851 research outputs found
sj-docx-1-jet-10.1177_15266028241231472 – Supplemental material for Multicenter Registry of Common Femoral Artery Disease Treated With Endovascular Revascularization Using Interwoven Nitinol Stents: An Observational Retrospective Study
No full textSupplemental material, sj-docx-1-jet-10.1177_15266028241231472 for Multicenter Registry of Common Femoral Artery Disease Treated With Endovascular Revascularization Using Interwoven Nitinol Stents: An Observational Retrospective Study by Kazunori Horie, Mitsuyoshi Takahara, Tatsuya Nakama, Kazuki Tobita, Akiko Tanaka, Yoshiaki Shintani, Yoshinori Tsubakimoto, Naoki Yoshioka, Naoki Hayakawa, Shinya Sasaki, Yo Iwata, Kenji Ogata, Tomonari Takagi, Tatsuki Doijiri and Masahiko Fujihara in Journal of Endovascular Therapy</p
THE RIGIDITY OF THE TRIPLY BONDED VAN DER WAALS COMPLEXES AND BIOMOLECULES
No full text{Tatamitani, Liu, Shimada, Ogata, Ottaviani, Maris, Caminati, and Alonso, , {\bf 124{Tatamitani and Ogata, JMSpec.{\bf 222{Newby, Peebles, and Peebles, , {\bf 108{Caminati, Dell'Erba, Favero, Maris, Melandri, Ottaviani, Velino, {\it Spectroscopy in the 21st CenturyAuthor Institution: Department of Chemistry, Faculty of Science, Shizuoka University, Shizuoka 422-8529 JapanThe rigidity of the van der Waals(vdW) complexes were investigated by monitoring the rotational spectra of several dimers of dimethylether(DME) with a small molecule. The FTMW spectrum of the DME monomer exhibits quartet splitting due to the internal rotation of two methyl tops. The vdW bonding, however, effectively reduces the large amplitude motions in the complex and forms a rigid assembly. The rigid assembly formed by the weak triple bonding may be related to that in the biomolecules such as DNA bases or proteins. The FTMW spectrum of the DME dimer }, 2739 (2002).} exhibited the {\it A-E}_2\cdots_2_2\cdots_2C=CFH }, 102 (2003).}, DMEOCS, and DMECO }JPC A{\bf108}, 11234(2004).} exhibited the singlet spectrum corresponding to a rigid conformation. Instead, the singly bonded vdW complex DME\cdots_2O }, p.52, Hayama, Japan (2002).} is flexible and exhibits not only inversion doublet but also multiplet spectrum due to the internal rotation of the methyl groups. Within an organism, biomolecules such as DNA or enzyme protein maintain their steric conformation with hydrogen bonds, where the identical biomolecules must be exactly the same steric conformation. On the other hand, the smaller binding energy is preferable for their constant repeating of association and dissociation. These conflict properties may be accomplished with the triple vdW bond which can form a rigid assembly with weak intermolecular bond
The Hachirogata Polder: Site Visit Report February/March 2017
No full textThis is a report on the visit of the Hachirogata polder of the author from 28 February 2017 to 2 March 2017. The land reclamation is located in the prefecture of Akita in Japan. The visit consisted of a field trip to the polder accompanied by Prof. Yasunori Kitao (Kyoto Women’s University) with interviews with local people, a visit of the polder museum, a visit to the village Ogata-Mura and the Municipal Office and an interview with Mr. Miyata, who has been mayor for thirty years of the village.Landscape Architectur
Influence of Endogenous Substances on Site-II to Site-I Displacement of Diclofenac Bound to Albumin in the Aqueous Humor of Patients with Cataract
No full textDiclofenac instillation is useful in preventing intraoperative miosis and macular edema caused by postoperative inflammation in cataract surgery; however, optimum efficacy is not attained when the instilled diclofenac strongly binds to albumin in patients’ aqueous humor. Therefore, a method that inhibits diclofenac binding and increases the concentration of its free fraction is needed. We conducted a basic study regarding the effects of inhibitors on the binding of instilled diclofenac to albumin and endogenous substances in aqueous humor. Aqueous humor samples from 16 patients were pooled together for analysis. The free fraction of diclofenac was measured using ultrafiltration methods in various experiments with pooled and mimic aqueous humor. Free fraction of diclofenac, a site II drug, in pooled aqueous humor was 0.363 0.013. The binding of diclofenac in the presence of phenylbutazone (PB), a site I inhibitor, was significantly inhibited (free fraction 0.496 0.013); however, no significant inhibition by ibuprofen, a site II inhibitor, (free fraction 0.379 0.004), was observed. The unexpected result was due to free fatty acids (FFAs; palmitic acid (PA)) and L-tryptophan (Trp). The inhibition of diclofenac binding by PB in the mimic aqueous humor containing these endogenous substances revealed significant binding inhibition in the presence of PA and Trp. Diclofenac is strongly rebound from site II to site I in the presence of FFAs and Trp in the aqueous humor because FFAs and Trp induce a conformational change in albumin. Therefore, PB significantly inhibits the binding of diclofenac to albumin.Citation: Saya Ishii, Mineo Ozaki, Norito Takamura, Kenji Ogata, Jin Tokunaga, Ryuji Ikeda, Influence of Endogenous Substances on Site-II to Site-I Displacement of Diclofenac Bound to Albumin in the Aqueous Humor of Patients with Cataract, Biological and Pharmaceutical Bulletin, 47(1), 213-220, 2024-01-20, https://doi.org/10.1248/bpb.b23-0030
