111,357 research outputs found
Als S. T. Herr Heinrich Carl Schimmelmann, Mit Mademoiselle Carolina Tugendreich Friedeborn, Sich den 2. Mart. 1747. Durch Priesterliche Copulation einseegnen ließ, Wolten Vier ergebenste Diener zu dieser, GOtt gebe! glücklich getroffenen Mariage hertzlich gratuliren Und zu fernerer Gunst und Wohlgewogenheit bestens recommendiren.
No full textHochzeitsglückwünsche auf Heinrich Carl Schimmelmann u. Carolina Tugendreich Friedeborn, 2. März 1747Autopsie nach dem Ex. der ULB Sachsen-Anhalt in HalleVorlage des Erscheinungsvermerks: Dresden, druckts Johann Christoph Krause
Il Trionfo Della Fedeltà : Dramma Pastorale Per Musica / Di E. T. P. A.
No full textNicht identisch mit VD18 14684721, dort abweichende Zierstücke auf S. 5 und 63Enth. 9 Kupferstiche der BeiträgerE. T. P. A. steht für Ermelinda Talea Pastorella Arcada und ist Pseud. von Maria Antonia Walpurgis von Bayern, Kurfürstin von Sachsen. - Verf. ermittelt im KVKAutopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Dresda. Nella Stamperia Regia per la Vedova Stössel, e Giovanni Carlo Krause. 1754.Frontisp. (Porträt, Kupferst.), Kupfert., 7 Ill. (Kupferst.
Inconsistências em ciência
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Filosofia, Florianópolis, 2014.Nos últimos anos, muitos filósofos da ciência (Lakatos 1978, Feyerabend 1988, Priest 1987, da Costa e French 2003, da Costa e Krause 2011) defenderam que certas teorias científicas são extremamente úteis e bem sucedidas, apesar de serem inconsistentes. Esta dissertação de mestrado procura analisar diversas formas de inconsistências em teorias científicas, tornando precisos os vários (e muitas vezes não equivalentes) conceitos de "inconsistência". O trabalho destaca o modo como inconsistências aparecem, ou podem aparecer, em diversos estágios na elaboração de uma teoria científica, pois para começarmos a falar sobre inconsistências em ciência - ou inconsistências em teorias científicas - precisamos assumir uma postura sobre o que são teorias, ou como elas deveriam ser concebidas, para assim avaliar casos de inconsistências em ciência de modo adequado. Todavia, apesar de parecer à primeira vista algo a ser evitado, nós poderíamos e deveríamos ir além e estudar teorias científicas inconsistentes (Bueno 2006). O passo crucial a ser tomado neste estudo é a mudança da lógica subjacente a teorias científicas inconsistentes. Assim, ao adotarmos, por exemplo, uma lógica para consistente, abarcamos a inconsistência evitando a trivialidade e proporcionando uma análise sem a perda de dados científicos importantes. Além disso, às vezes a única maneira de obtermos novos dados de um fenômeno científico é através de uma teoria inconsistente. A Teoria do Átomo de Bohr, por exemplo, apesar de inconsistente estabeleceu previsões corretas quanto ao comprimento de onda das linhas de emissão do espectro de hidrogênio. Desta forma, levando em conta os avanços sobre o entendimento das bases lógicas da ciência, o abandono de teorias científicas inconsistentes já não nos parece ser mais algo viável, já que algumas dessas nos ajudam a entender melhor certos aspectos científicos; assim, parece-nos no mínimo sensato investigar inconsistências em ciência.Abstract : In the last years, many philosophers of science (Lakatos 1978,Feyerabend 1988, Priest 1987, da Costa e French 2003, da Costa eKrause 2011) argued that certain scientific theories are extremely usefuland well succeeded, although inconsistent. This master's thesis iswilling to analyze the various forms of inconsistencies in scientifictheories, making accurate the many (and often not equivalent) conceptsof "inconsistency". This work stand out the way inconsistencies appear,or may appear, in different stages in the development of a scientifictheory, as to begin to deal with inconsistencies in science - orinconsistencies in scientific theories - we need to assume an attitudeabout what scientific theories are, or how they should be conceived, tothereby evaluate cases of inconsistencies in science in a proper way.However, although at first it seems something to be avoided, we couldand should go further and study inconsistent scientific theories (Bueno2006). The crucial step to be taken in this study is the shift of theunderling logic of the inconsistent theories. Therefore, adopting, forexample, a paraconsistent logic, we embrace the inconsistency avoidingthe triviality and providing an analysis without losing importantscientific data. Besides, sometimes the only way to get new data from ascientific phenomenon is through an inconsistent theory. The Bohr'sAtom Theory, for example, despite inconsistent, established correctpredictions regarding the wave length of the emission lines of thehydrogen spectrum. Thus, taking into account the progress of theunderstanding of the logical basis of science, the abandonment ofinconsistent scientific theories no longer seems to be somethingpracticable, since some of this help us to better understand certainscientific aspects; thereby, it seems at least reasonable to investigateinconsistencies in science
Michael D. Krause, approximately 1963-1964
No full textPortrait of Michael D. Krause, Norwich University Class of 1964, as a cadet
From single genomes to natural microbial communities : novel methods for the high-throughput analysis of genomic sequences
No full textKrause L. From single genomes to natural microbial communities : novel methods for the high-throughput analysis of genomic sequences. Bielefeld (Germany): Bielefeld University; 2007.Advances in sequencing technologies provide the opportunity to rapidly produce vast genomic data sets at a low price. In particular, the recently developed, ultra-fast 454 pyrosequencing has dramatically reduced the cost and time requirements per sequenced base pair. Furthermore, novel methods have been developed that enable sequencing of the 99 percent of microbes that are difficult to access with conventional, culture-dependent approaches. These culture-independent methods launch the exciting field of metagenomics - the study of the collective genomes (metagenomes) of free-living microbial communities.
