154 research outputs found
Au(I)- and Pt(II)-N-heterocyclic carbene complexes with picoline functionalized benzimidazolin-2-ylidene ligands; synthesis, structures,electrochemistry and cytotoxicity studies
No full textNovel Au(I)-N-heterocyclic carbene complexes, 1-methyl-3-(2-pyridylmethyl)-
benzimidazolylidenegold(I)-chloride, 1; 1-benzyl-3-(2-pyridylmethyl)-
benzimidazolylidenegold(I)chloride, 2; and Pt(II)-N-heterocyclic carbene complexes 1-methyl-3-(2-
pyridylmethyl) benzimidazolylidene platinum(II)chloride, 3; and 1-benzyl-3-(2-pyridylmethyl)
benzimidazolylidene platinum-(II)chloride, 4, have been synthesized, based on CN-donor proligands
1-alkyl-3-(2-pyridylmeth-yl)-benzimidazoliumchloride L1 and L2 [alkyl, R = –CH3 = L1;
R = –CH2Ph = L2]. All the compounds have been synthesized and characterized by different
spectroscopic methods. The Au(I) complexes 1 and 2 have been synthesized by a silver carbene
transfer method. The solid-state structures of 1 and 3 have been determined by single crystal
X-ray diffraction studies. The square planar Pt(II) complexes 3 and 4 show a reversible
Pt(II)/Pt(IV) couple at 0.69 eV and 0.67 eV respectively. Among the complexes 1–4, complexes 1
and 3 have been used for cytotoxicity studies on the cell lines B16F10 (mouse melanoma), HepG2
(human hepatocarcinoma) and HeLa (human cervical carcinoma). IC50 values are compared with
cisplatin, among 1 and 3, the Au(I) complex 1 is more effective than Pt(II) complex 3
Cytotoxicity of silver(I), gold(I) and gold(III) complexes of a pyridine wingtip substituted annelated N-heterocyclic carbene
No full textStarting from the proligand 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium chloride (1 HCl), three novel complexes [Ag(1)Cl] (2), [Au(1)Cl] (3) and [Au(1)Cl3] (4) were synthesized and characterized using various spectroscopic techniques. In addition, the structure of 2 was elucidated using single crystal X-ray diffraction analysis, which revealed that the carbene nucleus and the chloride ion bound to the silver(I) were nearly linear (165.37(9)??). The gold(I)-NHC complex 3 was synthesized via transmetallation from the aforementioned silver complex 2. Similarly, treatment of 3 with Au(SMe2)Cl afforded 4, ostensibly via a disproportionation process. The cytotoxicities of complexes 2, 3, and 4 were examined against HepG2 (human hepatocellular carcinoma), HCT 116 (human colorectal carcinoma), A549 (human lung adenocarcinoma), and MCF-7 (human breast adenocarcinoma) cells. Au(I)-NHC complex 3 exhibited a cytotoxicity that was similar to that of cisplatin towards all the four cancer cell lines tested; by comparison, Ag(I) NHC complex 2 and Au(III) NHC complex 4 appeared relatively less potent. Complex 3 was found to induce apoptosis in HepG2 cells.close0
Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties
No full textA novel Au(III)−N-heterocyclic carbene organometallic
complex supported by two N-heterocyclic carbene (NHC)
ligands was synthesized from Au(SMe2)Cl and 1-methyl-2-pyridin-2- yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate via a Ag intermediate. X-ray crystallography revealed the first example of a square planar geometry adopted by a Au(III) species stabilized by two NHCs and two chloride ligands. The aforementioned Au(I)− and Au(III)−NHC complexes were found to be more potent than cisplatin against the HCT 116, HepG2, A549, and MCF7 cell lines
Pd(II)–N-heterocyclic carbene complexes of 2,6-bis{N-methyl-(imidazolium/benzimidazolium)}pyrazinechloride: Synthesis, structure, catalysis and theoretical studies