<Research Reports>Antiferromagnetism inside the superconducting phase in locally inversion breaking CeRh₂As₂
No full textSpatial inversion symmetry in crystal structures is closely related to the superconducting (SC) and magnetic properties of materials. Various interesting phenomena caused by the breaking of the local inversion symmetry have been theoretically proposed. However, the experimental validation has not yet progressed owing to the lack of model materials. Quite recently, in CeRh₂As₂ (SC transition temperature Tsᴄ ～ 0.37 K), wherein the local inversion symmetry is broken at the Ce sites, an SC–SC phase transition at approximately 4 T was reported for H||c, which can be interpreted as a phase transition inside the SC phase from a low-field even-parity to a high-field odd-parity state. Such a phase transition is only expected in systems with locally broken inversion symmetry. Here we present evidence for antiferromagnetic (AFM) order inside the SC phase in CeRh₂As₂. The evidence is based on the observation of site-dependent linewidth broadening of the nuclear quadrupole resonance spectrum at two crystallographically inequivalent As sites. The onset temperature of antiferromagnetism Tɴ within an SC phase, with Tɴ < Tsᶜ, is quite unusual in systems wherein superconductivity coexists or competes with magnetism. In addition, this AFM ordering breaks the inversion symmetry of this system, resulting in the activation of an odd-parity magnetic multipole. Our observations show that CeRh₂As₂ is a promising system to study how the absence of local inversion symmetry induces or influences unconventional magnetic and SC states, as well as their interaction
Finding One’s Identity: Fukuzawa Yukichi About His Studies in Osaka (Chapter “Ogata School” From “The Autobiography of Elder Fukuzawa”)
No full textFukuzawa Yukichi (1835–1901) is rightly considered a person who made a significant contribution to introducing Western civilization to Japan. His writings on politics, society, state, pedagogy, i.e., products of “mature” Fukuzawa, are often being studied. However, Fukuzawa’s personality itself usually remains outside the scope of such studies. But it seems extremely important to understand how the personality of this outstanding educator, who dared to raise his hand against the fundamental values of the state and society of the Tokugawa era, was formed. This will allow us to understand not only Fukuzawa himself, but also the type of person who was in demand during the time of revolutionary change.In 1899 Fukuzawa published his autobiography (Fukuō Jiden). It is considered the first “full-fledged” work of the autobiographical genre in Japan. In this text, with unprecedented frankness for former Japan, the author talks about himself. Fukuzawa dictated the text to a stenographer, so his publication has all the usual properties of spontaneous oral speech: liveliness, vulgarisms, factual errors, repetitions, contradictory statements, spontaneity and some randomness. This does not change the fact that Fukuzawa was an observant man and an excellent storyteller. A significant part of the “Autobiography” is devoted to his childhood and youth, that is, the time when the formation of one’s personality occurs.In this publication, we provide a translation of a chapter dedicated to Fukuzawa’s studies at the Osaka School of Medicine, which was opened by Ogata Kōan (1810–1863), a famous doctor who practiced European medicine. About three thousand people graduated from his school. In Fukuzawa’s description, the students at this school were characterized by deviant behavior, which provided them with an identity different from the personality type that prevailed in Tokugawa Japan. Many graduates of the Ogata school later became famous and had a significant influence on the appearance of the new Japan, which was significantly different from the old Japan
Gravestone in cemetery, "Manzanar, a photograph essay: Manzanar today"
No full textA photograph of gravestone in cemetery. Engraved name reads: Ogata Toshiro, Baby Jerry Ogata. A page from: Manzanar, a photograph essay (csudh_uye_0001).The Chris S. Uyemura Manzanar Photograph Collection consists of a pictorial essay, “Manzanar, a photographic essay,” and additional loose photos, which were compiled and collected by Chris S. Uyemura. The essay contains photographs, texts, and newspaper clippings, and was submitted to Professor Donald T. Hata of the Department of History at CSU Dominguez Hills. The collection depicts the incarceration of people of Japanese ancestry in the Manzanar camp during World War II as well as reflects the events, contrasting with photographs of the Manznar National Historic Site, which illustrates what is left of the camp today. The collection was originally named as “Asian Pacific Studies Collection Box 14.
