696 research outputs found
IMPLEMENTASI METODE SIMA’AN Al-QUR’AN DALAM MENINGKATKAN HAFALAN SANTRI PUTRI PONDOK PESANTREN MAHASISWA AL-HIKAM MALANG
No full textThe Qur\u27anic sima\u27an method is used to maintain and strengthen the memorization of the Qur\u27an, so that the memorization is maintained and smooth. In sima\u27an activities, memorizers can mark verses that have similar sounds, making it easier for them to remember and compare. Pondok Pesantren Mahasiswa Al-Hikam Malang applies this method to help tahfidz students maintain their memorization. This study aims to describe the implementation of the sima\u27an Al-Qur\u27an method in improving the memorization of female tahfidz students in this pesantren, as well as identifying the supporting and inhibiting factors. Using a qualitative approach, this study collected data through interviews, observations, and documentation with data sources from ustadzah, administrators, and female tahfidz students. Analysis techniques include data reduction, data presentation, and conclusion drawing, and data validity is guaranteed by source triangulation. The results showed that the sima\u27an method was applied through ziyadah sima\u27an, muraja\u27ah, and joint sima\u27an activities. Supporting factors include self, parental support, ustadzah guidance, the role of administrators, strong intentions, and remembering the time of sima\u27an. The inhibiting factors include lack of accuracy, looking at the Mushaf when memorizing, laziness, the influence of cellphones, rushing, difficulty managing time, and mutasyabihat verse
Sonocrystallization, Nucleation of ammonium sulfate and alfa-lactose monohydrate due to ultrasonic irradiation
No full textExperiments were conducted to investigate the nucleation of ammonium sulfate and alfa-lactose monohydrate under ultrasonic irradiationIntensified Reaction & Separation SystemsProcess and EnergyMechanical, Maritime and Materials Engineerin
[[alternative]]An in vivo regulatory role of dehydroepiandrosterone in murine TNF-alfa and TGF-beta production
No full text[[abstract]]Dehydroepiandrosterone (DHEA) is a predominant androgen secreted by adrenal cortex. DHEA has been proposed to play an important role in regulating physiological and immunological system in mammals. Our previous report suggested that DHEA caused an enhancement in TNF-alfa and TGF-beta production by both P388D1 cells and peritoneal macrophage under in vitro condition. The specific aim of present study is to investigate whether DHEA have ability to regulate TNF-alfa and TGF-beta production under in vivo condition. Balb/c mice administrated DHEA subcutaneously were sacrificed at 72 hrs after the treatment, then the serum and peritoneal macrophages were collected. The peritoneal macrophages were cultured with LPS for a period of time and the supernatant was then collected. Both TNF-alfa and TGF-b concentration were quantified using ELISA kits. Results suggested that the TNF-alfa secretion by peritoneal macrophages from the mice injected with 50 ug per g body weight and 100 ug per g body weight of DHEA were significantly increased and reached peak 6 hr after incubation. However, the amount of TNF-alfa secretion by macrophages returned to control level when the dose higher than 100 ug per g body weight was given. Result from RT-PCR analysis confirmed the finding that expression of TNF-alfa mRNA was enhanced by in vivo administration of DHEA. By contrast, the serum level of TNF-alfa was not significantly affected by the drug treatment. The TGF-beta secretion by peritoneal macrophages under in vitro culture did not show a significant difference from mice receiving carrier (100 % ethanol). However, the serum level of TGF-beta of mice injected with 100 ug per g body weight of DHEA was significantly lower than the mice received carrier. Dexamethasone is a potent immunosuppressor. Mice injected 1ug per g body weight of dexamethasone showed a significant reduction in TNF-alfa secretion by peritoneal macrophages. However, injection of DHEA together with dexamethasone could overcome the immunosupressive effect of dexamethasone on TNF-alfa secretion. The serum level of TNF-alfa did not show a significant change in dexamethasone treated mice but it showed a significantly increase in the mice received both DHEA and dexamethasone. Mice received dexamethasone showed a significant increase in the serum level of TGF-beta. However, DHEA could not antagonize the augmented effect of dexamethasone on the serum level of TGF-beta. In conclusion, mice injected DHEA potentiated the TNF-alfa production by peritoneal macrophages but decreased the serum level of TGF-beta. Since the effect of DHEA on both TNF-alfa and TGF-beta production might be interfered by other factors under in vivo condition, the effect of DHEA on the serum level of TNF-alfa and the TGF-beta was not significant. In addition, DHEA might be an effective antagonist to overcome the suppressive effect of dexamethasone on TNF-alfa secretion in vivo.
