4,930 research outputs found
Burden of disease in treated rheumatoid arthritis patients: going beyond the joint
No full textItem does not contain fulltextOBJECTIVE: The disease burden in rheumatoid arthritis (RA) extends beyond the joint. This article evaluates the physical and psychosocial extra-articular burden of treated RA and relationships among diverse disease manifestations. METHODS: MEDLINE searches identified papers published in English from January 2003 to December 2012 that evaluated systemic complications and psychosocial aspects associated with RA. Preference was given to studies with randomized cohorts and large (>100) sample sizes. Of 378 articles identified in the initial search, 118 were selected for inclusion. RESULTS: RA is associated with multiple comorbidities and psychosocial impairments, including cardiovascular disease, osteoporosis, interstitial lung disease, infection, malignancies, fatigue, depression, cognitive dysfunction, reduced work performance, work disability, and decreased health-related quality of life. The etiology of the extra-articular burden may reflect the systemic inflammation and immune system alteration associated with RA, metabolic imbalances and side effects related to treatment, or the influence of comorbidities. Strategies that may help to reduce the extra-articular disease burden include personalized medicine and the potential introduction of treatments with new mechanisms of action. CONCLUSION: Despite improvements in treating joint disease, the extra-articular burden in RA remains substantial, encompassing multiple comorbidities and psychosocial impairments
Supplemental Material, edited_Supplement - Prevalence, Incidence, and Contributors of Subclinical Atheromatosis, Arteriosclerosis, and Arterial Hypertrophy in HIV-Infected Individuals: A Single-Center, 3-Year Prospective Study
No full textSupplemental Material, edited_Supplement for Prevalence, Incidence, and Contributors of Subclinical Atheromatosis, Arteriosclerosis, and Arterial Hypertrophy in HIV-Infected Individuals: A Single-Center, 3-Year Prospective Study by Mina Psichogiou, Chris J. Kapelios, Giorgos Konstantonis, Antonis Argyris, Euthimia Nasothimiou, Martha Papadopoulou, George Kitas, Theodoros G. Papaioannou, George L. Daikos, Petros P. Sfikakis, and Athanase D. Protogerou in Angiology</p
A plan of the town of Payta in the kingdom of Santa-Fee lying in the latitude of 5 d. 12 m. S* [cartographic material].
No full textPlan of the town of Paita, Peru.; Pl. [17/A] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313818
A Chart of the Pacific Ocean [cartographic material] : from the Equinoctial to the latitude of 39 1/2 d No.
No full textMap of the Pacific Ocean showing tracks of Nostra Senora de Cabadonga and routes taken by Commodore Anson.; "R.W. Seale sculp."; Pl. [28/A] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; Prime meridian: San Bernardino.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313979
A plan of Iuan Fernandes Island in the South Sea, lying in the latitude of 33d 40 m South, and West from the continent of Chili 110 leagues [cartographic material] : variation of the compass 10 d 00 m E.
No full textMap of Juan Fernandez Islands. Relief shown pictorially and by soundings.; Pl. [13/B] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313763
Cardiac inflammation and fibrosis patterns in systemic sclerosis, evaluated by magnetic resonance imaging: An update
No full textSystemic sclerosis (SSc) presents high morbidity/mortality, due to internal organ fibrosis, including the heart. Cardiac magnetic resonance (CMR) can perform myocardial function and tissue characterization in the same examination.The Lake Louise criteria (LLC) can identify recent myocardial inflammation using CMR. Abnormal values include: (a) myocardial over skeletal muscle ratio in STIRT2-W images >2, (b) early gadolinium enhancement values >4, (c) epicardial/intramyocardial late gadolinium enhancement (LGE). The diagnosis of myocarditis using LLC is considered if 2/3 criteria are positive.Parametric imaging including T2, native T1 mapping and extracellular volume fraction (ECV) has been recently used to diagnose inflammatory cardiomyopathy. According to expert recommendations, myocarditis should be considered if at least 2 indices, one T2 and one T1 parameter are positive, whereas native T1 mapping and ECV assess diffuse fibrosis or oedema, even in the absence of LGE. Moreover, transmural/subendocardial fibrosis following the distribution of coronary arteries and diffuse subendocardial fibrosis not related with epicardial coronary arteries are indicative of epicardial and micro-vascular coronary artery disease, respectively.To conclude, CMR can identify acute/active myocardial inflammation and myocardial infarction using classic and parametric indices in parallel with ventricular function evaluatio
Cardiovascular Magnetic Resonance for the Evaluation of Arrhythmogenic Substrates in Patients with Systemic Autoimmunity: An Update
No full textData Set of PLOS Computational Paper PCOMPBIOL-D-18-02181R1
No full textFigures Data of PLOS Computational paper:Modeling of the axon plasma membrane structure and its effects on protein diffusionAuthors: Yihao Zhang, Anastasios V. Tzingounis, and George LykotrafitisCorresponding Author: George Lykotrafitis, Ph.D.University of ConnecticutStorss, CT UNITED STATES</div
Letter from George W. Kimball, Tusayan National Forest, to Carl Hayden
No full textLetter from George W. Kimball to Carl Hayden with an enclosed map detailing the cattle and sheep allotments on the portion of the Tusyan Forest next to the Grand Canyon. Listed are names of permit holders in both stock and allotment that are most likely to trespass into the park. The names are: W. F. Griffin, W. W. Bass, H. R. Lauzon, Swanner and Griffin, Bankhead and Henderson, Martin Buggeln, Babbitt Brothers, Sanford Rowe, and P. D. Berry
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