86 research outputs found
ExPDrug: Integration of an interpretable neural network and knowledge graph for pathway-based drug repurposing
No full texthttp://dx.doi.org/10.13039/501100003653 Korea National Institute of Healthhttp://dx.doi.org/10.13039/501100014188 Korea Ministry of Science and IC
Reflections of a disk-less Inuk on Canada’s Eskimo identification system
No full textThis essay examines the reactions of several Inuit women to an identification system whereby from 1941 to 1978 the Canadian government required the Inuit to wear small numbered disks. The author presents each Inuk woman’s personal perspectives, including her own, through narratives, interviews, and songs. The second part discusses the historical context of the “Eskimo disk list” system and its repercussions decades after it was discontinued.Cet essai examine les réactions de plusieurs femmes inuit devant un système d’identification que le gouvernement canadien imposa aux Inuit de 1941 à 1978: ceux-ci devaient porter un petit disque sur lequel figurait le numéro qui leur avait été attribué. L’auteure présente le point de vue personnel de chacune de ces femmes inuit, incluant le sien, à travers des récits, des entrevues et des chansons. La deuxième partie discute du contexte historique du système «des numéros de disques inuit» et de ses répercussions plusieurs décennies après son abandon
Corrigendum: MONTI: A Multi-Omics Non-Negative Tensor Decomposition Framework for Gene-Level Integrative Analysis (Front. Genet, (2021), 12, (682841), 10.3389/fgene.2021.682841)
No full textCopyright © 2021 Jung, Kim, Rhee, Lim and Kim.There is an error in the Funding statement. The correct number for the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education is 2020M3C9A5085604. Corrected statement is given below:N
Atauttikkut: Combining home and research
No full textMy experience as an Inuk graduate student working in my hometown has taught me many lessons. It is not as simple as being Indigenous to be able to do good research in the Arctic. There are also risks taken when we decide to work in the same place that we grew up. In this chapter, I discuss doing marine mammal research in my home community of Iqaluit, Nunavut and reflect on what it is like to conduct fieldwork in the Arctic as an Inuk researcher
Qivittoq ja Arnaq : grönlantilaisten tarinoiden arkkityyppiset hahmot
No full textPro gradu -tutkielmassani tulkitsen videoteoksiani C. G. Jungin arkkityyppiteorian mukaan. Videoteosteni aiheina ovat grönlantilaisen miehen isoisän ja isoisoisien mystiset kokemukset. Tutkielmassani pohdin, millaisia arkkityyppisiä hahmoja, symboleja ja ilmiöitä videoteoksissani esiintyy, ja mitä ne Jungin teorian mukaan merkitsevät isoisille. Pohdin myös miten jungilaista metodia voisi käyttää työkaluna kuvataidetunnilla. Tutkielmani tarkoituksena on mahdollisesti synnyttää uutta kulttuurista tietoa, jota kuvataideopettajat voivat tarpeen tullen käyttää opetusmateriaalinaan kuvataidetunneilla, sekä havainnollistaa, miten Jungin arkkityyppiteoriaa voi käyttää kuvan visuaalisen kulttuurin rakenteen ja sisällön tutkimisessa.
Kevään 2008 Qivittoq – Wanderer-, kevään 2009 Arnaq – Woman- ja Inuk alla – Different Human -videoteokset kertovat erilaisista ihmisistä, kuten yliluonnollisia voimia omaavasta naisesta ja qivittoqeista, eräänlaisista vaeltajista. Kiinnostuin tutkimaan videoteoksiani niiden mielenkiintoisten tarinoiden vuoksi ja halusin viedä pitkäkestoisen taiteellisen prosessini astetta syvemmälle. Tutkielmani on laadullinen tapaustutkimus, jossa Jungin metodin kautta tutkin aineistoa soveltaen teorialähtöistä sisällönanalyysia hakien aineistosta aiheita temaattisesti, sekä soveltaen M-L von Franzin satuanalyysia.
