650 research outputs found
The influence of social processes on the timing of cancer diagnosis: a research agenda
No full textThis paper sets out to review the influence of social processes on the timing of the diagnosis of cancer and to explore the potential for promoting earlier diagnosis by addressing social factors that influence symptom recognition and the diagnostic process. Social processes refer to the means by which culture and social organisation may impact on timely cancer diagnosis. The paper calls for concerted action around an important and developing research agenda that may prove highly valuable in the quest to secure prompt diagnosis for cancer and through it improved outcomes for individuals. <br/
Brachylabis lenkoi Brindle 1968
No full textBrachylabis lenkoi Brindle, 1968a: 32, figs 1–2. Type material 2 ♂♂, paratypes, F3233.1424–1425, dried, mounted on card. Locality labels F3233.1424–1425: Barueri / SP, Brazil / 20.VIII.1967 / K. Lenko col. Taxonomy Anisolabididae, Brachylabidinae, Brachylabis lenkoi Brindle, 1968. Remark Index card entry: Sao Paolo.Published as part of Miles, Claire, 2015, The Earwig Collection (Dermaptera) of the Manchester Museum, UK, with a complete type catalogue, pp. 1-138 in European Journal of Taxonomy 141 on pages 72-73, DOI: 10.5852/ejt.2015.141, http://zenodo.org/record/382783
Nala saegeri Brindle 1968
No full textNala saegeri Brindle, 1968e: 21, figs 11–12. Type material 2 ♂♂, paratypes, F3233.1495, F3233.1497; 2 ♀♀, paratypes, F3233.1496, F3233.1498; dried, mounted on card. Locality labels F3233.1495, F3233.1497: Congo belge, P. N. G. / Miss. H. De Saeger / K. 17, 18-iv-1950 / Réc. H. De Saeger. 432. F3233.1496: Ssame data except date and number, 10 May 1950 and 504. F3233.1498: Same data as F3233.1496 except number, 506. Taxonomy Labiduridae, Nalinae, Nala saegeri Brindle, 1968.Published as part of Miles, Claire, 2015, The Earwig Collection (Dermaptera) of the Manchester Museum, UK, with a complete type catalogue, pp. 1-138 in European Journal of Taxonomy 141 on page 102, DOI: 10.5852/ejt.2015.141, http://zenodo.org/record/382783
Skalistes lucasi Brindle 1974
No full text<p> <i>Skalistes lucasi</i> Brindle, 1974 a: 5, figs 1–4.</p> Type material <p>4 ♂♂, paratypes, F3233.1785–1788; 4 ♀♀, paratypes, F3233.1789–1792; dried, mounted on pin.</p> Locality labels <p> F3233.1785, F3233.1789: Mexico: Chiapas-Oaxaca / border, 21 km W. Rizo / de Oro along ridge SE Cerro Baul, 1615 m. / 8-IX-1972, K. E. Lucas / within <i>Tillandisa</i> sp.</p> <p> F3233.1791: Same data except ‘within <i>Tillandsia guatamalensis</i> / specimen #: B3-’.</p> <p> F3233.1786: Same data except ‘within <i>Vriesia</i> sp’.</p> <p> F3233.1792: Same data except ‘within epiphytic <i>Vriesia</i> sp. / specimen #: B3-’.</p> <p>F3233.1787–1788, F3233.1790: Same data as F233.1792 except date 8 Jan. 1973.</p> Taxonomy <p> Forficulidae, Forficulinae, <i>Skalistes lucasi</i> Brindle, 1974.</p>Published as part of <i>Miles, Claire, 2015, The Earwig Collection (Dermaptera) of the Manchester Museum, UK, with a complete type catalogue, pp. 1-138 in European Journal of Taxonomy 141</i> on page 74, DOI: 10.5852/ejt.2015.141, <a href="http://zenodo.org/record/3827836">http://zenodo.org/record/3827836</a>
Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
No full textChantier qualité GAInternational audienceDifferential expression of the ASIP gene and its interaction with MC1R have provided basic insight into pigment-type switching in mammals. Here, we report the characterization of a specific red-haired skin transcript and a specific black-haired skin transcript in the ASIP gene in the black-and-tan Doberman Pinscher. It is also shown that the brindle-haired skin of the Boxer exhibits a deregulated expression resulting in various 5'-untranslated exons. Comparative sequence analysis revealed a short interspersed element and a poly(A) stretch inserted within the promoter region of the ASIP in the Boxer. Genotyping studies have shown that both insertions are also present in brindle and fawn animals of the Boxer and Great Dane breeds. Furthermore, we genotyped MC1R and K loci for their known variants that affect coat color in dogs. As expected, all animals were homozygotes (E(M) /E(M) ) for the mask mutation, and fawn animals were k(y) /k(y) . Unexpectedly, we found that all brindle animals were heterozygotes k(B) /k(y) . Our results suggest that differential expression of ASIP determine pigment-type switching in a MC1R and K allele-dependent manner in dogs
Mc1r, Agouti signaling protein (ASIP) and CBD103 are involved in brindle coat colour of Boxer and Great Dane dogs
No full textIn most mammals, variations in skin and hair colour (brown/black eumelanin and the red/yellow phaeomelanin) are mainly achieved by the interaction between two genes: Agouti signaling protein (ASIP) and melanocortin 1 receptor (Mc1r) encoding a ligand-receptor system that controls the eumelanin/pheomelanin switching. In domestic dogs, pigment type-switching is also controlled by an unexpected allele (CBD103) of K locus encoding a secreted protein (β-defensin) previously studied for its role in immunity. Interaction studies reveal that Mc1r is epistatic to variation at
