97 research outputs found
Microfossils from the Neogene deposits in the islands of Okinawa, Kume, and Ogami
No full textThe author reports pollen grains and spores from the Neogene Shiojiri Group in the islands of Okinawa, Kume. and Ogami. The number of the pollen grains and spores found is a few. The characteristics of each spore-pollen assemblage are closely similar: Palmae pollen grain of the Monocolpate type is excessively scarce. The appearance of the Tricolpate Quercus pollen grains shows relatively low percentage. In spite of such low percentage of the appearance of Palmae and Quercus, the spectrum does not show the expected increase of the pollen grains of Betulaceae, Juglandaceae, Ulmaceae etc. For the present this spore-pollen spectrum will be compared with that of the Yaeyama Group of the Iriomote island
Promoter Elements and Factors Involved In Hepatic Transcription of the Human Apoa-i Gene Positive and Negative Regulators Bind To Overlapping Sites
No full textDNase I footprinting analysis of the proximal apoA-I promoter sequences with rat liver nuclear extracts identified four protected regions: A, -22 to +17; B, -128 to -77; C, -175 to -148; and D, -220 to -190. Region D (-220 to -190) binds at least two distinct activities, designated AID1 and AID2, respectively, which can be separated by ion exchange chromatography. Region C (-175 to -148) forms five DNA protein complexes. Three of the complexes (2, 4, and 5) originate from the binding of more than one heat-stable nuclear factor, and two (1 and 3), from the binding of two heat-labile factors. The heat-stable factors bind in the -175 to -148 region and can be distinguished from C/EBP, which recognizes the same region, with DNA binding gel electrophoretic assays. Both factors 1 and 3 bind in the -168 to -148 apoA-I region. Despite the lack of a CCAAT motif in this region, the binding of factor 1 is competed out by oligonucleotides containing the binding sites of NFY and NFY*. Mutagenesis of the promoter region showed that mutations in the -171 to -166 and -158 to -153 regions diminished the binding of the heat-stable factors and reduced hepatic transcription to 14 and 8% of control, respectively. In contrast, a mutation in the -164 to -159 region abolished the binding of factor 1 and was associated with a 4.6-fold increase in hepatic transcription. These findings suggest that the heat-stable factors act as positive regulators, whereas factor 1 acts as a negative regulator in apoA-I gene transcription
Exploration of optimal dosing regimens with linezolid for renal impairment patients
No full text富山大学博士（医学）Article富山大学・富医薬博甲第383号・川筋 仁史・2022/03/23
公開論文
1.Kawasuji, H., Tsuji, Y., Ogami, C. et al. Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients. BMC Pharmacol Toxicol 22, 13 (2021). https://doi.org/10.1186/s40360-021-00479-w
2.Kawasuji, H.; Tsuji, Y.; Ogami, C.; Kaneda, M.; Murai, Y.; Kimoto, K.; Ueno, A.; Miyajima, Y.; Fukui, Y.; Sakamaki, I.; Yamamoto, Y. Initially Reduced Linezolid Dosing Regimen to Prevent Thrombocytopenia in Hemodialysis Patients. Antibiotics 2021, 10, 496. https://doi.org/10.3390/antibiotics1005049
A three-dimensional source-vorticity method for simulating incompressible potential flows around a deforming body without the Kutta condition
No full textFor predicting three-dimensional incompressible potential flows around a body accompanied by a wake vortex, surface singularity methods (i.e., panel methods) have been employed extensively, owing to their ease of use and low solution times. In the case of lifting/vortical flow, the Kutta condition is applied, in order to insure smooth flow at the trailing edge. However, the Kutta condition is inapplicable in the case of blunt bodies. For this reason, a three-dimensional source-vorticity method for simulating incompressible potential flows around a deforming body without using the Kutta condition is presented. For lifting/vortical flows, three components of the surface vorticity vectors are placed on the panels instead of the doublet as the unknowns. In place of the Kutta condition, additional equations are employed for determining the total circulations for the three vorticity components about the body. To validate the proposed method, simple examples, such as a sphere in a uniform flow and a sphere in an accelerated flow, are treated as non-lifting/non-vortical cases. For lifting/vortical cases where the Kutta condition cannot be applied, a rotating sphere in a uniform flow and a sphere with a vortex ring are considered. To assess the accuracy of the proposed method, the numerical results are compared with the analytical solutions. Finally, to highlight the applicability of the method in the case of unsteady lifting/vortical flow and to show its versatility as well as suitability in treating deforming bodies, a swimming great white shark is simulated with and without the wake vortex. Based on the results obtained in the absence of the wake vortex, it was found that, even in an inviscid flow, a thrust force is produced by the movement of the shark. Further, the results obtained for the case where a wake vortex was shed from the tail fin suggested that the wake vortex sheets decrease the amplitude of the side force and increase that of the thrust force. © 2017 The Author(s)journal articl
沖縄･久米･大神の新第三紀層産微化石
No full textThe author reports pollen grains and spores from the Neogene Shiojiri Group in the islands of Okinawa, Kume. and Ogami. The number of the pollen grains and spores found is a few. The characteristics of each spore-pollen assemblage are closely similar: Palmae pollen grain of the Monocolpate type is excessively scarce. The appearance of the Tricolpate Quercus pollen grains shows relatively low percentage. In spite of such low percentage of the appearance of Palmae and Quercus, the spectrum does not show the expected increase of the pollen grains of Betulaceae, Juglandaceae, Ulmaceae etc. For the present this spore-pollen spectrum will be compared with that of the Yaeyama Group of the Iriomote island.長崎大学教養部紀要. 自然科学. 1968, 8, p.32-38departmental bulletin pape
Dissimilarity between Heat and Momentum Transport for the Turbulent Stripes in Transitional Plane Couette Flow
No full textANALYSIS OF ENERGY SPECTRA BY THE VORTEX METHOD WITH ARTIFICIAL TURBULENCE
No full textFirst, in order to use as an inlet condition for turbulent simulation, a method is presented
which produces numerically an artificial turbulence, namely, a series of velocity fluctuations
of which frequency is Gaussian, and energy spectrum and root mean square correspond to
the given ones. Besides, the fluctuation data are determined by the characteristic parameters
of turbulent flows such as the inlet mean velocity, the kinematic viscosity, the Kolmogorov
scale and the integral time scale. Our examples show excellent accuracy and flexibility of
the method. Secondly, the vortex method has been studied to see the ability of the method
to deal with turbulent flows. It is found that the energy spectra produced by this agree well
with the ones given as the inlet condition, and that the vortex method is able to produce
turbulent flows with the given parameters described above
Influence of chewing on expression level of human beta-defensin 2 and secretory immunoglobulin A in the epithelium
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