860 research outputs found
Dexamethasone induces the expression of metalloproteinase inhibitor TIMP‐1 in the murine cerebral vascular endothelial cell line cEND
No full textIn many neuroinflammatory conditions, including multiple sclerosis (MS), encephalitis, meningitis, brain tumours and cerebral ischaemia, the matrix metalloproteinases (MMPs) play an important role in disrupting the blood-brain barrier (BBB). Normally under tight regulation, increased MMP-9 cerebrospinal fluid levels and excessive proteolytic activity is detected in the blood and cerebrospinal fluid in patients with acute MS. MMP-9 is a member of the type IV collagenases, which attack components of the endothelial basal lamina, including type IV collagen. The disruption of the BBB and clinical symptoms can be reduced with different inhibitors to MMPs including activators of tissue inhibitor of metalloproteinases-1 (TIMP-1), the cognate tissue inhibitor of MMP-9. Since intravenous glucocorticoid (GC) treatment reduces the levels of MMP-9 markedly in patients, we hypothesized that GC effects might be mediated by transcriptional activation of the TIMP-1 gene in addition to reported repressive effects on MMP-9 transcription. Our results provide direct evidence that GCs increase TIMP-1 in the brain endothelial cell line cEND, prevent alterations in microvascular integrin alpha 1 subunit expression and help maintain endothelial barrier function in response to pro-inflammatory stimuli (TNF alpha administration). GC-induced up-regulation of TIMP-1 expression by the CNS vascular endothelium may thus play a role in preservation of the endothelial basal lamina and maintain integrin alpha 1 and tight junction protein expression important for vessel wall integrity
The Spoken Wikipedia Corpora
No full textThe Spoken Wikipedia project unites volunteer readers of Wikipedia articles. Hundreds of spoken articles in multiple languages are available to users who are – for one reason or another – unable or unwilling to consume the written version of the article. Our resource, the Spoken Wikipedia Corpus, consolidates the Spoken Wikipediae, adding text segmentation, normalization, time-alignment and further annotations, making it accessible for research and fostering new ways of interacting with the material.
Timo Baumann and Arne Köhn and Felix Hennig. 2018. The Spoken Wikipedia Corpus Collection: Harvesting, Alignment and an Application to Hyperlistening, in Language Resources and Evaluation, Special Issue representing significant contributions of LREC 2016.
Arne Köhn, Florian Stegen, Timo Baumann. 2016. Mining the Spoken Wikipedia for Speech Data and Beyond, in Proceedings of the Tenth International Conference on Language Resources and Evaluation (LREC 2016).
CLARIN Metadata summary for The Spoken Wikipedia Corpora (CMDI-based)
Title: The Spoken Wikipedia Corpora
Description: The Spoken Wikipedia project unites volunteer readers of Wikipedia articles. Hundreds of spoken articles in multiple languages are available to users who are – for one reason or another – unable or unwilling to consume the written version of the article. Our resource, the Spoken Wikipedia Corpus, consolidates the Spoken Wikipediae, adding text segmentation, normalization, time-alignment and further annotations, making it accessible for research and fostering new ways of interacting with the material.
Publication date: 2017
Data owner: Timo Baumann - Universität Hamburg
Contributors: Timo Baumann (author), Arne Köhn (author), Florian Stegen (author)
Languages: English (eng), German (deu), Dutch (nld)
Size: 5397 article, 1005 hour
Segmentation units: other
Genre: encyclopedia
Modality: spoken
References: Timo Baumann; Arne Köhn; Felix Hennig (2018) The Spoken Wikipedia Corpus Collection: Harvesting, Alignment and an Application to Hyperlistening References: Arne Köhn; Florian Stegen; Timo Baumann (2016) Mining the Spoken Wikipedia for Speech Data and Beyon
Replication Data for: Efficient Application of Accelerator Cards for the Coupling Library preCICE
No full textThis dataset contains all testcase setup files and result files for the measurements presented in the Master's thesis with the title "Efficient Application of Accelerator Cards for the Coupling Library preCICE" (Author: Timo Pierre Schrader).
Furthermore, it contains the version of preCICE used throughout this thesis.