No full textThe multitopic pyrazine functionalized pro-ligand 2,6-bis(N-methylimidazolium)pyrazinedichloride, L-1; 2,6-bis(N-methylbenzimidazolium)pyrazinedichloride, L-2 and their respective Pd(II)–NHC complexes 1 and 2 have been synthesised and characterized by different spectroscopic methods and have been analyzed within a conceptual DFT framework. Single crystal X-ray structures of (L-1)PF6 and complex 1 have been determined. X-ray structure revels that 1 form a 12 member palladacycle. Both complex 1 and 2, catalyse the Suzuki coupling reaction very well and from experimental and theoretical findings it is concluded that complex 1 is slightly catalytically more active than 2
Pd(II)-N-heterocyclic carbene complexes of annelated ligand: Synthesis, characterization, and catalytic activity
No full textThe annelated imidazolium salt 1-methyl-2-(pyridin-2-yl)imidazo[1,5-a]pyridin-4-ylium hexaflurophosphate
(1HPF6) has been synthesized by via formylative cyclization of the corresponding Schiff base
2-acetylpyridyl-N-(2-pyridyl)methylamine using standard conditions followed by anion metathesis with
NH4PF6. Reaction of 1HPF6 with silver oxide and palladium chloride led to the formation of the palladium
complex [Pd(1)2Cl]PF6, 2. Subsequent reaction of 2 with AgPF6 gave the palladiumcomplex [Pd(1)2][PF6]2,
3. The complexes have been fully characterized by different spectroscopic techniques and finally the solid
state structures of 2 and 3 have been determined by single crystal X-ray diffraction studies. The catalytic
activities of 2 and 3 have been tested in the Suzuki–Miyaura coupling reactions of several activated parafunctionalized
aryl bromides with phenyl boronic acid to find that 2 is slightly more efficient than 3
Isoelectronic Pt(II)- and Au(III)-N-heterocyclic carbene complexes: a structural and biological comparison
No full textTo elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C boolean AND N)(C)Cl][PF6] (2) and [Au(C boolean AND N)(C)Cl][PF6](2) (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(III)-NHC complex is more potent than its Pt analogue
Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(iii)-complexes supported by a common N-heterocyclic carbene
No full textThe synthesis, structures and anticancer studies of a series of precious metal complexes supported by 1-methyl-2-(phenyl)imidazo[1,5-a]pyridine-2-ylidene (1) have been highlighted. The Ag(i) (2), Au(i) (3) and Au(iii) (4) complexes were prepared using standard methods and characterized by a range of techniques, including NMR spectroscopy, X-ray crystallography and elemental analyses. The in vitro cytotoxicity activities displayed by 2-4 were explored against human colon adenocarcinoma (HCT116), lung cancer (A549) and breast cancer (MCF7) cell lines. A series of assays showed that all of the complexes exhibited significant growth inhibition in the aforementioned cell lines. Inspection of the data collected revealed that the Au(i) and Ag(i) complexes were more potent than their Au(iii) congener, a trend that was found to be consistent with molecular docking studies that utilized BCL-2 as a model as this protein regulates cell death through apoptosis
STUDI LITERATUR ANALISIS PENERAPAN MODEL COOPERATIVE LEARNING DALAM PEMBELAJARAN PERMAINAN FUTSAL TERHADAP KEMAMPUAN PROBLEM SOLVING
No full textABSTRAK
Alviyan Dinda Kartika (1600089) Skripsi: Studi Literatur Analisis Penerapan Model Cooperative Learning dalam Pembelajaran Permainan Futsal terhadap Kemampuan Problem Solving. Skripsi ini dibimbing oleh Ibu Dr. Hj. Tite Juliantine, M,Pd dan Bapak Asep Sumpena, M.Pd Program Studi Pendidikan Jasmani Kesehatan dan Rekreasi, Fakultas Pendidikan Olahraga dan Kesehatan, Universitas Pendidikan Indonesia 2020.
