96 research outputs found
Maine Interview piece with Rushworth M. Kidder, ethicist, author and director
No full textMaine Interview piece with Rushworth M. Kidder, ethicist, author and director of the Institute for Global Ethics in Camden
Pulitzer Prize-winning Kidder speaks in fall lecture series
No full textPulitzer Prize-winning author Tracy Kidder spoke in the Institute for Leadership Studies’ Fall Leadership Lecture Series in partnership with Book Passage at Dominican University of California on September 28
G. E. Kidder Smith builds : the travel of architectural photography
No full textThe volume represents the very first book dedicated to George Everard Kidder Smith (1913–1997). It deals with his life and work underlining his ability to document and interpret historical architecture and the great buildings. His books were aimed at the layman, and books such as Brazil Builds, Italy Builds, The New Churches of Europe, Pictorial History of Architecture in America, to mention only a few of them, received tremendous critical and popular acclaim.
As an author, educator, photographer, and “builder” of books and exhibitions, G. E. Kidder Smith was a multidimensional figure within the wide-ranging field of North American architectural professionals in the second half of the twentieth century. From his start during the volatile years leading up to, during, and immediately following the Second World War, Kidder Smith excited the imagination of the general public as well as architecture professionals by publishing photographyrich books about new and old buildings in a range of countries. Although Kidder Smith was propelled in his travels by a powerful wanderlust, he was no flaneur.
He trained as an architect and he chose not to practice within the conventional strictures of an architecture office. Instead, Kidder Smith “designed,” researched, wrote, and photographed a remarkably diverse collection of books about architecture and the built environment. His work and life were deeply interwoven and punctuated by travel related to the research, writing, and promotion of books that sought to reveal the genius loci of the countries whose built environments he admired and wished to share with a broader audience.
From the early 1940s to the late 1950s his interest in architecture led him to describe visually the architectural and historical identity of many European countries. After his far-flung travels over the decades, with his wife Dorothea, Kidder Smith focused on his own country and produced a series of ambitious books focused on the United States. Kidder Smith’s vision and narrative betray the gaze of the traveler, the scholar, and the architect
Collected Stories
No full textKidder, Pulitzer Prize-winning author of The Soul of a New Machine (1981), comments on Hemingway’s collected stories: “At its best, his prose is far from simple, but to me it made the writing part of being a writer seem like the easy part. Once you’d performed heroic deeds—or, for the time being, imagined yourself performing them—you just told your story in declarative sentences strung together with lots of ands.
the Startup playbook: secrets of the fastest-growing startups from their founding entrepreneurs
No full textAccording to the Kauffman Index of Entrepreneurial Activity, more than 565,000 new businesses were created in 2010 in the United States alone?each one of them hoping to strike gold. The Startup Playbook will help them succeed. Going insider to insider with unprecedented access, New York Times bestselling author and Clickable CEO, David Kidder, shares the hard-hitting experiences of some of the world's most influential entrepreneurs and CEOs, revealing their most closely held advice
The Role of Signal Regulatory Protein Alpha in Hemophagocytic and Cytokine Storm Syndromes
No full textThe immune system not only eliminates pathogens and other untoward factors but effectively does so without incurring host-compromising collateral damage. Among the many leukocytes buttressing this balancing act,macrophages reside at the helm of innate immunity and orchestrate finely tuned immune responses by acquiring a phenotype bespoke to the underlying inflammatory insult, the optimal result of which is the swift removal of noxious stimuli and reversion to homeostasis thereafter. On rare occasion, macrophages become hyper-activated and potentiate inflammation that often proves life-threatening rather than life-saving, as is the case in hemophagocytic lymphohistiocytosis (HLH) and other cytokine storm syndromes (CSS). Improving our understanding of the mechanistic bases by which macrophage phenotypic plasticity and function are regulated in health and disease will better inform the diagnosis and management of these often-fatal disorders of inflammation. In our study, we explore the role of signal regulatory protein alpha (SIRPɑ) in pro-inflammatory macrophage activation under toll-like receptor (TLR) 9 agonist-driven secondary HLH (S-HLH) and cytokine storm. We show that depleting SIRPα (SIRPα-/-) in mice during TLR9-driven inflammation exacerbates and accelerates the onset of fulminant S-HLH, in which hemophagocytosis, hypercytokinemia, cytopenias, hyperferritinemia, and other HLH hallmarks were apparent. In contrast, mice expressing SIRPα, including those deficient of the SIRPαligand CD47 (CD47-/-), do not phenocopy SIRPαdeficiency and fail to fully develop S-HLH. Although interferon gamma (IFNγ) is largely considered a driver of HLH pathology, IFNγ neutralization did not prevent the precipitation of S-HLH in TLR9-inflamed SIRPα-/- mice, whereas macrophage depletion attenuated S-HLH in SIRPα-/- mice. Mechanistic studies confirmed that SIRPα not only restrains macrophages from acquiring a hemophagocytic phenotype, but also tempers their pro-inflammatory cytokine and ferritin secretion by negatively regulating Erk1/2 and p38 activation downstream of TLR9 signaling. In addition to TLR9 agonists, TLR2, TLR3 or TLR4 agonists, as well as TNFα, IL-6, or IL-17A, but not IFNγ, similarly induced S-HLH in SIRPα-/- mice but not SIRPα+ mice. The collective findings of this study suggest that CD47-dependent and CD47-independent SIRPɑ inhibition play a negative role in HLH pathogenesis by precluding macrophages from becoming hemophagocytic and hyper-activated under inflammation.Doctor of Philosophy (PhD)Biolog
