206 research outputs found
Back to the future: Valentin Magnan, French psychiatry, and the classification of mental diseases, 1885-1925
No full textOne of the most curious gaps in the historiography of French psychiatry is the era between the fin de siecle and the 1920's, years that overlapped the life and career of Valentin Magnan (1835-1916), a pivotal figure in the historical classification of mental diseases. Magnan was in many ways a tragic figure, someone who lived and worked at a time when circumstances conspired against him and his efforts to reform psychiatric classification. Essentially Magnan had the misfortune to practice psychiatry when Emil Kraepelin's influence began to spread beyond Germany's borders, sparking a nationalist reaction that penalized both French Kraepelinians and Magnan, whose theories shared similarities with Kraepelin's. But Magnan's stature also suffered because of the intense internecine quarrels that arose in late-19th-century French psychiatry. Magnan was no helpless victim, though, and there is reason to believe that some of the criticism directed at him was based on documented personal failings. Ultimately, Magnan's theory of psychiatric classification was overtaken by these and other events in French psychiatry, culminating in the emergence of a new national nosological paradigm that has dominated French psychiatry for most of the 20th century. Magnan was in many respects a pariah within French psychiatry by the early 20th century. An examination of his career casts light on this crucial turning-point in the history of French psychiatry and indicates why and how the new model of classification was more to the tastes of his medical colleagues.Abstracter: JSource type: Electronic(1
The Gnostic Author of Harold Bloom
No full textČlanak isprva kontekstualizira pojavu tzv. authorship studies koje su nastale kao svojevrsna reakcija na poststrukturalističko (R. Barthes i M. Foucault) redefiniranje autorstva. U taj se kontekst zatim pozicionira Harold Bloom. On je, naime, iz uvjerenja da su poststrukturalističke antihumanističke tendencije pokrenule degenerativne procese, pa u konačnici i rastakanje književnosti u prvi plan svoje književne teorije postavio kanon i autora. Dok se o prvome znatno pisalo, drugo – pitanje autorstva – u studijama o Bloomu uglavnom je zanemareno. Stoga se u članku pozornost pridaje ponajprije Bloomovu tumačenju autora. Nastoji se pokazati da njegovo shvaćanje autorstva (kao, uostalom, i kanona) proizlazi iz gnostičke tradicije (Valentin i Lurija). Autor je za Blooma, zaključuje se, ponajprije genij – onaj koji stvara potaknut „iskrom“, pneumom, božanstvom u dnu vlastita uma, što je zapravo također stanoviti antihumanizam.The article contextualizes at first the occurrence of the so-called authorship studies that arose as a kind of reaction to the post-structuralist (R. Barthes and M. Foucault) redefinition
of authorship. Harold Bloom then positioned himself in this context. Namely, from the belief that post-structuralist anti-humanist tendencies initiated degenerative processes, and ultimately the disintegration of literature, he placed the canon and the author at the forefront of his literary theory. While much has been written about the first term, the second—the question of the authorship—has been mostly neglected in Bloom studies. Therefore, the article focuses primarily on Bloom’s interpretation of the author. The article tries to show that his understanding of authorship (as well as the canon, after all) derives from the Gnostic tradition (Valentin and Luria). For Bloom, the author is, it is concluded, primarily a genius—one who creates inspired by a “spark,” a pneuma, a divinity at the bottom of one’s own mind, which is actually also a certain form of anti-humanism
Intention-Aware Routing to Minimise Delays at Electric Vehicle Charging Stations
No full textEn-route charging stations allow electric vehicles to greatly extend their range. However, as a full charge takes a considerable amount of time, there may be significant waiting times at peak hours. To address this problem, we propose a novel navigation system, which communicates its intentions (i.e., routing policies) to other drivers. Using these intentions, our system accurately predicts congestion at charging stations and suggests the most efficient route to its user. We achieve this by extending existing time-dependent stochastic routing algorithms to include the battery's state of charge and charging stations. Furthermore, we describe a novel technique for combining historical information with agent intentions to predict the queues at charging stations. Through simulations we show that our system leads to a significant increase in utility compared to existing approaches that do not explicitly model waiting times or use intentions, in some cases reducing waiting times by over 80% and achieving near-optimal overall journey times.Software and Computer TechnologyElectrical Engineering, Mathematics and Computer Scienc
Composition operators and a pull-back measure formula
No full textA pull-back measure formula obtained in some particular cases by E. A. Nordgren and this author is generalized in the framework of boundary measures for zero-free Nevanlinna class fuctions on the unit polydisk. The formula is used to characterize the zero-free Nevanlinna class functions which are solutions of Schröder\u27s equation induced by a polydisk automorphism ϕ (i.e. to determine the zero-free functionsf belonging to the Nevanlinna class which are solutions of the functional equationf ° π=λf, for some constant λ), thus generalizing earlier results obtained by R. Mortini and this author
