162 research outputs found
Cytotoxic, apoptotic, and oxidative effects of preserved and preservative-free brimonidine in a corneal epithelial cell line
No full textPurpose: This study aims to compare the cytotoxic, apoptotic, and oxidative effects of preserved and preservative-free forms of brimonidine 0.15% on the human corneal epithelial cell (HCEC) line. Methods: Time-dependent cytotoxicity studies were performed with the Alamar Blue method. For apoptotic studies, PE Annexin V and 7-amino-actinomycin (7-AAD) staining and flow cytometry were performed. Messenger RNA (mRNA) expressions of Bax, Bcl-2, and caspase-3, -9, -12, and protein expressions of Bax and Bcl-2 were evaluated by quantitative real-time polymerase chain reaction and Western blot method, respectively. Results: Cell viability was 76.4% with the preserved solution and 36.05% with the preservative-free solution at the fifth minute. No significant difference was observed with either solution at the 15-min mark, whereas cell viability did not change significantly after 1 h. In the apoptosis evaluation, it was observed that the preservative-free solution increased the early apoptotic activity to a greater degree (P 0.05). Conclusion: It was demonstrated that the preserved solution is less cytotoxic to the HCEC line in the early period, has less early apoptotic activity, and does not significantly increase ROS levels
EAF Ladle Steel Slag as a Geo-Material: Compaction and Shear Strength Characteristics
No full textİrem Zeynep Yıldırım (MEF Author)##nofulltext##The numerous issues associated with the excess steel slag that is disposed of in landfills every year can be reduced by using it as a geo-material. This paper provides the results of laboratory tests (i.e., sieve, hydrometer, specific gravity, compaction, compaction-particle degradation, and large-scale direct shear with a box size of 30.5 x 30.5 x 20 cm) performed on electric-arc-furnace ladle [EAF(L)] steel slag from a mini-mill in Indiana. Based on standard proctor test results, the maximum dry unit weight values of the EAF(L) steel slag were in the 16.8-to-20 kN/m(3) range at the optimum moisture contents of 11-13%. The results of the large-scale direct shear tests performed on EAF(L) steel slag, compacted at 95-100% relative compaction and sheared with normal stress ranging from 50 to 300 kPa, showed that it has excellent frictional characteristics, with friction angles between 40 and 45 degrees. Based on the results from this study, due to its shear strength characteristics, EAF(L) steel slag has the potential to be utilized as a geo-material to improve the shear strength of various marginal soils.WOS:0004370007000122-s2.0-85048741251Conference Proceedings Citation Index- ScienceProceedings PaperMartYÖK - 2017-1
Family Resilience and Dyadic Coping during the Outbreak of the COVID-19 Pandemic in Italy: Their Protective Role in Hedonic and Eudaimonic Well-Being
No full textfirst_pagesettingsOrder Article Reprints
Open AccessArticle
Family Resilience and Dyadic Coping during the Outbreak of the COVID-19 Pandemic in Italy: Their Protective Role in Hedonic and Eudaimonic Well-Being
by Francesca Giorgia Paleari 1,*ORCID,Irem Ertan 1ORCID,Lucrezia Cavagnis 1ORCID andSilvia Donato 2ORCID
1
Department of Human and Social Sciences, University of Bergamo, 24129 Bergamo, Italy
2
Department of Psychology, Università Cattolica del Sacro Cuore, 20123 Milan, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2023, 20(18), 6719; https://doi.org/10.3390/ijerph20186719
Received: 5 July 2023 / Revised: 14 August 2023 / Accepted: 25 August 2023 / Published: 6 September 2023
(This article belongs to the Special Issue Protecting and Promoting Family Members’ Psychological Health in Challenging Times)
Download Review Reports Versions Notes
Abstract
