83 research outputs found

    EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance

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    Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.This article has been made available through the Brunel Open Access Publishing Fund.A routine part of the process for developing National Institute for Health and Care Excellence (NICE) medical technologies guidance is a submission of clinical and economic evidence by the technology manufacturer. The Birmingham and Brunel Consortium External Assessment Centre (EAC; a consortium of the University of Birmingham and Brunel University) independently appraised the submission on the EXOGEN bone healing system for long bone fractures with non-union or delayed healing. This article is an overview of the original evidence submitted, the EAC’s findings, and the final NICE guidance issued.The Birmingham and Brunel Consortium is funded by NICE to act as an External Assessment Centre for the Medical Technologies Evaluation Programme

    Organized Pseudolegal Commercial Arguments in Canadian Inter-Partner Family Law Court Disputes

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    This article addresses the phenomenon of Organized Pseudolegal Commercial Arguments (OPCA) from the lens of inter-partner disputes. The author begins by briefly reviewing the history of OPCA in Canada, and then proceeds to conduct a Canada-wide survey of OPCA judgments that involve inter-spouse conflict. One of the primary cases focused on is the Alberta judgment, Meads v. Meads. The author finds that there are few OPCA judgments to draw from, which he concludes is a result of the character of OPCA pseudolegal concepts. These concepts are typically intended to target government and institutional actors, rather than private individuals, meaning that these arguments are ill suited to family law situations

    Don’t Tear Up Our World: Using Art and Activism to Engage the Youth of Appalachia

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    This round table discussion will focus on using art, activism, and activism through art to engage and support the youth of Appalachia. Too many of our young people leave the region after (or before) college graduation, taking with them the skills, knowledge, and energy to make this a better place to live and work. The “brain drain” has been especially impactful in West Virginia--the only state in the country to lose population instead of gain it--and Kentucky. The panel would include Robert Gipe, author of Trampoline and director of Higher Ground theater; Natalie Sypolt, writer and coordinator of the high school portion of the West Virginia Writers Workshop; Renee Nicholson, writer who also teaches ballet to the youth of WV and engages students through dance; and Rachael Meads, Director of Student Activities and Leadership and director of the Performing Arts series at Shepherd University. Our essential question is: How can the arts, activism, or activism through the arts be used to engage the young people of Appalachia and therefore encourage them to stay in the region, as well as improve the region? We would use our personal examples of working with students (children through college students) in creative writing, dance, theatre, and music. We also hope to bring young people from our various programs who will be attending the conference into the discussion, though they will not be listed as official presenters

    Zeigen, Sprechen und Meinen

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    Dieser Artikel zielt auf die Vermittlung der neueren Evolutionspsychologie mit der sozialpragmatistischen Kommunikationstheorie. Einerseits wird Meads These zum Ursprung der menschlichen Sprache unter Rückgriff auf Tomasellos Primaten- und Kleinkinderforschung kritisiert; andererseits werden, vor dem Hintergrund von Meads Theorie objektiver Bedeutung die Schwachstellen von Tomasellos subjektivistischen Kommunikationsbegriff identifiziert. Schließlich wird versucht, Tomasellos Erkenntnisse zur deiktischen Praxis in Meadschen Termini zu reformulieren und die objektive Bedeutung des Zeigens zu bestimmen. This article aims at the confrontation of classical pragmatistic communication-theory with some recent insights of the psychology of evolution. The first step is to criticize Mead’s notion of the origins of language on the basis of Tomasellos research concerning primates and infants. Conversely, the second step is a critique of Tomasellos subjectivistic concept of communication on the basis of Meads theory of objective meaning. Finally, the author tries to reformulate Tomasello’s findings in Mead’s terminology and to determine the objective meaning of pointing gestures

    Positron emission tomography/computerised tomography imaging in detecting and managing recurrent cervical cancer: systematic review of evidence, elicitation of subjective probabilities and economic modelling.

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    © Queen’s Printer and Controller of HMSO 2013. This work was produced by Meads et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising.Cancer of the uterine cervix is a common cause of mortality in women. After initial treatment women may be symptom free, but the cancer may recur within a few years. It is uncertain whether it is more clinically effective to survey asymptomatic women for signs of recurrence or to await symptoms or signs before using imaging.National Institute for Health Research Health Technology Assessment programm

    ROVIBRATIONALLY RFSOLVED. CONTINUOUS SUPERSONIC-JET FOURIER TRANSFORM INFRARED ABSORPTION SPECTROSCOPY OF WEAKLY BOUND DIMERS.