Kemampuan memecahkan masalah (Problem Solving) pada siswa seringkali menjadi sebuah hal yang krusial dalam pembelajaran, untuk kembali mengasah kemampuan Problem Solving hendaknya seorang guru harus pandai dalam menggunakan model dan media pembelajaran yang tepat. Penerapan model cooperative learning merupakan model yang menitik beratkan pembelajaran yang berpusat pada siswa, model cooperative learning akan menempatkan siswa pada situasi harus bekerja sama untuk berfikir kritis dalam setiap permasalahan yang diberikan. Pendidikan jasmani tentunya tidak akan terlepas dari materi yang akan di ajarkan, materi pembelajaran permainan futsal merupakan salah satu materi yang cukup sistematis dalam menunjang model cooperative learning dalam menjadikan pembelajaran yang lebih efektif. penerapan Model cooperative learning dalam pembelajaran permainan futsal bisa digunakan bisa mengarahkan kepada situasi permasalahan yang sistematis untuk melihat kemampuan pemecahan masalah (Problem Solving) dengan meneliti melalui studi literatur menggunakan literatur dari sumber jurnal yang ditemukan dari situs jurnal internasional dan nasional, setelah menemukan jurnal yang mencakup dan sesuai kriteria inklusi dengan penelitian penulis, lalu dibuat sebuah matriks yang meliputi nama dan tahun penulis, hasil penelitian, dan hasil penting yang dapat dipakai penulis.setelah itu hasil dari studi literatur akan di analisis oleh penulis dan disesuaikan dengan indikator yang ada dalam kemampuan Problem Solving.
Kata Kunci : Cooperative Learning, Problem Solving, Pembelajaran Permainan Futsal.
ABSTRACT
Alviyan Dinda Kartika (1600089) Literature Study Analysis of Cooperative Learning Model Application in Learning Futsal Game on Problem Solving. Under the guidance of Hj. Tite Juliantine, M,Pd and Bapak Asep Sumpena, M.Pd Health and Recreation Physical Education Study Program, Faculty of Sports and Health Education, Indonesian University of Education, 2020.
The ability to solve problems (Problem Solving) on students is often a crucial thing in learning, to re-hone the ability of Problem Solving should a teacher must be clever in using the appropriate learning models and media. The application of the cooperative learning model is a model that emphasizes student-centered learning, the cooperative learning model will place students in situations that they have to work together to think critically in any given problem. Physical education certainly will not be separated from the material to be taught, futsal game learning material is one of the material that is quite systematic in supporting cooperative learning model in making learning for making effective. The application of cooperative learning model in futsal game learning can be used to lead to systematic problem situations to see the problem solving ability (Problem Solving) by researching through literature studies from journal sources found from international and national journal sites, after finding journals that are cover and relevant with the author's research, then a matrix is made which includes the name and year of the author, the results of the study, and important results that can be used by the author. After that, the results of the literature study will be analyzed by the author and adjusted to the indicators that exist in the ability of Problem Solving .
Keyword: Problem Solving, Cooperative Learning, Futsal game learnin
PERJUANGAN TOKOH UTAMA NOVEL FOREVER SUNSET KARYA STANLEY MEULEN SEBUAH KAJIAN PSIKOLOGI SASTRA
No full textThesis of Wahyu Azkaria, NIM 13010111140111, is entitled The Struggle of Main Leader in the Novel Forever Sunset by Stanley Meulen: The Study of Literary Psychology.
This research is a literature research entirely obtained from written sources. Novel Forever Sunset is closely related to the psychology of the main character. The author uses the foundation of the theory of literary psychology to find the personality and struggle of the main character in the novel Forever Sunset by Stanley Meulen, previously the author uses the structural theory as a forming element of literary works of characters and characterizations, and the flow and the background or setting in the story. The method used is data collection, data analysis, and presentation of data analysis results.
This research produces three elements of psychology, namely: 1) Persona is the public personality shown by Dinda and Zora, 2) Anima is Zora's personality that is feminine or has a female soul. Meanwhile, the Animus is a personality of Dinda that is masculine or has a male soul., 3) Shadow or shadow is an archive that reflects the animal instincts inherited by Zora and Dinda as reflected in the novel, and 4) Self is the concept of wholeness and unity of personality considered very important by Zora and Dinda. Meanwhile, the struggle that is seen from Dinda and Zora as the main character, is the existence of their struggle to get the meaning of true love value.