Originator recombinant human follitropin alfa versus recombinant human follitropin alfa biosimilars in Spain: A cost-effectiveness analysis of assisted reproductive technology related to fresh embryo transfers
No full textThis study compared the cost per live birth and cost-effectiveness of the originator recombinant human follicle-stimulating hormone follitropin alfa (r-hFSH-alfa) and r-hFSH-alfa biosimilars for ovarian stimulation prior to assisted reproductive technology treatment in Spain. A decision tree model was developed, comprising pregnancy and live birth for one treatment cycle with fresh embryo transfer. Clinical inputs were based on a recent meta-analysis by Chua et al. [4]. Cost inputs were extracted from publicly available Spanish sources. The costs per live birth were lower with originator r-hFSH-alfa (€18,138) versus r-hFSH-alfa biosimilars (€20,377). The incremental cost-effectiveness ratio was €7208 for originator r-hFSH-alfa versus biosimilars. Drug acquisition costs for originator r-hFSH-alfa represented 10.5% of total costs in the base case analysis, and 6.2% in a treatment cycle resulting in live birth with one fresh embryo transfer. Results from the sensitivity analyses confirmed the robustness of the findings.sponsorship: This study was funded by Merck Healthcare KGaA, Darmstadt, Germany (CrossRef Funder ID:10.13039/100009945). Merck Healthcare KGaA, Darmstadt, Germany, designed and approved thestudy, took part in data collection and data analysis and contributed to the data interpretation and final draft of the manuscript. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. (Merck Healthcare KGaA, Darmstadt, Germany)status: Publishe
Environmental Management System Implementation into the Company Alfa 3, Ltd.
No full textBakalářská práce se zabývá problematikou implementace environmentálního manažerského systému v podniku ALFA 3, s.r.o. První část obsahuje obecnou charakteristiku environmentálního manažerského systému a vystihuje proces zavádění systému do podniku. V druhé části práce je představen podnik ALFA 3, s.r.o. Je zde vytvořen návrh pro implementaci environmentálního manažerského systému do podniku a zhodnocen současný stav, ke kterému jsou přiložena doporučení autorky.The bachelor work deals with questions of the environmental management system implementation into the Company ALFA 3, Ltd. The first part contains the general characteristic of the environmental management system and describes the process of implementation this system into the company. In the second part of the work there is introduced the Company ALFA 3, Ltd. There is created concept for the environmental management system implementation into the company and there is assessed the present state, which the author adds introduction to.Ústav ekonomiky a managementuStudentka seznámila s cíli bakalářské práce. V práci je zpracována implementace environmentálního manažerského systému, deskripce a podpora jeho implementace v podniku ALFA 3, s.r.o. a navržena doporučení pro další rozvoj podniku. Studentka odpověděla na otázky položené vedoucím práce 1. Porovnejte postup zavedení systému řízení jakosti a environmentálního manažerského systému ve sledovaném podniku. 2. Naznačte další vývoj v této oblasti. Jak je v podniku řešena problematika BOZP? Plánuje podnik zavedení integrovaného systému řízení?Dokončená práce s úspěšnou obhajobo
THE WOMEN CHARACTERS OF JUAN VALERA
No full textRights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Downloaded 18-Sep-2016 14:26:2
Human protein C concentrate in the treatment of purpura fulminans : a retrospective analysis of safety and outcome in 94 pediatric patients
No full textIntroduction: Purpura fulminans (PF) is a devastating complication of uncontrolled systemic inflammation, associated with high incidence of amputations, skin grafts and death. In this study, we aimed to clarify the clinical profile of pediatric patients with PF who improved with protein C (PC) treatment, explore treatment effects and safety, and to refine the prognostic significance of protein C plasma levels. Methods: In Germany, patients receiving protein C concentrate (Ceprotin(R), Baxter AG, Vienna, Austria) are registered. The database was used to locate all pediatric patients with PF treated with PC from 2002 to 2005 for this National, retrospective, multi-centered study. Results: Complete datasets were acquired in 94 patients, treated in 46 centers with human, non-activated protein C concentrate for purpura fulminans. PC was given for 2 days (median, range 1-24 days) with a median daily dose of 100 IU/kg. Plasma protein C levels increased from a median of 27% to a median of 71% under treatment. 22.3% of patients died, 77.7% survived to discharge. Skin grafts were required in 9.6%, amputations in 5.3%. PF recovered or improved in 79.8%, remained unchanged in 13.8% and deteriorated in 6.4%. Four adverse events occurred in 3 patients, none classified as severe. Non-survivors had lower protein C plasma levels (P < 0.05) and higher prevalence of coagulopathy at admission (P < 0.01). Time between admission and start of PC substitution was longer in patients who died compared to survivors (P = 0.03). Conclusions: This retrospective dataset shows that, compared to historic controls, only few pediatric patients with PF under PC substitution needed dermatoplasty and/or amputations. Apart from epistaxis, no bleeding was observed. Although the data comes from a retrospective study, the evidence we present suggests that PC had a beneficial impact on the need for dermatoplasty and amputations, pointing to the potential value of carrying out a prospective randomised controlled trial
