527 research outputs found
Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5
No full textIn vitro and in vivo toxicological evaluation of acyl glucuronides
No full text金沢大学博士(創薬科学)博士論文本文Full 以下に掲載：Toxicology in Vitro 30(1) pp.241-249 2015. Elsevier. 共著者：Atsushi Iwamura, Masahito Ito, Hideaki Mitsui, Jun Hasegawa, Keigo Kosaka, Ichiro Kino, Minoru Tsuda, Miki Nakajima, Tsuyoshi Yokoi, Toshiyuki Kumedoctoral thesi
ABO Blood Type and Risk of Peyronie’s Disease in Japanese Males
No full textPurpose: Although multiple mechanisms associated with Peyronie’s disease (PD) have been proposed, details regarding etiologic factors, especially genetic, remain unclear. We examined the relationship of the ABO blood type system, known as a
genetic factor associated with susceptibility to a number of diseases, with PD in Japanese males.
Materials and Methods: We compared 202 Japanese PD patients treated with surgery at our hospital between March 2004 and December 2019 with 846 randomly selected non-PD male patients who underwent urological surgery during the same period regarding distribution of ABO blood types. In addition, we assessed the risk of PD according to blood type group
among all study participants using odds ratio (OR) and 95% confidence interval (CI) calculations.
Results: The distribution of individual blood types in the control group was nearly the same as that in the general Japanese population. In contrast, O, A, B, and AB blood types were noted in 37.6%, 36.1%, 14.9% and 11.4%, respectively, of the PD patients, which was significantly different from the control group, where blood type O was found in 29.1% and B in 23.2% (p<0.05). Our results showed that as compared with patients with blood group B, those with another blood type were more likely to develop PD, among which type O had a significantly increased OR of 2.018 (CI, 1.271–3.205).
Conclusions: These are the first reported results showing that ABO blood type may be associated with risk of PD, though further investigations are needed
ABO Blood Type and Risk of Peyronie’s Disease in Japanese Males
No full textPurpose: Although multiple mechanisms associated with Peyronie’s disease (PD) have been proposed, details regarding etiologic factors, especially genetic, remain unclear. We examined the relationship of the ABO blood type system, known as a
genetic factor associated with susceptibility to a number of diseases, with PD in Japanese males.
Materials and Methods: We compared 202 Japanese PD patients treated with surgery at our hospital between March 2004 and December 2019 with 846 randomly selected non-PD male patients who underwent urological surgery during the same
period regarding distribution of ABO blood types. In addition, we assessed the risk of PD according to blood type group among all study participants using odds ratio (OR) and 95% confidence interval (CI) calculations.
Results: The distribution of individual blood types in the control group was nearly the same as that in the general Japanese population. In contrast, O, A, B, and AB blood types were noted in 37.6%, 36.1%, 14.9% and 11.4%, respectively, of the PD
patients, which was significantly different from the control group, where blood type O was found in 29.1% and B in 23.2% (p<0.05). Our results showed that as compared with patients with blood group B, those with another blood type were more
likely to develop PD, among which type O had a significantly increased OR of 2.018 (CI, 1.271–3.205).
Conclusions: These are the first reported results showing that ABO blood type may be associated with risk of PD, though further investigations are needed
ABO Blood Type and Risk of Peyronie’s Disease in Japanese Males
No full textPurpose: Although multiple mechanisms associated with Peyronie’s disease (PD) have been proposed, details regarding etiologic factors, especially genetic, remain unclear. We examined the relationship of the ABO blood type system, known as a
genetic factor associated with susceptibility to a number of diseases, with PD in Japanese males.
Materials and Methods: We compared 202 Japanese PD patients treated with surgery at our hospital between March 2004 and December 2019 with 846 randomly selected non-PD male patients who underwent urological surgery during the same
period regarding distribution of ABO blood types. In addition, we assessed the risk of PD according to blood type group among all study participants using odds ratio (OR) and 95% confidence interval (CI) calculations.
Results: The distribution of individual blood types in the control group was nearly the same as that in the general Japanese population. In contrast, O, A, B, and AB blood types were noted in 37.6%, 36.1%, 14.9% and 11.4%, respectively, of the PD
patients, which was significantly different from the control group, where blood type O was found in 29.1% and B in 23.2% (p<0.05). Our results showed that as compared with patients with blood group B, those with another blood type were more
likely to develop PD, among which type O had a significantly increased OR of 2.018 (CI, 1.271–3.205).
