55 research outputs found

    La sacculina e il "Regno dell'uomo". Edwin Ray Lankester, la degenerazione e il futuro della civiltà

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    Edwin Ray Lankester (1847-1929), a British zoologist and evolutionary biologist, described degeneration as one of three possible effects of natural selection (the others being “balance” and “elaboration”). He defined it as a gradual change of structure by which an organism becomes adapted to less various and complex conditions of life. Degeneration could result in atrophy or “suppression of form”, as in parasites. Lankester himself applied this idea to human societies, past and present, to warn that regression was as possible as progress. To him, degeneration was a law of life, based on observations in comparative anatomy and embryology. Still, one can wonder if the concept was not, as it were, ‘tainted’ with an axiological connotation since its first use by Lankester, as it had clearly been the case with its inventor, Morel. If so, its application to human affairs was not only understandable in their context, but, to some extent, inevitable. Some instances of the uses of degeneration in bio-social contexts are also discussed, including writings by the theologian Henry Drummond, the science fiction author H.G. Wells, the Belgian socialists Demoor, Massart and Vandervelde, and the entomologist William Morton Wheeler

    Reference integration architecture for mobile enterprise solutions

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    Nowadays, enterprises are facing several challenges associated with the design and implementation of mobile solutions for customers, employees and partners. One of the most important challenges is related to the integration between mobile applications and enterprise systems. In order to provide seamless integration, it is important to consider various aspects and challenges related to mobile solutions within the enterprise mobility strategy. This master thesis identifies and presents important challenges for enterprise mobility, mobile enterprise applications and mobile enterprise application integration, as well as various solutions and approaches to overcome them. Moreover, a reference architecture for integrating mobile enterprise applications and enterprise systems based on Web technologies is presented. The reference integration architecture describes the components, as well as the architectural and design patterns used to define its distribution, required to facilitate the integration between mobile enterprise applications and enterprise systems. Furthermore, the reference integration architecture can be used as a tool to identify infrastructure and integration requirements and to guide decision-making during the design and implementation of mobile enterprise solutions.Computer Science - Information Architecture trackSoftware & Computer TechnologyElectrical Engineering, Mathematics and Computer Scienc

    Gynaecological cancers

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    Occurrence of Sarcocystis Lankester, 1882, in wild geese in Saskatchewan

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    Skeletal and cardiac muscle from wild geese dead of avian cholera was examined and sarcocysts were found in skeletal muscle of 42 of 88 Lesser Snow Geese, Anser caerulescens caerulescens, 1 of 7 Ross Geese, Anser rossi, and 1 of 3 Canada Geese, Branta canadensis, collected during April and May in central Saskatchewan. Two types of microcysts were present in skeletal muscle; one type had finger-like protrusions on the primary cyst wall; the other had a relatively smooth primary cyst wall. Both types were found in one Lesser Snow Goose. Microscopic cysts were found in the heart of 8 of 150 Lesser Snow Geese and 3 of 35 Ross Geese. All myocardial cysts had a smooth primary wall..RE: 10 ref.; SC: ZA; CA; VE; PA; 0V; 2V; 0I; 0YSource type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0008-4301&isbn=&volume=59&issue=8&spage=1621&pages=1621-1624&date=1981&title=Canadian%20Journal%20of%20Zoology&atitle=Occurrence%20of%20Sarcocystis%20Lankester%2c%201882%2c%20in%20wild%20geese%20in%20Saskatchewan.&aulast=Wobeser&pid=%3Cauthor%3EWobeser%2c%20G%3bLeighton%2c%20F%20A%3bCawthorn%2c%20R%20J%3C%2Fauthor%3E%3CAN%3E19812286643%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3

    Paley, William: science and rhetoric in his natural theology

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    William Paley's Natural Theology is probably the nineteenth century's most well- known design argument. As such an influential book, it is almost expected that twentieth century intellectual historians should at least pay a footnote to it. In midst of all these studies about the impact of Natural Theology upon the nineteenth century, one key fact is forgotten: Natural Theology and its sources were written in the eighteenth century. It is the goal of this thesis to demonstrate that Paley's design argument must be compared to the intellectual climate of that time period. Chapters 1 and 2 outline the rhetorical argument and the tools that Paley used to persuade his polite eighteenth century audience. The majority of scientific sources and examples he used were well-known names and therefore implicitly contributed to the believability of his argument. Accordingly, chapters 3 and 4 investigate why Paley's scientific sources added credibility to Natural Theology. Chapters 5 and 6 examine the actual scientific data that Paley turned into examples for his design argument. Setting the rhetoric aside, what was the actual scientific picture communicated by his examples? In these chapters, we find that even though Paley argues against random change, he does support a morphological telic change—the development of a supplemental part based on a pre-existing, fixed body part. As every chapter of this thesis unfolds, it will become more apparent that Paley was an intellectual heir to the eighteenth century. He wrote in a polite manner and employed a body of standard eighteenth century natural philosophical knowledge. It is this context that must be addressed and seriously considered when studying the nineteenth century intellectual legacy of Natural Theology

    Nomenclatural notes in the Pleurothallidinae (Orchidaceae): miscellaneous

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    Nomenclatural amendments and notes are provided for taxa belonging to diverse genera within subtribe Pleurothallidinae (Orchidaceae) in order to comply with the International Code for algae, fungi, and plants. The proposed changes include new species, new names, new combinations, author citations, name spelling and synonymy. Brief notes are provided.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Jardín Botánico Lankester (JBL)UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologí

