1,720,983 research outputs found
Predicting long walking capacity from the timed 25-foot walk test in persons with multiple sclerosis - a potential simple aid to assist ambulation scoring?
No full textBackground: : In people with multiple sclerosis (pwMS), no formula exists to predict long walking capacity.Objective: : To examine the accuracy of the timed 25-foot walk (T25FW) to predict long walking in pwMS with various degrees of walking dysfunction. Methods: : A linear regression was made between the T25FW and the 6-minute walk test (6MWT) using data from 498 pwMS.Results: : Prediction showed an excellent agreement between actual and predicted 6MWT distances, with an acceptable error of 10%, which increased as walking dysfunction increased.Conclusions: : The T25WT provided acceptable prediction of the 6MWT in pwMS, although less accurate at higher degrees of dysfunction.The author(s) received no financial support for the research, authorship, and/or publication of this article.
The RIMS network (www.eurims.org) is acknowledged for facilitating inter European consultation and testing. All data-collecting centers REVAL Rehabilitation Research Center, Hasselt (D. Gijbels, I. Baert, B.O. Eijnde and I. Wens); Rehabilitation and
MS Center Overpelt, Overpelt (K. Knuts); National MS Center, Melsbroek (B. Gebara); Centre Neurologique et de R´eadaptation Fonctionelle, Fraiture-en-Condroz (B. B. Maertens de Noordhout); Charles University Prague and General Faculty Hospital, Prague (K. Rasova); MS Centers of Haslev and Ry (E. Jensen and A. Skjerbaek); West-Tallinn Central Hospital, Tallinn (Heigo Maamagi); ¨ Masku Neurological Rehabilitation Center, Masku (A. Romberg); School of Health Professions, Plymout
University, Plymouth, United Kingdom (J. Freeman); Norwegian Multiple Sclerosis Competence Center, Department of Neurology, and Department of Physiotherapy, Haukeland University Hospital, Bergen, Norway (T. Smedal); Poole hospital NHS foundation trust, Dorset, United Kingdom (H. Conyers); Eugenia Epalza D. Rehabilitation Center, Bilbao, Spain (IE.. Minguez); Helsinki MS-Neuvola, Finland (J. Gumse); MS Center Hakadal AS, Norway (A. Heric-Mansrud); Center for MS,
University Medical Center Ljubljana, Slovenia (A. Martic); Kongsgaarden Physiotherapy AS/Nordland Hospital Trust, Bodø, Norway (B. Norman); Hospital de Dia de Barcelona, CEMCat, Spain (C. Santoyo); Sheba Medical Center, Tel-Hashomer, Israel and The Mellen Center for MS Treatment and Research, Cleveland, USA (F. B´ethoux)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Sustained attention during prolonged walking in persons with multiple sclerosis
No full textIntroduction: Walking is a cognitively demanding activity, as has been shown in long-distance assessments. It is known that there is often a decrease in walking speed during long-distance walking in persons with multiple sclerosis (pwMS) which could be related to reduced sustained attention while performing simultaneously performing a prolonged motor task (i.e., long distance walking task). Objective: This study investigated sustained attention during prolonged walking in pwMS withdifferent levels of disabilityand compared it with healthy controls (HC). Methods: Thirty pwMS with mild disability (EDSS<4.0), 16 pwMS with moderate to severe disability (EDSS 4.0-6.5), and 27 age-gender matched HC performed the 6-Minute Walk Test (6MWT) with an auditory vigilance task. Participants were auditory provided a letter every 2.5s through a headphone and were instructed to say "yes" as fast as possible when they heard one of two selected letters (L and R) and asked to not respond on other letters to assess vigilance. The number of errors and average reaction time in the vigilance task, and distance walked per minute were measured. Distance Walked Index (DWI; change in walking distance between min 1 and min 6) was calculated to determine walking fatigability. Repeated measures ANOVAs (RMANOVAs) were conducted on each outcome variable with post-hoc corrections. Results: Significant group * time interaction effects were found for reaction times.Reaction times significantly increased in persons with mild disability and moderate to severe disability groups, with greater increase in pwMS with moderate to severe disability (13.22%). There was no change in reaction time between min 1 to min 6 in HCs. Significant time effects were found for walking distance and number of errors, but there was no group*time interaction. The DWI was not different between mildly disabled pwMS and HC (-10.22% vs.-6.54%), but those with moderate to severe disability showed a significantly greater change (-20.59%) than mildly disabled pwMS. Conclusion: Our findings showed that attention and walking speed deteriorated over time during the six minutes of walking, especially in pwMS with higher disabilities. Change in sustained attention may explain the decrease in walking speed, and it should be further examined
Sustained attention during prolonged walking in persons with multiple sclerosis
