47,425 research outputs found
Shifting waterscapes: explaining basin closure in the Lower Krishna Basin, South India
No full textRiver basins / Ecosystems / Protective irrigation / Irrigation programs / Water transfer / Water distribution / Water allocation / Groundwater depletion / Aquifers / Water scarcity / Water use / Drought / India / Lower Krishna Basin / Godavari Basin / Nagarjuna Sagar Project / Kolleru Lake
The Krishnacore Chronicles #17: Krishna Das interviewed by Mike Dines and Madhu Brata Das
No full textMadhu Brata das and Mike Dines interview Krishna Das from Invocation
Hydrological and environmental issues of interbasin water transfers in India: a case of the Krishna River Basin
No full textRiver basins / Water transfer / Environmental effects / Dams / Reservoirs / Water resources development / Irrigation requirements / Case studies / India / Krishna River / Godavari River
The Krishnacore Chronicles #5 Sevaparayana Krishna Das interviewed by Madhu Brata Das and Mike Dines
No full textAn interview with the incredible Sevaparayana Krishna Das from Traces of You
Les océans malades des hommes - Portrait
No full textPortrait de Krishna Das par Mr Paul Devuyst
"Krishna Das, chercheuse au laboratoire d’océanologie
de l’Université de Liège, dans le service
du professeur Jean-Marie Bouquegneau, s’intéresse aux
niveaux et aux effets des polluants toxiques tels
que les métaux lourds et autres composés organiques
qui s’accumulent dans les tissus de plusieurs
espèces marines de poissons, reptiles,
oiseaux et mammifères.
Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania
No full textLeishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the available drugs is being questioned owing to the toxicity for nonspecific distribution in human physiology and the reported drug-resistance developed by Leishmania donovani. Thus, a stimuli-responsive nanocarrier that allows specific localization and release of the drug in the lysosome has been highly sought after for addressing two crucial issues, lower drug toxicity and a higher drug efficacy. We report here a unique lysosome targeting polymeric nanocapsules, formed via inverse mini-emulsion technique, for stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line. A benign polymeric backbone, with a disulfide bonding susceptible to an oxidative cleavage, is utilized for the organelle-specific release of miltefosine. Oxidative rupture of the disulfide bond is induced by intracellular glutathione (GSH) as an endogenous stimulus. Such a stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line over a few hours helped in achieving an improved drug efficacy by 200 times as compared to pure miltefosine. Such a drug formulation could contribute to a new line of treatment for leishmaniasis.A. Das acknowledges SERB (India) Grants (CRG/2020/000492 and JCB/2017/000004) and DBT Grant (BT/PR22251/NNT/28/1274/2017) for supporting this research. N. Mukherjee acknowledges SERB (India) Grant PDF/2016/001437 and K. Das acknowledges the grant EMR/2015/001674 for supporting this research. Financial support from DST (DST/INSPIRE/03/2017/002477) is acknowledged by R.T. This manuscript bears CSMCRI registration no 7/2021.Pramanik, SK (corresponding author), CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
Mukherjee, N (corresponding author), CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, Kolkata 700032, India.
Chattopadhy, S (corresponding author), BITS Pilani, Pilani 403726, Goa, India.
Das, A (corresponding author), Indian Inst Sci Educ & Res Kolkata, Mohanpur 741246, W Bengal, India.
[email protected]; [email protected]; [email protected]
The lower Krishna Basin trajectory: relationships between basin development and downstream environmental degradation
No full textRiver basin development / Lakes / Environmental degradation / Ecosystems / Mangroves / Water allocation / Groundwater / Water quality / Salinity / Irrigated farming / Institutions / Irrigation canals / Rural development
Au(I)- and Pt(II)-N-heterocyclic carbene complexes with picoline functionalized benzimidazolin-2-ylidene ligands; synthesis, structures,electrochemistry and cytotoxicity studies
No full textNovel Au(I)-N-heterocyclic carbene complexes, 1-methyl-3-(2-pyridylmethyl)-
benzimidazolylidenegold(I)-chloride, 1; 1-benzyl-3-(2-pyridylmethyl)-
benzimidazolylidenegold(I)chloride, 2; and Pt(II)-N-heterocyclic carbene complexes 1-methyl-3-(2-
pyridylmethyl) benzimidazolylidene platinum(II)chloride, 3; and 1-benzyl-3-(2-pyridylmethyl)
benzimidazolylidene platinum-(II)chloride, 4, have been synthesized, based on CN-donor proligands
1-alkyl-3-(2-pyridylmeth-yl)-benzimidazoliumchloride L1 and L2 [alkyl, R = –CH3 = L1;
R = –CH2Ph = L2]. All the compounds have been synthesized and characterized by different
spectroscopic methods. The Au(I) complexes 1 and 2 have been synthesized by a silver carbene
transfer method. The solid-state structures of 1 and 3 have been determined by single crystal
X-ray diffraction studies. The square planar Pt(II) complexes 3 and 4 show a reversible
Pt(II)/Pt(IV) couple at 0.69 eV and 0.67 eV respectively. Among the complexes 1–4, complexes 1
and 3 have been used for cytotoxicity studies on the cell lines B16F10 (mouse melanoma), HepG2
(human hepatocarcinoma) and HeLa (human cervical carcinoma). IC50 values are compared with
cisplatin, among 1 and 3, the Au(I) complex 1 is more effective than Pt(II) complex 3
Integrated optical distributed Bragg reflector and distributed feedback lasers in Er:LiNbO3 waveguides with photorefractive gratings
No full textBijoy Krishna DasPaderborn, Univ., Diss., 200
Seminário sobre aquacultura 14 a 16 de dezembro de 1983
No full textA necessidade de desenvolver a aquacultura em Portugal obriga à escolha das espécies mais indicadas para tal finalidade. A propósito o autor chama a atenção para as graves consequências que podem advir das introduções e/ou transferências de animais aquáticos, quer para as espécies locais e meio ambiente, como para a para a saúde pública.Concerning the need to choose the most convenient species to cultivate in order to implement aquaculture in Portugal, the author draws the attention to the deleterious consequences of introductions and transfers of aquatic animals.Caixa Geral de Depósito
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