The COVID-19 pandemic outbreak has dramatically worsened people’s psychological well-being. Our aim was to examine for the first time the concurrent and longitudinal relations of family resilience with hedonic and eudaimonic well-being, and the moderating role of socio-demographics. For people having a romantic partner, we also explored whether family resilience and dyadic coping were uniquely related to well-being. One cross-sectional study (N = 325) and one 10-week follow-up study (N = 112) were carried out during the outbreak of the COVID-19 pandemic (April–May 2020) in Northern Italy. Adult participants completed an online questionnaire in both studies. Correlation, multivariate regression, and moderation analyses were carried out with IBM SPSS version 28 and its PROCESS macro. Significance of differences in correlation and regression coefficients was tested through Steiger’s procedure, Wald test, and SUEST method. Family resilience was found to relate more strongly to eudaimonic (versus hedonic) well-being concurrently and to hedonic (versus eudaimonic) well-being longitudinally. The concurrent or longitudinal relations with hedonic well-being were generally stronger for females, part-time workers, and people undergoing multiple stressors. For people having a romantic partner, family resilience was concurrently associated with well-being independently of dyadic coping, whereas dyadic coping was longitudinally related to well-being independently of family resilience. Family resilience was found to protect, in the short term, the psychological well-being of people facing the pandemic outbreak. Its protective role mainly concerned hedonic well-being and was more pronounced for more vulnerable people. For persons having a romantic partner, however, dyadic coping seemed to have equal, if not greater, positive short-term effects
Investigation of the effects of hypericum perforatum L. extract on the effectiveness of hyaluronic acid based gel formulation in vitro conditions
No full textCilt vücudu dış etkenlere karşı koruma, ısı düzenleme, duyusal algı, nem düzenleme ve bazı metabolik süreçlerde yer alan önemli bir dokudur. 20'li yaşlardan itibaren reaktif oksijen türleri (ROS), DNA mutasyonları, telomer kısalmaları, hormonal değişiklikler, UV radyasyonu (UVR), sigara, kimyasallar ve travma gibi çevresel faktörlerin neden olduğu dış etkilerle cilt elastikiyetini kaybetmekte ve nem seviyesi azalmaktadır. Bu nedenle, cilt elastikiyetini artırmak ve cildi nemli tutmak için, cilde ve bağ dokusuna uygun bileşenler sağlamak ve cilde etkili bir şekilde nüfuz edebilecek en güvenli formülü seçmek önemlidir. Formülasyon kapsamında kullanılan mikro emülsiyon sistemleri şeffaf, termodinamik olarak kararlı ve topikal uygulamalarda, özellikle kişisel bakım ürünlerinde büyük potansiyele sahiptir. Son zamanlarda Hyaluronik Asit tabanlı formülasyonlar özellikle yüksek su tutabilme kapasitesinden dolayı (Kendi ağırlığının 1000 katı) cildin nemlendirilmesinde, cildin elastikiyetinin korunmasında etkisi ile önem kazanmaktadır. Ayrıca doğal bir antioksidan ve antimikrobiyal madde oluğundan cildin korunmasında önemli ölçüde etkilidir. Fakat formülasyonların ciltte etkisinin arttırılması için yardımcı maddelerle geliştirilmelidir. Hypericum perforatum L.. bitkisi içeriğindeki Flavonoidler ve Polifenollerle ciltteki iltihaplanmayı sitokin üretimini inhibe ederek azaltırken, hiperisin ile serbest radikallere karşı koruma sağlamakta ve cildin onarım sürecini destekleyerek yaşlanma sürecini de geciktirmektedir. Bu tez çalışmasının amacı Hyaluronik asit tabanlı jel formülasyonuna sarı kantaron yağının eklenmesiyle nemlendirici özellikli ürünlerin oluşturulması ve oluşturulan ürünlerin, mikrobiyal güvenliği ve akabinde cilt membran geçirgenliğinin belirlenmesidir. Önerilen proje kapsamında öncelikle Hypericum perforatum L.. bitkisi formülasyonlarda kullanım kolaylığı sebebiyle yağ bazlı ekstre formunda temin edilmiştir. Ardından yardımcı bileşenler kullanılarak hyaluronik asit tabanlı jel (HA) formülasyonu oluşturulmuştur. Oluşturulan formülasyona Hypericum perforatum L.. yağı eklenerek Hyaluronik Asit-Hypericum perforatum L.. kompleks jel (HAHP) formülasyonu oluşturulmuştur. Elde edilen HAHP ve HA formülasyonlarından ürün güvenliğini belirlemek için mikrobiyal analizleri yapılarak Toplam Bakteri Sayımı, Salmonella ve