The thesis revolves around GPU acceleration of RBF data mapping in preCICE. See the README for more information how to build and run the testcase
sj-docx-1-eso-10.1177_23969873221145391 – Supplemental material for Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke
No full text1 page. -- Figure 2 ROC curves for predefined predictive models for sICH with log10 S-100B (black line) and without log10 S-100B (grey line) with AUC of 0.75 and 0.72 respectively.Supplemental material, sj-docx-1-eso-10.1177_23969873221145391 for Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke by Tim Honegger, Juliane Schweizer, Antonela Bicvic, Laura P Westphal, Valerie Schütz, Corinne Inauen, Thomas Pokorny, Katja Bracher, Marcel Arnold, Urs Fischer, Leo H Bonati, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Carlo Cereda, Georg Kägi, Joan Montaner, Alejandro Bustamante, Elena Palà, George Ntaios, Christian Foerch, Andreas Luft, Katharina Spanaus, Lanja Saleh, Arnold von Eckardstein, Markus Arnold and Mira Katan in European Stroke JournalFunding Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen ForschungPeer reviewe
Timo de Rijk: 'We plant the seed'; interview
No full textArt historian Timo de Rijk was appointed Professor of Design, Culture and Society in Delft and Leiden last September. He calls this combination ‘a real breakthrough’. ‘Leiden University studies the workings of culture, while TU Delft aims at creating new things. These are fundamentally different approaches. I am the bridge between the two.’Industrial Design Engineerin
Applying machine learning to root cause analysis in agile CI/CD software testing environments
No full textThis thesis evaluates machine learning classification and clustering algorithms with the aim of automating the root cause analysis of failed tests in agile software testing environments. The inefficiency of manually categorizing the root causes in terms of time and human resources motivates this work. The development and testing environments of an agile team at Ericsson Finland are used as this work's framework.
The author of the thesis extracts relevant features from the raw log data after interviewing the team's testing engineers (human experts).
The author puts his initial efforts into clustering the unlabeled data, and despite obtaining qualitative correlations between several clusters and failure root causes, the vagueness in the rest of the clusters leads to the consideration of labeling.
The author then carries out a new round of interviews with the testing engineers, which leads to the conceptualization of ground-truth categories for the test failures. With these, the human experts label the dataset accordingly.
A collection of artificial neural networks that either classify the data or pre-process it for clustering is then optimized by the author.
The best solution comes in the form of a classification multilayer perceptron that correctly assigns the failure category to new examples, on average, 88.9\% of the time.
The primary outcome of this thesis comes in the form of a methodology for the extraction of expert knowledge and its adaptation to machine learning techniques for test failure root cause analysis using test log data.
The proposed methodology constitutes a prototype or baseline approach towards achieving this objective in a corporate environment
sj-docx-1-eso-10.1177_23969873231174942 – Supplemental material for Ischaemic stroke despite antiplatelet therapy: Causes and outcomes
No full textSupplemental material, sj-docx-1-eso-10.1177_23969873231174942 for Ischaemic stroke despite antiplatelet therapy: Causes and outcomes by Norbert Silimon, Boudewijn Drop, Leander Clénin, Krassen Nedeltchev, Timo Kahles, Alexander A Tarnutzer, Mira Katan, Leo Bonati, Stephan Salmen, Sylvan Albert, Alexander Salerno, Emmanuel Carrera, Christian Berger, Nils Peters, Friedrich Medlin, Carlo Cereda, Manuel Bolognese, Georg Kägi, Susanne Renaud, Julien Niederhauser, Christophe Bonvin, Michael Schärer, Marie-Luise Mono, Andreas Luft, Biljana Rodic-Tatic, Urs Fischer, Simon Jung, Marcel Arnold, Thomas Meinel and David Seiffge in European Stroke Journal</p
Educación Artística Comunitaria en Finlandia: entrevista a Timo Jokela
No full textEste artículo presenta un estudio sobre la educación artística comunitaria en la Universidad de Laponia en Finlandia. En primer lugar se analizan las líneas principales de este modelo formativo y de su plan de estudios. En segundo lugar se presenta una entrevista con Timo Jokela, Decano de la Facultad de Arte y Diseño de la Universidad de Laponia y director del Departamento de Educación Artística en esa misma Facultad. En la entrevista Timo Jokela habla de las relaciones entre arte, medio ambiente, comunidad y educación partiendo de su propia experiencia como artista y centrado en el contexto finlandés. También sobre los aspectos sociales, culturales, artísticos y educativos que están implícitos en el modelo de educación artística comunitaria que se pone en práctica, como itinerario formativo, en la Universidad de Laponia.
