1,720,956 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Impact of sirtuin 3 on the oxidative and metabolic state of kidney and brain tissue in male and female mouse
No full textSirtuin 3 (SIRT3) pripada obitelji proteina sirtuina i glavna je mitohondrijska NAD+ ovisna deacetilaza. Sudjeluje u regulaciji staničnog metabolizma, oksidativnog stresa i transkripcije. Njegova pojačana aktivacija, što suplementima, a što zbog polimorfizama prirodno prisutnih u populaciji, pokazala se efikasnom metodom produljenja životnog vijeka modelnih organizama i čovjeka. U ovom istraživanju analiziran je njegov utjecaj na oksidativno i metaboličko stanje u tkivu bubrega i mozga. Istraživanje je provedeno na osamnaest tjedana starim mužjacima i ženkama miševa divljeg tipa i miševa s nedostatkom proteina SIRT3, pri normalnoj prehrani. Analizirana je ekspresija proteina uključenih u antioksidativnu obranu i metabolizam metodom Western blot. Na uzorcima tkiva bubrega i mozga provedena je analiza oksidativnih oštećenja proteina analizom karbonilacije, odnosno oštećenja lipida lipidnom peroksidacijom. Dodatno je određena aktivnost antioksidativnih enzima katalaze i superoksid dismutaze. U analizi ekspresije uočen je utjecaj SIRT3 na količinu proteina SOD2 u bubregu i PPARγ u mozgu. Oksidativna oštećenja sugeriraju protektivno djelovanje na lipide u mozgu i proteine u bubregu, a aktivnost antioksidativnih enzima varira s obzirom na spol i tip organa.Sirtuin 3 (SIRT3) belongs to the sirtuin protein family and is a key mitochondrial NAD+-dependent deacetylase. It is involved in regulating cellular metabolism, oxidative stress, and transcription. Its increased activation, either through supplements or due to naturally occurring polymorphisms in the population, has proven to be an effective method for extending the lifespan of model organisms and humans. In this study, its impact on oxidative and metabolic states in kidney and brain tissues was analyzed. The research was conducted on 18-week-old male and female wild-type mice and mice lacking the SIRT3 protein, under normal dietery conditions. The expression of proteins involved in antioxidant defense and metabolism was analyzed using the Western blot method. Oxidative damage to proteins in kidney and brain tissue samples was determined by analyzing carbonylation, and lipid damage was assessed through lipid peroxidation. Additionally, the activity of antioxidant enzymes catalase and superoxide dismutase was measured. The analysis of protein expression showed an influence of SIRT3 on the amount of SOD2 protein in the kidney and PPARγ in the brain. Oxidative damage suggests a protective effect on lipids in the brain and proteins in the kidney, while the activity of antioxidant enzymes varies depending on the sex and type of organ
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Evolution of vertebrate sex chromosomes
No full textSpolni kromosomi jedan su od glavnih sustava determinacije spola višestaničnih organizama, a od
autosoma se razlikuju u nizu specifičnih karakteristika koje mogu biti uzrok ili posljedica njihove
jedinstvene funkcije. Od njihova otkrića 1905. godine istraživane su njihove posebne karakteristike
i postavljani teorijski statistički modeli njihova postanka. Nakon razvoja molekularno bioloških
metoda istraživanja su se posvetila definiranju njihovih gena i puteva kojima utječu na
diferencijaciju spola. Pokazalo se kako su spolni kromosomi kralježnjaka iznimno raznolike i
dinamične strukture čime je otvoren put analizi njihove evolucijske prošlosti. Dakako, time su
prethodna teorijska razmatranja stavljena na kušnju i postavljena su vrlo važna pitanja koja ni danas
nemaju direktan odgovor. U sklopu ovoga rada pokušat ću odgovoriti na pitanja: koje su osnovne
karakteristike spolnih kromosoma; koje su paradigme ustanovljene za njihov nastanak te
podudaraju li se one sa stvarnim stanjem u većine kralježnjaka; jesu li istraživanja spolnih
kromosoma kralježnjaka dosegla svoj vrhunac te što nas još očekuje?Sex chromosomes are one of the main determinants of sex in multicellular organisms, and they
differ from autosomes in a number of specific characteristics that may be the cause or consequence
of their unique function. Since their discovery in 1905, their special characteristics have been
investigated through theoretical and statistical models. After the development of molecular
research methods in biology, research was mainly targeted at defining their genes and the pathways
that influence sex differentiation. Through this research it has been shown that the chromosomes
of vertebrates have an extremely diverse and dynamic structure. Because of that their evolution has
become a great puzzle. Of course, this put the previous theoretical considerations to the test and
raised very important questions that still do not have a direct answer. As part of this work, I will
try to answer the following questions: what are the basic characteristics of sex chromosomes; what
paradigms have been established for their origin and do experimental evidence in vertebrates match
what was previously tought; has the research of sex chromosomes of vertebrates reached its peak
and what else awaits us
Impact of sirtuin 3 on the oxidative and metabolic state of kidney and brain tissue in male and female mouse
No full textSirtuin 3 (SIRT3) pripada obitelji proteina sirtuina i glavna je mitohondrijska NAD+ ovisna deacetilaza. Sudjeluje u regulaciji staničnog metabolizma, oksidativnog stresa i transkripcije. Njegova pojačana aktivacija, što suplementima, a što zbog polimorfizama prirodno prisutnih u populaciji, pokazala se efikasnom metodom produljenja životnog vijeka modelnih organizama i čovjeka. U ovom istraživanju analiziran je njegov utjecaj na oksidativno i metaboličko stanje u tkivu bubrega i mozga. Istraživanje je provedeno na osamnaest tjedana starim mužjacima i ženkama miševa divljeg tipa i miševa s nedostatkom proteina SIRT3, pri normalnoj prehrani. Analizirana je ekspresija proteina uključenih u antioksidativnu obranu i metabolizam metodom Western blot. Na uzorcima tkiva bubrega i mozga provedena je analiza oksidativnih oštećenja proteina analizom karbonilacije, odnosno oštećenja lipida lipidnom peroksidacijom. Dodatno je određena aktivnost antioksidativnih enzima katalaze i superoksid dismutaze. U analizi ekspresije uočen je utjecaj SIRT3 na količinu proteina SOD2 u bubregu i PPARγ u mozgu. Oksidativna oštećenja sugeriraju protektivno djelovanje na lipide u mozgu i proteine u bubregu, a aktivnost antioksidativnih enzima varira s obzirom na spol i tip organa.Sirtuin 3 (SIRT3) belongs to the sirtuin protein family and is a key mitochondrial NAD+-dependent deacetylase. It is involved in regulating cellular metabolism, oxidative stress, and transcription. Its increased activation, either through supplements or due to naturally occurring polymorphisms in the population, has proven to be an effective method for extending the lifespan of model organisms and humans. In this study, its impact on oxidative and metabolic states in kidney and brain tissues was analyzed. The research was conducted on 18-week-old male and female wild-type mice and mice lacking the SIRT3 protein, under normal dietery conditions. The expression of proteins involved in antioxidant defense and metabolism was analyzed using the Western blot method. Oxidative damage to proteins in kidney and brain tissue samples was determined by analyzing carbonylation, and lipid damage was assessed through lipid peroxidation. Additionally, the activity of antioxidant enzymes catalase and superoxide dismutase was measured. The analysis of protein expression showed an influence of SIRT3 on the amount of SOD2 protein in the kidney and PPARγ in the brain. Oxidative damage suggests a protective effect on lipids in the brain and proteins in the kidney, while the activity of antioxidant enzymes varies depending on the sex and type of organ
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