122 research outputs found
Datainbrief_template – Supplemental material for Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia
No full textDatainbrief_template for Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia by Afaf Hamed Khalil, Marwa Abd el-Meguid, Mostafa Bastawy, Samah Rabei, Ramy Ali and Mohamed Hossam Eldin abd elmoneam in International Journal of Social Psychiatry</p
Effect of Polycyclic Aromatic Hydrocarbons (PAHs) on Modulate Genes Encoding Stress Related Proteins and Antioxidant Enzymes in Different Marine Fish Species of Red Sea Water
No full textPolycyclic aromatic hydrocarbons (PAHs) in the Red sea water were determined at Suez and Ismailia
governorates, Egypt. The sites were selected to represent areas with different activities of Suez Gulf water.
The concentrations of fifteen PAHs having two to six rings were determined by using HPLC with florescence
detection. The total average concentrations of the fifteen PAHs over the Suez governorate sites (S1 and S2)
were 1.45 and 0.34 ??g/l, respectively. However those for Ismailia governorate sites (I1 and I2) were 1.06 and 0.24
??g/l, respectively. PAHs having four to six rings were the predominant compounds in particulate matters.
The major sources of PAHs and their impacts on the health of certain types of fish such as Mullet and Sea-bass
species were studied through the effect on the expression of stress protein related genes. In addition,
expression of stress protein related genes (Cytochrome P450, CYP1A and metallothionein, MT-1A) and
antioxidant enzymes (Glutathione-S-Transferase and GST alpha) in liver tissues of Mullet and Sea-bass
collected from studied locations in Ismailia governorate and Suez gulf were assessed. The results revealed
alterations in the hepatic mRNA levels of CYP1A, MT-A and GST alpha genes in Mullet and Sea-bass collected
from S1 location at Suez gulf compared with I1 location at Ismailia governorate and with the S2 and I2 locations
as reference site. The current findings suggest that the genes encoding stress related proteins and antioxidant
enzymes studied in this paper represent valid biomarkers to detect variation of fish stress conditions attributed
to PAHs
Reinterpretasi Monumen Bagindo Aziz Chan Karya Arby Samah dalam Ikonografi Erwin Panofsky
No full textABSTRACTResearch was entered to trace the Bagindo Aziz Chan monument by Arby Samah trough the iconographicapproach put forward by Erwin Panofsky, as well as to uncover the reason for the contruction of themonument. The research uses qualitative methods of observation interviews and document.The figure Arby Samah described in the “Bagindo Aziz Chan Monument” is indeed a Bagindo figure,which was made using cement plaster technique, making the work began in 1973 by Arby Samah. Reliefsmade in the foundation of the statue tells the sequence of event killed Bagindo Aziz Chan. The use ofthe realist style found by the author on the Bagindo Aziz Chan monument although the cultivation ofthe statue still looks tough, but the delivery of the sign on the statue is the hope and ideals of BagindoAziz Chan during his leadership as mayor of Padang is clearly depicted. The making of the statue uses acement plaster which is a technique commonly technique. Used by sculpture artists in the 1970s. In 2005Bagindo Aziz Chan was awarded as a national hero from west Sumatera by the central government, andalso on July 19 the people of Padang commemorated the day of death of Bagindo Aziz Chan which was atribute to the leader of Padang. And also the name Bagindo Aziz Chan has been enshrined as the name ofa street and a building in the city of Padang.Keywords: Bagindo Aziz Chan Monument, Iconographic, Erwin Panofsky.ABSTRAKPenelitian dimaksudkan untuk menelusuri monumen Bagindo Aziz Chan karya Arby Samahmelalui pendekatan ikonografi yang dikemukakan oleh Erwin Panofsky, serta mengungkapalasan dibangunnya monumen tersebut. Penelitian ini menggunakan metode kualitatif yaitupengamatan, wawancara dan dokumen.Tokoh yang digambarkan Arby Samah pada karya “Monumen Bagindo Aziz Chan” ini memangsosok Bagindo Aziz Chan, yang dibuat memakai teknik plaster semen, pembuatan karya tersebutselesai