79,371 research outputs found

    Results of the Heart Protection Study: Can we still assume a class effect?

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    Statins share several common features including the mechanism of action, i.e. inhibition of HMG-CoA reductase, as well as LDL-cholesterol (LDL-C) and triglyceride lowering properties. However, statins show minor differences in chemical structure, lipophilicity that could translate into a different pharmacological properties. For example, simvastatin exerted a more favorable effect on HDL-C levels than did atorvastatin when higher doses of the two drugs were compared. Finally, the major considerations to chose between statins for CVD patient therapy include clinical benefits and safety (i.e. evidence-based medicine). Primary prevention trials with pravastatins and lovastatin and secondary prevention trials with pravastatin, fluvastatin and simvastatin have established the clinical benefits of statins. In addition, HPS study was designed to investigate the benefits of simvastatin 40 mg in a broad range of patients at high risk for heart disease including women, the elderly and those with a history of hearth attacks, diabetes, hypertension or vascular disease. The results show the ability of simvastatin to reduce all causes of mortality, vascular death and cardiovascular morbidity. The trial also confirms the safety of simvastatin 40 mg although 60% of patients were receiving additional pharmacological treatment. In summary, it appears that statins are not the same and the choice of the more appropriate statin in high-risk patients should be driven by the evidence-based medicine both in terms of safety and efficacy

    Wireless voice-based wheelchair controller system

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    In this paper, we present our work called wireless voice-based wheelchair controller system, which consists of an Android device and a control system that controls the movement of wheelchair using a DC motor. This project is aim to ease the burden for wheelchair user especially for elderly people to move around. The control system is build using the Yo-Yo (IOIO) platform that controls the DC motor, communicates with the Android phone application using RF receiver through a Bluetooth communication protocol and RF signal. The Android application is developed using Basic-4-Android (B4A) rapid development tool connected with one main control interface using voice command, D-pad and joystick to control the motor driver MD30C direction and speed through IOIO platform based on four condition

    A Relational Unsupervised Approach to Author Identification

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    In the last decades speaking and writing habits have changed. Many works faced the author identification task by exploiting frequencybased approaches, numeric techniques or writing style analysis. Following the last approach we propose a technique for author identification based on First-Order Logic. Specifically, we translate the complex data represented by natural language text to complex (relational) patterns that represent the writing style of an author. Then, we model an author as the result of clustering the relational descriptions associated to the sentences. The underlying idea is that such a model can express the typical way in which an author composes the sentences in his writings. So, if we can map such writing habits from the unknown-author model to the known-author model, we can conclude that the author is the same. Preliminary results are promising and the approach seems viable in real contexts since it does not need a training phase and performs well also with short texts

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation

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    The desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters

    Detection of weak stochastic forces in a parametrically stabilized micro-optomechanical system

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    Measuring a weak force is an important task for micromechanical systems, both when using devices as sensitive detectors and, particularly, in experiments of quantum mechanics. The optimal strategy for resolving a weak stochastic signal force on a huge background (typically given by thermal noise) is a crucial and debated topic, and the stability of the mechanical resonance is a further, related critical issue. We introduce and analyze the parametric control of the optical spring, which allows us to stabilize the resonance and provides a phase reference for the oscillator motion, yet conserving a free evolution in one quadrature of the phase space. We also study quantitatively the characteristics of our micro-optomechanical system as detector of stochastic force for short measurement times (for quick, high-resolution monitoring) as well as for the longer-term observations that optimize the sensitivity. We compare a simple strategy based on the evaluation of the variance of the displacement which is a widely used technique) with an optimal Wiener-Kolmogorov data analysis. We show that, due to the parametric stabilization of the effective susceptibility, we can more efficiently implement Wiener filtering, and we investigate how this strategy improves the performance of our system. We finally demonstrate the possibility to resolve stochastic force variations well below 1% of the thermal noise.MicroelectronicsElectrical Engineering, Mathematics and Computer Scienc

    Landsat MSS classification of fire fuel types in Wood Buffalo National Park, northern Canada

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    J1: Global Ecology & Biogeography Letters; M3: Article; Milne, David Franklin, Steven E. Wilson, Bradley A. Ghitter, Geoff Heathcott, Mark McCaffrey, Thomas M. Ow, Charlotte F. Y.; Source Information: Mar1994, Vol. 4 Issue 2, p33; Subject Term: FOREST fires; Author-Supplied Keyword: Canada (Wood Buffalo National Park); Author-Supplied Keyword: Forest fire; Author-Supplied Keyword: Fuel type classification; Author-Supplied Keyword: Landsat data; Number of Pages: 0p; Document Type: Articl

    Letter from A. F. Potter to Carl Hayden

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    Letter from A. F. Potter to Carl T. Hayden describing John H. Page's request to build a railway for the Canyon Copper Company as "impractical"

    Letter from A. F. Potter to John H. Page

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    Letter from A. F. Potter to John H. Page referring his request to build a railway to the District Forester at Albuquerque, New Mexico

    [Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]

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    Newspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
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