In light of the immense data sets produced, sequence analysis is still a contemporary, ongoing challenge in computational biology. Additionally, new demands arise from the short length of sequence reads produced by ultra-fast sequencing techniques. In the field of whole-genome research, accurate methods are required for identifying and functionally characterizing the gene content of organisms, thus reducing the required manual effort while at the same time producing high-quality annotations. On the other hand, metagenomes are nowadays routinely sequenced, and an increasing number of metagenomic projects is expected in the near future (Pennisi, 2007), but their computational analysis is still in its infancy.
In the presented thesis, state-of-the-art machine learning techniques as well as algorithmic and statistical methods are employed for the high-throughput analysis and characterization of large genomic data sets. First, the gene finding software GISMO was developed, which combines the search for protein domains using profile hidden Markov models (pHMMs) with a sequence composition-based classification using a Support Vector Machine. This combined strategy is able to unveil almost the complete gene content of prokaryotic genomes in a fully automated manner. GISMO has already been extensively employed in the international effort to "Annotate a Thousand Genomes" as well as in various genome annotation and re-annotation projects.
Furthermore, a novel gene finding algorithm for metagenomic data sets was developed. It is robust for most problems encountered when predicting genes in metagenomes, including short sequence length and low sequence quality. Thereby, the algorithm allows to hunt for novel, unknown genes carried by organisms that cannot be sequenced using conventional, culture dependent techniques.
Finally, methods were devised for characterizing short-read metagenomes obtained by pyrosequencing. Following the pHMM-based identification of gene fragments, the latter are categorized into functional groups. Additionally, the source organisms (taxonomic origins) of gene fragments are predicted. The resulting genetic and taxonomic profiles can in turn be used to unveil important trends in the gene content, metabolism, and species composition of the underlying microbial communities
Recognition of GT mismatches by Vsr mismatch endonuclease
No full textThe Vsr mismatch endonuclease recognises the sequence CTWGG (W = A or T) in which the underlined thymine is paired with guanine and nicks the DNA backbone on the 5?-side of the mispaired thymine. By using base analogues of G and T we have explored the functional groups on the mismatch pair which are recognised by the enzyme. Removal of the thymine 5-methyl group causes a 60% reduction in activity, while removing the 2-amino group of guanine reduces cleavage by 90%. Placing 2-aminopurine or nebularine opposite T generates mismatches which are cut at a much lower rate (0.1%). When either base is removed, generating a pseudoabasic site (1?,2?-dideoxyribose), the enzyme still produces site-specific cleavage, but at only 1% of the original rate. Although TT and CT mismatches at this position are cleaved at a low rate (~1%), mismatches with other bases (such as GA and AC) and Watson–Crick base pairs are not cleaved by the enzyme. There is also no cleavage when the mismatched T is replaced with difluorotoluene
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Cognitive Motor Control
No full textStöckel T, Land WM, Krause A, Schack T. Cognitive Motor Control. Presented at the Adaptive Modular Architectures for Rich Motor Skills (AMARSi) workshop, Innsbruck, Austria
If You Look Into The Cloud, Sometimes You Can Hear The Silence There
No full textThe following thesis is a collection of original poems written by Shaun Krause McGillis under the direction of professors Michele Glazer, Primus St. John, and adjunct professor B. T. Shaw during the course of Shaun Krause McGillis\u27s gradate studies at Portland State University
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