Qivittoq – Wanderer -teoksessa isoisoisän kohtaama qivittoq merkitsi hänelle piilotajuista halua aloittaa identifioitumis- ja individuaatio-prosessi varjo- ja vaeltaja-arkkityyppien kautta. Arnaq – Woman -teoksessa poliisipäällikön tapaaman anima-, äiti- ja noita-arkkityypin tehtävinä oli osoittaa poliisipäällikön henkinen sekamelska ja huono asenne. Inuk alla – Different Human -teoksessa isoisoisä kohtasi henki- ja Itse-arkkityypit papin ja qivittoqin välityksellä. Näiden arkkityyppien tehtävinä oli ilmaista isoisoisän piilotajuisen puolen tasapainottamista tietoisella puolella eli isoisoisä oli individuaatio-prosessin viimeisessä vaiheessa. Kuvataidetunnilla jungilaista metodia voisi soveltaa unien kautta, joista voi ammentaa piilotajunnan rikasta ainesta luovuuden harjoittamiseen ja mielikuvien rikastamiseen. Tutkielmani avasi laaja-alaisesti qivittoq-hahmon olemusta ja havainnollisti Jungin metodin käyttämistä taiteentutkimuksessa.In master`s thesis I interpret my short films by C. G. Jung`s theory of archetypes. Motifs of short films are about a greenlandic man´s grandfathers and great grandfather´s mystical experiences. I study which kind of archetypal figures, symbols, motifs and phenomenons these short films display and what they symbolize to grandfathers. I probe also how to use the method of Jung as a tool in fine arts classes. Purpose of this master`s thesis is to potentially create a new cultural knowledge which art teachers have possibility to use in their teaching work as teaching material. To illustrate how to practice Jung` s theory of archetypes in inquire of pictures visual, cultural structure and content.
Spring 2008 Qivittoq – Wanderer and spring 2009 Arnaq – Woman and Inuk alla – Different Human short films are telling about the meeting with special human beings, like mystical women and qivittoqs – certain kind of wanderers. I got interested of examining my short films for their interesting stories and I wanted to go deeper in my long lasting artistic process. In this qualitative case study master`s thesis I scrutinize the material by Jung`s method and apply theory-based content analysis by picking up thematically the motifs from the video material. I also partly apply M-L von Franz`s analysis of fairy tales.
In the short film Qivittoq – Wanderer great grandfather meets qivittoq and qivittoq signifies to the great grandfather`s will to begin his identification and individuation process by shadow and wanderer archetypes. In a short film Arnaq – Woman police officer encounters through the mystical woman his anima, mother and witch archetypes which indicate the police officer`s bad attitude or mental disorder. In a short film Inuk alla – Different Human great grandfather meets his spirit and Self archetype by the qivittoq and priest, which symbolize to the great grandfather`s unconscious side by balancing it with the conscious – great grandfather is at the end of individuation process. Jung`s method can be applied in art classes by using dreams which are the one way to catch material from unconsciousness into practicing creativity and enriching vizualization. My master`s thesis enlarged the image of qivittoq and illustrated how to use Jung`s method in art research
Braiding Voices: The Hybrid Musical Identity of Inuk Soprano Deantha Edmunds
No full textThis dissertation investigates the musical identity of Inuk soprano, Deantha Edmunds. The Truth and Reconciliation Commission of Canada has issued Calls to Action for Indigenous language and culture, which extend to music institutions. Western art music academies hold a hegemonic power over the telling of Canadian music history and performance practice, effectively gatekeeping music at the highest academic level. Consequently, Edmunds’ music has been periodically met with confusion. Therefore, this study focuses on Edmunds’ hybrid musical identity, demonstrating the significance and resistance of her compositions and performances. As an embedded case study, this dissertation centres on Edmunds’ performance career, studying how her performances question early music performance practice and challenge Western art music listeners. This qualitative methodology illustrates that Edmunds enacts Calls to Action through her compositions and performances, a claim which is triangulated by personal interviews with Edmunds conducted by the author, literature reviews of the history and music of the Moravian Inuit, Indigenous sound studies, identity politics, and the music aesthetics of Truth and Reconciliation. Edmunds consistently uses her talent and position to uplift Inuit music traditions, and this research amplifies Edmund’s aspirations for Truth and Reconciliation through music.
