836 research outputs found
Developing a Model for an Experiential Grammar Teaching Resource for Hul'q'umi'num' Primary Immersion Teachers
No full textThis paper describes a collaborative project to develop lessons for teaching selected grammatical patterns of Hul'q'umi'num' (Coast Salish) to Junior Kindergarten immersion students using experiential teaching methods. The lessons are intended to serve as a model for future grammar resources to support teachers in a planned primary immersion program. The project followed an Indigenist paradigm using principles of Community-Based Language Research to support a research partnership with staff and Elders at S-hxixnu-tun Lelum Primary School at Stz'uminus First Nation on Vancouver Island, BC. Over a short series of workshops, the research team members worked together to determine ways to model key grammatical concepts to Junior Kindergarten students without teaching them overtly. Although the original intent was to develop one sample unit, the resulting lessons will likely be applicable throughout the primary program. The workshops also supported future immersion teachers to learn more about Hul'q'umi'num' grammar, and about how to develop and implement experiential language lessons. The project is an innovative example of building on the considerable existing strengths of S-hxixnu-tun Lelum's current second-language program by adapting previous teaching materials for the Junior Kindergarten immersion context. References Gerdts, D.B. (1997a). 'i'lhe' xwulmuxwqun: tu nucam'at pookw. (Let's Speak Our First Nations Language: Book One) (2nd ed.). Nanaimo, Canada: Chemainus, Nanaimo and Nanoose First Nations and School District 68. Gerdts, D. B. (n.d). Hul'q'umi'num' (Island Halkomelem) language materials. Retrieved from: http://www.sfu.ca/~gerdts/HulquminumLanguageMaterials.html Gerdts, D.B., Edwards, L., Ulrich, C.H. & Compton, B.D. (Eds.) (1997). Hul'q'umi'num' words. An English-to-Hul'q'umi'num' and Hul'q'umi'num'-to-English dictionary. Nanaimo, Canada: Chemainus, Nanaimo and Nanoose First Nations and School District 68. Hukari, T.E. (2004). Comparing alphabets - new alphabetical order. (Unpublished document). Coast Salish Language Revitalization CURA project, Victoria, Canada. Hukari, T.E., & Peter, R.M. (1995). The Cowichan dictionary of the Hul'q'umi'num' dialect of the Coast Salish people. Duncan, Canada: Cowichan Tribes. Hul'q'umi'num' Language and Culture Collective (2016). Ta'ulthun sqwal. Hul'q'umi'num' language academy. Retrieved from: http://sqwal.hwulmuhwqun.ca/learn/ Hul'q'umi'num' Treaty Group (2008). Tatul'ut tthu Hul'q'umi'num': Introduction to Hul'q'umi'num'. Retrieved from: http://web.uvic.ca/hrd/salish/ Quw'utsun Syuw'entst Lelum (QSL) (2007). Quw'utsun Hul'q'umi'num' category dictionary. Duncan, Canada: Cowichan Tribes. Stz'uminus First Nation (2016b). The Stz'uminus Hul'q'umi'num Dictionary. Ladysmith, Canada: Stz'uminus First Natio
Dr D.B. Smuts : Onderstepoort staff
No full textScanned image of a photographic glass-plate negativeDr D.B. Smuts, Onderstepoort staff memberin the Section of Nutrition in the late 1930's. He was co-author of the article "The Nutritive Value of Animal Proteins.-
The Biological Values of Fishmeal, Whale and Fishmeal, Meatmeal, Meat and Bonemeal, Crayfishmeal, and White Fishmeal" published in the Onderstepoort Journal of Veterinary Science and Animal Industry, Volume 16, Numbers 1 and 2, January and April, 1941.Digitised by the Department of Library Services, University of Pretoria, 2019ab201
Letter, 1858 May 8, D.B. Sanchez (?) to Henry Honaker
No full textLetter regarding the sale of a bull. Last name of author unclear, possibly Sanchez or San..z
Continuous monitoring of the electrical potential across energy-transducing membranes using ion-selective electrodes. Application to submitochondrial particles and chromatophores.