Agouti and K loci. In this work, we examined Mc1r, ASIP and CBD103 as candidate genes for brindle or fawn Boxer and Great Dane animals. The brindle phenotype in domestic dogs consists of an irregular pattern of red-yellow stripes alternating with black-brown. We found that all brindle dogs are heterozygous for ΔG23 mutation
previously reported by Barsh’s team. In addition, we report for the fi rst time two interesting insertions in Agouti promoter region. The innovation of this work is the discovery of new alternative transcripts of Agouti that could be involved in brindle coat colour pattern in dogs. The interaction between CBD103 mutation and Agouti insertions promoting the different transcripts is discussed. This can be a starting point in better understanding their involvement in pigment switching leading to the brindle pattern formation
Caracterization of different 5’ ultranslated exons of the ASIP gene in blak-and-tan Doberman Pinscher and brindle Boxer dogs
No full textDifferential expression of the ASIP gene and its interaction with MC1R have provided basic insight into pigment-type switching in mammals. Here, we report the characterization of a specific red-haired skin transcript and a specific black-haired skin transcript in the ASIP gene in the black-and-tan Doberman Pinscher. It is also shown that the brindle-haired skin of the Boxer exhibits a deregulated expression resulting in various 5'-untranslated exons. Comparative sequence analysis revealed a short interspersed element and a poly(A) stretch inserted within the promoter region of the ASIP in the Boxer. Genotyping studies have shown that both insertions are also present in brindle and fawn animals of the Boxer and Great Dane breeds. Furthermore, we genotyped MC1R and K loci for their known variants that affect coat color in dogs. As expected, all animals were homozygotes (E(M) /E(M) ) for the mask mutation, and fawn animals were k(y) /k(y) . Unexpectedly, we found that all brindle animals were heterozygotes k(B) /k(y) . Our results suggest that differential expression of ASIP determine pigment-type switching in a MC1R and K allele-dependent manner in dogs
Penerapan Sistem Komposisi Serial Pada “El Polifemo de Oro” untuk Gitar Karya Reginald Smith Brindle (1917-2003)
No full textKarya El Polifemo de Oro merupakan salah satu repertoar gitar klasik yang menggunakan penerapan sistem serial pada komposisinya. Karya tersebut diciptakan oleh Reginald Smith Brindle seorang komponis dari Inggris. Penulis menggunakan metode Teoritikal dalam melakukan penelitian, yaitu menggunakan suatu teori untuk menganalisis karya tersebut. Di dalam skripsi ini dituliskan mengenai penerapan sistem serial pada El Polifemo de Oro, teori-teori sistem serial, dan macam-macam sistem serial. Hasil penelitian menunjukkan bahwa El Polifemo de Oro menggunakan sistem serial campuran atau biasa disebut free serialism sistem. The work of El Polifemo de Oro is one of the classical guitar repertoire which using the serialism in its compotition. The work was created by Reginald Smith Brindle a British composer. The author uses a Theoretical method of research into research, using many of theories to analyze the work. Studies indicate that work was proven to be using “free serialism system”.Keywords: El Polifemo de Oro; Reginald Smith Brindle; Serialis
Characterization of different 5’-untraslated exons of ASIP gene in black-and tan Doberman Pinsher and brindle Boxer dogs
No full textDifferential expression of the ASIP gene and its interaction with MC1R have provided basic insight into pigment-type switching in mammals. Here, we report the characterization of a specific red-haired skin transcript and a specific black-haired skin transcript in the ASIP gene in the black-and-tan Doberman Pinscher. It is also shown that the brindle-haired skin of the Boxer exhibits a deregulated expression resulting in various 5′-untranslated exons. Comparative sequence analysis revealed a short interspersed element and a poly(A) stretch inserted within the promoter region of the ASIP in the Boxer. Genotyping studies have shown that both insertions are also present in brindle and fawn animals of the Boxer and Great Dane breeds. Furthermore, we genotyped MC1R and K loci for their known variants that affect coat color in dogs. As expected, all animals were homozygotes (EM/EM) for the mask mutation, and fawn animals were ky/ky. Unexpectedly, we found that all brindle animals were heterozygotes kB/ky. Our results suggest that differential expression of ASIP determine pigment-type switching in a MC1R and K allele-dependent manner in dogs
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