mulai dilakukan pada tahun 1971 dan selesai pada tahun 1973 yang dibuat oleh ArbySamah. Relief yang dibuat pada landasan patung menceritakan urutan peristiwa terbunuhnyaBagindo Aziz Chan. Pemakaian gaya realis yang didapati penulis pada monumen BagindoAziz Chan walaupun penggarapan patung tersebut masih terlihat kasar, namun penyampaiantanda pada patung tersebut merupakan harapan dan cita-cita Bagindo Aziz Chan selamakepemimpinannya sebagai wali kota Padang tergambarkan dengan jelas. Pembuatan patungtersebut menggunakan teknik plaster semen yang merupakan teknik yang umum dipakai olehseniman patung pada tahun 1970-an. Pada tahun 2005 Bagindo Aziz Chan dianugrahi sebagaipahlawan nasional asal Sumatera Barat oleh pemerintah pusat, dan juga pada tanggal 19 Julimasyarakat kota Padang memperingati hari wafatnya Bagindo Aziz Chan yang merupakanpenghormatan kepada pemimpin kota Padang yang tegas dan berani tersebut. Dan juga namaBagindo Aziz Chan sudah diabadikan sebagai nama jalan dan gedung di kota Padang.Kata Kunci: Monumen Bagindo Aziz Chan, Ikonografi Erwin Panofsk
The Duckweed, Lemna minor Modulates Heavy Metal-Induced Oxidative Stress in the Nile Tilapia, Oreochromis niloticus
No full textA two-fold integrated research study was conducted; firstly, to understand the effects of copper (Cu) and zinc (Zn) on the growth and oxidative stress in Nile tilapia, Oreochromis niloticus; secondly, to study the beneficial effects of the duckweed Lemna minor L. as a heavy metal remover in wastewater. Experiments were conducted in mesocosms with and without duckweed. Tilapia fingerlings were exposed to Cu (0.004 and 0.02 mg L−1) and Zn (0.5 and 1.5 mg L−1) and fish fed for four weeks. We evaluated the fish growth performance, the hepatic DNA structure using comet assay, the expression of antioxidative genes (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase, GPx and glutathione-S-transferase, GST) and GPx and GST enzymatic activity. The results showed that Zn exhibited more pronounced toxic effects than Cu. A low dose of Cu did not influence the growth whereas higher doses of Cu and Zn significantly reduced the growth rate of tilapia compared to the control, but the addition of duckweed prevented weight loss. Furthermore, in the presence of a high dose of Cu and Zn, DNA damage decreased, antioxidant gene expressions and enzymatic activities increased. In conclusion, the results suggest that duckweed and Nile tilapia can be suitable candidates in metal remediation wastewater assessment programs
Modulatory effect of thymol on the immune response and susceptibility to Aeromonas hydrophila infection in Nile tilapia fish exposed to zinc oxide nanoparticles
No full textZinc oxide nanoparticles (ZnO-NPs) have many exciting properties that make their use in a continuous increase in various biomedical, industrial, and agricultural applications. This is associated with accumulation in the aquatic ecosystems and fish exposure with consequent deleterious effects. To determine the potential of thymol to counteract the immunotoxic effects of ZnO-NPs, Oreochromis niloticus was exposed to ZnO-NPs (1⁄5 LC50 =1.14 mg/L, for 28 days) with or without feeding a thymol-incorporated diet (1 or 2 g/kg diet). Our data demonstrated a reduction of aquaria water quality, leukopenia, and lymphopenia with a decrease in serum total protein, albumin, and globulin levels in exposed fish. At the same time, the stress indices (cortisol and glucose) were elevated in response to ZnO-NPs exposure. The exposed fish also revealed a decline in serum immunoglobulins, nitric oxide, and the activities of lysozyme and myeloperoxidase, in addition to reduced resistance to the Aeromonas hydrophila challenge. The RT-PCR analysis showed downregulation of antioxidant (SOD) superoxide dismutase and (CAT) catalase gene expression in the liver tissue with overexpression of the immune-related genes (TNF-α and IL-1β). Importantly, we found that thymol markedly protected against ZnO-NPs-induced immunotoxicity in fish co-supplemented with thymol (1 or 2 g/kg diet) in a dose-dependent manner. Our data confirm the immunoprotective and antibacterial effects of thymol in ZnO-NPs exposed fish, supporting the potential utility of thymol as a possible immunostimulant agent