Staphylococcus aereus, E. Coli ve Koliform mikroorganizmalarının varlığı test edilmiştir. Mikrobiyal analiz sonrası ürünlerde koruyucu etkinlik testi uygulanmıştır. Ardından HA ve HAHP formülasyonları 25 °C ve 45 °C, %60 nem aralığında 60 gün stabilite testine tabi tutulmuştur. Daha sonra HA ve HAHP formülasyonunun cilt yüzeyindeki in vitro deri geçirgenliği Franz Difüzyon Hücre yöntemi kullanılarak karşılaştırmalı olarak analiz edilmiştir. Hyaluronik asit tabanlı jel formülasyonu, belirlenen formül nominal miktarlarınca uygulandığında HA ve HAHP ürünü jel formuna dönüşmüştür. HA ve HAHP ürünlerinin mikrobiyal analizleri sonucu HA için toplam mikroorganizma sayımı 18 kob/gr , toplam küf ve maya sayımı: 11 kob/gr Staphylococcus aereus: 1 kob/gr Eshericia coli ve Koliform: 2 kob/gr , Salmonella: 0 kob/gr ve Candida albicans : 0 kob/gr olarak bulundu. HAHP için toplam mikroorganizma sayımı 11 kob/gr , toplam küf ve maya sayımı: 5 kob/gr Staphylococcus aereus: 1 kob/gr Eshericia coli ve Koliform: 0 kob/gr , Salmonella: 0 kob/gr ve Candida albicans : 0 kob/gr olarak bulundu. Koruyucu etkinlik test sonuçlarına göre HAHP'nin formülasyonunda yer alan Hypericum Perforatum' un antimikrobiyal etkisinden de yararlanılmış olup HA ürününe kıyasla % 12,5 logaritmik azalmayla sonuçlandığı ve etkinliğinin daha yüksek olduğu belirlenmiştir. Ürünlerin 60 gün stabilite sonuçlarına göre belirlenen kabul limitlerinde olduğu ve fiziksel bir farklılık oluşmadığı görülmüştür. HA ve HAHP in vitro membran geçirgenlikleri sırası ile 5.22×10−8 mol/cm² ve 3,47×10−8 mol/cm² bulunmuştur. Tez çalışmasında elde edilecek bilgiler ve çıktılar Hyalüronik Asit tabanlı jellerin ve yağlarla kombine edilmiş formlarının cilt yüzeyinde nemlendirici ve in vitro cilt geçirgenliğine etkileri yanında mikrobiyal ve koruyucu etkinliği de karşılaştırılmalı olarak belirlenecektir. Aynı zamanda yapılan çalışma ciltte kullanılan jel formülasyonlar ile ilgili literatüre katkı sağlayacak ve bu konuda yapılacak diğer çalışmalar için literatürde yer alan eksik verilere ışık tutacaktır.The skin protects the body against external factors, regulates heat, sense perception, regulates moisture and is involved in some metabolic processes. Starting from the age of 20, the skin loses its elasticity and its moisture level decreases due to external effects caused by environmental factors such as reactive oxygen species (ROS), DNA mutations, telomere shortening, hormonal changes, UV radiation (UVR), smoking, chemicals and trauma. Therefore, in order to increase skin elasticity and keep the skin moist, it is important to provide components suitable for the skin and connective tissue and to choose the safest formula that can effectively penetrate the skin. The microemulsion systems used in the formulation are transparent, thermodynamically stable and have great potential in topical applications, especially in personal care products. Recently, Hyaluronic Acid-based formulations are significantly effective in moisturizing the skin, maintaining skin elasticity and being a natural antioxidant and antimicrobial substance, especially due to their high water retention capacity (1000 times their own weight). However, in order to develop formulations and increase their effect on the skin, they should be developed with excipients. Hypericum perforatum L.. plant reduces inflammation in the skin by inhibiting cytokine production with Flavonoids and Polyphenols in its content, while providing protection against free radicals with hypericin and delaying the aging process by supporting the skin repair process. The aim of this thesis is to create moisturizing products by adding St. John's Wort oil to the hyaluronic acid-based gel formulation and to determine the microbial safety and subsequent skin membrane permeability of the products created. Within the scope of the proposed project, firstly Hypericum perforatum L.. plant was provided in oil form due to its ease of use in formulations. Then, hyaluronic acid-based gel (HA) formulation was created using auxiliary components. Hypericum perforatum L.. oil