No full textSensitivity analysis and experimental design of a stiff signal transduction pathway model
No full textSensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2]. The nuclear factor B (NF-B) signalling pathway is an important cellular signalling pathway, of which protein phosphorylation is a major factor controlling the activation of further downstream events. The NF-κB proteins regulate numerous genes that play important roles in inter- and intra-cellular signalling, cellular stress responses, cell growth, survival, and apoptosis. As such, its specificity and its role in the temporal control of gene expression are of crucial physiological interest
Information-theoretic sensitivity analysis: A general method for credit assignment in complex networks
No full textMost systems can be represented as networks that couple a series of nodes to each other via one or more edges, with typically unknown equations governing their quantitative behaviour. A major question then pertains to the importance of each of the elements that act as system inputs in determining the output(s). We show that any such system can be treated as a 'communication channel' for which the associations between inputs and outputs can be quantified via a decomposition of their mutual information into different components characterizing the main effect of individual inputs and their interactions. Unlike variance-based approaches, our novel methodology can easily accommodate correlated inputs. © 2007 The Royal Society
The Documentary Art of Filmmaker Michael Rubbo
No full textMichael Rubbo’s groundbreaking work has had a deep and enduring impact on documentary filmmaking worldwide, though his name has remained relatively unknown. In The Documentary Art of Michael Rubbo, author D.B. Jones traces Rubbo’s filmmaking from his days as a film student at Stanford, through his twenty years at the National Film Board of Canada, where Rubbo developed his distinct documentary style. Jones then describes Rubbo’s post-NFB venture into feature film directing, followed by Rubbo’s return to his native Australia, first as an executive with the Australian Broadcasting Corporation, and later as a director of feature-length documentaries and maker of short, personal films for YouTube. Exploring locales from Montreal to Vietnam, topics as diverse as plastic surgery and French Marxism, and from interviewing Margaret Atwood to documenting a failed attempt to interview Fidel Castro, Rubbo’s wide-ranging work establishes his innovative, personal, lyric, and spontaneous documentary style. In The Documentary Art of Michael Rubbo D.B. Jones reveals not only the depth of meaning in Rubbo’s films, but also the depth of their influence on filmmaking itself
The Documentary Art of Filmmaker Michael Rubbo
No full textMichael Rubbo’s groundbreaking work has had a deep and enduring impact on documentary filmmaking worldwide, though his name has remained relatively unknown. In The Documentary Art of Michael Rubbo, author D.B. Jones traces Rubbo’s filmmaking from his days as a film student at Stanford, through his twenty years at the National Film Board of Canada, where Rubbo developed his distinct documentary style. Jones then describes Rubbo’s post-NFB venture into feature film directing, followed by Rubbo’s return to his native Australia, first as an executive with the Australian Broadcasting Corporation, and later as a director of feature-length documentaries and maker of short, personal films for YouTube. Exploring locales from Montreal to Vietnam, topics as diverse as plastic surgery and French Marxism, and from interviewing Margaret Atwood to documenting a failed attempt to interview Fidel Castro, Rubbo’s wide-ranging work establishes his innovative, personal, lyric, and spontaneous documentary style. In The Documentary Art of Michael Rubbo D.B. Jones reveals not only the depth of meaning in Rubbo’s films, but also the depth of their influence on filmmaking itself
The Documentary Art of Filmmaker Michael Rubbo
No full textMichael Rubbo’s groundbreaking work has had a deep and enduring impact on documentary filmmaking worldwide, though his name has remained relatively unknown. In The Documentary Art of Michael Rubbo, author D.B. Jones traces Rubbo’s filmmaking from his days as a film student at Stanford, through his twenty years at the National Film Board of Canada, where Rubbo developed his distinct documentary style. Jones then describes Rubbo’s post-NFB venture into feature film directing, followed by Rubbo’s return to his native Australia, first as an executive with the Australian Broadcasting Corporation, and later as a director of feature-length documentaries and maker of short, personal films for YouTube.
Exploring locales from Montreal to Vietnam, topics as diverse as plastic surgery and French Marxism, and from interviewing Margaret Atwood to documenting a failed attempt to interview Fidel Castro, Rubbo’s wide-ranging work establishes his innovative, personal, lyric, and spontaneous documentary style. In The Documentary Art of Michael Rubbo D.B. Jones reveals not only the depth of meaning in Rubbo’s films, but also the depth of their influence on filmmaking itself.Ye
Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting1.
No full textThe chief and largely terminal element of normal blood clotting is considered to involve the polymerisation of the mainly α-helical fibrinogen to fibrin, with a binding mechanism involving ‘knobs and holes’ but with otherwise little change in protein secondary structure. We recognise, however, that extremely unusual mutations or mechanical stressing can cause fibrinogen to adopt a conformation containing extensive β-sheets. Similarly, prions can change morphology from a largely α-helical to largely β-sheet conformation, and the latter catalyses both the transition and the self-organising polymerisation of the β-sheet structures. Many other proteins can also do this, where it is known as amyloidogenesis. When fibrin is formed in samples from patients harbouring different diseases it can have widely varying diameters and morphologies. We here develop the idea, and summarise the evidence, that in many cases the anomalous fibrin fibre formation seen in such diseases actually amounts to amyloidogenesis. In particular, fibrin can interact with the amyloid-β (Aβ) protein that is misfolded in Alzheimer's disease. Seeing these unusual fibrin morphologies as true amyloids explains a great deal about fibrin(ogen) biology that was previously opaque, and provides novel strategies for treating such coagulopathies. The literature on blood clotting can usefully both inform and be informed by that on prions and on the many other widely recognised (β-)amyloid proteins. A preprint has been lodged in bioRxiv (Kell and Pretorius, 2016)
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