1,721,023 research outputs found
Intravascular large B-cell lymphoma colonizing cutaneous hemangiomas
No full textIntravascular large B-cell lymphoma is a malignant neoplasm characterized by the proliferation of large B cells (rarely of T lymphocytes) confined within the blood vessels. Although the disease can be limited to the skin, involvement of other organs is common. We report a case of intravascular large B-cell lymphoma colonizing the vessels of preexisting cutaneous cherry hemangiomas
Lupus erythematosus panniculitis (lupus profundus): Clinical, histopathological, and molecular analysis of nine cases
No full textBackground: The diagnosis of lupus erythematosus panniculitis (LEP) may be very difficult in cases in which involvement of the subcutaneous fat is the only manifestation of the disease. The main differential diagnosis is subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Methods: We performed a retrospective study reviewing the histopathologic features of 11 biopsy specimens from nine patients with LEP (M : F = 2 : 7; median age: 48 years; range: 20-71 years). Results: Histopathologically, all biopsies revealed a lobular panniculitis, with concomitant septal involvement in 82% of them. Dermal changes included the presence of superficial and deep infiltrates (82%) and mucin deposition (73%). The majority of cases (73%) presented also some form of epidermal involvement. The subcutaneous infiltrate was composed of lymphocytes in all cases, admixed with plasma cells in 91% of cases. Lymphoid follicles with reactive germinal centers were detected in 45% of cases. Immunohistochemistry showed a predominance of α/β-T-helper and cytotoxic lymphocytes in 80% of cases admixed with B lymphocytes. The polymerase chain reaction analysis of the T-cell receptor (TCR)-γ gene showed a polyclonal smear in all cases. Conclusions: Our study shows that the most useful histopathologic criteria for distinguishing LEP from SPTCL are the presence of involvement of the epidermis, lymphoid follicles with reactive germinal centers, mixed cell infiltrate with prominent plasma cells, clusters of B lymphocytes, and polyclonal TCR-γ gene rearrangement. © Blackwell Munksgaard 2005
Treatment of primary cutaneous B-cell lymphoma with rituximab
No full textRituximab is a genetically engineered antibody directed against the CD20 antigen. Intravenous administration of rituximab has been used for the treatment of patients with low-, intermediate-, and high-grade B-cell non-Hodgkin's lymphomas and is a registered treatment modality for this indication. Treatment of primary cutaneous B-cell lymphoma (CBCL) with intralesionally or systemically administered rituximab has been described only in a few cases
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Neue Strategien und Konzepte in Diagnostik und Nachsorge des malignen Melanoms
Get PDFHinsichtlich einer effizienten Nachsorge von Melanompatienten existieren entsprechende Empfehlungen, aber auch widersprüchliche Stellungnahmen hinsichtlich Intervalllänge und Umfang der Nachsorge. Das Melanom ist einer der malignen Tumoren mit den am schnellsten steigenden Inzidenzraten, was auch eine Steigerung der Mortalität bedingt. In der vorliegenden Arbeit werden neue diagnostische Strategien geprüft und in ein vorbestehendes Melanomnachsorgeschema aufgenommen, um Patientenbetreuung, die frühe Entdeckung von Metastasen, aber auch die Raten an rezidivfreiem - und Gesamtüberleben zu verbessern. In einer großen prospektiven Studie von 4 Jahren Dauer konnte der Ultraschall von Lymphknoten, Weichteilgewebe und in transit Strecken eher als die rein klinische Untersuchung Metastasen entdecken und führte auf diese Weise zu einer Verbesserung des rezidivfreien- und des Gesamtüberlebens. Die Feinnadelaspirationszytologie (FNAC) wurde in einer weltweit, zahlenmäßig führenden Studie durchgeführt um die verdächtigten Läsionen tatsächlich zu diagnostizieren. Dies geschah hierbei nahezu nicht-invasiv. Hohe Zahlen an Sensitivität und Spezifität dieser Methode konnten erreicht werden und eine Diagnose konnte auch in sehr kleinen Läsionen oder solchen in einer schwierigen Position etabliert werden. Bei letzteren Läsionen erwies sich auch die Hinzunahme einer ultraschallgesteuerten Drahtmarkierung als nützliches Procedere. Auf diese Weise konnte die Exzision dieser Läsionen in komplizierter Lage vereinfacht werden. Eine weitere Studie untersuchte die begleitende Anwendung der Untersuchung einer seriellen reverse Transskriptase Polymerasekettenreaktion (RT-PCR) zum Nachweis von Tyrosinase aus peripherem Blut von Hochrisikomelanompatienten. Patienten, die im Blut mindestens einmal positiv getestet wurden, zeigten ein signifikant höheres Risiko, krankheitsspezifisch am Melanom zu versterben, als Patienten, die stets ein negatives Resultat aufwiesen. Die Tyrosinase RT-PCR Untersuchungen konnten auch an geringen Mengen Material wie Feinnadelaspiraten oder dem Feinnadelpunktaten des Sentinel Node erfolgreich durchgeführt werden. Alle aufgezeigten Methoden erwiesen sich als effektiv und wurden deswegen in das bestehende Nachsorgeprogramm der Melanompatienten an der Charité, Berlin aufgenommen.There exist recommendations but also controversies about the necessity and effectiveness of a distinctive melanoma follow-up programme. Melanoma is one of the fastest increasing malignant tumours with increasing rates of incidence and mortality. In this work new strategies are implemented in a pre-existing melanoma follow-up schedule in order to ameliorate the care for patients, the detection of metastases and the relapse-free and overall survival rates. In a large prospective study taking four years the ultrasound of lymph nodes, soft tissues and in transit distances was shown to earlier detect recurrences than the clinical examination thus significantly enhancing recurrence-free and overall survival. Fine needle aspiration cytology (FNAC) has been performed in a large, worldwide leading study to verify the suspected lesions in a nearly non-invasive way. High percentages in sensitivity and specificity could be achieved also in small lesions or lesions in an unfavourable localization. The latter lesions have been shown to be better detectable by a marking procedure. An anchor wire has been sonographically placed within such a lesion to improve the successful excision. A further study examined the value of serial RT-PCR testing from peripheral blood in melanoma patients. Patients, who have been tested at least once positive, had a higher risk ratio to die disease-specifically from melanoma. This result has been highly significant. RT-PCR examinations could also be applied in small amounts of material such as fine needle aspirations or material of FNA C of the sentinel node. All modalities could be proven to be effective and therefore are included in the melanoma follow-up programme of the Charité, Humboldt University of Berlin
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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