was added to the created formulation and Hyaluronic Acid-Hypericum perforatum L. complex gel (HAHP) formulation was created. In order to determine the product safety of the obtained HAHP and HA formulations, microbial analyses were performed to determine the Total Bacteria Count, Salmonella and Staphylococcus Aereus, E. Coli and Coliform microorganisms. After the microbial analysis, a preservative efficacy test was applied to the products. Then, HA and HAHP formulations were subjected to a 60-day stability test at 25 °C and 45 °C, 60% humidity. Then, in vitro skin permeability of HA and HAHP formulation on the skin surface was comparatively analyzed using the Franz Diffusion Cell method. When the hyaluronic acid-based gel formulation was applied in nominal amounts of the determined formula, the HA and HAHP product turned into a gel form. As a result of microbial analysis of HA and HAHP products, total microorganism count for HA was found to be 18, total mold and yeast count: 11, Staphylococcus aereus: 1, Eschericia Coli and Coliform: 2, Salmonella: 0 and Candida Albicans: 0. For HAHP, total microorganism count was found to be 11, total mold and yeast count: 5, Staphylococcus aereus: 1, Eschericia coli and Coliform: 0, Salmonella: 0 and Candida albicans: 0. According to the preservative efficacy test results, the antimicrobial effect of Hypericum Perforatum in the formulation of HAHP was also utilized and it was determined that it resulted in a 12.5% logarithmic decrease compared to the HA product and its effectiveness was higher. According to the 60-day stability results of the products, it was observed that they were within the determined acceptance limits and no pHysical difference occurred. HA and HAHP in vitro membrane permeabilities were found to be 5.22×10−8 mol/cm² and 3.47×10−8 mol/cm², respectively. The information and outputs to be obtained within the scope of the project will enable the comparative determination of the moisturizing effect of Hyaluronic Acid-based gels and their forms combined with oils on the skin surface and the in vitro skin permeability, and will determine their microbial and protective effectiveness. We also believe that we have shed light on the missing data in the literature for other studies to be conducted on this subject.Bu tez çalışması Selçuk Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü (BAP) tarafından 24201088 nolu proje ile desteklenmiştir
Derivative formulas related to unification of generating functions for Sheffer type sequences
No full textInternational Conference on Numerical Analysis and Applied Mathematics (ICNAAM) -- SEP 13-18, 2018 -- Rhodes, GREECEKUCUKOGLU, IREM/0000-0001-9100-2252The main aim of this paper is to present partial derivative formulas for an unification, which was introduced by the author in "Unification of the generating functions for Sheffer type sequences and their applications, preprint", of Sheffer type sequences including the Peters polynomials, the Boole polynomials, the Changhee polynomials, the Simsek polynomials and the Korobov polynomials of the first kind. By making use of these derivative formulas, we provide a recurrence relation and a derivative formula for this unification. Furthermore, by using recurrence relation for this unification, we present miscellaneous special cases of this unification. Finally, we give some derivative formulas related to the well-known Sheffer type sequences such us the Peters polynomials and the Simsek polynomials.European Soc Computat Methods Sci & Eng
The Traces of Feminism in Essays of Elif Şafak
No full textBu çalışmamızda, Elif Şafak’ın gazete ve dergilerde yayınlanan deneme yazılarını
derlediği dört deneme kitabı, sabit karşılaştırmalı analiz ve söylem analizi yöntemleriyle
incelenerek, bu kitaplarda yer alan yazılardaki kadın-erkek, kadın-kadın ikili karşıtlıkları,
yazarın kadına özgün bakış açısı ve bu bakış açısında yazarın feminist söylemleriyle
çelişen ifadeler olup olmadığı, yazarın egemen ataerkil söylemin yeniden üretilmesine
katkıda bulunup bulunmadığı tespit edilmeye çalışılmıştır.