2006 Author Recognition Bibliography
No full texthttps://scholarworks.gvsu.edu/authorrecognition/1008/thumbnail.jp
Acceptance conditions in automated negotiation
No full textIn every negotiation with a deadline, one of the negotiating parties has to accept an offer to avoid a break off. A break off is usually an undesirable outcome for both parties, therefore it is important that a negotiator employs a proficient mechanism to decide under which conditions to accept. When designing such conditions one is faced with the acceptance dilemma: accepting the current offer may be suboptimal, as better offers may still be presented. On the other hand, accepting too late may prevent an agreement from being reached, resulting in a break off with no gain for either party. Motivated by the challenges of bilateral negotiations between automated agents and by the results and insights of the automated negotiating agents competition (ANAC), we classify and compare state-of-the-art generic acceptance conditions. We focus on decoupled acceptance conditions, i.e. conditions that do not depend on the bidding strategy that is used. We performed extensive experiments to compare the performance of acceptance conditions in combination with a broad range of bidding strategies and negotiation domains. Furthermore we propose new acceptance conditions and we demonstrate that they outperform the other conditions that we study. In particular, it is shown that they outperform the standard acceptance condition of comparing the current offer with the offer the agent is ready to send out. We also provide insight in to why some conditions work better than others and investigate correlations between the properties of the negotiation environment and the efficacy of acceptance conditions.MediamaticsElectrical Engineering, Mathematics and Computer Scienc
Habitat area and local habitat conditions outweigh fragmentation effects on insect communities in vineyards
No full textData and R scripts for the paper Bosco et al. 2022, "Habitat area and local habitat conditions outweigh fragmentation effects on insect communities in vineyards"
Data: 3 different insect groups (ground beetles=GB, leafhoppers=LH, wild bees=WB) with each 2 csv files:
- SXY file containing the study design information (S), environmental predictors (X) and species abundance data (Y)
- the TP file containing the trait information (different traits per group)
R scripts: 4 different scripts going through the data reading, cleaning, modeling specification, modeling, and model assessment process (R scripts from O. Ovaskainen, M. Jones, O. Opedal)
For more information please contact the corresponding author of the paper: Laura Bosc
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.
No full textMalaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality control in 227 samples from Africa, Asia and Oceania provides genome-wide estimates of allele frequency distribution, population structure and linkage disequilibrium. By comparing the genetic diversity of individual infections with that of the local parasite population, we derive a metric of within-host diversity that is related to the level of inbreeding in the population. An open-access web application has been established for the exploration of regional differences in allele frequency and of highly differentiated loci in the P. falciparum genome
The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans
No full textOpen Access via PMC2649417Peer reviewe
Charge control of biomolecules by photocleavage in high vacuum
No full textThis thesis summarizes the work performed from March 2020 – April 2024 as part of a collaboration between the Köhler group (University of Basel), Marcel Mayor (University of Basel) and the Arndt group (University of Vienna). The author YH designed experiments in collaboration with the Arndt group and performed synthesis of photocleavable tags and bioconjugation at the University of Basel. The gas-phase cleavage experiments were carried out by the collaborating group of Markus Arndt at the University of Vienna.
Different photocleavable tags, which can be cleaved under different wavelengths, were designed and synthesized. The optimized tags were then attached to a series of biomolecules. Charged particles can be generated by ESI/MALDI, after which positive/negative charges can be removed by photo-induced cleavage with a laser to achieve neutralization.
In chapter 1, a BODIPY-based photocleavable tag was designed and synthesized for the application with 532 nm laser under positive mode.
In chapter 2, redesigned Ru(II) complexes were investigated for the application with 355 nm laser under positive mode.
In chapter 3, a new photocleavage mechanism of Ru(II) complexes under concomitant electron transfer was explored.
In chapter 4, two generations of rotaxanes stoppered with a Ru(II)-photocage were explored for the removal of multiple charges with a single bond cleavage.
In chapter 5, a nitrodibenzofuran-based photocleavable tag was investigated for the application with 355 nm laser under negative mode.
In parallel, new bioconjugation methods were developed for the attachment of photocleavable tags in chapter 6
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