96 research outputs found
Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab
No full textSaeko Kuwahara-Ota, Yoshiaki Chinen, Yoshimi Mizuno, Tomoko Takimoto-Shimomura, Yayoi Matsumura-Kimoto, Kazuna Tanba, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Junya Kuroda Department of Medicine, Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan Abstract: Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially posttransplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis. Eighteen months after achieving second complete remission by salvage immunochemotherapy with rituximab, the patient was complicated by pneumonia, with chest computed tomography finding showing disseminated nodular shadows with ground-glass opacity in both lungs. While empiric antibiotic and antifungal therapies did not improve the pneumonia, polymerase chain reaction–based viral screening tests on his bronchoalveolar lavage fluid detected the presence of HHV-6 DNA, and ganciclovir treatment quickly resolved the pneumonia, indicating that he suffered from HHV-6 pneumonitis. He had no other HHV-6–related end-organ damage, such as encephalitis. This case suggests that, although extremely rare, HHV-6 reactivation should be considered as one of the candidate pathogens for pulmonary complications of uncertain etiology in patients who have been treated with intensive immunosuppressive chemotherapy, even without hematopoietic stem cell transplantation. Furthermore, polymerase chain reaction–based viral screening testing on bronchoalveolar lavage fluid is a powerful diagnostic tool for pneumonitis due to viral reactivation, including HHV-6 reactivation. Keywords: human herpesvirus-6, pneumonitis, viral reactivation, lymphom
Fluorination of Ketones Using Iodotoluene Difluoride
No full textFluorination of ketones was achieved by the reaction of silyl enol ethers with iodotoluene difluoride in the presence of BF3·OEt2 and a Et3N·HF complex
α-Fluorination of β-dicarbonyl compounds using p-iodotoluene difluoride under neutral conditions
No full textA selective introduction of a fluorine atom into the α-position of β-dicarbonyl compounds was achieved using p-iodotoluene difluoride. The reaction proceeded under mild conditions and monofluorination of β-ketoesters, ketoamides, and diketones selectively took place
Semantic web link analysis to discover social relationship in academic communities
No full textTo discover how precisely links among researchers’ Web sites capture the ties of academic communities, this study conducts Web citation analysis. 3,878 Web sites of computer scientists and their 8,811 articles are assessed. 200 most frequently cited researchers from them are subjected to Web author cocitation analysis and compared to bibliographical data. As a result, a cluster of researchers on the Web becomes a superset of bibliographical one, that is, a community representing a larger research field. We then develop Web link ontology that defines various relationships among researchers to apply metadata annotation to the links among 200 sites. Findings: 1) since intellectual ties analysis separates off sociocognitive ties, it results into a better approximation of bibliographical author cocitation, 2) since sociocognitive ties analysis can utilize various links not only coauthor networks, diverse kinds of social connections can be found, 3) merging intellectual ties and sociocognitive ties analyses detect gatekeepers who bridges research fields on social networks. 1
Study of Abū Tālib al-Makkī
No full textThe aims of this thesis are to evaluate the present status of scholarship on Abū Tālib al-Makkī (d. 386/996) and to expand the basis of further research on him by
analysing him in a multi-dimensional way. This study challenges the conventional
view that al-Makkī’s Qūt al-qulūb (‘The Nourishment of Hearts’) is a Sufi work.
Part 1 introduces modern scholarship on al-Makkī. It also demonstrates
several issues which are tackled in this thesis. The present study focuses on a
metaphorical image of the heart, which is also shared in various cultures. By looking
at this common idea, Part 2 first attempts to explore the nature of the Qūt within the
context of Sufism and religion in general. This part provides a summarised
translation of part of the Qūt, where the author elucidates his view of the heart. The
intention of this annotated translation is to provide easy access to the key thought of
al-Makkī in the Qūt, for the first time in English, on the basis of a critical edition of
this book. Lastly Part 2 discusses the authenticity of al-Makkī’s alleged work, Ilm
al-qulūb (‘The Knowledge of Hearts’).
Part 3 analyses the influence of al-Makkī within and beyond Islam.
Considering the limited area of the study of al-Makkī , this part first examines
numerous works in various fields from his time until the twelfth/eighteenth century.
This is to evaluate how he was perceived in Muslim scholarship and to explore areas
which have not been discussed thoroughly before. Finally this thesis looks at the
Andalusian Jewish scholar, Ibn Bāqūdā(d. some time after 472/1080) and his book
al-Hidāya ilā farā'id al-qulūb (‘The Right Guidance to the Religious Duties of
Hearts’). A possible link between the two authors has been sometimes pointed out;
however, it has not been studied exhaustively.
Through exploring various aspects of al-Makkī and his writing, the present
thesis attempts to open up the study of the Qūt beyond Sufism and to offer an
opportunity to give further thought on the essential features of the mystical
dimensions of Islam
Enhancement of Requirements Specification Traceability by Model Driven Requirements Analysis Employing Automatic Prototype Generation
No full textSpecific functions of TGF-beta isoforms in studies of tooth enamel regeneration.
No full text研究成果の概要（和文）：エナメル質形成に関わる重要な生理活性物質の一つであるtransforming growth factor beta (TGF-β)について、そのタンパク質動態と役割について注目して研究を行った。生体内でTGF-βはエナメル形成の初期から成熟期まで幅広く役割を担っているようであるが、本研究では成熟期における各種トランスポーター機構の発現、上皮間葉転換およびアポトーシス誘導（細胞死）に影響を与えている可能性を示した。また同種の３つのTGF-βアイソフォーム毎で異なる応答性を示した。本研究の成果が将来の歯牙再生医療への足掛かりとなることを期待している。研究成果の概要（英文）：Transforming growth factor beta (TGF-β), one of the most important bioactive substances involved in enamel formation, was investigated with a focus on its protein dynamics and role. In vivo, TGF-β appears to play a wide range of roles from the early stages of enamel formation to maturation, and this study showed that it may influence the expression of various transporter mechanisms, epithelial-mesenchymal transition and apoptosis induction (cell death) during the maturation phase. The three TGF-β isoforms of the same species also showed different responses. It is hoped that the results of this study will serve as a stepping stone for future tooth regeneration medicine.・2024(令和6)年度 科学研究費補助金 若手研究 研究成果報告書・研究期間 (年度)：2020-04-01 – 2025-03-31・研究分野：歯学・小児歯科学・口腔生化学・研究成果の学術的意義や社会的意義 : 本研究では、エナメル質形成に関わる重要な生理活性物質の動態や役割について新たな知見を得た。特に、人体の様々な細胞から産生されるTGF-βアイソフォーム間による影響を検証することで、形成不全や腫瘍化に至る異常なシグナルについて明らかとするきっかけを得た。これらの成果は正常なエナメル質形成のメカニズム解明に迫ることのみならず、既に臨床応用されている歯牙・歯周組織再生医療への応用の可能性を秘めている。安全で確かな医学の発展のため、このような確かな基礎研究を土台とした新たな医療技術の構築が可能となれば、その学術的および社会的意義は非常に高い。研究課題/領域番号 : 20K18794research repor
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