Sabit karşılaştırmalı analiz yöntemiyle, dört kitap taranmış ve çalışmamıza uygun
olabilecek, tekrar gösteren temalar çerçevesinde metin örnekleri seçilmiş, bu örnekler,
gruplara ayrılarak, yukarıda adı geçen başlıklara ve temalara hizmet edip etmediği,
mevcut teoriler baz alınarak saptanmaya çalışılmış ve eleştirel söylem analizi yöntemi ile
değerlendirilmiştir.
Feminizmin elbette ki tek bir görüşü ya da algısı bulunmamaktadır. Bu konuda üretilmiş
sayısız teori mevcuttur. Bu çalışmada özellikle feminizmin çıkış noktası olarak ele alınan
ikili karşıtlıklar/ikilikler baz alınmıştır. Diğer temalar da ikili karşıtlıklar/ikilikler
üzerinden, yeni karşıtlıklar kümeleri yaratılıp yaratılmadığı, mevcut kümelerin beslenip
beslenilmediği dikkate alınarak şekillendirilmiştir. Sonuçta Şafak’ın kadın erkek ikili
karşıtlıklar kümesine hizmet eden, ataerkil söylemi yeniden üreten, kendi içerisinde yeni
kadınlık kümeleri ya da stereotipler yaratan ve bir kümeyi diğerine ötekileştiren
açıklamaları, karşılaştırmalı örneklerle tespit edilmiştir.In this body of work, four books by Elif Şafak containing her essays published in
various newspapers and magazines are discussed constant comparative analysis and
discourse analysis to derive binary oppositions in male-female & female-female
relationships, the female-centered perspective of the author and consecutive feminist
approach to identify if her point of view conflicts with the feminist rhetoric or
contributes to the reproduction of the dominant patriarchal discourse.
The four books have been dealt with using constant comparative analysis and relevant
repeating themes have been selected and categorized to compare with existing theories,
identify if they serve the feminist discourse and analyze in relation to the topics
mentioned above in the light of critical discourse analysis.
Feminism supersedes any single perspective or perception. A limitless number of
theories have been constructed in this subject. This analysis focuses on binary
oppositions/dualities as a starting point. The rest of the themes have been developed
considering binary oppositions/dualities, whether they reproduce new sets of
oppositions or nurture existing sets of discourse. As a conclusion, examples in Şafak’s
bibliography which complement the set of male-female binary oppositions, reproduce
the patriarchal discourse, produce new sets or stereotypes of femininity or otherize one
set to another have been identified with comparative examples
Gaziantep O?uzeli-Dokuzyol village reuse proposal; Example of Ezogelin Barak culture center
No full textDokuzyol village is a settlement 17 km away from Gaziantep Oǧuzeli district, within the Barak Plain boundaries. The old name of this village is Uruş; it is also known as Ezo Gelin's village because it is the birthplace of the legendary Ezo Gelin in folklore. There are traditional abode buildings in the village, but some have been abandoned, and village people have started to prefer reinforced concrete structures. Rural architecture is an embodiment of cultural heritage; therefore, preserving and transferring it to future generations is an essential cultural continuity element. The main reason for choosing this village is that there are examples of traditional abode architecture. To maintain the Barak Culture, an abode cultural center named Ezo Gelin was built in 2018. Cultural center seldom is used and haven't served its main purpose. The aim of this research is develop a renovation for Ezo Gelin Barak Culture Center, which was built with great investment but not used and to draw attention the abode building in the village. In this research adobe buildings of Dokuzyol village were documented with traditional method and function suggestions for the protection of buildings have been developed within scope of the Interior Architecture education survey course. It has been suggested that some of the unused abode buildings in the village to serve for the new function of Ezo Gelin Barak Culture Center. The proposal developed for Ezo Gelin Barak Cultural Center aims to contribute to rural tourism and cultural heritage. © 2022 Author(s)
Evaluating distance education performance within the scope of architectural education
No full textTurkey is affected by the COVID-19 pandemic widely as well as all around the world. There is also a global impact in the field of education. Several precautions were taken for preventing infection from COVID-19 at a minimal level. One of the taken precautions is launching a distance education system (DES). DES started to practice from primary to higher education easily and swiftly. This system is an alternative to the existing education system. However, universities' architecture departments that have theoretical courses besides applied courses, are known that they are hard to put to set, moreover, most of them hesitate to start distance education due to characteristics of architectural education. Architectural education teaches codifying phenomenon, concepts, thoughts visually with the help of symbols and teach to analyse these codes. This tenet involves different processes from a student's former education life. Therefore, to