594 research outputs found
Fixing education for the AI age: Conrad Wolfram
No full textConrad Wolfram is the CEO and co-founder of Wolfram Research Europe and Strategic Director of Wolfram Research. He is a leading advocate for mathematics education reform and author of “The Math(s) Fix: An Education Blueprint for the AI Age”. He recently gave a public lecture at LSE on this topic. The following is an edited version of an interview by Neil Olver in the Mathematics Department
Wolfram von Eschenbach Gesellschaft - Stellungnahme und Presseerklärung
No full textWolfram von Eschenbach Gesellschaft e.V. - 02.10.2006 Betreff: Badische Landesbibliothek Karlsruhe - Stellungnahme und Presseerklärung Mit Entsetzen und Empörung haben die Mitglieder der Wolfram von Eschenbach-Gesellschaft davon Kenntnis erhalten, dass die Regierung des Landes Baden-Württemberg sich in einem beispiellosen „Deal“ anschickt, die renommierte Badische Landesbibliothek durch den Verkauf ihrer wertvollsten Handschriftenbestände in ihrem Kern zu zerstören. Als wissenschaftliche Gese..
Who are the Disciples and Admirers of an Author?
No full textWebcast sponsored by the Irving K. Barber Learning Centre and hosted by SLAIS. Recitation (the act of citing a given author or her/his works multiple times) provides an indication of the influence of a cited author. This study investigated patterns of citation and recitation across frequently cited authors' works to better understand how broadly citers have been influenced by cited authors and their publications. Dietmar Wolfram is Interim Dean & Professor School of Information Studies, University of Wisconsin-Milwaukee.Arts, Faculty ofLibrary, Archival and Information Studies (SLAIS), School ofUnreviewedFacult
Deleveraging mit Zwangsanleihen
No full textFür Wolfram F. Richter, Universität Dortmund, sind die verschiedenen Krisen im Kern Kreditkrisen. Deshalb sei es riskant, die Lösung der Krise in Strategien zu suchen, die sich in einer Refinanzierung von Schulden durch Schulden erschöpfen. Geboten sei deshalb weniger eine Umschuldung oder eine Hebelung von Kreditvolumina, sondern ein Rückbau der Verschuldung im öffentlichen und finanziellen Sektor unter Vermeidung einer Kreditklemme für die Realwirtschaft. Um dieses Ziel zu erreichen, sollten, nach Ansicht von Wolfram Richter, die Staaten des Euroraums die koordinierte Begebung von Zwangsanleihen in Erwägung ziehen
Deleveraging mit Zwangsanleihen
No full textFür Wolfram F. Richter, Universität Dortmund, sind die verschiedenen Krisen im Kern Kreditkrisen. Deshalb sei es riskant, die Lösung der Krise in Strategien zu suchen, die sich in einer Refinanzierung von Schulden durch Schulden erschöpfen. Geboten sei deshalb weniger eine Umschuldung oder eine Hebelung von Kreditvolumina, sondern ein Rückbau der Verschuldung im öffentlichen und finanziellen Sektor unter Vermeidung einer Kreditklemme für die Realwirtschaft. Um dieses Ziel zu erreichen, sollten, nach Ansicht von Wolfram Richter, die Staaten des Euroraums die koordinierte Begebung von Zwangsanleihen in Erwägung ziehen.
Interest rate convexity and the volatility smile
No full textWhen pricing the convexity effect in irregular interest rate derivatives such as, e.g., Libor-in-arrears or CMS, one often ignores the volatility smile, which is quite pronounced in the interest rate options market. This note solves the problem of convexity by replicating the irregular interest flow or option with liquidly traded options with different strikes thereby taking into account the volatility smile. This idea is known among practitioners for pricing CMS caps. We approach the problem on a more general scale and apply the result to various examples. --interest rate options,volatility smile,convexity,,option replication
Comprehensive overview of disease models for Wolfram syndrome : toward effective treatments
No full textWolfram syndrome (OMIM 222300) is a rare autosomal recessive disease with a devastating array of symptoms, including diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing loss, and neurological dysfunction. The discovery of the causative gene, WFS1, has propelled research on this disease. However, a comprehensive understanding of the function of WFS1 remains unknown, making the development of effective treatment a pressing challenge. To bridge these knowledge gaps, disease models for Wolfram syndrome are indispensable, and understanding the characteristics of each model is critical. This review will provide a summary of the current knowledge regarding WFS1 function and offer a comprehensive overview of established disease models for Wolfram syndrome, covering animal models such as mice, rats, flies, and zebrafish, along with induced pluripotent stem cell (iPSC)-derived human cellular models. These models replicate key aspects of Wolfram syndrome, contributing to a deeper understanding of its pathogenesis and providing a platform for discovering potential therapeutic approaches
Algebraic properties and the finite rank problem for Toeplitz operators on the Segal–Bargmann space
No full textAbstractWe study three different problems in the area of Toeplitz operators on the Segal–Bargmann space in Cn. Extending results obtained previously by the first author and Y.L. Lee, and by the second author, we first determine the commutant of a given Toeplitz operator with a radial symbol belonging to the class Sym>0(Cn) of symbols having certain growth at infinity. We then provide explicit examples of zero-products of non-trivial Toeplitz operators. These examples show the essential difference between Toeplitz operators on the Segal–Bargmann space and on the Bergman space over the unit ball. Finally, we discuss the “finite rank problem”. We show that there are no non-trivial rank one Toeplitz operators Tf for f∈Sym>0(Cn). In all these problems, the growth at infinity of the symbols plays a crucial role
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome
No full textFull author list omitted for brevity. For the full list of authors, see article.Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease. Despite the underlying importance of ER dysfunction in Wolfram syndrome and the identification of two causative genes, Wolfram syndrome 1 (WFS1) and Wolfram syndrome 2 (WFS2), a molecular mechanism linking the ER to death of neurons and β cells has not been elucidated. Here we implicate calpain 2 in the mechanism of cell death in Wolfram syndrome. Calpain 2 is negatively regulated by WFS2, and elevated activation of calpain 2 by WFS2-knockdown correlates with cell death. Calpain activation is also induced by high cytosolic calcium mediated by the loss of function of WFS1. Calpain hyperactivation is observed in the WFS1 knockout mouse as well as in neural progenitor cells derived from induced pluripotent stem (iPS) cells of Wolfram syndrome patients. A small-scale small-molecule screen targeting ER calcium homeostasis reveals that dantrolene can prevent cell death in neural progenitor cells derived from Wolfram syndrome iPS cells. Our results demonstrate that calpain and the pathway leading its activation provides potential therapeutic targets for Wolfram syndrome and other ER diseases
Core-Shell-Structured Tungsten Composite Powders
No full textKern-Mantel strukturierte Wolfram-KompositpulverCore-Shell-Structured Tungsten Composite Powder
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