Performance Improvement Analysis of Alfa 6 Stone Crusher Unit Using RCM2 Method
No full textSeiring dengan pertumbuhan Indonesia, bertumbuh pula infrastrukturnya, dan dengan tumbuhnya infrastruktur tersebut muncullah permintaan akan bahan bangunan, termasuk didalamnya batu andesit, untuk memenuhi permintaan tersebut ada beberapa tambang yang menambang dan mengolah batu tersebut, salah satunya adalah PT. Alfa Granitama, tugas akhir ini akan berfokus pada perawatan salah satu sistem crusher yang dimiliki oleh PT. Alfa Granitama, khususnya sistem crusher alfa 6. Crusher alfa 6 saat ini beroperasi di bawah target produktivitas yang ditetapkan oleh perusahaan, tugas akhir ini bertujuan untuk meringankan masalah tersebut dengan mengusulkan peningkatan ketersediaan crusher alfa 6 dengan meminimalkan waktu henti yang disebabkan oleh masalah pemeliharaan. Meningkatkan ketersediaan crusher alfa 6 diharapkan akan meningkatkan jumlah batu yang dapat diproses oleh perusahaan, untuk mengurangi waktu henti yang disebabkan oleh pemeliharaan, tesis ini akan menggunakan metode Reliability Centered Maintenance 2 (RCM 2) dengan harapan dapat meningkatkan keandalan unit penghancur batu alfa 6, penulis juga akan melihat ketersediaan saat ini dan menggunakan alat lain seperti diagram pareto untuk memberikan gambaran yang lebih jelas dan menggunakan temuan penelitian untuk memberikan saran perbaikan.
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As Indonesia grow, so does its infrastructure, and with the infrastructure grows come demand for construction materials not least of which is andesite stone, in order to fulfill this demand there are quarries that mine and process such stone, one of them is PT. Alfa Granitama, this thesis will focus on the maintenance of one of the crusher system owned by PT. Alfa Granitama, specifically the alfa 6 crusher system. The alfa 6 crusher is currently operating under the productivity target set by the company, this thesis aim to alleviate the issue by proposing to increase the availability of the alfa 6 crusher by minimizing the downtime caused by maintenance issues. Increasing the availability of the alfa 6 crusher would increase the amount of stone that could be processed by the company, in order to reduce the downtime caused by maintenance this thesis will use Reliability Centered Maintenance 2 (RCM 2) method in hopes of improving the reliability of Alfa 6 stone crusher unit, the author will also look at the current availability and use other tools such as pareto diagram to give a clearer picture and use the findings to give improvement suggestions
Entrepreneurial Features of the Small Companies’ Employees – on the Example of the Alfa Enterprise
No full textIt was indicated in the article, that entrepreneurial features characterize the
owner, people on managerial positions, as well as regular workers employed by the
Alfa enterprise. Employees’ entrepreneurial attributes in most cases coincide with
the attributes of the owner, which contributes to building the enterprises’ market
value. The obtained conclusions are an inspiration to the author in marking the direction
of further research and a basis for an invitation to a discussion for all the
people interested in this issu
Logistic flows at Alfa Laval - An analysis of the possibilities for optimizing Alfa Laval's airborne freight flows.
No full textAt Alfa Laval there are about 400 000 shipments every year that either go by sea, air, rail or road freight. To date there is no company strategy covering the entire transport domain although there are a lot of projects working on different parts of the problem. The question is how to optimise the transportation system at Alfa Laval and to do that without increasing the transport cost for the company. The problem with delays and possibility for different transport modes will also be addressed. To do this the author has first distinguish the geographical transportation flows to find an applicable area. Then find a suitable theory for optimising the rate between the transportation systems and in the end apply theories on the existing transportation pattern and recommend changes in the freight flows. The geographical partitioning has resulted in a production site in Tumba, Sweden, and was selected as a representative. Furthermore, the analysis has been done on the freights sent by air, both standard and express, to the largest recipients in Asia. The analysis shows that if there is a possibility to change between the different modes of transport an increase in the DOT, delivery-on-time, can be accomplished with 4,4% in average for the freights sent between the different areas
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