Conclusions: These are the first reported results showing that ABO blood type may be associated with risk of PD, though further investigations are needed
Scarless lymphatic venous anastomosis for latent and early-stage lymphoedema using indocyanine green lymphography and non-invasive instruments for visualising subcutaneous vein
No full textBackground: Lymphoedema can be treated conservatively or surgically. Early treatment is important, but the surgical indication and the effect of surgery on pain in lymphoedema-affected limbs have not been described. The objective of this study was to examine the effect of low-invasive scarless lymphatic venous anastomosis (LVA) for early or latent lymphoedema. Methods: LVA was performed in six patients (eight legs) with leg lymphoedema between April 2010 and March 2011. Lymphoedema was stage 0 (defined as subclinical) in three patients (five legs) and stage 1 in three patients (three legs). Subjective symptoms, circumference of the affected leg and a lymphoscintigram were evaluated before and 6 months after surgery. Preoperatively, subcutaneous lymph vessels and veins were identified non-invasively using ICG lymphoscintigraphy and non-invasive instruments for visualising subcutaneous vein, AccuVein system, through the skin. These vessels and veins were secured with vessel loops passed underneath and side-to-side anastomosed under a surgical microscope. Results: Subjective symptoms improved after surgery in all patients. The leg circumference improved in stage 1 cases, which all had an increased circumference before surgery. Lymph retention was observed on preoperative lymphoscintigraphy in all six patients and was improved after surgery in all cases. Conclusions: Scarless LVA performed through a small incision improves abnormal lymph circulation and subjective symptoms in cases of early lymphoedema, in which the limb circumference has just started to increase, and latent lymphoedema, in which the circumference has not increased, but abnormal findings on lymphoscintigraphy or subjective symptoms are present
Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species
No full textWe have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the up-regulation of MKP-1 by dexamethasone in endothelial cells. Knowledge of the molecular basis of this new alternative way of glucocorticoid action could facilitate the identification of new antiinflammatory drug targets. Thus, the aim of our study was to elucidate the underlying molecular mechanisms. Using Western blot analysis, we found that dexamethasone rapidly activates ERK, c-jun Nterminal kinase (JNK), and p38 MAPK in human umbilical vein endothelial cells. By applying the kinase inhibitors PD98059 (MAPK kinase-1) and SP600125 (JNK), ERK and JNK were shown to be crucial for the induction of MKP-1. Using EMSA and a decoy oligonucleotide approach, the transcription factors activator protein-1 (activated by ERK and JNK) and cAMP response element-binding protein (activated by ERK) were found to be involved in the up-regulation of MKP-1 by dexamethasone. Interestingly, dexamethasone induces the generation of reactive oxygen species (measured by dihydrofluorescein assay), which participate in the signaling process by triggering JNK activation. Our work elucidates a novel alternative mechanism for transducing antiinflammatory effects of glucocorticoids in the human endothelium. Thus, our study adds valuable information to the efforts made to find new antiinflammatory principles utilized by glucocorticoids. This might help to gain new therapeutic options to limit glucocorticoid side effects and to overcome resistance
Основные аспекты развития внешней экономической деятельности корпорации Мицуи с 2000 года
No full textДанная работа посвящена одному из самых влиятельных конгломератов, а именно Мицуи. Главным образом в работе ведется речь о Mitsui & Co., Ltd., занимающей ведущее положение среди всех филиалов, принадлежащих группе компаний Мицуи. Она участвует в общем управлении и организации всей деятельности, работает в сферах: добычи, переработки и производства железа и стали, минеральных и металлургических ресурсов, производства машин и создания инфраструктуры, разработки химических веществ, энергетики, инноваций и корпоративного развития. Компания ведет свой бизнес в 7 основных географических направлениях: Северная, Центральная и Южная Америка, Европа, Россия и страны СНГ, Африка, Центральная Азия и Ближний Восток, Восточная и Юго-Восточная Азия, Океания. Имея настолько крупную сферу влияния в мировой экономике, Мицуи явилась ключевым аспектом, которому посвящена диссертация.
