17 research outputs found
Pametna kuća i merna nesigurnost
No full textLab. assignment No. 7 for Measuring systems in computer engineering course at the University of Belgrade - School of Electrical Engineering (http://automatika.etf.rs/sr/13e053msr) in 2019 (it was No. 9 in 2017 and 2018).
Author would like to thank BSc students - demonstrators Uroš Kukić and Dušan Prokić for their valuable feedback for assignments improvements.</p
Pametna kuća i merna nesigurnost
No full textLab. assignment No. 9 for Measurement computing devices course at the University of Belgrade - School of Electrical Engineering (http://automatika.etf.rs/sr/13e053msr) in 2018.
Author would like to thank BSc students - demonstrators Uroš Kukić and Dušan Prokić for their valuable feedback for assignment's improvements.This lab. has Arduino code
"Pametna kuća" i merna nesigurnost
No full text<p>Lab. assignments No. 4-5 for Measuring systems in computer engineering course at the <a href="https://www.etf.bg.ac.rs/en">University of Belgrade - School of Electrical Engineering</a> (<a href="https://automatika.etf.bg.ac.rs/sr/13e053msr/">https://automatika.etf.bg.ac.rs/sr/13e053msr/</a>) in 2023.</p><p>In 2020 and 2021 it was No. 4 (it was No. 9 in 2017 and 2018, and No. 7 in 2019).</p><p>Author would like to thank BSc students - demonstrators Uroš Kukić, Dušan Prokić, Pavle Radojković, Bogdan Badnjarević, and Nikola Valzorio for their valuable feedback for assignments improvements. Also, special thanks to BSc students in school year 2021/22 Marina Zlatković, Filip Starčević, Sonja Grubor, and Vladimir Janković.</p><p>This lab. comes with Arduino code.</p>
Investigation of Aldehyde Oxidase Inhibition by Clopidogrel and its Thiol Metabolite
No full textAldehyde oxidase (AO) is an enzyme that metabolizes drugs containing aromatic azaheterocycles. Small thiol-containing molecules have been reported to inactivate AO. Clopidogrel is an antiplatelet agent used to treat cardiovascular diseases. Clopidogrel is a prodrug that is bioactivated in vivo by cytochrome P450 enzymes CYP3A4 and CYP2C19 into a thiol metabolite. Our research aims to explore whether the clopidogrel thiol metabolite can inhibit AO, leading to potential drug-drug interactions when co-administered with other drugs that are metabolized by AO. In order to determine whether the prodrug clopidogrel and/or its thiol metabolite inhibit AO, O6-benzylguanine (AO substrate) was incubated with human liver S9 (AO and cytochrome P450 enzyme source) in the presence and absence of clopidogrel or the clopidogrel thiol metabolite. AO activity was then determined by measuring formation of 8-oxo-benzylguanine via LC-MS/MS. An unknown concentration (≤ 250 uM) of the thiol metabolite produced 50-65% inhibition of AO activity, whereas 50 uM clopidogrel produced only 15-20% inhibition, regardless of the presence of NADPH (co-factor required for cytochrome P450-mediated conversion of clopidogrel to the thiol metabolite). In addition, the AO inhibition observed in the presence of the thiol metabolite was concentration-dependent. These preliminary studies indicate that the thiol metabolite of clopidogrel may inhibit AO, but additional experiments are required to confirm these data. Importantly, the clinical relevance of these findings will be highly dependent on the concentrations of thiol metabolite achieved in patients treated with clopidogrel relative to the concentrations required to inhibit AO
An examination of a proposal for an environment studies centre
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
Researchers can access this thesis by asking their local university, institution or public library to
make a request on their behalf. Monash staff and postgraduate students can use the link in the References field
Traditional Game Module Development: An Alternative To Stimulate Early Childhood Language Development
No full textThis research produced a product in the form of a traditional West Kalimantan game book. The research that will be carried out using Research & Development (R & D) research for west Kalimantan traditional game resources the author obtained through observation and interviews as well as documentation as data analysis and data reinforcement as well as evidence of the implementation of research activities. Meanwhile, the locus of this study was conducted in the Coastal area of West Kalimantan, which focused on Tanjung Satai Village, Pulau Maya District, North Kayong Regency. This coastal area refers to the village area located on the island surrounded by the sea, namely the Karimata Strait. This research shows that the results of West Kalimantan traditional games, especially Mimi and Kotaplus, are able to stimulate the development of early childhood language aged 6 to 6 years. In addition, the presence of hand movements in the game stimulates the physical-motor and cognitive development of the child
Elevated intracranial pressure after head trauma can be suppressed by antisecretory factor—a pilot study