Re-interpreting Kidder Smith’s Italy Builds: crossovers between photography and architecture
No full textGeorge Everard Kidder Smith (1913-1997) was an American architect and photographer. Photo historian Robert Elwall (1953-2012) considered him as an “architectural photographer on the run” because he travelled widely and “seldom taking more than fifteen minutes over a shot, never using lights and relying on local labs to process his films, yet still producing consistently impressive, richly textured prints”[1]. Trained also as an architectural writer and, like many of his generation, using the camera as a tool of analysis and memory, Kidder Smith knew a certain amount of history but by no means considered himself an historian. His book Italy Builds: Its modern architecture and native inheritance (1955) is a collection of astonishing architectural photographs, data and critical comment upon the traditional and modern architecture. The many forms of visual narratives adopted by the author became a valuable index to the kind of building the young mid-twentieth-century architect was prepared to see when he travelled Italy. He thus simply records what has interested him in the architecture of the past and present, and the photographs and explanatory text directly reveal how he has seen it. His eyes goes first toward the primitive: the solid, earth-heavy shapes of masonry, the panels of brickwork, the skeletons of wood, the directly functional types, the solemn personi cation of human qualities in the landscape. When Kidder Smith turns to contemporary Italian architecture he consequently develops new standards of judgments. He encapsulates in his photographs the great range of Italy’s modernist experience, always elegant, and usually with an intelligent touch
Extracellular microRNAs initiate immunostimulation via activating toll-like receptor signaling pathways
No full textAbstract Since the discovery of the stability of extracellular microRNAs (miRNAs) in plasma and other body fluids about a decade ago, an increasing body of literature has addressed the function of extracellular miRNAs as novel regulators of gene expression. Although many of these studies have demonstrated that extracellular miRNAs modulate the target genes of recipient cells in a conventional base-pairing manner after exosome-mediated secretion and uptake of miRNAs, recent studies have shown that extracellular miRNAs can also play an unconventional role by rapidly modulating innate immunity and neuron excitation via directly binding to Toll-like receptors (TLRs). In this review, we will summarize the literature incremented from studying the direct activation of TLR signaling pathways by miRNAs and miRNA-like fragments in modulating immune responses
Meta Analysis for Benefits Transfer – Toward Value Estimates for Some Outputs of Multifunctional Agriculture
No full textAs a contribution to valuing the outputs of multifunctional agriculture, we report three new meta analyses estimating value functions for agricultural conservation program impacts on water quality, wetlands, and upland habitat and open space. As is often the case in valuation, where methods have yet to be standardized, the data sets are relatively small and noisy. With a clear objective of benefits transfer, we seek robust parameter estimates for key RHS variables, even at the cost of some loss of goodness of fit. We present our estimated full equations, and benefits transfer values calculated from equations estimated after backward elimination of insignificant variables, and offer a rationale for this approach to benefits transfer.meta analysis, benefits transfer, multifunctional agriculture, Resource /Energy Economics and Policy,
Assessment of the safety of US nuclear weapons and related nuclear test requirements: A post-Bush Initiative update
No full textThe Nuclear Weapons Reduction Initiative announced by President Bush on September 27, 1991, is described herein as set forth in Defense Secretary Cheney`s Nuclear Arsenal Reduction Order issued September 28, 1991. The implications of the Bush Initiative for improved nuclear weapons safety are assessed in response to a request by US Senators Harkin, Kennedy, and Wirth to the Lawrence Livermore National Laboratory that the author prepare such an assessment. The author provides an estimate of the number of nuclear tests needed to accomplish a variety of specified warhead safety upgrades, then uses the results of this estimate to answer three questions posed by the Senators. These questions concern pit reuse and the number of nuclear tests needed for specified safety upgrades of those ballistic missiles not scheduled for retirement, namely the Minuteman III, C4, and D5 missiles
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