Immunosuppressive Effects of Thallium Toxicity in Nile Tilapia Fingerlings: Elucidating the Rescue Role of Astragalus membranaceus Polysaccharides
No full textThis study evaluated the immunotoxic effects of thallium (Tl) in Nile tilapia fingerlings and the recovery role of dietary Astragalus membranaceus polysaccharides (ASs). An 8-week experiment was designed where 180 fishes were randomly and equally assigned in triplicates into the six groups: the control group (CNT) was reared in unpolluted water and fed a commercial diet, two groups were fed a well-balanced commercial diet plus 1.5 and 3.0 g AS/kg diet (AS0.15 and AS0.30), respectively, the fourth group was exposed to a sublethal dose of Tl (41.9 μg l(−1)) [equal to 1/10 of 96-h lethal concentration 50 (LC50)], and the last two groups were fed 0.15 and 0.3% AS, respectively, and concurrently exposed to Tl (41.9 μg l(−1)) (AS0.15+Tl and AS0.30+Tl). Fish hematobiochemical parameters, serum immunity [nitric oxide, total immunoglobulin M (IgM) levels, and lysozyme activity], transcription of hepatic interferon-γ (IFN-γ), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), and resistance to Aeromonas hydrophila (A. hydrophila) were assessed. Hematobiochemical parameters and serum immune indices were significantly decreased in the fish group exposed to sublethal Tl concentration compared to the CNT group. Furthermore, Tl exposure significantly induced overexpression of IL-1β, TNF-α, and IFN-γ genes (4.22-, 5.45-, and 4.57-fold higher, respectively) compared to CNT values. Tl exposure also increased the cumulative mortality (%) in Nile tilapia challenged with A. hydrophila. Remarkably, the groups fed AS0.15+Tl and AS0.30+Tl significantly ameliorated all the aforementioned parameters, but did not reach CNT values. Our findings suggest the possible immunomodulating roles of dietary AS in recovering the immunotoxic effects of Tl in Nile tilapia. We can conclude that dietary AS would be useful for maintaining the immunity of Nile tilapia fingerlings
The prevention impact of the green algal extract against genetic toxicity and antioxidant enzyme alteration in the Mozambique tilapia
No full textAlgal studies are primary for ecological risk assessment and toxicology by evaluating lethal and sub-lethal toxic impacts of potential toxicants on inhabitants of numerous ecosystems. Dunaliella salina, a green marine alga, is characterized by its carotenoid accumulation and is widely used in many health and nutritional products. Our experiment was designed to evaluate algal extract's ability to inhibit genetic alterations induced by mutagen agents such as dioxin in the Mozambique tilapia. The expression of three stress genes was examined: heat shock protein 90 (Hsp90), CYP1A1 as one of the main cytochrome P450 enzymes, and metallothionein (MT). The study exhibited a characteristic sensitivity to metal treatments. Liver samples were collected from all fish to analyze bio-indicators, including superoxide dismutase (SOD), malondialdehyde (MDA), and reactive oxygen species (ROS). While gills samples were used for DNA fragmentation assay. Results showed that oxidative stress in the dioxin group's liver significantly changed indicators. However, the dioxin group significantly increased the SOD, MDA enzyme activities, and ROS formation. Interestingly, the genes Hsp90, CYP1A1, and MT expression were significantly down-regulated in Dunaliella salina groups. Nevertheless, DNA fragmentation in gill organs was affected by exposure to dioxin in fish. Thus, it was concluded that the methanolic extract of an isolated strain Dunaliella salina is effective against mutagen agent dioxin by inhibiting genetic alterations in fish organs with an antioxidant defense system to conquer oxidative damage
Astaxanthin Mitigates Thiacloprid-Induced Liver Injury and Immunotoxicity in Male Rats