reach the aims of architectural education features' and actualization level of learning is essential. Professional schools give privileged status to systemic, preferably scientific knowledge, and the schools' prevailing epistemology of practice, treats professional competence as the application ok privileged knowledge to instrumental problems of practice. When architectural education is considered as a process to gain essential skills, it can be seen that how active learning is important. It does not seem possible to perform "active learning"requirements with the distance education system's existing opportunities and architecture students will perform "passive learning"during DES is thought. This study focuses on how DES is made productive for architectural education which started to use due to the COVID-19 pandemic. The main aim of this research is to determine problems of architecture students and instructors related to distance architecture education and offering solutions. Additionally, this research goals to contribute to the limited distance architecture education system. To reach these aims questionnaire forms were constituted toward interviews with both architecture students and instructors and from the literature review. Questionnaires were prepared separately for students and lecturers. This procedure aims to offer an integrated solution by gathering different perspectives of participants. Data of the project were acquired by applying online questionnaires to participants via e-mail. Obtained data were analysed statistically using SPSS 22.0 software. This research will make a remarkable contribution about how active learning at applied courses can be increased during DES at architectural schools by presenting qualitative and quantitative findings. © 2022 Author(s)
Self‐Regulation: Relations with Theory of Mind and Social Behaviour
No full textHarma, Mehmet/0000-0002-3955-1526; Korucu, Irem/0000-0001-7185-2284It is argued that self-regulation skill is necessary both for displaying constructive behaviour and for controlling negative social behaviour, and self-regulation might affect social behaviours by increasing the ability to understand others' minds. In this research, in order to examine different aspects of self-regulation and their similarities and differences in terms of their relations with other constructs, we focused on both effortful control and executive function and investigated their concurrent associations with socially competent and aggressive behaviours and theory of mind (ToM). The participants were 212 preschool children in Turkey. We assessed executive functions with behavioural measures and effortful control with mother reports. We used six tasks for comprehensive assessment of mental state understanding. Children's social competency and aggressive behaviour were assessed with teacher reports. Structural equation modelling results showed that when age and receptive language were controlled, ToM was significantly associated with social competence but not aggressive behaviour. Both effortful control and executive functions were significantly related to social competency and ToM; the pathways from each self-regulation skill were similar in strength. ToM was linked with social competence, but it did not have a mediating role in the relations of self-regulation with social competence. The findings highlighted the importance of self-regulation for socio-cognitive and social development in the preschool years. Copyright (c) 2016 John Wiley & Sons, Ltd.Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK 111 K404]This study is part of the MA thesis of the first author, Irem Korucu, who is currently at Purdue University. The data were drawn from a larger project supported by The Scientific and Technological Research Council of Turkey (TUBITAK 111 K404) awarded to the second author, Bilge Selcuk (Yagmurlu). We are grateful to the parents and children who participated in the study
Multidimensional Bernstein polynomials and Bezier curves: Analysis of machine learning algorithm for facial expression recognition based on curvature
No full textKUCUKOGLU, IREM/0000-0001-9100-2252; SIMSEK, BUKET/0000-0001-8372-2129In this paper, by using partial derivative formulas of generating functions for the multidimensional unification of the Bernstein basis functions and their functional equations, we derive derivative formulas and identities for these basis functions and their generating functions. We also give a conjecture and some open questions related to not only subdivision property of these basis functions, but also solutions of a higher-order special differential equations. Moreover, we provide an implementation for a real world problem of human facial expression recognition with the help of curvature of Bezier curves whose machine learning supported by statistical evaluations on feature vectors using in the aforementioned machine learning algorithm. (C) 2018 Elsevier Inc. All rights reserved.Scientific Research Project Administration of Akdeniz UniversityAkdeniz UniversityThe third author was supported by the Scientific Research Project Administration of Akdeniz Universit
- …
