercise therapy to slow the OA disease progression and to repair damaged cartilage. The findings from this research provide the potential for developing novel agents to slow the pathophysiologic mechanisms and to treat OA in the young and old. <br/
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
Get PDF© 2018, The Author(s). The original version of this article contained an error in the name of the author Ramachandran S. Vasan, which was incorrectly given as Vasan S. Ramachandran. This has now been corrected in both the PDF and HTML versions of the article
SmartProvenance
No full textFull text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided Link to Article).Blockchain technology has evolved from being an immutable ledger of transactions for cryptocurrencies to a programmable interactive environment for building distributed reliable applications. Although the blockchain technology has been used to address various challenges, to our knowledge none of the previous work focused on using Blockchain to develop a secure and immutable scientific data provenance management framework that automatically verifies the provenance records. In this work, we leverage Blockchain as a platform to facilitate trustworthy data provenance collection, verification, and management. The developed system utilizes smart contracts and open provenance model (OPM) to record immutable data trails. We show that our proposed framework can securely capture and validate provenance data that prevents any malicious modification to the captured data as long as the majority of the participants are honest. ©2018 Copyright held by the owner/author(s). Publication rights licensed to Association for Computing Machinery.The research reported herein was supported in part by NIH award 1R01HG006844, NSF awards CNS-1111529, CICI-1547324, and IIS- 1633331 and ARO award W911NF-17-1-0356.Erik Jonsson School of Engineering and Computer Scienc
Computational chemistry and molecular modeling : principles and applications / K.I. Ramachandran, G. Deepa, K. Namboori.
No full text"An exclusive URL (http://www.amrita.edu/cen/ccmm/) for this book with the required support materials has been provided for readers ..."--Preface.pharmacy bookfair2015Includes bibliographical references and index.xxi, 397 pages
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