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Bioactive fungal metabolites
No full textFungi represent one of the seven kingdoms of living organisms [1] and their secondary metabolites display a
broad range of biological activities. We have recently reviewed those fungal metabolites that display anticancer
activity, both from terrestrial [2, 3] and marine [4] origins. We have also highlighted in these three reviews [2-4],
the currently known biological events that enable various types of cancers, including metastatic ones to display high
levels of chemoresistance. Some fungal metabolites are able to overcome certain of these biological barriers leading
to cancer chemoresistance. For example, fusicoccin A, isolated from Fusicoccum amygdali, down-regulates focal
adhesion kinase (FAK) activity and induces cytostatic activity in glioblastoma (GBM) cells [5]. Ophiobolin A, isolated from Bipolaris species, induces paraptosis in GBM cells through the disruption of internal potassium ion homeostasis [6]. GBM are highly chemoresistant [7] as melanomas against which sphaeropsidin A, isolated from Diplodia cupressi, also displays marked anticancer activity through the disruption of melanoma cell ion homeostasis
[8]. We recently highlighted in a special issue of Current Medicinal Chemistry, the potential of targeting ion channels / transporters to combat various types of cancers associated with dismal prognoses [9].
Fungal metabolite-related anticancer activity is further analyzed by two contributions in the current special issue.
Wolf-Rainer Abraham (Helmholtz Centre for Infection Research, Chemical Microbiology, Braunschweig, Germany) has contributed a review entitled “Fumitremorgins and Relatives – from Tremorgenic Compounds to Valuable Anti-Cancer Drugs”. Fumitremorgins are mycotoxins that can also inhibit cancer cell proliferation and impair
their drug resistance.
Cristina Prandi (Department of Chemistry, Universita’ degli Studi di Torino, Torino, Italy) and her collaborators
have contributed a review entitled “Fungal anticancer metabolites: synthesis towards drug discovery”. Prandi and
her colleagues highlight the role of total synthesis in sustaining the pharmacological development of fungal metabolites and as an alternative to isolation in the field of cancer research.
The current special issue then presents five other contributions that do not relate to anticancer activity of fungal
metabolites, while emphasizing a broad spectrum of other biological activities.
Peter Proksch (Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf,
Düsseldorf, Germany) and his colleagues have contributed a review entitled “Natural Products from Deep-SeaDerived Fungi ̶ a New Source of Novel Bioactive Compounds?”. As reported by Proksch and colleagues, up to
now, over 200 new metabolites have been identified from deep-sea fungi, and it has been assumed in the literature
that the unique environment of the deep sea will give rise to equally unprecedented natural products. Proksch and
colleagues critically evaluate whether the data published so far really supports the notion that these fungi are a
promising source of new bioactive chemical entities.
Alessio Cimmino (Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Napoli, Italy) and his
colleagues have contributed a review entitled “Bioactive Metabolites from Pathogenic and Endophytic Fungi of
Forest Trees”. As emphasized by Cimmino and his colleagues, fungi play an important role in terrestrial ecosystems
by interacting positively or negatively with plants. Furthermore, temperate forests represent an enormous reservoir
of fungal diversity. The review provided by Cimmino and colleagues focuses on the secondary metabolites produced by pathogenic and endophytic fungi of forest trees with a focus on their biological activities.
Andrea Chini (Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología- Consejo Superior de Investigaciones Científicas, Madrid, Spain) and his colleagues have contributed a review entitled “Fungal
production and manipulation of plant hormones”. Chini and colleagues state that among the plant molecules that
regulate plant-fungus interactions, phytohormones play a critical role because they modulate various aspects of
plant development, defenses and stress responses. Chini and colleagues emphasize the fact that, intriguingly, fungi
can also produce phytohormones, although the actual role of fungal-produced phytohormones in plant-fungus interactions is poorly understood. Chini and colleagues thus provide an overview of the recent discoveries in fungal production of phytohormone, their putative role as endogenous fungal signals and how fungi manipulate plant hormone balance to their benefit.
Maurizio Vurro (Institute of Science of Food Production, National Research Council, Bari, Italy) and his colleagues have contributed a review entitled “Fungal Phytotoxins in Sustainable Weed Management”. Vurro and colleagues reevaluate the fact that fungal phytotoxins are natural secondary metabolites produced by plant pathogenic
fungi during host–pathogen interactions. The review provided by Vurro and colleagues aims to summarize studies
on the possibility of using such metabolites as tools in biological and integrated weed management, for example, as
novel and environmentally friendly herbicides; as biomarkers for the selection of more efficacious biocontrol
agents; as templates for novel compounds; and as sources of novel mechanisms of action. Vurro and colleagues also
discuss the limiting factors for utilizing these metabolites in practice.