Keywords: Novel Forever Sunset, Literary Psychology, Struggle Key Leader
ANALISIS KESALAHAN SISWA DALAM MENYELESAIKAN SOAL CERITA BANGUN RUANG KELAS V SDN SLIPI 15 JAKARTA
No full textABSTRAK
ANALISIS KESALAHAN SISWA DALAM MENYELESAIKAN SOAL CERITA BANGUN RUANG KELAS V SDN SLIPI 15 JAKARTA
Dinda Pratiwi
Program Studi Pendidikan Guru Sekolah Dasar, Kampus Daerah Serang,
Universitas Pendidikan Indonesia
[email protected]
Abstrak
Penelitian ini dilatarbelakangi oleh rendahnya kemampuan siswa kelas VC SDN Slipi 15 Jakarta dalam memahami permasalahan dalam soal cerita. Kebanyakan siswa mengalami kesulitan dalam menyelesaikan soal cerita sehingga banyak ditemukan kesalahan dalam penyelesaiannya. Kesalahan-kesalahan pada penelitian ini akan dianalisis berdasarkan prosedur Newman. Prosedur itu terdiri dari 5 jenis kesalahan yaitu kesalahan membaca (reading errors), kesalahan memahami (comprehension errors), kesalahan transformasi (tansformation error), kesalahan keterampilan proses (process skill errors), dan terakhir yaitu kesalahan penulisan jawaban akhir (encoding errors). Adapun jenis pada penelitian ini adalah kualitatif deskriptif. Penelitian ini bertujuan untuk mendeskripsikan kesalahan siswa dalam menyelesaikan soal cerita bangun ruang materi volume kubus dan balok serta faktor penyebabnya. Subjek pada penelitian ini adalah 24 orang siswa kelas VC yang melakukan kesalahan menurut prosedur Newman. Instrumen yang digunakan dalam penelitian ini yaitu penulis sendiri dan dibantu oleh soal tes cerita berbentuk uraian sebanyak 3 soal, wawancara semi terstruktur, dan dokumentasi dalam bentuk foto dan rekaman wawancara. Hasil penelitian menunjukkan bahwa semua siswa kelas VC melakukan kesalahan sehingga sebanyak 24 orang siswa akan diwawancarai untuk mengetahui penyebabnya. Kesalahan yang terjadi adalah kesalahan membaca sebanyak 22,2%, kesalahan memahami sebanyak 55,5%, kesalahan transformasi sebanyak 50%, kesalahan keterampilan proses sebanyak 100%, dan kesalahan penulisan jawaban akhir sebanyak 100%. Faktor penyebabnya adalah faktor pribadi siswa, faktor penguasaan konsep, dan faktor kemampuan membaca dan menulis. Adapun solusi yang dapat dilakukan adalah dengan menerapkan pembiasaan strategi pemecahan masalah dengan menggunakan prosedur Newman, memberikan latihan-latihan soal cerita, dan bisa menerapkan suit perkalian untuk meningkatkan kemampuan berhitung siswa.
Kata kunci: Soal Cerita, Bangun Ruang, Prosedur Newman.
ABSTRACT
STUDENT ERROR ANALYSIS IN COMPLETING STORY QUESTIONS IN CLASS V SDN SLIPI 15 JAKARTA
Dinda Pratiwi
Elementary school education studies program, regional campus,
Indonesian university of education
[email protected]
Abstract
This research is motivated by the low ability of VC class students at SDN Slipi 15 Jakarta in understanding the problems in the story. Most students have difficulty in solving story problems so that many errors are found in solving them. The errors in this study will be analyzed based on the Newman procedure. The procedure consists of 5 types of errors, namely reading errors, comprehension errors, transformation errors, process skill errors, and finally, encoding errors. The type in this research is descriptive qualitative. This study aims to describe students' errors in solving story problems with the volume of cubes and blocks and the factors that cause them. The subjects in this study were 24 students of VC class who made mistakes according to Newman's procedure. The instrument used in this study is the author himself and assisted by story test questions in the form of a description of 3 questions, semi-structured interviews, and documentation in the form of photos and interview recordings. The results showed that all VC class students made mistakes so that as many as 24 students would be interviewed to find out the cause. The errors that occur are reading errors as much as 22.2%, understanding errors as much as 55.5%, transformation errors as much as 50%, processing skills errors as much as 100%, and writing errors in the final answer as much as 100%. The causative factor is the student's personal factor, the concept mastery factor, and the reading and writing ability factor. The solution that can be done is to apply habituation of problem solving strategies using the Newman procedure, provide story questions exercises, and can apply multiplication suits to improve students' numeracy skills.
Keywords: Story Questions, Build Space, Newman’s Procedur
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