1,720,997 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Engineering of impurity doped regions in semiconducting BaSi[2] by MBE for thin film solar cells application
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Generation and characterization of cancer cells resistant to an anticancer drug candidate targeting DNA replication-initiation proteins and studies of these proteins
No full textResistance to chemotherapeutics abrogates the efficacy of current cancer therapies and presents an additional layer of adversities to anticancer drug development. Several commonly prescribed anti-cancer drugs have some form of resistance related challenges. Therefore, studying the underlying mechanisms of drug resistance in cancer cells will increase our understanding and reveal important information that can be used to overcome resistance and improve cancer therapy. We examined the resistance mechanisms of M2, a drug candidate targeting the MCM complex. A resistant cell model (R10) was generated through exposure to gradually increasing doses of M2 (up to 500 ng/ml). Upon characterization, R10 showed 6.3-fold more resistance to M2 compared to the sensitive counterpart. Additionally, R10 exhibited many intrinsic phenotypic characteristics such as enhanced antiapoptotic potential, increased doubling time, slow cell cycle progression and variation in the level of chromatin bound MCM. Furthermore, the heterogenous and dynamic nature of resistant cancer population (R10) led us to study the resistance mechanisms in single-cell clones (SCCs), to dissect the complex heterogeneity of resistance. We isolated SCCs from R10. The detailed analysis of 6 clones revealed broadly different drug resistance mechanisms. We found that three clones showed specific resistance (SR1-3) only to M2 while the other three clones displayed multidrug resistance (MR1-3). Our results demonstrated that MR clones exhibit reduced drug uptake potential in comparison to the parental cell line. Moreover, the upregulation of mesenchymal markers, MCM2, -5 & -7p is consistent with the aggressive nature and metastatic potential of the SR and MR clones. In a chemically confined microenvironment, multi-daughter cell formation was observed in different cancer cell lines. In addition to this, we studied the role of NOC3p in Eukaryotic ORC Dimerization and DNA Replication. Our co-IP results showed that ORC dimerization is NOC3p dependent in budding yeast and human cells. Furthermore, the confirmation of these novel processes of protein dimerization in human cells through cryo-EM will help to screen for anticancer agents targeting these proteins in cancer cells. Taken together, our data provide evidence of heterogeneity within the M2-resistant cancer cell population, including an increase in MCM expression, a reduction in drug uptake, EMT acquisition and multipolar mitosis in a chemically altered environment. These findings highlight the ability of resistant cancer cells to evolve sub clonal populations and necessitates clonal based treatment strategies to overcome resistance.</p
Concord between Palestinian Resistance and Literature: A Historico-Literary Analysis of Darwish’s Works
Full text linkThis research explores the last seventy years of the Palestinian Arabs’ political struggle for their recognition as a sovereign nation-state as reflected in the poetic and prose works of Palestinian national poet, Mahmoud Darwish (1941-2008). Given the relationship between life and literature, the Palestinian situation can be best revealed through their own cultural productions, especially literature. Darwish has utilized his sense of exile and cultural memory to realize the ideals of Palestinian home and its requisite identity. His writings constitute an integral part of Palestinian resistance literature. His works are reflective of a deep aesthetic sense coupled with a profound political understanding of the ground facts within and outside Palestine. He contests the legitimacy of a sustained foreign occupation and at the same time stresses the need of preserving national cultural heritage. He stresses the need of both intellectual and political resistance to the gradual encroachment caused by the colonial settlement regime. The present research has sought to figure out the dimensions of Darwish’s poetic and intellectual contribution to the volatile geopolitical issue of the resistance to a hegemonic control
Engineering of impurity doped regions in semiconducting BaSi[2] by MBE for thin film solar cells application
No full text筑波大学University of Tsukuba博士（工学）Doctor of Philosophy in Engineeringtext2012On t.p. "[2]" is subscript
Includes bibliographical references (p. 83-85)doctoral thesi
Engineering of impurity doped regions in semiconducting BaSi[2] by MBE for thin film solar cells application
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