Stefano Superchi (Dipartimento di Scienze, Università della Basilicata, Potenza, Italy) and his colleagues have
contributed a review entitled “Absolute Configuration Determination by Quantum Mechanical Calculation of Chiroptical Spectra: Basics and Applications to Fungal Metabolites”. Superchi and colleagues thus review the application of quantum mechanical simulations of chiroptical properties, i.e. electronic circular dichroism, optical rotation,
and vibrational circular dichroism, for the assignment of the absolute configuration of naturally occurring chiral metabolites of fungal origin.
REFERENCES
[1] Ruggiero, M.A.; Gordon, D.P.; Orrell, T.M.; Bailly, N.; Bourgoin, T.; Brusca, R.C.; Cavalier-Smith, T.; Guiry, M.D.; Kirk, P.M. A
higher level classification of all living organisms. PLoS One, 2015, 10, e0119248.
[2] Evidente, A.; Kornienko, A.; Cimmino, A.; Andolfi, A.; Lefranc, F.; Mathieu, V.; Kiss, R. Fungal metabolites with anticancer activity. Nat. Prod. Rep., 2014, 31, 617-627.
[3] Kornienko, A.; Evidente, A.; Vurro, M.; Mathieu, V.; Cimmino, A.; Evidente, M.; van Otterlo, W.A.; Dasari, R.; Lefranc, F.; Kiss, R.
Toward a cancer drug of fungal origin. Med. Res. Rev., 2015, 35, 937-67.
[4] Gomes, N.G.; Lefranc, F.; Kijjoa, A.; Kiss, R. Can some marine-derived fungal metabolites become actual anticancer agents? Mar.
Drugs, 2015, 13, 3950-3991.
[5] Bury, M.; Andolfi, A.; Rogister, B.; Cimmino, A.; Mégalizzi, V.; Mathieu, V.; Feron, O.; Evidente, A.; Kiss, R. Fusiccocin A, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinases. Trans. Oncol., 2013, 6, 112-123.
[6] Bury, M.; Girault, A.; Mégalizzi, V.; Spiegl-Kreinecker, S.; Mathieu, V.; Berger, W.; Evidente, A.; Kornienko, A.; Gailly, P.; Vandier, C.; Kiss, R. Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity.
Cell Death Dis., 2013, 4, e561.
[7] Lefranc, F.; Brotchi, J.; Kiss, R. Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the
resistance of migrating glioblastoma cells to apoptosis. J. Clin. Oncol., 2005, 23, 2411-2422.
[8] Mathieu, V.; Chantôme, A.; Lefranc, F.; Cimmino, A.; Miklos, W.; Paulitschke, V.; Mohr, T.; Maddau, L.; Kornienko, A.; Berger,
W.; Vandier, C.; Evidente, A.; Delpire, E.; Kiss, R. Sphaeropsidin A shows promising activity against drug-resistant cancer cells by
targeting regulatory volume increase. Cell Mol. Life Sci., 2015, 72, 3731-3746.
[9] Kiss, R. Ion channels and cancers. Curr. Med. Chem., 2012, 19, 625-626
Kiss Ferencz esperesi székfoglalója
No full textKiss Ferenc ; kiadja az Alsószabolcs-Hajduvidéki Református Egyházmegy
Valentine. A Kiss Is Never a Miss
No full textA boy gives a girl a kiss. Text: To my valentine, A kiss is never a miss, but it takes a real miss to make the kiss. Date is approximate.https://egrove.olemiss.edu/romance_revelry/1000/thumbnail.jp
Umgebungen von Butyin und Bél / J. Kiss scr. A. Mück sc.
No full textUMGEBUNGEN VON BUTYIN UND BÉL / J. KISS SCR. A. MÜCK SC.