Первая глава посвящена краткому историческому очерку. В ней описано становление компании Мицуи с середины XVII в. С того времени как Такатоси Сокубэй, не имея никакого представления о предпринимательской деятельности, рискнул и променял военное дело на торговое. Также описаны основные изменения в организации и структуре компании, вызванные различными историческими событиями того времени. Но в основном внимание уделено XX в.
Вторая глава посвящена развитию внешней экономической деятельности в сфере индустриальных проектов, а именно области металлургии, минеральных ресурсов, химии и энергоресурсов и сфере продовольствия.
Для лучшего понимания и изучения вопроса исторического становления Мицуи автор использует работы российских японоведов и литературу зарубежных авторов. Особое внимание автор уделяет работе Jay P Pederson. «International Directory of Company Histories, Vol. 28. Mitsui & Co., Ltd. History.».
В данной работе была предпринята попытка выявить особенности и характерные черты функционирования инвестиционной деятельности Mitsui&Co. с 2000-ого года, изложить ее основные аспекты развития и выделить основные географические направления, в которых она имеет определенную сферу влияния.This paper presents one of the most influential conglomerate, which name is Mitsui. It is mostly talked about Mitsui & Co., Ltd., which takes a leading place in the group of companies of Mitsui. It participates in the general management and the organization of all activity, works in next spheres: production, processing and production of iron and steel, mineral and metallurgical resources, production of cars and creation of infrastructure, development of chemicals, power, innovations and corporate development. The company makes the business in 7 main geographical directions: North, Central and South America, Europe, Russia and CIS countries, Africa, Central Asia and Middle East, East and Southeast Asia, Oceania. Having so large sphere of influence in world economy, Mitsui is the key aspect to which the thesis is devoted.
The first chapter is devoted to a short history of Mitsui house. The paper describes the formation of the company of Mitsui from the middle of the 17th century. Since that time when Takatoshi Sokubei had risked and exchanged military activity for trade without any idea of business. The main changes in the organization and structure of the company caused by various historical events of that time are also described. But generally the attention is paid 20th century.
The second chapter is devoted to the development of external economic activity in the sphere of industrial projects, namely the field of metallurgy, mineral resources, chemistry and energy resources and the sphere the food industry.
For the best understanding and studying of a question of historical formation of Mitsui the author uses works of the Russian Japanologists and literature of foreign authors. The author pays special attention to work of Jay P Pederson. "International Directory of Company Histories, Vol. 28. Mitsui & Co., Ltd. History."
In this paper it has been made an attempt to reveal features and characteristic features of functioning of investment activity of Mitsui&Co. from 2000th year to state its main aspects of development and to allocate the main geographical directions in which she has a certain sphere of influence
Before main banks : a selective historical overview of Japan's prewar financialsystem
No full textThe postwar experience of the Japanese banking system has received considerable attention recently partly because conditions in defeated Japan in 1945 (including high inflation and the need to switch from a military to a civilian economy) are similar to those in transition economies today. Policymakers in transition economies can learn a good deal from the experiences of Japan's postwar financial system but should remember that Japan also experienced extraordinary industrial growth and financial institution building in the late nineteenth and early twentieth centuries. Lessons to be learned from that experience include the following: Business conglomerates that did not continue to depend on government patronage were more successful than others in making the transition to a modern industrial economy. Banks that made a conscious effort to reduce their dependence on central bank credit were more successful than those that did not. The establishment of procedures for punishing defaulting borrowers helped the development of the payments system. Limits on the amount of lending to related parties appear to have contributed to financial stability (and could have contributed more if the newer"zaibatsu"had been as prudent as the older ones). Bank bailouts without accompanying reform (such as those the Bank of Japan undertook in 1920 and 1922) probably increased the likelihood of a more serious crisis, such as that of 1927. Capital standards - the minimum capital requirements established in the 1927 law - were a viable means of encouraging bank consolidation and more prudent lending. The public financial system served as a buffer when the banking sector was downsized.Banks&Banking Reform,Payment Systems&Infrastructure,Financial Intermediation,Financial Crisis Management&Restructuring,Decentralization,Financial Intermediation,Financial Crisis Management&Restructuring,Municipal Financial Management,Banking Law,Banks&Banking Reform
Granulating Processes. II. Apparent Specific Volume and Breaking Strength of Solid/Liquid Mixed System in Relation to the Filling Properties
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