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    1. R.F. Meads, C.L. Hartz, R. R. Lucchese and J.W. Bevan, Chem Phys. Lett. 206, 488(1993)Author Institution: Department of Chemistry, M.I.T.; Department of Chemistry, Texas A\&M UniversityRovibrational analysis of the ν1\nu_{1} and ν2\nu_{2} vibrational bands of OCH35ClOC-H^{35}Cl and OCH37ClOC-H^{37}Cl have been carried out using continuous supersonic-jet, Fourier transform, infra-red absorption spectroscopy. The following molecular parameters were determined (in cm1cm^{-1}). For OCH35Cl:ν1=2851.76061(21):B1=0.0560443(31):D1=1.795(80)×107:ν2=2155.50001(13):B2=0.0554824(10):D2=1.650(15)×107OC-H^{35}Cl: \nu_{1}=2851.76061(21): B^{\prime}_{1}= 0.0560443(31): D^{\prime}_{1}=1.795(80) \times 10^{-7}: \nu_{2}=2155.50001(13): B^{\prime}_{2}=0.0554824(10): D^{\prime}_{2}=1.650(15) \times 10^{-7}: For OCH37Cl:ν1=2849.67217(54):B1=0.0547611(55):D1=1.63(11)×107:ν2=2155.50626(62):B2=0.0542013(21):D2=1.48(16)×;107OC-H^{37}Cl: \nu_{1}=2849.67217(54): B^{\prime}_{1}=0.0547611(55): D^{\prime}_{1}=1.63(11) \times 10^{-7}: \nu_{2}=2155.50626(62):B^{\prime}_{2}=0.0542013(21): D^{\prime}_{2}=1.48(16) \times; 10^{-7}. Additionally, ro-vibrationally resolved spectra of the weakly bound complexes of ArHCl,N2HClAr-HCl, N_{2}-HCl and (HCl)2(HCl)_{2} will also be presented to illustrate the utility that SSJ-FTIR offers to the spectroscopic studies of gas-phase molecular species

    Self-management toolkit and delivery strategy for end-of-life pain:the mixed methods feasibility study

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    Background: pain affects most people approaching the end of life and can be severe for some. Opioid analgesia is effective, but evidence is needed about how best to support patients in managing these medicines.Objectives: to develop a self-management support toolkit (SMST) and delivery strategy and to test the feasibility of evaluating this intervention in a future definitive trial.Design: Phase I – evidence synthesis and qualitative interviews with patients and carers. Phase II – qualitative semistructured focus groups and interviews with patients, carers and specialist palliative care health professionals. Phase III – multicentre mixed-methods single-arm pre–post observational feasibility study.Participants: Phase I – six patients and carers. Phase II – 15 patients, four carers and 19 professionals. Phase III – 19 patients recruited to intervention that experienced pain, living at home and were treated with strong opioid analgesia. Process evaluation interviews with 13 patients, seven carers and 11 study nurses.Intervention: Self-Management of Analgesia and Related Treatments at the end of life (SMART) intervention comprising a SMST and a four-step educational delivery approach by clinical nurse specialists in palliative care over 6 weeks.Main outcome measures: recruitment rate, treatment fidelity, treatment acceptability, patient-reported outcomes (such as scores on the Brief Pain Inventory, Self-Efficacy for Managing Chronic Disease Scale, Edmonton Symptom Assessment Scale, EuroQol-5 Dimensions, Satisfaction with Information about Medicines Scale, and feasibility of collecting data on health-care resource use for economic evaluation).Results: Phase I – key themes on supported self-management were identified from evidence synthesis and qualitative interviews. Phase II – the SMST was developed and refined. The delivery approach was nested within a nurse–patient consultation. Phase III – intervention was delivered to 17 (89%) patients, follow-up data at 6 weeks were available on 15 patients. Overall, the intervention was viewed as acceptable and valued. Descriptive analysis of patient-reported outcomes suggested that interference from pain and self-efficacy were likely to be candidates for primary outcomes in a future trial. No adverse events related to the intervention were reported. The health economic analysis suggested that SMART could be cost-effective. We identified key limitations and considerations for a future trial: improve recruitment through widening eligibility criteria, refine the SMST resources content, enhance fidelity of intervention delivery, secure research nurse support at recruiting sites, refine trial procedures (including withdrawal process and data collection frequency), and consider a cluster randomised design with nurse as cluster unit.Limitations: (1) The recruitment rate was lower than anticipated. (2) The content of the intervention was focused on strong opioids only. (3) The fidelity of intervention delivery was limited by the need for ongoing training and support. (4) Recruitment sites where clinical research nurse support was not secured had lower recruitment rates. (5) The process for recording withdrawal was not sufficiently detailed. (6) The number of follow-up visits was considered burdensome for some participants. (7) The feasibility trial did not have a control arm or assess randomisation processes.Conclusions: a future randomised controlled trial is feasible and acceptable