[Specialkarte von Ungarn, Kroatien und Slavonien] (-)
Umgebungen von Butyin und Bél / J. Kiss scr. A. Mück sc. (L.10.) ( -
KISS: Stochastic Packet Inspection Classifier for UDP Traffic
No full textThis paper proposes KISS, a novel Internet classifica- tion engine. Motivated by the expected raise of UDP traffic, which stems from the momentum of Peer-to-Peer (P2P) streaming appli- cations, we propose a novel classification framework that leverages on statistical characterization of payload. Statistical signatures are derived by the means of a Chi-Square-like test, which extracts the protocol "format," but ignores the protocol "semantic" and "synchronization" rules. The signatures feed a decision process based either on the geometric distance among samples, or on Sup- port Vector Machines. KISS is very accurate, and its signatures are intrinsically robust to packet sampling, reordering, and flow asym- metry, so that it can be used on almost any network. KISS is tested in different scenarios, considering traditional client-server proto- cols, VoIP, and both traditional and new P2P Internet applications. Results are astonishing. The average True Positive percentage is 99.6%, with the worst case equal to 98.1,% while results are al- most perfect when dealing with new P2P streaming applications
Kiss Apple
No full textThis is one of hundreds of 60-second radio spots created by the Center for East Asian Studies (CEAS) for Kansas Public Radio (KPR). The purpose of this outreach program is to introduce the people of Kansas to the culture and current issues of East Asia.Broadcast Transcript: Spicy kimchee and garlicky fish. Standard fare in Korea. Good for the health, sure, but for the breath? Not so much. So in an attempt to promote healthy eating along with kissably fresh breath, Korean scientists have developed the tiny kiss apple. Apples are known to be natural breath fresheners but chomping down on an after dinner regulation size fruit could ruin the romantic mood. Hence the kiss apple. The ping-pong ball sized fruit can be popped in the mouth whole. Not content with nature's toothbrush as it is, the developers are already dreaming of mass producing a better kiss apple, one that offers enhanced odor control. So, unlike Snow White, South Korean lovebirds can skip the coma and go directly from biting the apple to enjoying the awakening kiss. #boyd #ceas #hacker #SouthKore
Interdiszciplináris pedagógia, tanárok, értelmiségiek. A VI. Kiss Árpád Emlékkonferencia
No full text1999-ben Báthory Zoltán, Kozma Tamás és Kiss Endre, illetve az általuk képviselt szervezetek, jelesül az MTA Pedagógiai Bizottsága, a Debreceni Egyetem Neveléstudományi Tanszéke, valamint az ELTE Filozófiai Tanszéke összefogott, hogy Kiss Árpád halálának 20. évfordulójára emlékkonferenciát szervezzenek. Több cél is motiválta az életrehívókat. Egyrészt azt kívánták elérni, hogy Kiss Árpád (s vele kiváló kortársai és az egész történelmi korszak) szellemi hagyatékát, „egy európai értelemben művelt és fogant pedagógiá”-t, méltó módon ápolhassák az utódok. Alkalmat és keretet kívántak biztosítani azoknak a szakmai beszélgetéseknek és baráti találkozásoknak, melyek során a résztvevők a konferencia névadójára és a vele társítható sokrétű problematikára emlékezhetnek
Sosiaalisen median strategia Radio Kissille : Case Radio Kiss, Bauer Media Oy
No full textTämän opinnäytetyön tarkoituksena oli luoda Radio Kissille toimiva sosiaalisen median strategia, jota käytetään apuvälineenä osana markkinointisuunnitelmaa. Sosiaalisen median strategian luonti oli välttämätöntä, jotta Radio Kiss kykenee saavuttamaan aseman uskottavana sisällöntuottajana radiotaajuuden lisäksi myös sosiaalisessa mediassa.
Onnistunut sosiaalisen median strategia vahvistaa brändin tunnettavuutta ja brändiuskollisuutta, kasvattaa konversiota sekä parantaa yrityksen ja kohdeyleisön välistä vuorovaikutusta, Työssä käydään läpi myös sosiaalisen median trendejä, hyötyjä sekä haittoja radiokanavan toiminnalle.
Opinnäytetyö toteutettiin toimeksiantona Bauer Media Oy:lle, ja sen ensisijaisena tavoitteena oli luoda strategia, joka vahvistaa vuorovaikutussuhdetta Radio Kissin seuraajien kanssa. Jotta Radio Kiss voi olla uskottava radiokanava, sen on oltava siellä, missä kohderyhmäkin on. Siksi taustalle luotiin johdonmukainen, säännöllinen ja tavoitteellinen sosiaalisen median strategia, joka laadittiin Paul Smithin kehittämän SOSTAC-suunnittelumallin avulla. Malli valikoitui avuksi strategian luomiselle siksi, että Radio Kissillä ei ole ollut aikaisemmin sosiaalisen median strategiaa, ja siitä haluttiin mahdollisimman yksityiskohtainen.