No full text© 2020, The Author(s). Background: Control of intracranial pressure (ICP) is a key element in neurointensive care for directing treatment decisions in patients with severe traumatic brain injury (TBI). The anti-inflammatory protein antisecretory factor (AF) has been demonstrated to reduce experimentally induced high ICP in animal models. This report describes the first steps to investigate the uptake, safety, and influence of AF for reduction of elevated ICP in patients with TBI in a clinical setting. Method: Four patients with severe TBI (Glasgow Coma Scale < 9) that required neurointensive care with ICP monitoring due to signs of refractory intracranial hypertension were investigated. One hundred milliliters of Salovum®, a commercially available egg yolk powder with high contents of AF peptides, was administrated either via nasogastric (patients 1 and 2) or rectal tube (patients 2, 3, and 4) every 8 h for 2 to 3 days as a supplement to the conventional neurointensive care. ICP was registered continuously. Plasma levels of AF were measured by enzyme-linked immunosorbent assay (ELISA) to confirm that Salovum® was absorbed appropriately into the bloodstream. Results: In the first two patients, we observed that when delivered by the nasogastric route, there was an accumulation of the Salovum® solution in the stomach with difficulties to control ICP due to impaired gastric emptying. Therefore, we tested to administer Salovum® rectally. In the third and fourth patients, who both showed radiological signs of extensive brain edema, ICP could be controlled during the course of rectal administration of Salovum®. The ICP reduction was statistically significant and was accompanied by an increase in blood levels of AF. No adverse events that could be attributed to AF treatment or the rectal approach for Salovum® administration were observed. Conclusions: The outcomes suggest that AF can act as a suppressor of high ICP induced by traumatic brain edema. Use of AF may offer a new therapeutic option for targeting cerebral edema in clinical practice
Drug-Eluting Bead, Irinotecan (DEBIRI) Therapy for Refractory Colorectal Liver Metastasis:A Systematic Review
No full textColorectal cancer and related mortality present a profound challenge in its management, even in this modern age. Even today, colorectal cancer-related deaths rank third in the world. Despite having multiple lines of chemotherapy, combined with radiotherapy and chemoembolization techniques, after or before surgical resection, the five-year survival rate is approximately 20%. Drug-eluting bead, irinotecan (DEBIRI) is a new technique that involves embolization of the feeding vessels to the tumour and delivering irinotecan for its chemotherapeutic effects. A significant amount of literature compares DEBIRI as an adjunct to various lines of chemotherapy. However, so far, not much data are available on DEBIRI as a singular treatment for those patients who have had multiple chemotherapies and still progressing and are not fit for liver resection. In this systematic review, we aim to highlight and bring together the results of those studies that focused on this specific patient group. A systematic search of the literature involving three large databases (published between January 2017 and July 2022), excluding languages other than English, was conducted to identify articles documenting patients who had disease progression despite chemotherapy and were not fit for surgical resection. The level of evidence and the quality check were assessed by two independent reviewers, and consensus with the senior author resolved disagreements. Out of seven studies that met the final criteria, we found a pooled cohort of 302 patients. The mean age of the patients was 61.2 years, ranging from 40.7 to 84 years. The most commonly used DEBIRI beads were M1 (70-150 um) and M2 (100-300 um), but two studies reported the use of 40 um as well. The total number of DEBIRI treatments performed in our pooled cohort was 904. The majority of the studies reported only G1/G2 toxicities among the patients, with maximal toxicity of G4 in a few selected patients. The median overall survival in our pooled cohort was 19.52 months. The median progression-free survival in our data was 5.76 months. Our systematic review concludes that DEBIRI is undoubtedly a useful treatment modality with an acceptable toxicity profile. This treatment offers a good overall survival benefit for refractory colorectal liver metastasis.</p
АНАЛИЗ И ОЦЕНКА ЭКОНОМИЧЕСКОЙ ЭФФЕКТИВНОСТИ РИСК-МЕНЕДЖМЕНТА
No full textEnterprise-wide risk management is a relatively new scientific and practical area of a corporate government, which has a special mission to deal with corporate risks and exposures and to achieve beneficial risk management outcomes. Risk management has a wide range of methods, techniques and tools, but quite expensive, but in the case of a successful application, can stimulate an increase in the company's value. Nevertheless, despite its relevance, risk management reluctantly introduced to the company, this is due, primarily, to the inability to pre-determine the economic impact of existing activities. Most methods for assessing the cost-effectiveness of risk management, as a rule, designed to assess the economic impact after the fact, in this article, the author has provided the tools for assessing the financial and economic impact of the implementation of risk management in advance.Общеотраслевой риск-менеджмент является относительно новым научно-практическим направлением корпоративного управления, основная цель которого – создавать дополнительные преимущества для компании и нивелировать негативные последствия неопределенности. Управление рисками обладает широким набором методов, техники и инструментов, однако достаточно затратно, но в случае успешного применения способно стимулировать увеличение стоимости компании. Несмотря на свою актуальность, риск-менеджмент неохотно внедряется в работу компаний, связано это, в первую очередь, с невозможностью заранее определить экономический эффект от осуществляемых мероприятий. Большинство методов, позволяющих оценить экономическую эффективность риск-менеджмента, как правило, предназначены для оценки экономического эффекта постфактум, в настоящей статье автор предоставил инструментарий, позволяющий оценить финансовый и экономический эффект от внедрения риск-менеджмента заранее