    O nazwach handlowych polskich miodów pitnych – między tradycją a nowoczesnością

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    TRADE NAMES OF POLISH MEADS – BETWEEN TRADITION AND MODERNITY The aim of the study is to analyze and classify the trade names of Polish meads. The research material consists of 256 names of liquors which were divided into two groups: names of direct motivation and names of conventional motivation. The analysis of the motivation of the collected onyms made it possible for the author to highlight two marketing strategies used in the promotion of mead. On the one hand, a large group of names presents honey as a traditional alcohol with a long history. On the other hand, the motivations of many of the collected chrematonyms follow the opposite tendency, which is an attempt to present mead as a modern, interesting and intriguing alcohol

    Konsekvenser av rollövertagandet : ”I”, ”me” och individualiteten

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    Consequences of role taking: the ”I”, the ”me” and individuality This paper analyzes the tendency of taking the ”I” and the ”me” in G. H. Meads theory of role taking as two separate, qualitatively different parts of human personality, the ”I” being of individual origin, the ”me” of social. In the original Meadian sense role taking gives rise to both the ”I” and the ”me”. They are dialectically united rather than dualistically separated aspects. They refer to the joint functional power of the subject, finding itself as an object, mediated by the Other. As a consequence, the link between body and the social world becomes theoretically more stringent, as the body is given its place as a cognitive social object among others, this by contrast to interpretations where the body is left as an object mainly outside the human social experience and as a source of agency sui generis, a conception which is in opposition to Meads. The stress on the ”I”-phase, as related to body and concrete action in combination with its direct relation to the ”me”-phase, actualizes Mead as a forerunner in modern biologic/neurologic research on human perceptual, motivational and intentional capacity.Swedish Mead interpreters are critically analyzed. Interpretations of Charon, Giddens, Joas and Habermas are partly scrutinized. The author defines the conceptual pair in terms of activity, subjectivity, temporal relativity and distance.Sociologisk Forsknings digitala arkiv</p

    Konsekvenser av rollövertagandet [Elektronisk resurs] : ”I”, ”me” och individualiteten

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    Consequences of role taking: the ”I”, the ”me” and individualityThis paper analyzes the tendency of taking the ”I” and the ”me” in G. H. Meads theory of role taking as two separate, qualitatively different parts of human personality, the ”I” being of individual origin, the ”me” of social. In the original Meadian sense role taking gives rise to both the ”I” and the ”me”. They are dialectically united rather than dualistically separated aspects. They refer to the joint functional power of the subject, finding itself as an object, mediated by the Other. As a consequence, the link between body and the social world becomes theoretically more stringent, as the body is given its place as a cognitive social object among others, this by contrast to interpretations where the body is left as an object mainly outside the human social experience and as a source of agency sui generis, a conception which is in opposition to Meads.The stress on the ”I”-phase, as related to body and concrete action in combination with its direct relation to the ”me”-phase, actualizes Mead as a forerunner in modern biologic/neurologic research on human perceptual, motivational and intentional capacity.Swedish Mead interpreters are critically analyzed. Interpretations of Charon, Giddens, Joas and Habermas are partly scrutinized.The author defines the conceptual pair in terms of activity, subjectivity, temporal relativity and distance.</p
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