This article presents a study on community-based art education at the University of Lapland in Finland. First, the main guidelines of this training model and its curriculum are analysed. Second, the author includes an interview with Timo Jokela, Dean of the Faculty of Art and Design of The University of Lapland in Finland and Director of the Department of Art Education at the same faculty. In the interview Timo Jokela draws upon his own experience as an artist in Finland to talk about the relationships between art, the environment, community and education. He also talks about the social, cultural, artistic and educational aspects, which are central to the community-based art education scheme in place at The University of Lapland
sj-pdf-2-eso-10.1177_23969873231174942 – Supplemental material for Ischaemic stroke despite antiplatelet therapy: Causes and outcomes
No full textSupplemental material, sj-pdf-2-eso-10.1177_23969873231174942 for Ischaemic stroke despite antiplatelet therapy: Causes and outcomes by Norbert Silimon, Boudewijn Drop, Leander Clénin, Krassen Nedeltchev, Timo Kahles, Alexander A Tarnutzer, Mira Katan, Leo Bonati, Stephan Salmen, Sylvan Albert, Alexander Salerno, Emmanuel Carrera, Christian Berger, Nils Peters, Friedrich Medlin, Carlo Cereda, Manuel Bolognese, Georg Kägi, Susanne Renaud, Julien Niederhauser, Christophe Bonvin, Michael Schärer, Marie-Luise Mono, Andreas Luft, Biljana Rodic-Tatic, Urs Fischer, Simon Jung, Marcel Arnold, Thomas Meinel and David Seiffge in European Stroke Journal</p
Ei-ladattavan hybridiauton esilämmitys : vaikutukset järjestelmän toimintakykyyn
No full textTämän opinnäytetyön tarkoituksena oli tutkia ja selvittää sähköisen esilämmityksen vaikutuksia hybridijärjestelmän toimintaan. Työssä tarkasteltiin erityisesti vaikutuksia matkaan joka ajettiin pelkästään käyttämällä sähköä auton hybridiakustosta. Samalla seurattiin auton polttoaineen keskikulutuksen muutoksia. Nämä vaikutukset saatiin parhaiten näkyviin, ajamalla samoja reittejä esilämmitetyllä ja ilman esilämmitystä olevalla autolla sekä vertailemalla näistä saatuja tuloksia.
Työssä käytettävä hybridiauto on tekijän omistuksessa ja omassa käytössä. Autoa käytetään pääsääntöisesti taajamaliikenteessä, mutta myös maantie- ja moottoritienopeuksissa. Ajaminen koostuu tekijän normaalista auton käytöstä. Työhön kuuluu kolme eri vaihetta. Ensimmäisessä vaiheessa autoa esilämmitettiin ennen jokaista kotona suoritettua liikkeellelähtöä, työn tekemisen aikana voimassa olleiden suosituksien mukaisesti. Toisessa vaiheessa autoa ei esilämmitetty ennen ajoon lähtöä. Kolmannessa vaiheessa tulokset kirjattiin muistiin ja analysoitiin.
Hybridijärjestelmän käyttö vähentää polttoaineen kulutusta ja päästöjä verrattuna pelkästään polttomoottorilla varustettuun autoon. Auton esilämmitys parantaa sekä ajoturvallisuutta että mukavuutta, kun lämpötila on pakkasella tai lähellä nollaa. Esilämmitetty moottori saavuttaa nopeammin normaalin käyntilämpötilan verrattuna moottoriin, jota ei ole esilämmitetty ennen ajoon lähtöä. Kun moottori käy normaalilla käyntilämpötilallaan, päästöt ja polttoaineen kulutus pienentyvät verrattuna kylmänä käyvään moottoriin. Myös käynnistyksen päästöjä saadaan pienennettyä esilämmityksellä.
Autolla on ajettu pääsääntöisesti lyhyitä matkoja, jolloin järjestelmän polttomoottori ei ole saavuttanut normaalia käyntilämpötilaansa. Työn tuloksena havaittiin, että esilämmitys vaikuttaa myönteisesti hybridijärjestelmän kykyyn käyttää pelkästään sähkömoottoria auton liikuttamiseen. Tämä tulos on ennakko-odotusten mukainen.The purpose of the thesis was to study the effects of electronic preheating on the operation of a hybrid system. The impact of the trip, which was driven by using only electricity from the car hybrid battery, was specifically examined in this thesis. At the same time, changes in the average fuel consumption of the car were tracked. The effects were best noticed driving the same routes with a preheated car and the car without preheating, and comparing the results.
The hybrid car used in the work is owned and used by the author. The car is mainly used in urban area but also at highway speeds. Driving consists of the author´s normal car use. The work involved three different phases. In the first phase, the car was preheated before each start-up at home, in accordance with the recommendations in force at the time of the work. In the second phase, the car was not preheated before start-ups. In the third phase, the results were reported and analyzed.
Using a hybrid system in a car reduces fuel consumption and emissions compared to a car with an internal combustion engine only. Car preheating improves both driving safely and comfort when the temperature is low or near zero degrees. A preheated engine reaches faster its normal operating temperature compared to an engine that has not been preheated before driving. When the engine is running at its normal operating temperature, emissions and fuel consumption are reduced compared to a cold engine. Start-up emissions can also be reduced by preheating.
The car has been mainly driven for short distances, whereupon the internal combustion engine of the system has not reached its normal operating temperature. The study shows that preheating has a positive effect on the ability of the hybrid system to use only an electric motor to move the car. This result is in line with the expectations
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