Key findings reveal that Edmunds’ compositions and performances reclaim and redefine the colonial construct of music performance. Her compositions, such as her album Connections (2022) and her song-cycle Angmalukisaa 2024, braid Indigenous aesthetics into Western art music, reaffirming historically discounted Inuit voices. For authentic Inuit translations, Edmunds turns to Inuit Elders for guidance, deepening her connection to her community and furthering her efforts for language revitalization. Her music and storytelling are rooted in Indigenous history, promoting Truth and Reconciliation.
This research was made possible by Edmunds’ generous engagement with non-Indigenous listeners. This dissertation argues that Edmund’s music effectively reorients the definition of performance in Western art music. Leveraging her positionality, Edmunds creates a pathway to resilience for future Indigenous generations, especially her daughter Annabelle, whom she includes in her performances. In this way, Edmunds creates a living legacy that incites further research on listening positionality, performance theories, music scholarship, and Indigenous studies.D.M.A
TimesVector-Web: A Web Service for Analysing Time Course Transcriptome Data with Multiple Conditions
No full textFrom time course gene expression data, we may identify genes that modulate in a certain pattern across time. Such patterns are advantageous to investigate the transcriptomic response to a certain condition. Especially, it is of interest to compare two or more conditions to detect gene expression patterns that significantly differ between them. Time course analysis can become difficult using traditional differentially expressed gene (DEG) analysis methods since they are based on pair-wise sample comparison instead of a series of time points. Most importantly, the related tools are mostly available as local Software, requiring technical expertise. Here, we present TimesVector-web, which is an easy to use web service for analysing time course gene expression data with multiple conditions. The web-service was developed to (1) alleviate the burden for analyzing multi-class time course data and (2) provide downstream analysis on the results for biological interpretation including TF, miRNA target, gene ontology and pathway analysis. TimesVector-web was validated using three case studies that use both microarray and RNA-seq time course data and showed that the results captured important biological findings from the original studies
A review on multi-omics integration for aiding study design of large scale TCGA cancer datasets
No full textAbstract Background Rapid advancements in high-throughput sequencing technologies allow for detailed and accurate measurement of omics features within their biological context. The integration of different omics types creates heterogeneous datasets, presenting challenges in analysis due to variations in measurement units, sample numbers, and features. Currently, there is a lack of generalized guidelines for making decisions in multi-omics study design (MOSD), such as selecting an appropriate number of samples and features, type of preprocessing and integration for robust analysis results. We propose a suggestive guideline for MOSD, involving nine important factors: sample size, feature selection, preprocessing strategy, noise characterization, class balance, number of classes, cancer subtype combination, omics combination, and clinical features. Results To assess the effectiveness of our proposed MOSD guidelines, we designed and conducted seven benchmark tests using 10 clustering methods on various TCGA cancer datasets with an objective of clustering cancer subtypes. The results indicated robust performance in terms of cancer subtype discrimination when adhering to the following criteria: 26 or more samples per class, selecting less than 10% of omics features, maintaining a sample balance under a 3:1 ratio, and keeping the noise level below 30%. Feature selection was particularly important, improving clustering performance by 34%. Conclusion These findings provide evidence-based recommendations for MOSD, enabling researchers to optimize analytical approaches and enhance the reliability of results across cancer datasets. The proposed MOSD framework offers a suggestive guideline addressing both computational and biological factors for multi-omics data integration
An Improved Cross-Layering Design for IPv6 Fast Handover with IEEE 802.16m Entry Before Break Handover
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