SOSTAC-suunnittelumalli sisältää tilanneanalyysin, tavoitteet, toimintasuunnitelman, taktiikan, toimintatavat ja kontrolloinnin. Pääkanaviksi valittiin toimituksen kesken Facebook sekä Instagram, mutta strategiaa voidaan hyödyntää myös muiden sosiaalisen median kanavien kehittämisessä sekä strategian laadinnassa.
Osana työtä toteutettiin kvalitatiivinen kyselytutkimus Radio Kissin seuraajien käyttäytymisestä ja toiveista eri sosiaalisen median kanavien osalta. Kuukauden auki ollut tutkimus julkaistiin Facebookissa sekä Instagram Stories -alustalla, ja se keräsi yhteensä 150 vastausta. Kysely antoi pohjaa strategian luonnille antaen osviittaa siitä, mitä kanavia seuraajat käyttävät, minkälaista sisältöä he toivovat Radio Kissin sosiaalisen median kanaviin, ja kuinka usein.
Kyselytutkimusta sekä aikaisempia tilastoja ja analytiikkaa hyödyntäen luotiin sosiaalisen median strategia, jota voidaan soveltaa myös muiden radiokanavien sosiaalisen median strategioiden luomiseen.The purpose of this thesis is to create a systematic social media strategy for Radio Kiss. Strategy is part of the radio station’s marketing strategy and it works as an aid to Radio Kiss employees on daily devices. It is necessary to create a social media strategy for Radio Kiss, in order that station can reach its goal as a credible content provider in social media platforms. Successful social media strategy strengthens station’s credibility and brand’s loyalty among followers and listeners. It increases conversion and improves interaction between the company and the target audience. Facebook and Instagram were chosen as the main channels because of popularity and target audience’s preferences.
This thesis also examines the relationship between social media and the radio station and discuss the advantages and disadvantages of social media use. It is told how and why a radio station should create a social media strategy. It also reviews social media’s past and upcoming trends in 2019.
The primary aim of this thesis is to improve interaction between the followers and the Radio Kiss through social media with the help of the systematic strategy. This strategy is a development work that was done as an assignment by Bauer Media Oy.
In order for Radio Kiss to be a credible radio channel, it must be where the target audience is. Therefore a consistent, regular and goal-oriented social media strategy was created by using SOSTAC planning model developed by Paul Smith. This planning model was chosen because it’s specific steps, which contains situation analysis, objectives, strategy, tactics, action and controls. SWOT analysis were also integrate with the strategy’s situation analysis.
A qualitative research which was released in Radio Kiss’ Facebook and Instagram Stories - platform gave a lot of new information about the behavior and wishes of the followers of Radio Kiss in relation to various social media channels. The research gave some indication of which channels followers use, what kind of content they want to see on Radio Kiss's channels, when and how often. The social media strategy was developed by considering these results given by a qualitative research.
This strategy gives the company the opportunity to engage the followers increasingly with Radio Kiss. The information in the thesis can be used for planning social media strategy of any radio stations
Podcast Interview: "Bling of the month" Barbara Flückiger. Episode 1
No full textThe podcast is produced at the Film University Babelsberg (Germany) within the framework of the research project "The Cinematic Face of Cities." The research project is sponsored for three years by the "German Federal Ministry of Education
and Research" under the scheme "Small Disciplines — High Potential". The moderator and producer is Dr. Anna Luise Kiss.
The first "Bling of the month" is Barbara Flückiger. They talked about her ERC project "Film Colour". https://www.film.uzh.ch/en/research/projects/verbund/ERC-Advanced-Grant-FilmColors.html.
The news is about the book "Fiction and Imagination in Early Cinema" by Mario Slugan and an award that might be interesting for scholars conducting production studies.
And in her diary, Dr. Anna Luise Kiss will tell you something about two pieces of advice that were given to her, regarding the writing of applications for research funding
Podcast Interview: "Bling of the month" Noemi Daugaard. Episode 5
No full textThe podcast is produced at the Film University Babelsberg (Germany) within the framework of the research project "The Cinematic Face of Cities." The research project is sponsored for three years by the "German Federal Ministry of Education
and Research" under the scheme "Small Disciplines — High Potential". The moderator and producer is Dr. Anna Luise Kiss.
In this episode, you first hear an interview with Noemi Daugaard. We talked about a paper she wrote together with Josephine Diecke on how colour film technology and society influence each other
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