No full textIntroduction: Accelerated early CGMV loss occurs in interferon-treated RMS patients. Methods: CGMV was quantified in randomized phase 3 (SUNBEAM-NCT02294058, RADIANCE-NCT02047734) trials comparing oral ozanimod 0.92 and 0.46mg/day with intramuscular interferon 30μg/ week and an ongoing, open-label extension trial (DAYBREAK-NCT02576717) of ozanimod 0.92mg/day in RMS. MRI was performed at months 6 (SUNBEAM), 12 (RADIANCE/SUNBEAM), and 24 (RADIANCE), then every 12 months (DAYBREAK). CGMV was analyzed through DAYBREAK month 36. Results: The rate of CGMV loss was greater (P<0.001) with inter-feron than ozanimod 0.92mg during SUNBEAM/RADIANCE: LS mean percentage change from baseline was-0.67% vs-0.02%, respectively, at month 6 and-1.04% vs-0.16% at month 12 in SUNBEAM, and-0.80% vs-0.13% at month 12 and-1.26% vs-0.53% at month 24 in RADIANCE. Switching from interferon to ozanimod reversed CGMV loss in year 1 of DAYBREAK. Thereafter, annualized rates of CGMV loss were similar among participants who switched from interferon and those continuously treated with ozanimod. Patients continuously treated with ozani-mod lost less CGMV in DAYBREAK relative to RADIANCE/ SUNBEAM baseline than patients initially treated with interferon. Conclusion: Switching from interferon to ozanimod reversed CGMV loss. Earlier treatment with ozanimod led to less CGMV loss over 4-5 years, supporting early ozanimod use. This abstract has been previously presented at AAN 202
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Sustained attention during prolonged walking in persons with multiple sclerosis
No full textIntroduction: Accelerated early CGMV loss occurs in interferon-treated RMS patients. Methods: CGMV was quantified in randomized phase 3 (SUNBEAM-NCT02294058, RADIANCE-NCT02047734) trials comparing oral ozanimod 0.92 and 0.46mg/day with intramuscular interferon 30μg/ week and an ongoing, open-label extension trial (DAYBREAK-NCT02576717) of ozanimod 0.92mg/day in RMS. MRI was performed at months 6 (SUNBEAM), 12 (RADIANCE/SUNBEAM), and 24 (RADIANCE), then every 12 months (DAYBREAK). CGMV was analyzed through DAYBREAK month 36. Results: The rate of CGMV loss was greater (P<0.001) with inter-feron than ozanimod 0.92mg during SUNBEAM/RADIANCE: LS mean percentage change from baseline was-0.67% vs-0.02%, respectively, at month 6 and-1.04% vs-0.16% at month 12 in SUNBEAM, and-0.80% vs-0.13% at month 12 and-1.26% vs-0.53% at month 24 in RADIANCE. Switching from interferon to ozanimod reversed CGMV loss in year 1 of DAYBREAK. Thereafter, annualized rates of CGMV loss were similar among participants who switched from interferon and those continuously treated with ozanimod. Patients continuously treated with ozani-mod lost less CGMV in DAYBREAK relative to RADIANCE/ SUNBEAM baseline than patients initially treated with interferon. Conclusion: Switching from interferon to ozanimod reversed CGMV loss. Earlier treatment with ozanimod led to less CGMV loss over 4-5 years, supporting early ozanimod use. This abstract has been previously presented at AAN 202
Sex-Based Differences in Oxygen Cost of Walking and Energy Equivalents in Minimally Disabled Individuals With Multiple Sclerosis and Controls
No full textBackground: Elevated oxygen cost of walking and energy equivalents are reported for highly and moderately disabled individuals with multiple sclerosis (MS). However, less is known about minimally impaired individuals. Moreover, no sex-based data on the metabolic rates of individuals with MS are available. In this cross-sectional study, the metabolic rates and temporospatial parameters of gait during overground walking in minimally disabled individuals with MS versus matched controls were quantified and whether sex-based differences occur was examined. Methods: Sixty-nine minimally impaired adults with MS (37, relapsing-remitting MS [RRMS]; 32, clinically isolated syndrome [CIS]) and 25 matched controls completed two 6-minute walking bouts at comfortable and fast speeds. The oxygen cost of walking, energy equivalents, and respiratory exchange ratio were recorded through breath-by-breath open-circuit spirometry. Gait analysis was performed via a portable electronic walkway. Results: At comfortable but not at fast speed, men with RRMS showed higher oxygen cost of walking than men with CIS (+17.9%, P =.04) and male controls (+21.3%, P =.03). In the RRMS group, men showed higher oxygen cost of walking (+19.2%, P =.04) and energy equivalents (+19.2%, P =.02) than women. Elevated oxygen cost of walking and energy equivalents in men were paralleled by significantly larger base of support and step time asymmetry during walking. Conclusions: Metabolic demands are elevated while walking in minimally disabled individuals with RRMS. Furthermore, higher energy demands occur in men, probably due to increased step symmetry and base of support. Clinicians are advised to follow energy expenditure metrics collected while walking because they can indicate a decrease in fitness, even in the early phase of M
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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