No full textThiacloprid (TCP) is a widely used neonicotinoid insecticide with a probable toxic hazard to animals and human beings. This hazard has intensified the demand for natural compounds to alleviate the expected toxic insults. This study aimed at determining whether astaxanthin (ASX) could mitigate the hepatotoxic effect of TCP and diminish its suppressive effect on immune responses in rats. Animals received TCP by gavage at 62.1 mg/kg (1/10th LD50) with or without ASX at 40 mg/kg for 60 days. Intoxicated rats showed modulation of serum transaminases and protein profiles. The hemagglutination antibody titer to sheep red blood cells (SRBC) and the number of plaque-forming cells in the spleen were reduced. The cell-mediated immunity and phagocytosis were suppressed, while serum interleukins IL-1β, IL-6, and IL-10 were elevated. Additionally, malondialdehyde, nitric oxide, and 8-hydroxy-2′-deoxyguanosine levels were increased in the liver, spleen, and thymus, with depletion of glutathione and suppression of superoxide dismutase and catalase activities. The expressions of inducible nitric oxide synthase and the high mobility group box protein 1 genes were upregulated with histomorphological alterations in the aforementioned organs. Cotreatment with ASX markedly ameliorated the toxic effects of TCP, and all markers showed a regression trend towards control values. Collectively, our data suggest that the protective effects of ASX on the liver and immune system of TCP-treated animals depend upon improving the antioxidant status and relieving the inflammatory response, and thus it may be used as a promising therapeutic agent to provide superior hepato- and immunoprotection
Thiacloprid Induced Developmental Neurotoxicity via ROS-Oxidative Injury and Inflammation in Chicken Embryo: The Possible Attenuating Role of Chicoric and Rosmarinic Acids
No full textInsecticides are widely employed in agriculture to control pests and as major factors for enhancing crop productivity. Thiacloprid (TH) is one of the most-used insecticides worldwide. In this study, the negative impact of TH on the brain tissue of developing chicken embryo models and the modulatory effect of chicoric (CA) and rosmarinic (RA) acids were investigated. The eggs were injected in ovo with different doses of TH (0.1, 1, 10, and 100 μg/egg). TH significantly increased the oxidative damage in the brain of exposed embryos in a dose-dependent manner (p p p p < 0.05). In conclusion, TH is suggested to be a possible neurotoxic to embryos of vertebrates including human. The study also revealed the antioxidant, anti-inflammatory, genoprotective, and antiapoptotic property of CA and RA against TH toxicity
Samah seleem: the popular novel and the origins of the novel
No full textBu çalışma öncelikle, Semah Selim’in romancılığın esaslarına dair araştırma ve incelemelerini tanımlamaya yöneliktir. Bu minvalde Arap romancılığına ait başarılı öncü çalışmalarda Avrupa romancılığından etkilenimin, Arap kültüründen ve özellikle Arap halk kültüründen etkilenim ölçüsünde olmadığı betimlenmiştir. Her ne kadar yazar, temelsiz tercümelerin revaç bulmasında popüler romanların baskın etkisini gündeme getirmiş olsa bile yazarların konu seçiminde toplum zevkinin ve ilgisinin önemli rollleri olduğu bir vakıadırThis study primarily aims at introducing Dr. Samah Seleem’s work and academic endeavor concerning the popular novel and its origin/ the origin of novel to the readers. Her work has revealed that the beginnings of that novel are not attributed to the impact of European achievements. Rather, they could be attributed to the Arabian legacy and its popular roots in particular as the audience has played a major role in directing the writers’ attention to their areas of interest. However, the author thinks that the popular novels had tremendously led to the preponderance of fake translations.تسعى هذه الدراسة أّواًل للتعريف بجهود الدكتوره سماح سليم، واشتغاًلتها بالبحث
عن أصول الرواية، والتي انتهت فيها إلى أ ّن إرهاصات ال ِّرواية العربّية ًل تعود
ُّرها بالتراث العربي،
ُّرها بالنتاجات األوروبية، بقدر ما هي تعود إلى تأث
لعالقة تأث
اب حول
وخا َّصة ال ّشعبي. حيث كان لذائقة الجمهور الدور الكبير في توجيه ال ُكتَّ
رى المؤلفة أن الروايا ِت ال َّشعبي َة الموضوعات التي يهتمون بها، وإن كانت َت كان لها
دو ٌر ُمهٌّم في رواج الترجمات الكاذبة
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