    Flora costaricensis. Family #39 Orchidaceae: Tribe Cymbidieae: Subtribe Zygopetalinae

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    Although they only represent a small portion (around four percent) of the Costa Rican orchid flora, species of Zygopetalinae are frequently grown (and often avidly collected) for horticultural purposes, and their study is crucial to understanding distribution patterns and species frequency as the first step to establish conservation priorities. Among the genera of Zygopetalinae, Dichaea constitutes a particularly common element in any type of vegetation in the country, and its taxonomic treatment should have a certain utility to field botanists working in Costa Rica. Sixteen genera (including a natural hybrid genus) and 60 species are treated. The work was based on direct examination of the available specimens deposited at AMES, CR, INB, K, M, SEL, USJ, and W; the spirit collection of Lankester Botanical Garden (JBL-Spirit); and scrutiny of digital images fromthe collections kept at F, NY, MO, and US. To ensure nomenclature stability, many of the Costa Rican taxa in the group were recently typified, and additional lectotypes are selected here for Cryptarrhena guatemalensis Schltr. (AMES), Kefersteinia subquadrata Schltr. (AMES), and Warczewiczella caloglossa Schltr. (AMES). Many of the descriptions of individual species are based on those appearing in recent generic revisions by the author; they include the observed variations among specimens native from Costa Rica. All the treated taxa are illustrated with one or more ink illustrations. With the exceptions of D. acostae Schltr., D. gracillima C.Schweinf., and D. gomez-lauritoi Pupulin, which are known only from the dried material of the type collections, the illustrations of all the remaining taxa were prepared by the author on the basis of living specimens with the aid of a stereomicroscope fitted with a drawing tube. As in the previous volume of this series on Costa Rican Orchidaceae, the illustrations are arranged according to their occurrence in the keys to facilitate the comparison of closely allied taxa.Universidad de Costa Rica/[814-A4-068]/UCR/Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Jardín Botánico Lankester (JBL

    Correction: Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study (Bone Marrow Transplantation, (2020), 55, 8, (1540-1551), 10.1038/s41409-020-0854-0)

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    The article “Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study,” written by Andre Manfred Willasch, Christina Peters, Petr Sedláček, Jean-Hugues Dalle, Vassiliki Kitra-Roussou, Akif Yesilipek, Jacek Wachowiak, Arjan Lankester, Arcangelo Prete, Amir Ali Hamidieh, Marianne Ifversen, Jochen Buechner, Gergely Kriván, Rose-Marie Hamladji, Cristina Diaz-de-Heredia, Elena Skorobogatova, Gérard Michel, Franco Locatelli, Alice Bertaina, Paul Veys, Sophie Dupont, Reuven Or, Tayfun Güngör, Olga Aleinikova, Sabina Sufliarska, Mikael Sundin, Jelena Rascon, Ain Kaare, Damir Nemet, Franca Fagioli, Thomas Erich Klingebiel, Jan Styczynski, Marc Bierings, Kálmán Nagy, Manuel Abecasis, Boris Afanasyev, Marc Ansari, Kim Vettenranta, Amal Alseraihy, Alicja Chybicka, Stephen Robinson, Yves Bertrand, Alphan Kupesiz, Ardeshir Ghavamzadeh, Antonio Campos, Herbert Pichler, Arnaud Dalissier, Myriam Labopin, Selim Corbacioglu, Adriana Balduzzi, Jacques-Emmanuel Galimard, Peter Bader, on behalf of the EBMT Paediatric Diseases Working Party, was originally published online first without Open Access. After publication in volume 55, issue 8, page 1540–1551, the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 InternationalS License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/ 4.0. Open access funding was enabled and organized by Projekt DEAL

    Craspedacusta Sowerbyi Lankester 1880 and Cordylophora Lacustris Allman 1871 in Western Lake Erie (Coelenterata)

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    Author Institution: Department of Biological Sciences, Wright State University, Dayton, Ohio 45431, and Department of Botany, The Ohio State University, Columbus, Ohio 43210Thirty-seven stations, representing a variety of rocky habitats in the Lake Erie island region were sampled over a three-year period. Rock samples were hand-picked by diving and identification made from living material. The colonial hydroid Cordylophora lacustris was collected at fourteen widely separated locations. The minute polyp form of the freshwater jellyfish Craspedacusta sowerbyi was collected at all of the stations sampled. New hydranth buds, frustules, and medusoid buds were produced in the laboratory by the polyps collected

    Improved outcome of HSCT in STAT1 gain-of-function disease following JAK inhibition bridging.

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    Germline gain-of-function (GOF) mutations in signal transducer and activator of transcription 1 () are associated with infections, including chronic mucocutaneous candidiasis and autoimmunity. Morbidity is high, and disease manifestations can be life-threatening. Curative allogeneic hematopoietic stem cell transplantation (HSCT) historically has had poor outcomes. We identified 36 patients with STAT1 GOF disease, receiving 40 HSCT procedures in 2010-2023, in a combined effort of the EBMT-IEWP and the PIDTC. Median age at first transplant was 11 years (range 1 - 33). Indications for HSCT were combined immunodeficiency, severe and/or refractory infections, and autoimmunity. Acute GvHD occurred in 22/40 HSCT procedures; 5 patients suffered from grade III/IV acute GvHD. One patient had chronic GvHD. Overall survival was 72.2%, and event-free survival was 55.6%, markedly improved from an earlier report on HSCT for STAT1 GOF disease. Patients with an HCT-CI score of 1 or higher had worse outcome. Pre-treatment with Janus kinase (JAK) inhibitors was associated with better event-free survival
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