Topical dorzolamide for macular edema in the early phase after vitrectomy and epiretinal membrane removal
No full textTakahiro Suzuki, Kenji Hayakawa, Yoshihiro Nakagawa, Hiromi Onouchi, Masafumi Ogata, Kenji KawaiDepartment of Ophthalmology, Tokai University School of Medicine, Isehara, JapanBackground: The purpose of this study was to evaluate prospectively the efficacy of a topical carbonic anhydrase inhibitor in macular edema after vitrectomy.Methods: Forty patients were included, all of whom had undergone vitrectomy combined with phacoemulsification and intraocular lens implantation for epiretinal membrane. Twenty eyes from 40 patients received topical 2% dorzolamide three times a day. The patients were followed up for at least 3 months. In this study, we evaluated the effect of dorzolamide on visual acuity, intraocular pressure, central macular thickness, and aqueous flare.Results: Mean logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity preoperatively and 2 weeks, 1 month, and 3 months after surgery was 0.48 ± 0.23, 0.60 ± 0.16, 0.40 ± 0.29, and 0.24 ± 0.32, respectively, in the treatment group, and 0.40 ± 0.09, 0.44 ± 0.12, 0.32 ± 0.10, and 0.16 ± 0.09, respectively, in the control group. No statistically significant difference was observed between the two groups. Mean central macular thickness preoperatively and at 2 weeks and 3 months after surgery was 572.6, 427.2, and 333.4 µm, respectively, in the treatment group, and 571.4, 485.2, and 388.4 µm, respectively, in the control group. Mean aqueous flare preoperatively, and 1 month and 3 months after surgery was 8.6, 34.2, and 23.5 photon counts per millisecond (pc/ms), respectively, in the treatment group, and 9.7, 24.7, and 23.4 pc/ms, respectively, in the control group. No statistically significant differences were observed between data from the two groups. However, statistically significant (P < 0.05) differences in mean central macular thickness at 1 month and mean aqueous flare at 2 weeks after surgery were found between the treatment group (358.8 µm, 36.8 pc/ms) and the control group (467.8 µm, 64.0 pc/ms). Differences in mean intraocular pressure preoperatively and at 2 weeks, 1 month, and 3 months after surgery were not statistically significant between the two groups. Intraocular pressure never exceeded 21 mmHg.Conclusion: Topical dorzolamide significantly reduced mean central macular thickness at 1 month and mean aqueous flare at 2 weeks after surgery for epiretinal membrane compared with controls. Although further investigation of more cases and longer follow-up are needed, this study suggests that topical dorzolamide can be efficacious in reducing macular edema in the early phase after vitrectomy via its anti-inflammatory effect.Keywords: macular edema, dorzolamide, epiretinal membrane, vitrectomy, anti-inflammator
ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype
No full text主査 : 島田英昭 / タイトル : ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype / 著者 : Shinsuke Hirabayashi, Kentaro Ohki, Kazuhiko Nakabayashi, Hitoshi Ichikawa, Yukihide Momozawa, Kohji Okamura, Akinori Yaguchi, Kazuki Terada, Yuya Saito, Ai Yoshimi, Hiroko Ogata-Kawata, Hiromi Sakamoto, Motohiro Kato, Junya Fujimura, Moeko Hino, Akitoshi Kinoshita, Harumi Kakuda, Hidemitsu Kurosawa, Keisuke Kato, Ryosuke Kajiwara, Koichi Moriwaki, Tsuyoshi Morimoto, Kozue Nakamura, Yasushi Noguchi, Tomoo Osumi, Kazuo Sakashita, Junko Takita, Yuki Yuza, Koich Matsuda, Teruhiko Yoshida, Kenji Matsumoto, Kenichiro Hata, Michiaki Kubo, Yoichi Matsubara, Takashi Fukushima, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, Nobutaka Kiyokawa / 掲載誌 : Haematologica / 巻号・発行年等 : 102(1):118-129, 201
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